Yuri Pritykin
Assistant Professor, Computer Science and the Lewis-Sigler Institute for Integrative Genomics

Areas of Research: Computational biology, functional genomics, single-cell technologies, immunology
  • Computer Science and the Lewis-Sigler Institute for Integrative Genomics

Research Lab
245 Carl Icahn Lab

Faculty Assistant:
Lee Morgan

We use applied statistics, machine learning and efficient algorithms to address fundamental problems in biology and medicine. We develop computational methods for better design and integrative analysis of high-throughput functional genomic assays and perturbation experiments, with a focus on multi-modal single-cell technologies. We apply these methods to study regulatory genomics of cell function and cell-cell interactions *in vivo* in close collaboration with experimental biologists, with a focus on immunology and cancer.

Selected publications

Yuri Pritykin*, Joris van der Veeken*, Allison Pine, Yi Zhong, Merve Sahin, Linas Mazutis, Dana Pe’er, Alexander Rudensky, Christina Leslie (2020). A unified atlas of CD8 T cell dysfunctional states in cancer and infection. bioRxiv. https://doi.org/10.1101/2020.07.25.220673

Xiaoyi Li*, Yuri Pritykin*, Carla P Concepcion*, Yuheng Lu, Gaspare La Rocca, Minsi Zhang, Bryan King, Peter J Cook, Yu Wah Au, Olesja Popow, Joao A.Paulo, Hannah G Otis, Chiara Mastroleo, Paul Ogrodowski, Ryan Schreiner, Kevin M Haigis, Doron Betel, Christina S Leslie, Andrea Ventura (2020). High-Resolution in vivo identification of miRNA targets by Halo-enhanced Ago2 pull-down. Molecular Cell. https://doi.org/10.1016/j.molcel.2020.05.009

Chrysothemis C Brown, Herman Gudjonson, Yuri Pritykin, Deeksha Deep, Vincent-Philippe Lavallée, Alejandra Mendoza, Rachel Fromme, Linas Mazutis, Charlotte Ariyan, Christina Leslie, Dana Pe’er, Alexander Y Rudensky (2019). Transcriptional basis of mouse and human dendritic cell heterogeneity. Cell. https://doi.org/10.1016/j.cell.2019.09.035

Catherine Konopacki*, Yuri Pritykin*, Yury Rubtsov, Christina S. Leslie, Alexander Y. Rudensky (2019). Transcription factor Foxp1 regulates Foxp3 chromatin binding and coordinates regulatory T cell function. Nature Immunology. https://doi.org/10.1038/s41590-018-0291-z

Alexendar R Perez*, Yuri Pritykin*, Joana A Vidigal*, Sagar Chhangawala, Lee Zamparo, Christina S Leslie, Andrea Ventura (2017). GuideScan software for improved single and paired CRISPR guide RNA design. Nature Biotechnology. https://doi.org/10.1038/nbt.3804

* equal contribution