Explore research across seven disciplines.

Now in its third decade, the LSI is building upon its strong nucleus of a thoroughly modern institute for genomics and systems biology, with its combination of high-throughput technologies, advanced computational analytics, and quantitative modeling, to expand into a wide range of areas including mammalian systems biology, human evolution and population genomics, and the temporal dynamics and quantitative characterization and visualization of conserved cellular processes.

  • Performing quantitative experimentation and developing sophisticated theoretical analyses to model biological systems.

  • Developing novel computational methods for analyzing genomes.

  • Determining how genetic variation leads to evolutionary change and the frequency and distribution of genetic variants in a population.

  • Developing novel experimental methods and approaches that allow large-scale analysis of genes, regulatory regions, transcripts, and proteins in both bulk samples and single cells. 

  • Discovering genetic connections between complex traits and large-scale genomics data through statistical methods.

  • Applying modern experimental, computational, and mathematical methods to develop models and better understanding of the development and aging processes.

  • Developing and applying cutting-edge metabolomics and proteomics methods to better understand complex biological systems.