List of Faculty Publications

Below is a list of Faculty publications imported from PubMed or manually added. By default, publications are sorted by year with titles displayed in ascending alphabetical order.
Shortcuts: Wühr, Martin | Wingreen, Ned | Wieschaus, Eric | Troyanskaya, Olga | Tilghman, Shirley | Storey, John | Singh, Mona | Shvartsman, Stanislav | Shaevitz, Joshua | Rabinowitz, Joshua | Murphy, Coleen | Levine, Michael {Levine, Michael S.} | Gregor, Thomas | Botstein, David | Bialek, William | Ayroles, Julien | Andolfatto, Peter | Akey, Joshua

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Oligonucleotide Array Sequence Analysis
T. O. Nielsen, Hsu, F. D., O'Connell, J. X., C Gilks, B., Sorensen, P. H. B., Linn, S., West, R. B., Liu, C. Long, Botstein, D., Brown, P. O., and van de Rijn, M., Tissue microarray validation of epidermal growth factor receptor and SALL2 in synovial sarcoma with comparison to tumors of similar histology., Am J Pathol, vol. 163, no. 4, pp. 1449-56, 2003.
D. Gresham, Usaite, R., Germann, S. Manuela, Lisby, M., Botstein, D., and Regenberg, B., Adaptation to diverse nitrogen-limited environments by deletion or extrachromosomal element formation of the GAP1 locus., Proc Natl Acad Sci U S A, vol. 107, no. 43, pp. 18551-6, 2010.
J. R. Pollack, Sørlie, T., Perou, C. M., Rees, C. A., Jeffrey, S. S., Lonning, P. E., Tibshirani, R., Botstein, D., Børresen-Dale, A. - L., and Brown, P. O., Microarray analysis reveals a major direct role of DNA copy number alteration in the transcriptional program of human breast tumors., Proc Natl Acad Sci U S A, vol. 99, no. 20, pp. 12963-8, 2002.
M. J. Brauer, Saldanha, A. J., Dolinski, K., and Botstein, D., Homeostatic adjustment and metabolic remodeling in glucose-limited yeast cultures., Mol Biol Cell, vol. 16, no. 5, pp. 2503-17, 2005.
M. Diehn, Sherlock, G., Binkley, G., Jin, H., Matese, J. C., Hernandez-Boussard, T., Rees, C. A., J Cherry, M., Botstein, D., Brown, P. O., and Alizadeh, A. A., SOURCE: a unified genomic resource of functional annotations, ontologies, and gene expression data., Nucleic Acids Res, vol. 31, no. 1, pp. 219-23, 2003.
N. Slavov, Airoldi, E. M., van Oudenaarden, A., and Botstein, D., A conserved cell growth cycle can account for the environmental stress responses of divergent eukaryotes., Mol Biol Cell, vol. 23, no. 10, pp. 1986-97, 2012.
M. L. Whitfield, Sherlock, G., Saldanha, A. J., Murray, J. I., Ball, C. A., Alexander, K. E., Matese, J. C., Perou, C. M., Hurt, M. M., Brown, P. O., and Botstein, D., Identification of genes periodically expressed in the human cell cycle and their expression in tumors., Mol Biol Cell, vol. 13, no. 6, pp. 1977-2000, 2002.
X. Chen, Leung, S. Y., Yuen, S. T., Chu, K. - M., Ji, J., Li, R., S Y Chan, A., Law, S., Troyanskaya, O. G., Wong, J., So, S., Botstein, D., and Brown, P. O., Variation in gene expression patterns in human gastric cancers., Mol Biol Cell, vol. 14, no. 8, pp. 3208-15, 2003.
Y. Liang, Diehn, M., Watson, N., Bollen, A. W., Aldape, K. D., M Nicholas, K., Lamborn, K. R., Berger, M. S., Botstein, D., Brown, P. O., and Israel, M. A., Gene expression profiling reveals molecularly and clinically distinct subtypes of glioblastoma multiforme., Proc Natl Acad Sci U S A, vol. 102, no. 16, pp. 5814-9, 2005.
O. G. Troyanskaya, Dolinski, K., Owen, A. B., Altman, R. B., and Botstein, D., A Bayesian framework for combining heterogeneous data sources for gene function prediction (in Saccharomyces cerevisiae)., Proc Natl Acad Sci U S A, vol. 100, no. 14, pp. 8348-53, 2003.
O. Alter, Brown, P. O., and Botstein, D., Generalized singular value decomposition for comparative analysis of genome-scale expression data sets of two different organisms., Proc Natl Acad Sci U S A, vol. 100, no. 6, pp. 3351-6, 2003.
S. S. Jeffrey, Fero, M. J., Børresen-Dale, A. - L., and Botstein, D., Expression array technology in the diagnosis and treatment of breast cancer., Mol Interv, vol. 2, no. 2, pp. 101-9, 2002.
