List of Faculty Publications

Below is a list of Faculty publications imported from PubMed or manually added. By default, publications are sorted by year with titles displayed in ascending alphabetical order.
Shortcuts: Wühr, Martin | Wingreen, Ned | Wieschaus, Eric | Troyanskaya, Olga | Tilghman, Shirley | Storey, John | Singh, Mona | Shvartsman, Stanislav | Shaevitz, Joshua | Rabinowitz, Joshua | Murphy, Coleen | Levine, Michael {Levine, Michael S.} | Gregor, Thomas | Botstein, David | Bialek, William | Ayroles, Julien | Andolfatto, Peter | Akey, Joshua

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 
Bacterial Proteins
D. E. Coulter and Wieschaus, E., Gene activities and segmental patterning in Drosophila: analysis of odd-skipped and pair-rule double mutants., Genes Dev, vol. 2, no. 12B, pp. 1812-23, 1988.
T. Mora, Yu, H., Sowa, Y., and Wingreen, N. S., Steps in the bacterial flagellar motor., PLoS Comput Biol, vol. 5, no. 10, p. e1000540, 2009.
S. Wang, Furchtgott, L., Huang, K. Casey, and Shaevitz, J. W., Helical insertion of peptidoglycan produces chiral ordering of the bacterial cell wall., Proc Natl Acad Sci U S A, vol. 109, no. 10, pp. E595-604, 2012.
A. Vincent, Blankenship, J. T., and Wieschaus, E., Integration of the head and trunk segmentation systems controls cephalic furrow formation in Drosophila., Development, vol. 124, no. 19, pp. 3747-54, 1997.
E. J. Banigan, Gelbart, M. A., Gitai, Z., Wingreen, N. S., and Liu, A. J., Filament depolymerization can explain chromosome pulling during bacterial mitosis., PLoS Comput Biol, vol. 7, no. 9, p. e1002145, 2011.
K. Casey Huang and Wingreen, N. S., Min-protein oscillations in round bacteria., Phys Biol, vol. 1, no. 3-4, pp. 229-35, 2004.
S. van Teeffelen, Shaevitz, J. W., and Gitai, Z., Image analysis in fluorescence microscopy: bacterial dynamics as a case study., Bioessays, vol. 34, no. 5, pp. 427-36, 2012.
T. Mora, Bai, F., Che, Y. - S., Minamino, T., Namba, K., and Wingreen, N. S., Non-genetic individuality in Escherichia coli motor switching., Phys Biol, vol. 8, no. 2, p. 024001, 2011.
D. Greenfield, McEvoy, A. L., Shroff, H., Crooks, G. E., Wingreen, N. S., Betzig, E., and Liphardt, J., Self-organization of the Escherichia coli chemotaxis network imaged with super-resolution light microscopy., PLoS Biol, vol. 7, no. 6, p. e1000137, 2009.
K. C. Tu, Long, T., Svenningsen, S. L., Wingreen, N. S., and Bassler, B. L., Negative feedback loops involving small regulatory RNAs precisely control the Vibrio harveyi quorum-sensing response., Mol Cell, vol. 37, no. 4, pp. 567-79, 2010.
Z. Khan, Amini, S., Bloom, J. S., Ruse, C., Caudy, A. A., Kruglyak, L., Singh, M., Perlman, D. H., and Tavazoie, S., Accurate proteome-wide protein quantification from high-resolution 15N mass spectra., Genome Biol, vol. 12, no. 12, p. R122, 2011.
S. Wang and Wingreen, N. S., Cell shape can mediate the spatial organization of the bacterial cytoskeleton., Biophys J, vol. 104, no. 3, pp. 541-52, 2013.
C. N. Peterson, Levchenko, I., Rabinowitz, J. D., Baker, T. A., and Silhavy, T. J., RpoS proteolysis is controlled directly by ATP levels in Escherichia coli., Genes Dev, vol. 26, no. 6, pp. 548-53, 2012.
A. J. Pompeani, Irgon, J. J., Berger, M. F., Bulyk, M. L., Wingreen, N. S., and Bassler, B. L., The Vibrio harveyi master quorum-sensing regulator, LuxR, a TetR-type protein is both an activator and a repressor: DNA recognition and binding specificity at target promoters., Mol Microbiol, vol. 70, no. 1, pp. 76-88, 2008.
R. G. Endres, Falke, J. J., and Wingreen, N. S., Chemotaxis receptor complexes: from signaling to assembly., PLoS Comput Biol, vol. 3, no. 7, p. e150, 2007.
R. G. Endres, Oleksiuk, O., Hansen, C. H., Meir, Y., Sourjik, V., and Wingreen, N. S., Variable sizes of Escherichia coli chemoreceptor signaling teams., Mol Syst Biol, vol. 4, p. 211, 2008.
S. - W. Teng, Schaffer, J. N., Tu, K. C., Mehta, P., Lu, W., Ong, N. P., Bassler, B. L., and Wingreen, N. S., Active regulation of receptor ratios controls integration of quorum-sensing signals in Vibrio harveyi., Mol Syst Biol, vol. 7, p. 491, 2011.
L. R. Swem, Swem, D. L., Wingreen, N. S., and Bassler, B. L., Deducing receptor signaling parameters from in vivo analysis: LuxN/AI-1 quorum sensing in Vibrio harveyi., Cell, vol. 134, no. 3, pp. 461-73, 2008.
S. Neumann, Hansen, C. H., Wingreen, N. S., and Sourjik, V., Differences in signalling by directly and indirectly binding ligands in bacterial chemotaxis., EMBO J, vol. 29, no. 20, pp. 3484-95, 2010.
C. P. Broedersz, Wang, X., Meir, Y., Loparo, J. J., Rudner, D. Z., and Wingreen, N. S., Condensation and localization of the partitioning protein ParB on the bacterial chromosome., Proc Natl Acad Sci U S A, vol. 111, no. 24, pp. 8809-14, 2014.
W. - L. Ng, Wei, Y., Perez, L. J., Cong, J., Long, T., Koch, M., Semmelhack, M. F., Wingreen, N. S., and Bassler, B. L., Probing bacterial transmembrane histidine kinase receptor-ligand interactions with natural and synthetic molecules., Proc Natl Acad Sci U S A, vol. 107, no. 12, pp. 5575-80, 2010.
