List of Faculty Publications

Below is a list of Faculty publications imported from PubMed or manually added. By default, publications are sorted by year with titles displayed in ascending alphabetical order.
Shortcuts: Wühr, Martin | Wingreen, Ned | Wieschaus, Eric | Troyanskaya, Olga | Tilghman, Shirley | Storey, John | Singh, Mona | Shvartsman, Stanislav | Shaevitz, Joshua | Rabinowitz, Joshua | Murphy, Coleen | Levine, Michael {Levine, Michael S.} | Gregor, Thomas | Botstein, David | Bialek, William | Ayroles, Julien | Andolfatto, Peter | Akey, Joshua

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 
Transcription Factors
B. P. Berman, Nibu, Y., Pfeiffer, B. D., Tomancak, P., Celniker, S. E., Levine, M., Rubin, G. M., and Eisen, M. B., Exploiting transcription factor binding site clustering to identify cis-regulatory modules involved in pattern formation in the Drosophila genome., Proc Natl Acad Sci U S A, vol. 99, no. 2, pp. 757-62, 2002.
C. Rauskolb and Wieschaus, E., Coordinate regulation of downstream genes by extradenticle and the homeotic selector proteins., EMBO J, vol. 13, no. 15, pp. 3561-9, 1994.
F. Biemar, Zinzen, R., Ronshaugen, M., Sementchenko, V., J Manak, R., and Levine, M. S., Spatial regulation of microRNA gene expression in the Drosophila embryo., Proc Natl Acad Sci U S A, vol. 102, no. 44, pp. 15907-11, 2005.
M. W. Perry, Bothma, J. P., Luu, R. D., and Levine, M., Precision of hunchback expression in the Drosophila embryo., Curr Biol, vol. 22, no. 23, pp. 2247-52, 2012.
J. - T. Chi, Chang, H. Y., Haraldsen, G., Jahnsen, F. L., Troyanskaya, O. G., Chang, D. S., Wang, Z., Rockson, S. G., van de Rijn, M., Botstein, D., and Brown, P. O., Endothelial cell diversity revealed by global expression profiling., Proc Natl Acad Sci U S A, vol. 100, no. 19, pp. 10623-8, 2003.
H. A. Müller and Wieschaus, E., armadillo, bazooka, and stardust are critical for early stages in formation of the zonula adherens and maintenance of the polarized blastoderm epithelium in Drosophila., J Cell Biol, vol. 134, no. 1, pp. 149-63, 1996.
N. D. Trinklein, Murray, J. I., Hartman, S. J., Botstein, D., and Myers, R. M., The role of heat shock transcription factor 1 in the genome-wide regulation of the mammalian heat shock response., Mol Biol Cell, vol. 15, no. 3, pp. 1254-61, 2004.
P. Morize, Christiansen, A. E., Costa, M., Parks, S., and Wieschaus, E., Hyperactivation of the folded gastrulation pathway induces specific cell shape changes., Development, vol. 125, no. 4, pp. 589-97, 1998.
C. T. Murphy, McCarroll, S. A., Bargmann, C. I., Fraser, A., Kamath, R. S., Ahringer, J., Li, H., and Kenyon, C., Genes that act downstream of DAF-16 to influence the lifespan of Caenorhabditis elegans., Nature, vol. 424, no. 6946, pp. 277-83, 2003.
D. Ghersi and Singh, M., Interaction-based discovery of functionally important genes in cancers., Nucleic Acids Res, vol. 42, no. 3, p. e18, 2014.
G. Tkačik, Callan, C. G., and Bialek, W., Information flow and optimization in transcriptional regulation., Proc Natl Acad Sci U S A, vol. 105, no. 34, pp. 12265-70, 2008.
M. Peifer and Wieschaus, E., The product of the Drosophila melanogaster segment polarity gene armadillo is highly conserved in sequence and expression in the housefly Musca domestica., J Mol Evol, vol. 36, no. 3, pp. 224-33, 1993.
J. - W. Hong, Hendrix, D. A., and Levine, M. S., Shadow enhancers as a source of evolutionary novelty., Science, vol. 321, no. 5894, p. 1314, 2008.
C. A. Rushlow and Shvartsman, S. Y., Temporal dynamics, spatial range, and transcriptional interpretation of the Dorsal morphogen gradient., Curr Opin Genet Dev, vol. 22, no. 6, pp. 542-6, 2012.
B. Riggleman, Schedl, P., and Wieschaus, E., Spatial expression of the Drosophila segment polarity gene armadillo is posttranscriptionally regulated by wingless., Cell, vol. 63, no. 3, pp. 549-60, 1990.
P. Armand, Knapp, A. C., Hirsch, A. J., Wieschaus, E. F., and Cole, M. D., A novel basic helix-loop-helix protein is expressed in muscle attachment sites of the Drosophila epidermis., Mol Cell Biol, vol. 14, no. 6, pp. 4145-54, 1994.
C. T. Murphy, Lee, S. - J., and Kenyon, C., Tissue entrainment by feedback regulation of insulin gene expression in the endoderm of Caenorhabditis elegans., Proc Natl Acad Sci U S A, vol. 104, no. 48, pp. 19046-50, 2007.
S. R McIsaac, Gibney, P. A., Chandran, S. S., Benjamin, K. R., and Botstein, D., Synthetic biology tools for programming gene expression without nutritional perturbations in Saccharomyces cerevisiae., Nucleic Acids Res, vol. 42, no. 6, p. e48, 2014.
J. H. Millonig, Emerson, J. A., Levorse, J. M., and Tilghman, S. M., Molecular analysis of the distal enhancer of the mouse alpha-fetoprotein gene., Mol Cell Biol, vol. 15, no. 7, pp. 3848-56, 1995.
P. A. Leighton, Saam, J. R., Ingram, R. S., Stewart, C. L., and Tilghman, S. M., An enhancer deletion affects both H19 and Igf2 expression., Genes Dev, vol. 9, no. 17, pp. 2079-89, 1995.
J. Cowden and Levine, M., The Snail repressor positions Notch signaling in the Drosophila embryo., Development, vol. 129, no. 7, pp. 1785-93, 2002.
H. Yoshimoto, Saltsman, K., Gasch, A. P., Li, H. Xia, Ogawa, N., Botstein, D., Brown, P. O., and Cyert, M. S., Genome-wide analysis of gene expression regulated by the calcineurin/Crz1p signaling pathway in Saccharomyces cerevisiae., J Biol Chem, vol. 277, no. 34, pp. 31079-88, 2002.
