TitleTime and length scales of autocrine signals in three dimensions.
Publication TypeJournal Article
Year of Publication2007
AuthorsCoppey, M, Berezhkovskii, AM, Sealfon, SC, Shvartsman, SY
JournalBiophys J
Volume93
Issue6
Pagination1917-22
Date Published2007 Sep 15
KeywordsAutocrine Communication, Biophysical Phenomena, Biophysics, Cells, Cultured, Dendritic Cells, Interferons, Ligands, Models, Biological, Paracrine Communication
Abstract

A model of autocrine signaling in cultures of suspended cells is developed on the basis of the effective medium approximation. The fraction of autocrine ligands, the mean and distribution of distances traveled by paracrine ligands before binding, as well as the mean and distribution of the ligand lifetime are derived. Interferon signaling by dendritic immune cells is considered as an illustration.
Alternate JournalBiophys. J.