C. H. Hansen, Endres, R. G., and Wingreen, N. S., Chemotaxis in Escherichia coli: a molecular model for robust precise adaptation., PLoS Comput Biol, vol. 4, no. 1, p. e1, 2008.
J. Yuan and Rabinowitz, J. D., Differentiating metabolites formed from de novo synthesis versus macromolecule decomposition., J Am Chem Soc, vol. 129, no. 30, pp. 9294-5, 2007.
A. R. Ureta, Endres, R. G., Wingreen, N. S., and Silhavy, T. J., Kinetic analysis of the assembly of the outer membrane protein LamB in Escherichia coli mutants each lacking a secretion or targeting factor in a different cellular compartment., J Bacteriol, vol. 189, no. 2, pp. 446-54, 2007.
Y. Meir, Jakovljevic, V., Oleksiuk, O., Sourjik, V., and Wingreen, N. S., Precision and kinetics of adaptation in bacterial chemotaxis., Biophys J, vol. 99, no. 9, pp. 2766-74, 2010.
T. Long, Tu, K. C., Wang, Y., Mehta, P., Ong, N. P., Bassler, B. L., and Wingreen, N. S., Quantifying the integration of quorum-sensing signals with single-cell resolution., PLoS Biol, vol. 7, no. 3, p. e68, 2009.
R. G. Endres and Wingreen, N. S., Precise adaptation in bacterial chemotaxis through "assistance neighborhoods"., Proc Natl Acad Sci U S A, vol. 103, no. 35, pp. 13040-4, 2006.
T. Mignot and Shaevitz, J. W., Active and passive mechanisms of intracellular transport and localization in bacteria., Curr Opin Microbiol, vol. 11, no. 6, pp. 580-5, 2008.
T. M. Bartlett, Bratton, B. P., Duvshani, A., Miguel, A., Sheng, Y., Martin, N. R., Nguyen, J. P., Persat, A., Desmarais, S. M., VanNieuwenhze, M. S., Huang, K. Casey, Zhu, J., Shaevitz, J. W., and Gitai, Z., A Periplasmic Polymer Curves Vibrio cholerae and Promotes Pathogenesis., Cell, vol. 168, no. 1-2, pp. 172-185.e15, 2017.
C. M. Waters, Lu, W., Rabinowitz, J. D., and Bassler, B. L., Quorum sensing controls biofilm formation in Vibrio cholerae through modulation of cyclic di-GMP levels and repression of vpsT., J Bacteriol, vol. 190, no. 7, pp. 2527-36, 2008.
E. Emberly and Wingreen, N. S., Hourglass model for a protein-based circadian oscillator., Phys Rev Lett, vol. 96, no. 3, p. 038303, 2006.
K. Jim, Parmar, K., Singh, M., and Tavazoie, S., A cross-genomic approach for systematic mapping of phenotypic traits to genes., Genome Res, vol. 14, no. 1, pp. 109-15, 2004.
Bacteriophage lambda
D. Botstein, Ira Herskowitz: 1946-2003., Genetics, vol. 166, no. 2, pp. 653-60, 2004.
Base Sequence
H. Yoo-Warren, Pachnis, V., Ingram, R. S., and Tilghman, S. M., Two regulatory domains flank the mouse H19 gene., Mol Cell Biol, vol. 8, no. 11, pp. 4707-15, 1988.
M. H. Feuerman, Godbout, R., Ingram, R. S., and Tilghman, S. M., Tissue-specific transcription of the mouse alpha-fetoprotein gene promoter is dependent on HNF-1., Mol Cell Biol, vol. 9, no. 10, pp. 4204-12, 1989.
D. Papatsenko, Kislyuk, A., Levine, M., and Dubchak, I., Conservation patterns in different functional sequence categories of divergent Drosophila species., Genomics, vol. 88, no. 4, pp. 431-42, 2006.
P. B. Vrana, Guan, X. J., Ingram, R. S., and Tilghman, S. M., Genomic imprinting is disrupted in interspecific Peromyscus hybrids., Nat Genet, vol. 20, no. 4, pp. 362-5, 1998.
W. Wang, J Cherry, M., Nochomovitz, Y., Jolly, E., Botstein, D., and Li, H., Inference of combinatorial regulation in yeast transcriptional networks: a case study of sporulation., Proc Natl Acad Sci U S A, vol. 102, no. 6, pp. 1998-2003, 2005.
D. Garrigan, Kingan, S. B., Geneva, A. J., Andolfatto, P., Clark, A. G., Thornton, K. R., and Presgraves, D. C., Genome sequencing reveals complex speciation in the Drosophila simulans clade., Genome Res, vol. 22, no. 8, pp. 1499-511, 2012.
J. M. Rossi, Burke, D. T., Leung, J. C., Koos, D. S., Chen, H., and Tilghman, S. M., Genomic analysis using a yeast artificial chromosome library with mouse DNA inserts., Proc Natl Acad Sci U S A, vol. 89, no. 6, pp. 2456-60, 1992.
Z. Khan, Bloom, J. S., Kruglyak, L., and Singh, M., A practical algorithm for finding maximal exact matches in large sequence datasets using sparse suffix arrays., Bioinformatics, vol. 25, no. 13, pp. 1609-16, 2009.
B. Davidson and Levine, M., Evolutionary origins of the vertebrate heart: Specification of the cardiac lineage in Ciona intestinalis., Proc Natl Acad Sci U S A, vol. 100, no. 20, pp. 11469-73, 2003.
A. Bejsovec and Wieschaus, E., Signaling activities of the Drosophila wingless gene are separately mutable and appear to be transduced at the cell surface., Genetics, vol. 139, no. 1, pp. 309-20, 1995.
K. C. Tu, Long, T., Svenningsen, S. L., Wingreen, N. S., and Bassler, B. L., Negative feedback loops involving small regulatory RNAs precisely control the Vibrio harveyi quorum-sensing response., Mol Cell, vol. 37, no. 4, pp. 567-79, 2010.
S. E. Cole, Levorse, J. M., Tilghman, S. M., and Vogt, T. F., Clock regulatory elements control cyclic expression of Lunatic fringe during somitogenesis., Dev Cell, vol. 3, no. 1, pp. 75-84, 2002.
