The mission of the Center for Quantitative Biology was to discover on a systems level how biological molecules interact and respond to their environment using advanced computational methods. The Center for Quantitative Biology at Princeton University's Lewis-Sigler Institute was established in August 2004 by NIH grant P50 GM071508 from the National Institute of General Medical Sciences (NIGMS), one of the National Institutes of Health (NIH). The Lewis-Sigler Institute served as the center's hub, with this website providing links to resources and publications associated with the Center. Additional information can be found at the National Centers for Systems Biology portal. The Princeton Center was headed by David Botstein, Principal Investigator, from 2004-2014, until the 10 year mandatory sunset on the program. The mission of the Center was to discover on a systems level how biological molecules interact and respond to their environment using advanced computational methods. The Center grant supported research programs in system-level biology and a broad array of infrastructure. Thanks in part to Center funds, we now have at Princeton fully functional core facilities that provide state-of-the-art research technologies in computation, HTP-sequencing, mass spectrometry, and imaging. All data, tools, and resources that emerged from the Center are freely and publicly available.