V. Lakhina, Arey, R. N., Kaletsky, R., Kauffman, A., Stein, G., Keyes, W., Xu, D., and Murphy, C. T., Genome-wide functional analysis of CREB/long-term memory-dependent transcription reveals distinct basal and memory gene expression programs., Neuron, vol. 85, no. 2, pp. 330-45, 2015.
Y. Guan, Yao, V., Tsui, K., Gebbia, M., Dunham, M. J., Nislow, C., and Troyanskaya, O. G., Nucleosome-coupled expression differences in closely-related species., BMC Genomics, vol. 12, p. 466, 2011.
S. - J. Lee, Murphy, C. T., and Kenyon, C., Glucose shortens the life span of C. elegans by downregulating DAF-16/FOXO activity and aquaporin gene expression., Cell Metab, vol. 10, no. 5, pp. 379-91, 2009.
M. W. Perry, Boettiger, A. N., and Levine, M., Multiple enhancers ensure precision of gap gene-expression patterns in the Drosophila embryo., Proc Natl Acad Sci U S A, vol. 108, no. 33, pp. 13570-5, 2011.
M. Peifer and Wieschaus, E., The segment polarity gene armadillo encodes a functionally modular protein that is the Drosophila homolog of human plakoglobin., Cell, vol. 63, no. 6, pp. 1167-76, 1990.
P. Jiang and Singh, M., CCAT: Combinatorial Code Analysis Tool for transcriptional regulation., Nucleic Acids Res, vol. 42, no. 5, pp. 2833-47, 2014.
S. C. Little, Tikhonov, M., and Gregor, T., Precise developmental gene expression arises from globally stochastic transcriptional activity., Cell, vol. 154, no. 4, pp. 789-800, 2013.
R. P. Oliveira, Abate, J. Porter, Dilks, K., Landis, J., Ashraf, J., Murphy, C. T., and T Blackwell, K., Condition-adapted stress and longevity gene regulation by Caenorhabditis elegans SKN-1/Nrf., Aging Cell, vol. 8, no. 5, pp. 524-41, 2009.
V. C. Calhoun, Stathopoulos, A., and Levine, M., Promoter-proximal tethering elements regulate enhancer-promoter specificity in the Drosophila Antennapedia complex., Proc Natl Acad Sci U S A, vol. 99, no. 14, pp. 9243-7, 2002.
F. Liu, Morrison, A. H., and Gregor, T., Dynamic interpretation of maternal inputs by the Drosophila segmentation gene network., Proc Natl Acad Sci U S A, vol. 110, no. 17, pp. 6724-9, 2013.
K. Senger, Armstrong, G. W., Rowell, W. J., Kwan, J. M., Markstein, M., and Levine, M., Immunity regulatory DNAs share common organizational features in Drosophila., Mol Cell, vol. 13, no. 1, pp. 19-32, 2004.
C. Kenyon and Murphy, C. T., Enrichment of regulatory motifs upstream of predicted DAF-16 targets., Nat Genet, vol. 38, no. 4, pp. 397-8; author reply 398, 2006.
A. Jaźwińska, Kirov, N., Wieschaus, E., Roth, S., and Rushlow, C., The Drosophila gene brinker reveals a novel mechanism of Dpp target gene regulation., Cell, vol. 96, no. 4, pp. 563-73, 1999.
V. S. Chopra, Hong, J. - W., and Levine, M., Regulation of Hox gene activity by transcriptional elongation in Drosophila., Curr Biol, vol. 19, no. 8, pp. 688-93, 2009.
D. E. Coulter and Wieschaus, E., Gene activities and segmental patterning in Drosophila: analysis of odd-skipped and pair-rule double mutants., Genes Dev, vol. 2, no. 12B, pp. 1812-23, 1988.
M. Peifer, McCrea, P. D., Green, K. J., Wieschaus, E., and Gumbiner, B. M., The vertebrate adhesive junction proteins beta-catenin and plakoglobin and the Drosophila segment polarity gene armadillo form a multigene family with similar properties., J Cell Biol, vol. 118, no. 3, pp. 681-91, 1992.
N. S. Tolwinski and Wieschaus, E., Armadillo nuclear import is regulated by cytoplasmic anchor Axin and nuclear anchor dTCF/Pan., Development, vol. 128, no. 11, pp. 2107-17, 2001.
B. Davidson, Shi, W., and Levine, M., Uncoupling heart cell specification and migration in the simple chordate Ciona intestinalis., Development, vol. 132, no. 21, pp. 4811-8, 2005.
B. Haley, Hendrix, D., Trang, V., and Levine, M., A simplified miRNA-based gene silencing method for Drosophila melanogaster., Dev Biol, vol. 321, no. 2, pp. 482-90, 2008.
J. W. Shaevitz, Abbondanzieri, E. A., Landick, R., and Block, S. M., Backtracking by single RNA polymerase molecules observed at near-base-pair resolution., Nature, vol. 426, no. 6967, pp. 684-7, 2003.
S. R McIsaac, Silverman, S. J., McClean, M. N., Gibney, P. A., Macinskas, J., Hickman, M. J., Petti, A. A., and Botstein, D., Fast-acting and nearly gratuitous induction of gene expression and protein depletion in Saccharomyces cerevisiae., Mol Biol Cell, vol. 22, no. 22, pp. 4447-59, 2011.
J. Cande, Goltsev, Y., and Levine, M. S., Conservation of enhancer location in divergent insects., Proc Natl Acad Sci U S A, vol. 106, no. 34, pp. 14414-9, 2009.
J. - W. Hong, Hendrix, D. A., Papatsenko, D., and Levine, M. S., How the Dorsal gradient works: insights from postgenome technologies., Proc Natl Acad Sci U S A, vol. 105, no. 51, pp. 20072-6, 2008.
W. Wang, J Cherry, M., Botstein, D., and Li, H., A systematic approach to reconstructing transcription networks in Saccharomycescerevisiae., Proc Natl Acad Sci U S A, vol. 99, no. 26, pp. 16893-8, 2002.
N. S. Tolwinski, Wehrli, M., Rives, A., Erdeniz, N., DiNardo, S., and Wieschaus, E., Wg/Wnt signal can be transmitted through arrow/LRP5,6 and Axin independently of Zw3/Gsk3beta activity., Dev Cell, vol. 4, no. 3, pp. 407-18, 2003.
M. A. Postner and Wieschaus, E. F., The nullo protein is a component of the actin-myosin network that mediates cellularization in Drosophila melanogaster embryos., J Cell Sci, vol. 107 ( Pt 7), pp. 1863-73, 1994.
J. J. Zartman, Yakoby, N., Bristow, C. A., Zhou, X., Schlichting, K., Dahmann, C., and Shvartsman, S. Y., Cad74A is regulated by BR and is required for robust dorsal appendage formation in Drosophila oogenesis., Dev Biol, vol. 322, no. 2, pp. 289-301, 2008.