L. L. Sandell, Guan, X. - J., Ingram, R., and Tilghman, S. M., Gatm, a creatine synthesis enzyme, is imprinted in mouse placenta., Proc Natl Acad Sci U S A, vol. 100, no. 8, pp. 4622-7, 2003.
V. Pachnis, Brannan, C. I., and Tilghman, S. M., The structure and expression of a novel gene activated in early mouse embryogenesis., EMBO J, vol. 7, no. 3, pp. 673-81, 1988.
E. K. Farley, Olson, K. M., Zhang, W., Brandt, A. J., Rokhsar, D. S., and Levine, M. S., Suboptimization of developmental enhancers., Science, vol. 350, no. 6258, pp. 325-8, 2015.
D. E. Coulter, Swaykus, E. A., Beran-Koehn, M. A., Goldberg, D., Wieschaus, E., and Schedl, P., Molecular analysis of odd-skipped, a zinc finger encoding segmentation gene with a novel pair-rule expression pattern., EMBO J, vol. 9, no. 11, pp. 3795-804, 1990.
J. A. Emerson, Vacher, J., Cirillo, L. A., Tilghman, S. M., and Tyner, A. L., The zonal expression of alpha-fetoprotein transgenes in the livers of adult mice., Dev Dyn, vol. 195, no. 1, pp. 55-66, 1992.
M. Peifer and Wieschaus, E., The product of the Drosophila melanogaster segment polarity gene armadillo is highly conserved in sequence and expression in the housefly Musca domestica., J Mol Evol, vol. 36, no. 3, pp. 224-33, 1993.
M. A. Cleary, van Raamsdonk, C. D., Levorse, J., Zheng, B., Bradley, A., and Tilghman, S. M., Disruption of an imprinted gene cluster by a targeted chromosomal translocation in mice., Nat Genet, vol. 29, no. 1, pp. 78-82, 2001.
D. Papatsenko, Goltsev, Y., and Levine, M., Organization of developmental enhancers in the Drosophila embryo., Nucleic Acids Res, vol. 37, no. 17, pp. 5665-77, 2009.
A. B. Bowman, Levorse, J. M., Ingram, R. S., and Tilghman, S. M., Functional characterization of a testis-specific DNA binding activity at the H19/Igf2 imprinting control region., Mol Cell Biol, vol. 23, no. 22, pp. 8345-51, 2003.
D. L. Metallinos, Oppenheimer, A. J., Rinchik, E. M., Russell, L. B., Dietrich, W., and Tilghman, S. M., Fine structure mapping and deletion analysis of the murine piebald locus., Genetics, vol. 136, no. 1, pp. 217-23, 1994.
C. D. van Raamsdonk and Tilghman, S. M., Dosage requirement and allelic expression of PAX6 during lens placode formation., Development, vol. 127, no. 24, pp. 5439-48, 2000.
X. J. Guan, Arhin, G., Leung, J., and Tilghman, S. M., Linkage between vitamin D-binding protein and alpha-fetoprotein in the mouse., Mamm Genome, vol. 7, no. 2, pp. 103-6, 1996.
J. A. Capra, Paeschke, K., Singh, M., and Zakian, V. A., G-quadruplex DNA sequences are evolutionarily conserved and associated with distinct genomic features in Saccharomyces cerevisiae., PLoS Comput Biol, vol. 6, no. 7, p. e1000861, 2010.
S. M. Tilghman, Lessons learned, promises kept: a biologist's eye view of the Genome Project., Genome Res, vol. 6, no. 9, pp. 773-80, 1996.
D. A. Hendrix, Hong, J. - W., Zeitlinger, J., Rokhsar, D. S., and Levine, M. S., Promoter elements associated with RNA Pol II stalling in the Drosophila embryo., Proc Natl Acad Sci U S A, vol. 105, no. 22, pp. 7762-7, 2008.
J. Vacher, Camper, S. A., Krumlauf, R., Compton, R. S., and Tilghman, S. M., raf regulates the postnatal repression of the mouse alpha-fetoprotein gene at the posttranscriptional level., Mol Cell Biol, vol. 12, no. 2, pp. 856-64, 1992.
J. A. Zallen, Cohen, Y., Hudson, A. M., Cooley, L., Wieschaus, E., and Schejter, E. D., SCAR is a primary regulator of Arp2/3-dependent morphological events in Drosophila., J Cell Biol, vol. 156, no. 4, pp. 689-701, 2002.
D. N. Keys, Levine, M., Harland, R. M., and Wallingford, J. B., Control of intercalation is cell-autonomous in the notochord of Ciona intestinalis., Dev Biol, vol. 246, no. 2, pp. 329-40, 2002.
P. R. Haddrill, Thornton, K. R., Charlesworth, B., and Andolfatto, P., Multilocus patterns of nucleotide variability and the demographic and selection history of Drosophila melanogaster populations., Genome Res, vol. 15, no. 6, pp. 790-9, 2005.
A. Pane, Jiang, P., Zhao, D. Yanling, Singh, M., and Schüpbach, T., The Cutoff protein regulates piRNA cluster expression and piRNA production in the Drosophila germline., EMBO J, vol. 30, no. 22, pp. 4601-15, 2011.
J. F. Ayroles, Carbone, M. Anna, Stone, E. A., Jordan, K. W., Lyman, R. F., Magwire, M. M., Rollmann, S. M., Duncan, L. H., Lawrence, F., Anholt, R. R. H., and Mackay, T. F. C., Systems genetics of complex traits in Drosophila melanogaster., Nat Genet, vol. 41, no. 3, pp. 299-307, 2009.
C. Rauskolb, Peifer, M., and Wieschaus, E., extradenticle, a regulator of homeotic gene activity, is a homolog of the homeobox-containing human proto-oncogene pbx1., Cell, vol. 74, no. 6, pp. 1101-12, 1993.
C. Cao, Lemaire, L. A., Wang, W., Yoon, P. H., Choi, Y. A., Parsons, L. R., Matese, J. C., Wang, W., Levine, M., and Chen, K., Comprehensive single-cell transcriptome lineages of a proto-vertebrate., Nature, vol. 571, no. 7765, pp. 349-354, 2019.
