On the utility of short intron sequences as a reference for the detection of positive and negative selection in Drosophila.

Title	On the utility of short intron sequences as a reference for the detection of positive and negative selection in Drosophila.
Publication Type	Journal Article
Year of Publication	2010
Authors	Parsch, J, Novozhilov, S, Saminadin-Peter, SS, Wong, KM, Andolfatto, P
Journal	Mol Biol Evol
Volume	27
Issue	6
Pagination	1226-34
Date Published	2010 Jun
Keywords	Animals, Databases, Genetic, Drosophila, Evolution, Molecular, Genetic Linkage, Genetics, Population, INDEL Mutation, Introns, Polymorphism, Genetic, Selection, Genetic, Statistics, Nonparametric
Abstract	The detection of selection, both positive and negative, acting on a DNA sequence or class of nucleotide sites requires comparison with a reference sequence that is unaffected by selection. In Drosophila, recent findings of widespread selective constraint, as well as adaptive evolution, in both coding and noncoding regions highlight the difficulties in choosing such a reference sequence. Here, we investigate the utility of short intron sequences as a reference for the detection of selection. For a set of 119 Drosophila melanogaster genes containing 195 short introns (
Alternate Journal	Mol. Biol. Evol.