P. Mehta, Goyal, S., and Wingreen, N. S., A quantitative comparison of sRNA-based and protein-based gene regulation., Mol Syst Biol, vol. 4, p. 221, 2008.
D. E. Coulter, Swaykus, E. A., Beran-Koehn, M. A., Goldberg, D., Wieschaus, E., and Schedl, P., Molecular analysis of odd-skipped, a zinc finger encoding segmentation gene with a novel pair-rule expression pattern., EMBO J, vol. 9, no. 11, pp. 3795-804, 1990.
R. G. Tepper, Murphy, C. T., and Bussemaker, H. J., DAF-16 and PQM-1: partners in longevity., Aging (Albany NY), vol. 6, no. 1, pp. 5-6, 2014.
M. E. Schaner, Ross, D. T., Ciaravino, G., Sorlie, T., Troyanskaya, O., Diehn, M., Wang, Y. C., Duran, G. E., Sikic, T. L., Caldeira, S., Skomedal, H., Tu, I. - P., Hernandez-Boussard, T., Johnson, S. W., O'Dwyer, P. J., Fero, M. J., Kristensen, G. B., Borresen-Dale, A. - L., Hastie, T., Tibshirani, R., van de Rijn, M., Teng, N. N., Longacre, T. A., Botstein, D., Brown, P. O., and Sikic, B. I., Gene expression patterns in ovarian carcinomas., Mol Biol Cell, vol. 14, no. 11, pp. 4376-86, 2003.
A. - L. Hsu, Murphy, C. T., and Kenyon, C., Regulation of aging and age-related disease by DAF-16 and heat-shock factor., Science, vol. 300, no. 5622, pp. 1142-5, 2003.
T. Caspary, Cleary, M. A., Baker, C. C., Guan, X. J., and Tilghman, S. M., Multiple mechanisms regulate imprinting of the mouse distal chromosome 7 gene cluster., Mol Cell Biol, vol. 18, no. 6, pp. 3466-74, 1998.
E. Semenova, Wang, X. F., Jablonski, M. M., Levorse, J., and Tilghman, S. M., An engineered 800 kilobase deletion of Uchl3 and Lmo7 on mouse chromosome 14 causes defects in viability, postnatal growth and degeneration of muscle and retina., Hum Mol Genet, vol. 12, no. 11, pp. 1301-12, 2003.
S. E. Cole, Levorse, J. M., Tilghman, S. M., and Vogt, T. F., Clock regulatory elements control cyclic expression of Lunatic fringe during somitogenesis., Dev Cell, vol. 3, no. 1, pp. 75-84, 2002.
C. Huttenhower, K Mutungu, T., Indik, N., Yang, W., Schroeder, M., Forman, J. J., Troyanskaya, O. G., and Coller, H. A., Detailing regulatory networks through large scale data integration., Bioinformatics, vol. 25, no. 24, pp. 3267-74, 2009.
C. Rauskolb, Smith, K. M., Peifer, M., and Wieschaus, E., extradenticle determines segmental identities throughout Drosophila development., Development, vol. 121, no. 11, pp. 3663-73, 1995.
G. Tkačik, Walczak, A. M., and Bialek, W., Optimizing information flow in small genetic networks. III. A self-interacting gene., Phys Rev E Stat Nonlin Soft Matter Phys, vol. 85, no. 4 Pt 1, p. 041903, 2012.
D. S. A. Simakov, Cheung, L. S., Pismen, L. M., and Shvartsman, S. Y., EGFR-dependent network interactions that pattern Drosophila eggshell appendages., Development, vol. 139, no. 15, pp. 2814-20, 2012.
M. Peifer, Orsulic, S., Sweeton, D., and Wieschaus, E., A role for the Drosophila segment polarity gene armadillo in cell adhesion and cytoskeletal integrity during oogenesis., Development, vol. 118, no. 4, pp. 1191-207, 1993.
J. S. Kanodia, Liang, H. - L., Kim, Y., Lim, B., Zhan, M., Lu, H., Rushlow, C. A., and Shvartsman, S. Y., Pattern formation by graded and uniform signals in the early Drosophila embryo., Biophys J, vol. 102, no. 3, pp. 427-33, 2012.
J. N. Landis and Murphy, C. T., Integration of diverse inputs in the regulation of Caenorhabditis elegans DAF-16/FOXO., Dev Dyn, vol. 239, no. 5, pp. 1405-12, 2010.
D. Munro, Ghersi, D., and Singh, M., Two critical positions in zinc finger domains are heavily mutated in three human cancer types., PLoS Comput Biol, vol. 14, no. 6, p. e1006290, 2018.
G. Tkačik and Bialek, W., Diffusion, dimensionality, and noise in transcriptional regulation., Phys Rev E Stat Nonlin Soft Matter Phys, vol. 79, no. 5 Pt 1, p. 051901, 2009.
D. Papatsenko and Levine, M., Quantitative analysis of binding motifs mediating diverse spatial readouts of the Dorsal gradient in the Drosophila embryo., Proc Natl Acad Sci U S A, vol. 102, no. 14, pp. 4966-71, 2005.
E. Wagner and Levine, M., FGF signaling establishes the anterior border of the Ciona neural tube., Development, vol. 139, no. 13, pp. 2351-9, 2012.
D. Papatsenko, Goltsev, Y., and Levine, M., Organization of developmental enhancers in the Drosophila embryo., Nucleic Acids Res, vol. 37, no. 17, pp. 5665-77, 2009.
W. Wang, J Cherry, M., Nochomovitz, Y., Jolly, E., Botstein, D., and Li, H., Inference of combinatorial regulation in yeast transcriptional networks: a case study of sporulation., Proc Natl Acad Sci U S A, vol. 102, no. 6, pp. 1998-2003, 2005.
J. Vacher and Tilghman, S. M., Dominant negative regulation of the mouse alpha-fetoprotein gene in adult liver., Science, vol. 250, no. 4988, pp. 1732-5, 1990.
S. De Renzis, Yu, J., Zinzen, R., and Wieschaus, E., Dorsal-ventral pattern of Delta trafficking is established by a Snail-Tom-Neuralized pathway., Dev Cell, vol. 10, no. 2, pp. 257-64, 2006.
A. V. Persikov, Rowland, E. F., Oakes, B. L., Singh, M., and Noyes, M. B., Deep sequencing of large library selections allows computational discovery of diverse sets of zinc fingers that bind common targets., Nucleic Acids Res, vol. 42, no. 3, pp. 1497-508, 2014.