L. Christiaen, Stolfi, A., Davidson, B., and Levine, M., Spatio-temporal intersection of Lhx3 and Tbx6 defines the cardiac field through synergistic activation of Mesp., Dev Biol, vol. 328, no. 2, pp. 552-60, 2009.
Y. Kim, Iagovitina, A., Ishihara, K., Fitzgerald, K. M., Deplancke, B., Papatsenko, D., and Shvartsman, S. Y., Context-dependent transcriptional interpretation of mitogen activated protein kinase signaling in the Drosophila embryo., Chaos, vol. 23, no. 2, p. 025105, 2013.
T. Mora, Walczak, A. M., Bialek, W., and Callan, C. G., Maximum entropy models for antibody diversity., Proc Natl Acad Sci U S A, vol. 107, no. 12, pp. 5405-10, 2010.
T. P. O'Brien, Metallinos, D. L., Chen, H., Shin, M. K., and Tilghman, S. M., Complementation mapping of skeletal and central nervous system abnormalities in mice of the piebald deletion complex., Genetics, vol. 143, no. 1, pp. 447-61, 1996.
D. G. Fisk, Ball, C. A., Dolinski, K., Engel, S. R., Hong, E. L., Issel-Tarver, L., Schwartz, K., Sethuraman, A., Botstein, D., and J Cherry, M., Saccharomyces cerevisiae S288C genome annotation: a working hypothesis., Yeast, vol. 23, no. 12, pp. 857-65, 2006.
A. S. Putnam, J Scriber, M., and Andolfatto, P., Discordant divergence times among Z-chromosome regions between two ecologically distinct swallowtail butterfly species., Evolution, vol. 61, no. 4, pp. 912-27, 2007.
M. Lagha, Bothma, J. P., Esposito, E., Ng, S., Stefanik, L., Tsui, C., Johnston, J., Chen, K., Gilmour, D. S., Zeitlinger, J., and Levine, M. S., Paused Pol II coordinates tissue morphogenesis in the Drosophila embryo., Cell, vol. 153, no. 5, pp. 976-87, 2013.
O. G. Troyanskaya, Arbell, O., Koren, Y., Landau, G. M., and Bolshoy, A., Sequence complexity profiles of prokaryotic genomic sequences: a fast algorithm for calculating linguistic complexity., Bioinformatics, vol. 18, no. 5, pp. 679-88, 2002.
L. J. Kurihara, Semenova, E., Levorse, J. M., and Tilghman, S. M., Expression and functional analysis of Uch-L3 during mouse development., Mol Cell Biol, vol. 20, no. 7, pp. 2498-504, 2000.
M. Markstein, Markstein, P., Markstein, V., and Levine, M. S., Genome-wide analysis of clustered Dorsal binding sites identifies putative target genes in the Drosophila embryo., Proc Natl Acad Sci U S A, vol. 99, no. 2, pp. 763-8, 2002.
K. Thornton, Bachtrog, D., and Andolfatto, P., X chromosomes and autosomes evolve at similar rates in Drosophila: no evidence for faster-X protein evolution., Genome Res, vol. 16, no. 4, pp. 498-504, 2006.
A. V. Persikov, Osada, R., and Singh, M., Predicting DNA recognition by Cys2His2 zinc finger proteins., Bioinformatics, vol. 25, no. 1, pp. 22-9, 2009.
E. D. Schejter and Wieschaus, E., bottleneck acts as a regulator of the microfilament network governing cellularization of the Drosophila embryo., Cell, vol. 75, no. 2, pp. 373-85, 1993.
B. Riggleman, Wieschaus, E., and Schedl, P., Molecular analysis of the armadillo locus: uniformly distributed transcripts and a protein with novel internal repeats are associated with a Drosophila segment polarity gene., Genes Dev, vol. 3, no. 1, pp. 96-113, 1989.
L. S. Rose and Wieschaus, E., The Drosophila cellularization gene nullo produces a blastoderm-specific transcript whose levels respond to the nucleocytoplasmic ratio., Genes Dev, vol. 6, no. 7, pp. 1255-68, 1992.
R. Godbout, Ingram, R. S., and Tilghman, S. M., Fine-structure mapping of the three mouse alpha-fetoprotein gene enhancers., Mol Cell Biol, vol. 8, no. 3, pp. 1169-78, 1988.
C. Huttenhower and Troyanskaya, O. G., Assessing the functional structure of genomic data., Bioinformatics, vol. 24, no. 13, pp. i330-8, 2008.
P. A. Leighton, Ingram, R. S., Eggenschwiler, J., Efstratiadis, A., and Tilghman, S. M., Disruption of imprinting caused by deletion of the H19 gene region in mice., Nature, vol. 375, no. 6526, pp. 34-9, 1995.
R. Mukhopadhyay, Emberly, E., Tang, C., and Wingreen, N. S., Statistical mechanics of RNA folding: importance of alphabet size., Phys Rev E Stat Nonlin Soft Matter Phys, vol. 68, no. 4 Pt 1, p. 041904, 2003.
S. De Renzis, Elemento, O., Tavazoie, S., and Wieschaus, E. F., Unmasking activation of the zygotic genome using chromosomal deletions in the Drosophila embryo., PLoS Biol, vol. 5, no. 5, p. e117, 2007.
X. Chen, Leung, S. Y., Yuen, S. T., Chu, K. - M., Ji, J., Li, R., S Y Chan, A., Law, S., Troyanskaya, O. G., Wong, J., So, S., Botstein, D., and Brown, P. O., Variation in gene expression patterns in human gastric cancers., Mol Biol Cell, vol. 14, no. 8, pp. 3208-15, 2003.
C. I. Brannan, Dees, E. C., Ingram, R. S., and Tilghman, S. M., The product of the H19 gene may function as an RNA., Mol Cell Biol, vol. 10, no. 1, pp. 28-36, 1990.
P. A. Leighton, Saam, J. R., Ingram, R. S., Stewart, C. L., and Tilghman, S. M., An enhancer deletion affects both H19 and Igf2 expression., Genes Dev, vol. 9, no. 17, pp. 2079-89, 1995.
M. Shakoury-Elizeh, Tiedeman, J., Rashford, J., Ferea, T., Demeter, J., Garcia, E., Rolfes, R., Brown, P. O., Botstein, D., and Philpott, C. C., Transcriptional remodeling in response to iron deprivation in Saccharomyces cerevisiae., Mol Biol Cell, vol. 15, no. 3, pp. 1233-43, 2004.
M. Markstein, Zinzen, R., Markstein, P., Yee, K. - P., Erives, A., Stathopoulos, A., and Levine, M., A regulatory code for neurogenic gene expression in the Drosophila embryo., Development, vol. 131, no. 10, pp. 2387-94, 2004.
I. S. Lossos, Alizadeh, A. A., Diehn, M., Warnke, R., Thorstenson, Y., Oefner, P. J., Brown, P. O., Botstein, D., and Levy, R., Transformation of follicular lymphoma to diffuse large-cell lymphoma: alternative patterns with increased or decreased expression of c-myc and its regulated genes., Proc Natl Acad Sci U S A, vol. 99, no. 13, pp. 8886-91, 2002.
D. Gresham, Usaite, R., Germann, S. Manuela, Lisby, M., Botstein, D., and Regenberg, B., Adaptation to diverse nitrogen-limited environments by deletion or extrachromosomal element formation of the GAP1 locus., Proc Natl Acad Sci U S A, vol. 107, no. 43, pp. 18551-6, 2010.
J. M. Rossi, Chen, H., and Tilghman, S. M., Genetic map of the fused locus on mouse chromosome 17., Genomics, vol. 23, no. 1, pp. 178-84, 1994.
A. Fuchs, Cheung, L. S., Charbonnier, E., Shvartsman, S. Y., and Pyrowolakis, G., Transcriptional interpretation of the EGF receptor signaling gradient., Proc Natl Acad Sci U S A, vol. 109, no. 5, pp. 1572-7, 2012.
M. D. Chikina, Huttenhower, C., Murphy, C. T., and Troyanskaya, O. G., Global prediction of tissue-specific gene expression and context-dependent gene networks in Caenorhabditis elegans., PLoS Comput Biol, vol. 5, no. 6, p. e1000417, 2009.
J. Cande, Goltsev, Y., and Levine, M. S., Conservation of enhancer location in divergent insects., Proc Natl Acad Sci U S A, vol. 106, no. 34, pp. 14414-9, 2009.
D. J. Katz, Beer, M. A., Levorse, J. M., and Tilghman, S. M., Functional characterization of a novel Ku70/80 pause site at the H19/Igf2 imprinting control region., Mol Cell Biol, vol. 25, no. 10, pp. 3855-63, 2005.
D. Papatsenko and Levine, M., Quantitative analysis of binding motifs mediating diverse spatial readouts of the Dorsal gradient in the Drosophila embryo., Proc Natl Acad Sci U S A, vol. 102, no. 14, pp. 4966-71, 2005.
S. Parks and Wieschaus, E., The Drosophila gastrulation gene concertina encodes a G alpha-like protein., Cell, vol. 64, no. 2, pp. 447-58, 1991.
P. Andolfatto, J Scriber, M., and Charlesworth, B., No association between mitochondrial DNA haplotypes and a female-limited mimicry phenotype in Papilio glaucus., Evolution, vol. 57, no. 2, pp. 305-16, 2003.
P. R. Haddrill, Charlesworth, B., Halligan, D. L., and Andolfatto, P., Patterns of intron sequence evolution in Drosophila are dependent upon length and GC content., Genome Biol, vol. 6, no. 8, p. R67, 2005.
T. J. Vasicek, Zeng, L., Guan, X. J., Zhang, T., Costantini, F., and Tilghman, S. M., Two dominant mutations in the mouse fused gene are the result of transposon insertions., Genetics, vol. 147, no. 2, pp. 777-86, 1997.
A. Stathopoulos and Levine, M., Localized repressors delineate the neurogenic ectoderm in the early Drosophila embryo., Dev Biol, vol. 280, no. 2, pp. 482-93, 2005.
R. Papazyan, Sun, Z., Kim, Y. Hoon, Titchenell, P. M., Hill, D. A., Lu, W., Damle, M., Wan, M., Zhang, Y., Briggs, E. R., Rabinowitz, J. D., and Lazar, M. A., Physiological Suppression of Lipotoxic Liver Damage by Complementary Actions of HDAC3 and SCAP/SREBP., Cell Metab, vol. 24, no. 6, pp. 863-874, 2016.
P. Armand, Knapp, A. C., Hirsch, A. J., Wieschaus, E. F., and Cole, M. D., A novel basic helix-loop-helix protein is expressed in muscle attachment sites of the Drosophila epidermis., Mol Cell Biol, vol. 14, no. 6, pp. 4145-54, 1994.
S. R McIsaac, Oakes, B. L., Botstein, D., and Noyes, M. B., Rapid synthesis and screening of chemically activated transcription factors with GFP-based reporters., J Vis Exp, no. 81, p. e51153, 2013.
K. Pfeifer and Tilghman, S. M., Allele-specific gene expression in mammals: the curious case of the imprinted RNAs., Genes Dev, vol. 8, no. 16, pp. 1867-74, 1994.
M. Costa, Wilson, E. T., and Wieschaus, E., A putative cell signal encoded by the folded gastrulation gene coordinates cell shape changes during Drosophila gastrulation., Cell, vol. 76, no. 6, pp. 1075-89, 1994.
K. C. Rowe, Singhal, S., Macmanes, M. D., Ayroles, J. F., Morelli, T. Lyn, Rubidge, E. M., Bi, K., and Moritz, C. C., Museum genomics: low-cost and high-accuracy genetic data from historical specimens., Mol Ecol Resour, vol. 11, no. 6, pp. 1082-92, 2011.
J. V. Schmidt, Matteson, P. G., Jones, B. K., Guan, X. J., and Tilghman, S. M., The Dlk1 and Gtl2 genes are linked and reciprocally imprinted., Genes Dev, vol. 14, no. 16, pp. 1997-2002, 2000.
J. H. Millonig, Emerson, J. A., Levorse, J. M., and Tilghman, S. M., Molecular analysis of the distal enhancer of the mouse alpha-fetoprotein gene., Mol Cell Biol, vol. 15, no. 7, pp. 3848-56, 1995.