B. Houchmandzadeh, Wieschaus, E., and Leibler, S., Establishment of developmental precision and proportions in the early Drosophila embryo., Nature, vol. 415, no. 6873, pp. 798-802, 2002.
E. W. Trotter, Kao, C. M. - F., Berenfeld, L., Botstein, D., Petsko, G. A., and Gray, J. V., Misfolded proteins are competent to mediate a subset of the responses to heat shock in Saccharomyces cerevisiae., J Biol Chem, vol. 277, no. 47, pp. 44817-25, 2002.
M. Peifer and Wieschaus, E., Mutations in the Drosophila gene extradenticle affect the way specific homeo domain proteins regulate segmental identity., Genes Dev, vol. 4, no. 7, pp. 1209-23, 1990.
J. J. Zartman and Shvartsman, S. Y., Enhancer organization: transistor with a twist or something in a different vein?, Curr Biol, vol. 17, no. 24, pp. R1048-50, 2007.
J. P. Bothma, Garcia, H. G., Esposito, E., Schlissel, G., Gregor, T., and Levine, M., Dynamic regulation of eve stripe 2 expression reveals transcriptional bursts in living Drosophila embryos., Proc Natl Acad Sci U S A, vol. 111, no. 29, pp. 10598-603, 2014.
V. C. Calhoun and Levine, M., Long-range enhancer-promoter interactions in the Scr-Antp interval of the Drosophila Antennapedia complex., Proc Natl Acad Sci U S A, vol. 100, no. 17, pp. 9878-83, 2003.
S. R McIsaac, Oakes, B. L., Botstein, D., and Noyes, M. B., Rapid synthesis and screening of chemically activated transcription factors with GFP-based reporters., J Vis Exp, no. 81, p. e51153, 2013.
S. Hayashi, Rubinfeld, B., Souza, B., Polakis, P., Wieschaus, E., and Levine, A. J., A Drosophila homolog of the tumor suppressor gene adenomatous polyposis coli down-regulates beta-catenin but its zygotic expression is not essential for the regulation of Armadillo., Proc Natl Acad Sci U S A, vol. 94, no. 1, pp. 242-7, 1997.
J. H. Fong, Keating, A. E., and Singh, M., Predicting specificity in bZIP coiled-coil protein interactions., Genome Biol, vol. 5, no. 2, p. R11, 2004.
L. Christiaen, Stolfi, A., Davidson, B., and Levine, M., Spatio-temporal intersection of Lhx3 and Tbx6 defines the cardiac field through synergistic activation of Mesp., Dev Biol, vol. 328, no. 2, pp. 552-60, 2009.
D. Papatsenko and Levine, M. S., Dual regulation by the Hunchback gradient in the Drosophila embryo., Proc Natl Acad Sci U S A, vol. 105, no. 8, pp. 2901-6, 2008.
A. A. Petti, R McIsaac, S., Ho-Shing, O., Bussemaker, H. J., and Botstein, D., Combinatorial control of diverse metabolic and physiological functions by transcriptional regulators of the yeast sulfur assimilation pathway., Mol Biol Cell, vol. 23, no. 15, pp. 3008-24, 2012.
J. P. Bothma, Magliocco, J., and Levine, M., The snail repressor inhibits release, not elongation, of paused Pol II in the Drosophila embryo., Curr Biol, vol. 21, no. 18, pp. 1571-7, 2011.
M. Shakoury-Elizeh, Tiedeman, J., Rashford, J., Ferea, T., Demeter, J., Garcia, E., Rolfes, R., Brown, P. O., Botstein, D., and Philpott, C. C., Transcriptional remodeling in response to iron deprivation in Saccharomyces cerevisiae., Mol Biol Cell, vol. 15, no. 3, pp. 1233-43, 2004.
M. Ronen and Botstein, D., Transcriptional response of steady-state yeast cultures to transient perturbations in carbon source., Proc Natl Acad Sci U S A, vol. 103, no. 2, pp. 389-94, 2006.
G. Tkačik, Gregor, T., and Bialek, W., The role of input noise in transcriptional regulation., PLoS One, vol. 3, no. 7, p. e2774, 2008.
A. Bejsovec and Wieschaus, E., Signaling activities of the Drosophila wingless gene are separately mutable and appear to be transduced at the cell surface., Genetics, vol. 139, no. 1, pp. 309-20, 1995.
D. Krotov, Dubuis, J. O., Gregor, T., and Bialek, W., Morphogenesis at criticality., Proc Natl Acad Sci U S A, vol. 111, no. 10, pp. 3683-8, 2014.
A. Stolfi and Levine, M., Neuronal subtype specification in the spinal cord of a protovertebrate., Development, vol. 138, no. 5, pp. 995-1004, 2011.
T. Gregor, Tank, D. W., Wieschaus, E. F., and Bialek, W., Probing the limits to positional information., Cell, vol. 130, no. 1, pp. 153-64, 2007.
M. Shapira, Segal, E., and Botstein, D., Disruption of yeast forkhead-associated cell cycle transcription by oxidative stress., Mol Biol Cell, vol. 15, no. 12, pp. 5659-69, 2004.
C. T. Murphy, The search for DAF-16/FOXO transcriptional targets: approaches and discoveries., Exp Gerontol, vol. 41, no. 10, pp. 910-21, 2006.
E. Bae, Calhoun, V. C., Levine, M., Lewis, E. B., and Drewell, R. A., Characterization of the intergenic RNA profile at abdominal-A and Abdominal-B in the Drosophila bithorax complex., Proc Natl Acad Sci U S A, vol. 99, no. 26, pp. 16847-52, 2002.
K. M. Kapheim, Pan, H., Li, C., Salzberg, S. L., Puiu, D., Magoc, T., Robertson, H. M., Hudson, M. E., Venkat, A., Fischman, B. J., Hernandez, A., Yandell, M., Ence, D., Holt, C., Yocum, G. D., Kemp, W. P., Bosch, J., Waterhouse, R. M., Zdobnov, E. M., Stolle, E., F Kraus, B., Helbing, S., Moritz, R. F. A., Glastad, K. M., Hunt, B. G., Goodisman, M. A. D., Hauser, F., Grimmelikhuijzen, C. J. P., Pinheiro, D. Guariz, Nunes, F. Morais Fra, Soares, M. Prioli Mir, Tanaka, É. Donato, Simões, Z. Luz Paulin, Hartfelder, K., Evans, J. D., Barribeau, S. M., Johnson, R. M., Massey, J. H., Southey, B. R., Hasselmann, M., Hamacher, D., Biewer, M., Kent, C. F., Zayed, A., Blatti, C., Sinha, S., J Johnston, S., Hanrahan, S. J., Kocher, S. D., Wang, J., Robinson, G. E., and Zhang, G., Social evolution. Genomic signatures of evolutionary transitions from solitary to group living., Science, vol. 348, no. 6239, pp. 1139-43, 2015.