V. Hilgers, Perry, M. W., Hendrix, D., Stark, A., Levine, M., and Haley, B., Neural-specific elongation of 3' UTRs during Drosophila development., Proc Natl Acad Sci U S A, vol. 108, no. 38, pp. 15864-9, 2011.
D. Hendrix, Levine, M., and Shi, W., miRTRAP, a computational method for the systematic identification of miRNAs from high throughput sequencing data., Genome Biol, vol. 11, no. 4, p. R39, 2010.
Basic Helix-Loop-Helix Transcription Factors
P. Armand, Knapp, A. C., Hirsch, A. J., Wieschaus, E. F., and Cole, M. D., A novel basic helix-loop-helix protein is expressed in muscle attachment sites of the Drosophila epidermis., Mol Cell Biol, vol. 14, no. 6, pp. 4145-54, 1994.
A. Helman, Lim, B., Andreu, M. José, Kim, Y., Shestkin, T., Lu, H., Jiménez, G., Shvartsman, S. Y., and Paroush, Z. 'ev, RTK signaling modulates the Dorsal gradient., Development, vol. 139, no. 16, pp. 3032-9, 2012.
J. Cowden and Levine, M., The Snail repressor positions Notch signaling in the Drosophila embryo., Development, vol. 129, no. 7, pp. 1785-93, 2002.
S. E. Cole, Levorse, J. M., Tilghman, S. M., and Vogt, T. F., Clock regulatory elements control cyclic expression of Lunatic fringe during somitogenesis., Dev Cell, vol. 3, no. 1, pp. 75-84, 2002.
T. Caspary, Cleary, M. A., Baker, C. C., Guan, X. J., and Tilghman, S. M., Multiple mechanisms regulate imprinting of the mouse distal chromosome 7 gene cluster., Mol Cell Biol, vol. 18, no. 6, pp. 3466-74, 1998.
Y. Kim, Paroush, Z. 'ev, Nairz, K., Hafen, E., Jiménez, G., and Shvartsman, S. Y., Substrate-dependent control of MAPK phosphorylation in vivo., Mol Syst Biol, vol. 7, p. 467, 2011.
L. Christiaen, Stolfi, A., Davidson, B., and Levine, M., Spatio-temporal intersection of Lhx3 and Tbx6 defines the cardiac field through synergistic activation of Mesp., Dev Biol, vol. 328, no. 2, pp. 552-60, 2009.
B. Davidson, Shi, W., and Levine, M., Uncoupling heart cell specification and migration in the simple chordate Ciona intestinalis., Development, vol. 132, no. 21, pp. 4811-8, 2005.
G. T. Reeves, Kalifa, R., Klein, D. E., Lemmon, M. A., and Shvartsman, S. Y., Computational analysis of EGFR inhibition by Argos., Dev Biol, vol. 284, no. 2, pp. 523-35, 2005.
P. A. Leighton, Saam, J. R., Ingram, R. S., Stewart, C. L., and Tilghman, S. M., An enhancer deletion affects both H19 and Igf2 expression., Genes Dev, vol. 9, no. 17, pp. 2079-89, 1995.
Bayes Theorem
A. Pop, Huttenhower, C., Iyer-Pascuzzi, A., Benfey, P. N., and Troyanskaya, O. G., Integrated functional networks of process, tissue, and developmental stage specific interactions in Arabidopsis thaliana., BMC Syst Biol, vol. 4, p. 180, 2010.
M. D. Chikina and Troyanskaya, O. G., Accurate quantification of functional analogy among close homologs., PLoS Comput Biol, vol. 7, no. 2, p. e1001074, 2011.
P. H. Bradley, Brauer, M. J., Rabinowitz, J. D., and Troyanskaya, O. G., Coordinated concentration changes of transcripts and metabolites in Saccharomyces cerevisiae., PLoS Comput Biol, vol. 5, no. 1, p. e1000270, 2009.
Y. -suk Lee, Krishnan, A., Zhu, Q., and Troyanskaya, O. G., Ontology-aware classification of tissue and cell-type signals in gene expression profiles across platforms and technologies., Bioinformatics, vol. 29, no. 23, pp. 3036-44, 2013.
O. G. Troyanskaya, Dolinski, K., Owen, A. B., Altman, R. B., and Botstein, D., A Bayesian framework for combining heterogeneous data sources for gene function prediction (in Saccharomyces cerevisiae)., Proc Natl Acad Sci U S A, vol. 100, no. 14, pp. 8348-53, 2003.
Y. Guan, Ackert-Bicknell, C. L., Kell, B., Troyanskaya, O. G., and Hibbs, M. A., Functional genomics complements quantitative genetics in identifying disease-gene associations., PLoS Comput Biol, vol. 6, no. 11, p. e1000991, 2010.
D. J. Wilson, Hernandez, R. D., Andolfatto, P., and Przeworski, M., A population genetics-phylogenetics approach to inferring natural selection in coding sequences., PLoS Genet, vol. 7, no. 12, p. e1002395, 2011.
C. Huttenhower, K Mutungu, T., Indik, N., Yang, W., Schroeder, M., Forman, J. J., Troyanskaya, O. G., and Coller, H. A., Detailing regulatory networks through large scale data integration., Bioinformatics, vol. 25, no. 24, pp. 3267-74, 2009.
Y. Guan, Myers, C. L., Lu, R., Lemischka, I. R., Bult, C. J., and Troyanskaya, O. G., A genomewide functional network for the laboratory mouse., PLoS Comput Biol, vol. 4, no. 9, p. e1000165, 2008.
D. Gorenshteyn, Zaslavsky, E., Fribourg, M., Park, C. Y., Wong, A. K., Tadych, A., Hartmann, B. M., Albrecht, R. A., García-Sastre, A., Kleinstein, S. H., Troyanskaya, O. G., and Sealfon, S. C., Interactive Big Data Resource to Elucidate Human Immune Pathways and Diseases., Immunity, vol. 43, no. 3, pp. 605-14, 2015.
C. Huttenhower, Hibbs, M., Myers, C., and Troyanskaya, O. G., A scalable method for integration and functional analysis of multiple microarray datasets., Bioinformatics, vol. 22, no. 23, pp. 2890-7, 2006.