L. A. Goentoro, Yakoby, N., Goodhouse, J., Schüpbach, T., and Shvartsman, S. Y., Quantitative analysis of the GAL4/UAS system in Drosophila oogenesis., Genesis, vol. 44, no. 2, pp. 66-74, 2006.
R. Osada, Zaslavsky, E., and Singh, M., Comparative analysis of methods for representing and searching for transcription factor binding sites., Bioinformatics, vol. 20, no. 18, pp. 3516-25, 2004.
J. Zhou and Troyanskaya, O. G., Global quantitative modeling of chromatin factor interactions., PLoS Comput Biol, vol. 10, no. 3, p. e1003525, 2014.
T. Schupbach and Wieschaus, E., Probing for gene specificity in epithelial development., Int J Dev Biol, vol. 42, no. 3, pp. 249-55, 1998.
S. A. Camper and Tilghman, S. M., Postnatal repression of the alpha-fetoprotein gene is enhancer independent., Genes Dev, vol. 3, no. 4, pp. 537-46, 1989.
A. Erives and Levine, M., Coordinate enhancers share common organizational features in the Drosophila genome., Proc Natl Acad Sci U S A, vol. 101, no. 11, pp. 3851-6, 2004.
Y. Nibu, Senger, K., and Levine, M., CtBP-independent repression in the Drosophila embryo., Mol Cell Biol, vol. 23, no. 11, pp. 3990-9, 2003.
G. Rizki, Iwata, T. Naoko, Li, J., Riedel, C. G., Picard, C. Lafontaine, Jan, M., Murphy, C. T., and Lee, S. Sylvia, The evolutionarily conserved longevity determinants HCF-1 and SIR-2.1/SIRT1 collaborate to regulate DAF-16/FOXO., PLoS Genet, vol. 7, no. 9, p. e1002235, 2011.
A. Stolfi, T Gainous, B., Young, J. J., Mori, A., Levine, M., and Christiaen, L., Early chordate origins of the vertebrate second heart field., Science, vol. 329, no. 5991, pp. 565-8, 2010.
A. C. Martin, Gelbart, M., Fernandez-Gonzalez, R., Kaschube, M., and Wieschaus, E. F., Integration of contractile forces during tissue invagination., J Cell Biol, vol. 188, no. 5, pp. 735-49, 2010.
L. R. Swem, Swem, D. L., Wingreen, N. S., and Bassler, B. L., Deducing receptor signaling parameters from in vivo analysis: LuxN/AI-1 quorum sensing in Vibrio harveyi., Cell, vol. 134, no. 3, pp. 461-73, 2008.
G. Tkačik, Callan, C. G., and Bialek, W., Information capacity of genetic regulatory elements., Phys Rev E Stat Nonlin Soft Matter Phys, vol. 78, no. 1 Pt 1, p. 011910, 2008.
G. Tkačik, Walczak, A. M., and Bialek, W., Optimizing information flow in small genetic networks., Phys Rev E Stat Nonlin Soft Matter Phys, vol. 80, no. 3 Pt 1, p. 031920, 2009.
T. O. Nielsen, Hsu, F. D., O'Connell, J. X., C Gilks, B., Sorensen, P. H. B., Linn, S., West, R. B., Liu, C. Long, Botstein, D., Brown, P. O., and van de Rijn, M., Tissue microarray validation of epidermal growth factor receptor and SALL2 in synovial sarcoma with comparison to tumors of similar histology., Am J Pathol, vol. 163, no. 4, pp. 1449-56, 2003.
J. P. Bothma, Garcia, H. G., Ng, S., Perry, M. W., Gregor, T., and Levine, M., Enhancer additivity and non-additivity are determined by enhancer strength in the Drosophila embryo., Elife, vol. 4, 2015.
M. Peifer, Sweeton, D., Casey, M., and Wieschaus, E., wingless signal and Zeste-white 3 kinase trigger opposing changes in the intracellular distribution of Armadillo., Development, vol. 120, no. 2, pp. 369-80, 1994.
B. Riggleman, Wieschaus, E., and Schedl, P., Molecular analysis of the armadillo locus: uniformly distributed transcripts and a protein with novel internal repeats are associated with a Drosophila segment polarity gene., Genes Dev, vol. 3, no. 1, pp. 96-113, 1989.
M. Markstein and Levine, M., Decoding cis-regulatory DNAs in the Drosophila genome., Curr Opin Genet Dev, vol. 12, no. 5, pp. 601-6, 2002.
V. Lakhina, Arey, R. N., Kaletsky, R., Kauffman, A., Stein, G., Keyes, W., Xu, D., and Murphy, C. T., Genome-wide functional analysis of CREB/long-term memory-dependent transcription reveals distinct basal and memory gene expression programs., Neuron, vol. 85, no. 2, pp. 330-45, 2015.
C. Y. Ewald, Landis, J. N., Abate, J. Porter, Murphy, C. T., and T Blackwell, K., Dauer-independent insulin/IGF-1-signalling implicates collagen remodelling in longevity., Nature, vol. 519, no. 7541, pp. 97-101, 2015.
M. Markstein, Zinzen, R., Markstein, P., Yee, K. - P., Erives, A., Stathopoulos, A., and Levine, M., A regulatory code for neurogenic gene expression in the Drosophila embryo., Development, vol. 131, no. 10, pp. 2387-94, 2004.
Transcription, Genetic
C. Rauskolb and Wieschaus, E., Coordinate regulation of downstream genes by extradenticle and the homeotic selector proteins., EMBO J, vol. 13, no. 15, pp. 3561-9, 1994.
E. Wieschaus, Embryonic transcription and the control of developmental pathways., Genetics, vol. 142, no. 1, pp. 5-10, 1996.
K. Sayama, Diehn, M., Matsuda, K., Lunderius, C., Tsai, M., Tam, S. - Y., Botstein, D., Brown, P. O., and Galli, S. J., Transcriptional response of human mast cells stimulated via the Fc(epsilon)RI and identification of mast cells as a source of IL-11., BMC Immunol, vol. 3, p. 5, 2002.
H. Yoo-Warren, Pachnis, V., Ingram, R. S., and Tilghman, S. M., Two regulatory domains flank the mouse H19 gene., Mol Cell Biol, vol. 8, no. 11, pp. 4707-15, 1988.
B. P. Berman, Nibu, Y., Pfeiffer, B. D., Tomancak, P., Celniker, S. E., Levine, M., Rubin, G. M., and Eisen, M. B., Exploiting transcription factor binding site clustering to identify cis-regulatory modules involved in pattern formation in the Drosophila genome., Proc Natl Acad Sci U S A, vol. 99, no. 2, pp. 757-62, 2002.
R. Godbout and Tilghman, S. M., Configuration of the alpha-fetoprotein regulatory domain during development., Genes Dev, vol. 2, no. 8, pp. 949-56, 1988.
A. C. Edwards, Ayroles, J. F., Stone, E. A., Carbone, M. Anna, Lyman, R. F., and Mackay, T. F. C., A transcriptional network associated with natural variation in Drosophila aggressive behavior., Genome Biol, vol. 10, no. 7, p. R76, 2009.
D. Mancini-Dinardo, Steele, S. J. S., Levorse, J. M., Ingram, R. S., and Tilghman, S. M., Elongation of the Kcnq1ot1 transcript is required for genomic imprinting of neighboring genes., Genes Dev, vol. 20, no. 10, pp. 1268-82, 2006.
F. Biemar, Zinzen, R., Ronshaugen, M., Sementchenko, V., J Manak, R., and Levine, M. S., Spatial regulation of microRNA gene expression in the Drosophila embryo., Proc Natl Acad Sci U S A, vol. 102, no. 44, pp. 15907-11, 2005.
B. Riggleman, Schedl, P., and Wieschaus, E., Spatial expression of the Drosophila segment polarity gene armadillo is posttranscriptionally regulated by wingless., Cell, vol. 63, no. 3, pp. 549-60, 1990.
R. Papazyan, Sun, Z., Kim, Y. Hoon, Titchenell, P. M., Hill, D. A., Lu, W., Damle, M., Wan, M., Zhang, Y., Briggs, E. R., Rabinowitz, J. D., and Lazar, M. A., Physiological Suppression of Lipotoxic Liver Damage by Complementary Actions of HDAC3 and SCAP/SREBP., Cell Metab, vol. 24, no. 6, pp. 863-874, 2016.
P. Armand, Knapp, A. C., Hirsch, A. J., Wieschaus, E. F., and Cole, M. D., A novel basic helix-loop-helix protein is expressed in muscle attachment sites of the Drosophila epidermis., Mol Cell Biol, vol. 14, no. 6, pp. 4145-54, 1994.
C. T. Murphy, McCarroll, S. A., Bargmann, C. I., Fraser, A., Kamath, R. S., Ahringer, J., Li, H., and Kenyon, C., Genes that act downstream of DAF-16 to influence the lifespan of Caenorhabditis elegans., Nature, vol. 424, no. 6946, pp. 277-83, 2003.
G. Tkačik, Callan, C. G., and Bialek, W., Information flow and optimization in transcriptional regulation., Proc Natl Acad Sci U S A, vol. 105, no. 34, pp. 12265-70, 2008.
L. S. Rose and Wieschaus, E., The Drosophila cellularization gene nullo produces a blastoderm-specific transcript whose levels respond to the nucleocytoplasmic ratio., Genes Dev, vol. 6, no. 7, pp. 1255-68, 1992.
P. A. Leighton, Ingram, R. S., Eggenschwiler, J., Efstratiadis, A., and Tilghman, S. M., Disruption of imprinting caused by deletion of the H19 gene region in mice., Nature, vol. 375, no. 6526, pp. 34-9, 1995.
J. R. Pollack, Sørlie, T., Perou, C. M., Rees, C. A., Jeffrey, S. S., Lonning, P. E., Tibshirani, R., Botstein, D., Børresen-Dale, A. - L., and Brown, P. O., Microarray analysis reveals a major direct role of DNA copy number alteration in the transcriptional program of human breast tumors., Proc Natl Acad Sci U S A, vol. 99, no. 20, pp. 12963-8, 2002.
R. Godbout, Ingram, R. S., and Tilghman, S. M., Fine-structure mapping of the three mouse alpha-fetoprotein gene enhancers., Mol Cell Biol, vol. 8, no. 3, pp. 1169-78, 1988.
P. Jiang and Singh, M., CCAT: Combinatorial Code Analysis Tool for transcriptional regulation., Nucleic Acids Res, vol. 42, no. 5, pp. 2833-47, 2014.
E. A. Abbondanzieri, Shaevitz, J. W., and Block, S. M., Picocalorimetry of transcription by RNA polymerase., Biophys J, vol. 89, no. 6, pp. L61-3, 2005.
M. J. Hickman, Petti, A. A., Ho-Shing, O., Silverman, S. J., R McIsaac, S., Lee, T. A., and Botstein, D., Coordinated regulation of sulfur and phospholipid metabolism reflects the importance of methylation in the growth of yeast., Mol Biol Cell, vol. 22, no. 21, pp. 4192-204, 2011.
M. M. Klosinska, Crutchfield, C. A., Bradley, P. H., Rabinowitz, J. D., and Broach, J. R., Yeast cells can access distinct quiescent states., Genes Dev, vol. 25, no. 4, pp. 336-49, 2011.
M. A. Postner and Wieschaus, E. F., The nullo protein is a component of the actin-myosin network that mediates cellularization in Drosophila melanogaster embryos., J Cell Sci, vol. 107 ( Pt 7), pp. 1863-73, 1994.
B. He, Caudy, A., Parsons, L., Rosebrock, A., Pane, A., Raj, S., and Wieschaus, E., Mapping the pericentric heterochromatin by comparative genomic hybridization analysis and chromosome deletions in Drosophila melanogaster., Genome Res, vol. 22, no. 12, pp. 2507-19, 2012.
V. S. Chopra, Hong, J. - W., and Levine, M., Regulation of Hox gene activity by transcriptional elongation in Drosophila., Curr Biol, vol. 19, no. 8, pp. 688-93, 2009.
S. C. Little, Tikhonov, M., and Gregor, T., Precise developmental gene expression arises from globally stochastic transcriptional activity., Cell, vol. 154, no. 4, pp. 789-800, 2013.
N. Slavov and Botstein, D., Decoupling nutrient signaling from growth rate causes aerobic glycolysis and deregulation of cell size and gene expression., Mol Biol Cell, vol. 24, no. 2, pp. 157-68, 2013.
P. H. Bradley, Brauer, M. J., Rabinowitz, J. D., and Troyanskaya, O. G., Coordinated concentration changes of transcripts and metabolites in Saccharomyces cerevisiae., PLoS Comput Biol, vol. 5, no. 1, p. e1000270, 2009.
J. P. Roose, Diehn, M., Tomlinson, M. G., Lin, J., Alizadeh, A. A., Botstein, D., Brown, P. O., and Weiss, A., T cell receptor-independent basal signaling via Erk and Abl kinases suppresses RAG gene expression., PLoS Biol, vol. 1, no. 2, p. E53, 2003.