K. Thornton and Andolfatto, P., Approximate Bayesian inference reveals evidence for a recent, severe bottleneck in a Netherlands population of Drosophila melanogaster., Genetics, vol. 172, no. 3, pp. 1607-19, 2006.
Y. Guan, Dunham, M. J., and Troyanskaya, O. G., Functional analysis of gene duplications in Saccharomyces cerevisiae., Genetics, vol. 175, no. 2, pp. 933-43, 2007.
C. Huttenhower and Troyanskaya, O. G., Bayesian data integration: a functional perspective., Comput Syst Bioinformatics Conf, pp. 341-51, 2006.
Z. Barutcuoglu, Schapire, R. E., and Troyanskaya, O. G., Hierarchical multi-label prediction of gene function., Bioinformatics, vol. 22, no. 7, pp. 830-6, 2006.
U. Ober, Ayroles, J. F., Stone, E. A., Richards, S., Zhu, D., Gibbs, R. A., Stricker, C., Gianola, D., Schlather, M., Mackay, T. F. C., and Simianer, H., Using whole-genome sequence data to predict quantitative trait phenotypes in Drosophila melanogaster., PLoS Genet, vol. 8, no. 5, p. e1002685, 2012.
C. Huttenhower, Haley, E. M., Hibbs, M. A., Dumeaux, V., Barrett, D. R., Coller, H. A., and Troyanskaya, O. G., Exploring the human genome with functional maps., Genome Res, vol. 19, no. 6, pp. 1093-106, 2009.
C. S. Greene and Troyanskaya, O. G., Integrative systems biology for data-driven knowledge discovery., Semin Nephrol, vol. 30, no. 5, pp. 443-54, 2010.
C. Y. Park, Wong, A. K., Greene, C. S., Rowland, J., Guan, Y., Bongo, L. A., Burdine, R. D., and Troyanskaya, O. G., Functional knowledge transfer for high-accuracy prediction of under-studied biological processes., PLoS Comput Biol, vol. 9, no. 3, p. e1002957, 2013.
C. S. Greene and Troyanskaya, O. G., Chapter 2: Data-driven view of disease biology., PLoS Comput Biol, vol. 8, no. 12, p. e1002816, 2012.
C. L. Myers, Robson, D., Wible, A., Hibbs, M. A., Chiriac, C., Theesfeld, C. L., Dolinski, K., and Troyanskaya, O. G., Discovery of biological networks from diverse functional genomic data., Genome Biol, vol. 6, no. 13, p. R114, 2005.
J. P. Huelsenbeck and Andolfatto, P., Inference of population structure under a Dirichlet process model., Genetics, vol. 175, no. 4, pp. 1787-802, 2007.
A. S. Putnam, J Scriber, M., and Andolfatto, P., Discordant divergence times among Z-chromosome regions between two ecologically distinct swallowtail butterfly species., Evolution, vol. 61, no. 4, pp. 912-27, 2007.
Y. Deng, Coen, P., Sun, M., and Shaevitz, J. W., Efficient multiple object tracking using mutually repulsive active membranes., PLoS One, vol. 8, no. 6, p. e65769, 2013.
Y. Guan, Myers, C. L., Hess, D. C., Barutcuoglu, Z., Caudy, A. A., and Troyanskaya, O. G., Predicting gene function in a hierarchical context with an ensemble of classifiers., Genome Biol, vol. 9 Suppl 1, p. S3, 2008.
J. D. Jensen, Thornton, K. R., and Andolfatto, P., An approximate bayesian estimator suggests strong, recurrent selective sweeps in Drosophila., PLoS Genet, vol. 4, no. 9, p. e1000198, 2008.
C. Y. Park, Hess, D. C., Huttenhower, C., and Troyanskaya, O. G., Simultaneous genome-wide inference of physical, genetic, regulatory, and functional pathway components., PLoS Comput Biol, vol. 6, no. 11, p. e1001009, 2010.
Bees
J. Doran Cande, Chopra, V. S., and Levine, M., Evolving enhancer-promoter interactions within the tinman complex of the flour beetle, Tribolium castaneum., Development, vol. 136, no. 18, pp. 3153-60, 2009.
D. A. Galbraith, Kocher, S. D., Glenn, T., Albert, I., Hunt, G. J., Strassmann, J. E., Queller, D. C., and Grozinger, C. M., Testing the kinship theory of intragenomic conflict in honey bees (Apis mellifera)., Proc Natl Acad Sci U S A, vol. 113, no. 4, pp. 1020-5, 2016.
P. Engel, Kwong, W. K., McFrederick, Q., Anderson, K. E., Barribeau, S. Michael, Chandler, J. Angus, R Cornman, S., Dainat, J., de Miranda, J. R., Doublet, V., Emery, O., Evans, J. D., Farinelli, L., Flenniken, M. L., Granberg, F., Grasis, J. A., Gauthier, L., Hayer, J., Koch, H., Kocher, S., Martinson, V. G., Moran, N., Munoz-Torres, M., Newton, I., Paxton, R. J., Powell, E., Sadd, B. M., Schmid-Hempel, P., Schmid-Hempel, R., Song, S. Jin, Schwarz, R. S., vanEngelsdorp, D., and Dainat, B., The Bee Microbiome: Impact on Bee Health and Model for Evolution and Ecology of Host-Microbe Interactions., MBio, vol. 7, no. 2, pp. e02164-15, 2016.
S. D. Kocher, Tsuruda, J. M., Gibson, J. D., Emore, C. M., Arechavaleta-Velasco, M. E., Queller, D. C., Strassmann, J. E., Grozinger, C. M., Gribskov, M. R., San Miguel, P., Westerman, R., and Hunt, G. J., A Search for Parent-of-Origin Effects on Honey Bee Gene Expression., G3 (Bethesda), vol. 5, no. 8, pp. 1657-62, 2015.