R. P. Oliveira, Abate, J. Porter, Dilks, K., Landis, J., Ashraf, J., Murphy, C. T., and T Blackwell, K., Condition-adapted stress and longevity gene regulation by Caenorhabditis elegans SKN-1/Nrf., Aging Cell, vol. 8, no. 5, pp. 524-41, 2009.
W. Wang, J Cherry, M., Botstein, D., and Li, H., A systematic approach to reconstructing transcription networks in Saccharomycescerevisiae., Proc Natl Acad Sci U S A, vol. 99, no. 26, pp. 16893-8, 2002.
M. E. Brunkow and Tilghman, S. M., Ectopic expression of the H19 gene in mice causes prenatal lethality., Genes Dev, vol. 5, no. 6, pp. 1092-101, 1991.
V. S. Chopra, Kong, N., and Levine, M., Transcriptional repression via antilooping in the Drosophila embryo., Proc Natl Acad Sci U S A, vol. 109, no. 24, pp. 9460-4, 2012.
K. C. Tu, Long, T., Svenningsen, S. L., Wingreen, N. S., and Bassler, B. L., Negative feedback loops involving small regulatory RNAs precisely control the Vibrio harveyi quorum-sensing response., Mol Cell, vol. 37, no. 4, pp. 567-79, 2010.
J. W. Shaevitz, Abbondanzieri, E. A., Landick, R., and Block, S. M., Backtracking by single RNA polymerase molecules observed at near-base-pair resolution., Nature, vol. 426, no. 6967, pp. 684-7, 2003.
M. D. Chikina and Troyanskaya, O. G., An effective statistical evaluation of ChIPseq dataset similarity., Bioinformatics, vol. 28, no. 5, pp. 607-13, 2012.
J. A. Emerson, Vacher, J., Cirillo, L. A., Tilghman, S. M., and Tyner, A. L., The zonal expression of alpha-fetoprotein transgenes in the livers of adult mice., Dev Dyn, vol. 195, no. 1, pp. 55-66, 1992.
C. I. Brannan, Dees, E. C., Ingram, R. S., and Tilghman, S. M., The product of the H19 gene may function as an RNA., Mol Cell Biol, vol. 10, no. 1, pp. 28-36, 1990.
W. Wang, J Cherry, M., Nochomovitz, Y., Jolly, E., Botstein, D., and Li, H., Inference of combinatorial regulation in yeast transcriptional networks: a case study of sporulation., Proc Natl Acad Sci U S A, vol. 102, no. 6, pp. 1998-2003, 2005.
A. L. Tyner, Godbout, R., Compton, R. S., and Tilghman, S. M., The ontogeny of alpha-fetoprotein gene expression in the mouse gastrointestinal tract., J Cell Biol, vol. 110, no. 4, pp. 915-27, 1990.
J. Vacher and Tilghman, S. M., Dominant negative regulation of the mouse alpha-fetoprotein gene in adult liver., Science, vol. 250, no. 4988, pp. 1732-5, 1990.
M. Lagha, Bothma, J. P., and Levine, M., Mechanisms of transcriptional precision in animal development., Trends Genet, vol. 28, no. 8, pp. 409-16, 2012.
J. Zhou, Park, C. Y., Theesfeld, C. L., Wong, A. K., Yuan, Y., Scheckel, C., Fak, J. J., Funk, J., Yao, K., Tajima, Y., Packer, A., Darnell, R. B., and Troyanskaya, O. G., Whole-genome deep-learning analysis identifies contribution of noncoding mutations to autism risk., Nat Genet, vol. 51, no. 6, pp. 973-980, 2019.
S. - W. Teng, Schaffer, J. N., Tu, K. C., Mehta, P., Lu, W., Ong, N. P., Bassler, B. L., and Wingreen, N. S., Active regulation of receptor ratios controls integration of quorum-sensing signals in Vibrio harveyi., Mol Syst Biol, vol. 7, p. 491, 2011.
M. Shapira, Segal, E., and Botstein, D., Disruption of yeast forkhead-associated cell cycle transcription by oxidative stress., Mol Biol Cell, vol. 15, no. 12, pp. 5659-69, 2004.
W. Bailis, Shyer, J. A., Zhao, J., Canaveras, J. Carlos Gar, Khazal, F. J. Al, Qu, R., Steach, H. R., Bielecki, P., Khan, O., Jackson, R., Kluger, Y., Maher, L. J., Rabinowitz, J., Craft, J., and Flavell, R. A., Distinct modes of mitochondrial metabolism uncouple T cell differentiation and function., Nature, vol. 571, no. 7765, pp. 403-407, 2019.
J. P. Bothma, Garcia, H. G., Esposito, E., Schlissel, G., Gregor, T., and Levine, M., Dynamic regulation of eve stripe 2 expression reveals transcriptional bursts in living Drosophila embryos., Proc Natl Acad Sci U S A, vol. 111, no. 29, pp. 10598-603, 2014.
S. Di Talia and Wieschaus, E. F., Short-term integration of Cdc25 dynamics controls mitotic entry during Drosophila gastrulation., Dev Cell, vol. 22, no. 4, pp. 763-74, 2012.
M. Ronen and Botstein, D., Transcriptional response of steady-state yeast cultures to transient perturbations in carbon source., Proc Natl Acad Sci U S A, vol. 103, no. 2, pp. 389-94, 2006.
S. R McIsaac, Oakes, B. L., Wang, X., Dummit, K. A., Botstein, D., and Noyes, M. B., Synthetic gene expression perturbation systems with rapid, tunable, single-gene specificity in yeast., Nucleic Acids Res, vol. 41, no. 4, p. e57, 2013.
A. Stolfi and Levine, M., Neuronal subtype specification in the spinal cord of a protovertebrate., Development, vol. 138, no. 5, pp. 995-1004, 2011.
M. Costa, Wilson, E. T., and Wieschaus, E., A putative cell signal encoded by the folded gastrulation gene coordinates cell shape changes during Drosophila gastrulation., Cell, vol. 76, no. 6, pp. 1075-89, 1994.
G. Tkačik, Gregor, T., and Bialek, W., The role of input noise in transcriptional regulation., PLoS One, vol. 3, no. 7, p. e2774, 2008.
E. A. Abbondanzieri, Greenleaf, W. J., Shaevitz, J. W., Landick, R., and Block, S. M., Direct observation of base-pair stepping by RNA polymerase., Nature, vol. 438, no. 7067, pp. 460-5, 2005.
J. P. Bothma, Magliocco, J., and Levine, M., The snail repressor inhibits release, not elongation, of paused Pol II in the Drosophila embryo., Curr Biol, vol. 21, no. 18, pp. 1571-7, 2011.