K. M. Kapheim, Pan, H., Li, C., Salzberg, S. L., Puiu, D., Magoc, T., Robertson, H. M., Hudson, M. E., Venkat, A., Fischman, B. J., Hernandez, A., Yandell, M., Ence, D., Holt, C., Yocum, G. D., Kemp, W. P., Bosch, J., Waterhouse, R. M., Zdobnov, E. M., Stolle, E., F Kraus, B., Helbing, S., Moritz, R. F. A., Glastad, K. M., Hunt, B. G., Goodisman, M. A. D., Hauser, F., Grimmelikhuijzen, C. J. P., Pinheiro, D. Guariz, Nunes, F. Morais Fra, Soares, M. Prioli Mir, Tanaka, É. Donato, Simões, Z. Luz Paulin, Hartfelder, K., Evans, J. D., Barribeau, S. M., Johnson, R. M., Massey, J. H., Southey, B. R., Hasselmann, M., Hamacher, D., Biewer, M., Kent, C. F., Zayed, A., Blatti, C., Sinha, S., J Johnston, S., Hanrahan, S. J., Kocher, S. D., Wang, J., Robinson, G. E., and Zhang, G., Social evolution. Genomic signatures of evolutionary transitions from solitary to group living., Science, vol. 348, no. 6239, pp. 1139-43, 2015.
S. D. Kocher, Ayroles, J. F., Stone, E. A., and Grozinger, C. M., Individual variation in pheromone response correlates with reproductive traits and brain gene expression in worker honey bees., PLoS One, vol. 5, no. 2, p. e9116, 2010.
Behavior
G. J. Stephens, Osborne, L. C., and Bialek, W., Searching for simplicity in the analysis of neurons and behavior., Proc Natl Acad Sci U S A, vol. 108 Suppl 3, pp. 15565-71, 2011.
Behavior, Animal
J. P. Nguyen, Shipley, F. B., Linder, A. N., Plummer, G. S., Liu, M., Setru, S. U., Shaevitz, J. W., and Leifer, A. M., Whole-brain calcium imaging with cellular resolution in freely behaving Caenorhabditis elegans., Proc Natl Acad Sci U S A, vol. 113, no. 8, pp. E1074-81, 2016.
G. J. Stephens, Johnson-Kerner, B., Bialek, W., and Ryu, W. S., Dimensionality and dynamics in the behavior of C. elegans., PLoS Comput Biol, vol. 4, no. 4, p. e1000028, 2008.
U. Klibaite, Berman, G. J., Cande, J., Stern, D. L., and Shaevitz, J. W., An unsupervised method for quantifying the behavior of paired animals., Phys Biol, vol. 14, no. 1, p. 015006, 2017.
A. C. Edwards, Ayroles, J. F., Stone, E. A., Carbone, M. Anna, Lyman, R. F., and Mackay, T. F. C., A transcriptional network associated with natural variation in Drosophila aggressive behavior., Genome Biol, vol. 10, no. 7, p. R76, 2009.
A. L. Kauffman, Ashraf, J. M., M Corces-Zimmerman, R., Landis, J. N., and Murphy, C. T., Insulin signaling and dietary restriction differentially influence the decline of learning and memory with age., PLoS Biol, vol. 8, no. 5, p. e1000372, 2010.
W. Bialek, Cavagna, A., Giardina, I., Mora, T., Pohl, O., Silvestri, E., Viale, M., and Walczak, A. M., Social interactions dominate speed control in poising natural flocks near criticality., Proc Natl Acad Sci U S A, vol. 111, no. 20, pp. 7212-7, 2014.
Y. Deng, Coen, P., Sun, M., and Shaevitz, J. W., Efficient multiple object tracking using mutually repulsive active membranes., PLoS One, vol. 8, no. 6, p. e65769, 2013.
G. J. Stephens, de Mesquita, M. Bueno, Ryu, W. S., and Bialek, W., Emergence of long timescales and stereotyped behaviors in Caenorhabditis elegans., Proc Natl Acad Sci U S A, vol. 108, no. 18, pp. 7286-9, 2011.
beta Catenin
N. S. Tolwinski and Wieschaus, E., A nuclear function for armadillo/beta-catenin., PLoS Biol, vol. 2, no. 4, p. E95, 2004.
T. Schupbach and Wieschaus, E., Probing for gene specificity in epithelial development., Int J Dev Biol, vol. 42, no. 3, pp. 249-55, 1998.
S. Hayashi, Rubinfeld, B., Souza, B., Polakis, P., Wieschaus, E., and Levine, A. J., A Drosophila homolog of the tumor suppressor gene adenomatous polyposis coli down-regulates beta-catenin but its zygotic expression is not essential for the regulation of Armadillo., Proc Natl Acad Sci U S A, vol. 94, no. 1, pp. 242-7, 1997.
Y. Ahmed, Hayashi, S., Levine, A., and Wieschaus, E., Regulation of armadillo by a Drosophila APC inhibits neuronal apoptosis during retinal development., Cell, vol. 93, no. 7, pp. 1171-82, 1998.
M. Peifer, McCrea, P. D., Green, K. J., Wieschaus, E., and Gumbiner, B. M., The vertebrate adhesive junction proteins beta-catenin and plakoglobin and the Drosophila segment polarity gene armadillo form a multigene family with similar properties., J Cell Biol, vol. 118, no. 3, pp. 681-91, 1992.
L. Christiaen, Stolfi, A., Davidson, B., and Levine, M., Spatio-temporal intersection of Lhx3 and Tbx6 defines the cardiac field through synergistic activation of Mesp., Dev Biol, vol. 328, no. 2, pp. 552-60, 2009.
M. Peifer and Wieschaus, E., The product of the Drosophila melanogaster segment polarity gene armadillo is highly conserved in sequence and expression in the housefly Musca domestica., J Mol Evol, vol. 36, no. 3, pp. 224-33, 1993.
Y. Ahmed, Nouri, A., and Wieschaus, E., Drosophila Apc1 and Apc2 regulate Wingless transduction throughout development., Development, vol. 129, no. 7, pp. 1751-62, 2002.
N. S. Tolwinski and Wieschaus, E., A nuclear escort for beta-catenin., Nat Cell Biol, vol. 6, no. 7, pp. 579-80, 2004.
beta-Transducin Repeat-Containing Proteins
D. Ghersi and Singh, M., Interaction-based discovery of functionally important genes in cancers., Nucleic Acids Res, vol. 42, no. 3, p. e18, 2014.

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