A. Fuchs, Cheung, L. S., Charbonnier, E., Shvartsman, S. Y., and Pyrowolakis, G., Transcriptional interpretation of the EGF receptor signaling gradient., Proc Natl Acad Sci U S A, vol. 109, no. 5, pp. 1572-7, 2012.
E. Wieschaus and Sweeton, D., Requirements for X-linked zygotic gene activity during cellularization of early Drosophila embryos., Development, vol. 104, no. 3, pp. 483-93, 1988.
J. Zhou and Troyanskaya, O. G., Global quantitative modeling of chromatin factor interactions., PLoS Comput Biol, vol. 10, no. 3, p. e1003525, 2014.
E. Bae, Calhoun, V. C., Levine, M., Lewis, E. B., and Drewell, R. A., Characterization of the intergenic RNA profile at abdominal-A and Abdominal-B in the Drosophila bithorax complex., Proc Natl Acad Sci U S A, vol. 99, no. 26, pp. 16847-52, 2002.
C. T. Murphy, The search for DAF-16/FOXO transcriptional targets: approaches and discoveries., Exp Gerontol, vol. 41, no. 10, pp. 910-21, 2006.
A. A. Petti, Crutchfield, C. A., Rabinowitz, J. D., and Botstein, D., Survival of starving yeast is correlated with oxidative stress response and nonrespiratory mitochondrial function., Proc Natl Acad Sci U S A, vol. 108, no. 45, pp. E1089-98, 2011.
S. A. Camper and Tilghman, S. M., Postnatal repression of the alpha-fetoprotein gene is enhancer independent., Genes Dev, vol. 3, no. 4, pp. 537-46, 1989.
G. Rizki, Iwata, T. Naoko, Li, J., Riedel, C. G., Picard, C. Lafontaine, Jan, M., Murphy, C. T., and Lee, S. Sylvia, The evolutionarily conserved longevity determinants HCF-1 and SIR-2.1/SIRT1 collaborate to regulate DAF-16/FOXO., PLoS Genet, vol. 7, no. 9, p. e1002235, 2011.
T. J. Vasicek, Zeng, L., Guan, X. J., Zhang, T., Costantini, F., and Tilghman, S. M., Two dominant mutations in the mouse fused gene are the result of transposon insertions., Genetics, vol. 147, no. 2, pp. 777-86, 1997.
G. Tkačik, Callan, C. G., and Bialek, W., Information capacity of genetic regulatory elements., Phys Rev E Stat Nonlin Soft Matter Phys, vol. 78, no. 1 Pt 1, p. 011910, 2008.
M. Markstein and Levine, M., Decoding cis-regulatory DNAs in the Drosophila genome., Curr Opin Genet Dev, vol. 12, no. 5, pp. 601-6, 2002.
M. J. Brauer, Huttenhower, C., Airoldi, E. M., Rosenstein, R., Matese, J. C., Gresham, D., Boer, V. M., Troyanskaya, O. G., and Botstein, D., Coordination of growth rate, cell cycle, stress response, and metabolic activity in yeast., Mol Biol Cell, vol. 19, no. 1, pp. 352-67, 2008.
M. Lagha, Bothma, J. P., Esposito, E., Ng, S., Stefanik, L., Tsui, C., Johnston, J., Chen, K., Gilmour, D. S., Zeitlinger, J., and Levine, M. S., Paused Pol II coordinates tissue morphogenesis in the Drosophila embryo., Cell, vol. 153, no. 5, pp. 976-87, 2013.
M. Levine, Cattoglio, C., and Tjian, R., Looping back to leap forward: transcription enters a new era., Cell, vol. 157, no. 1, pp. 13-25, 2014.
P. Jumbo-Lucioni, Ayroles, J. F., Chambers, M. Moses, Jordan, K. W., Leips, J., Mackay, T. Fc, and De Luca, M., Systems genetics analysis of body weight and energy metabolism traits in Drosophila melanogaster., BMC Genomics, vol. 11, p. 297, 2010.
C. D. van Raamsdonk and Tilghman, S. M., Optimizing the detection of nascent transcripts by RNA fluorescence in situ hybridization., Nucleic Acids Res, vol. 29, no. 8, pp. E42-2, 2001.
A. Pane, Jiang, P., Zhao, D. Yanling, Singh, M., and Schüpbach, T., The Cutoff protein regulates piRNA cluster expression and piRNA production in the Drosophila germline., EMBO J, vol. 30, no. 22, pp. 4601-15, 2011.
E. D. Schejter and Wieschaus, E., bottleneck acts as a regulator of the microfilament network governing cellularization of the Drosophila embryo., Cell, vol. 75, no. 2, pp. 373-85, 1993.
B. T. Spear and Tilghman, S. M., Role of alpha-fetoprotein regulatory elements in transcriptional activation in transient heterokaryons., Mol Cell Biol, vol. 10, no. 10, pp. 5047-54, 1990.
M. L. Whitfield, Sherlock, G., Saldanha, A. J., Murray, J. I., Ball, C. A., Alexander, K. E., Matese, J. C., Perou, C. M., Hurt, M. M., Brown, P. O., and Botstein, D., Identification of genes periodically expressed in the human cell cycle and their expression in tumors., Mol Biol Cell, vol. 13, no. 6, pp. 1977-2000, 2002.
X. Lu, Li, J. M., Elemento, O., Tavazoie, S., and Wieschaus, E. F., Coupling of zygotic transcription to mitotic control at the Drosophila mid-blastula transition., Development, vol. 136, no. 12, pp. 2101-10, 2009.
S. R McIsaac, Petti, A. A., Bussemaker, H. J., and Botstein, D., Perturbation-based analysis and modeling of combinatorial regulation in the yeast sulfur assimilation pathway., Mol Biol Cell, vol. 23, no. 15, pp. 2993-3007, 2012.
M. Levine and Tjian, R., Transcription regulation and animal diversity., Nature, vol. 424, no. 6945, pp. 147-51, 2003.
Y. Kim, Iagovitina, A., Ishihara, K., Fitzgerald, K. M., Deplancke, B., Papatsenko, D., and Shvartsman, S. Y., Context-dependent transcriptional interpretation of mitogen activated protein kinase signaling in the Drosophila embryo., Chaos, vol. 23, no. 2, p. 025105, 2013.
L. Christiaen, Davidson, B., Kawashima, T., Powell, W., Nolla, H., Vranizan, K., and Levine, M., The transcription/migration interface in heart precursors of Ciona intestinalis., Science, vol. 320, no. 5881, pp. 1349-52, 2008.

Pages