X. Chen, Cheung, S. Tim, So, S., Fan, S. Tat, Barry, C., Higgins, J., Lai, K. - M., Ji, J., Dudoit, S., Ng, I. O. L., van de Rijn, M., Botstein, D., and Brown, P. O., Gene expression patterns in human liver cancers., Mol Biol Cell, vol. 13, no. 6, pp. 1929-39, 2002.
O. G. Troyanskaya, Garber, M. E., Brown, P. O., Botstein, D., and Altman, R. B., Nonparametric methods for identifying differentially expressed genes in microarray data., Bioinformatics, vol. 18, no. 11, pp. 1454-61, 2002.
J. R. Pollack, van de Rijn, M., and Botstein, D., Challenges in developing a molecular characterization of cancer., Semin Oncol, vol. 29, no. 3, pp. 280-5, 2002.
T. Sorlie, Tibshirani, R., Parker, J., Hastie, T., Marron, J. S., Nobel, A., Deng, S., Johnsen, H., Pesich, R., Geisler, S., Demeter, J., Perou, C. M., Lønning, P. E., Brown, P. O., Børresen-Dale, A. - L., and Botstein, D., Repeated observation of breast tumor subtypes in independent gene expression data sets., Proc Natl Acad Sci U S A, vol. 100, no. 14, pp. 8418-23, 2003.
R. Shyamsundar, Kim, Y. H., Higgins, J. P., Montgomery, K., Jorden, M., Sethuraman, A., van de Rijn, M., Botstein, D., Brown, P. O., and Pollack, J. R., A DNA microarray survey of gene expression in normal human tissues., Genome Biol, vol. 6, no. 3, p. R22, 2005.
J. C. Boldrick, Alizadeh, A. A., Diehn, M., Dudoit, S., Liu, C. Long, Belcher, C. E., Botstein, D., Staudt, L. M., Brown, P. O., and Relman, D. A., Stereotyped and specific gene expression programs in human innate immune responses to bacteria., Proc Natl Acad Sci U S A, vol. 99, no. 2, pp. 972-7, 2002.
J. Schacherer, Ruderfer, D. M., Gresham, D., Dolinski, K., Botstein, D., and Kruglyak, L., Genome-wide analysis of nucleotide-level variation in commonly used Saccharomyces cerevisiae strains., PLoS One, vol. 2, no. 3, p. e322, 2007.
C. A. Rees, Demeter, J., Matese, J. C., Botstein, D., and Sherlock, G., GeneXplorer: an interactive web application for microarray data visualization and analysis., BMC Bioinformatics, vol. 5, p. 141, 2004.
M. Diehn, Bhattacharya, R., Botstein, D., and Brown, P. O., Genome-scale identification of membrane-associated human mRNAs., PLoS Genet, vol. 2, no. 1, p. e11, 2006.
M. Shakoury-Elizeh, Tiedeman, J., Rashford, J., Ferea, T., Demeter, J., Garcia, E., Rolfes, R., Brown, P. O., Botstein, D., and Philpott, C. C., Transcriptional remodeling in response to iron deprivation in Saccharomyces cerevisiae., Mol Biol Cell, vol. 15, no. 3, pp. 1233-43, 2004.
E. Segal, Shapira, M., Regev, iv, A., Pe'er, D., Botstein, D., Koller, D., and Friedman, N., Module networks: identifying regulatory modules and their condition-specific regulators from gene expression data., Nat Genet, vol. 34, no. 2, pp. 166-76, 2003.
J. Isaac Murray, Whitfield, M. L., Trinklein, N. D., Myers, R. M., Brown, P. O., and Botstein, D., Diverse and specific gene expression responses to stresses in cultured human cells., Mol Biol Cell, vol. 15, no. 5, pp. 2361-74, 2004.
K. S. Smith, Chanda, S. K., Lingbeek, M., Ross, D. T., Botstein, D., van Lohuizen, M., and Cleary, M. L., Bmi-1 regulation of INK4A-ARF is a downstream requirement for transformation of hematopoietic progenitors by E2a-Pbx1., Mol Cell, vol. 12, no. 2, pp. 393-400, 2003.
I. - P. Tu, Schaner, M., Diehn, M., Sikic, B. I., Brown, P. O., Botstein, D., and Fero, M. J., A method for detecting and correcting feature misidentification on expression microarrays., BMC Genomics, vol. 5, p. 64, 2004.
D. Gresham, Curry, B., Ward, A., D Gordon, B., Brizuela, L., Kruglyak, L., and Botstein, D., Optimized detection of sequence variation in heterozygous genomes using DNA microarrays with isothermal-melting probes., Proc Natl Acad Sci U S A, vol. 107, no. 4, pp. 1482-7, 2010.
H. Y. Chang, Chi, J. - T., Dudoit, S., Bondre, C., van de Rijn, M., Botstein, D., and Brown, P. O., Diversity, topographic differentiation, and positional memory in human fibroblasts., Proc Natl Acad Sci U S A, vol. 99, no. 20, pp. 12877-82, 2002.
S. Y. Leung, Chen, X., Chu, K. M., Yuen, S. T., Mathy, J., Ji, J., S Y Chan, A., Li, R., Law, S., Troyanskaya, O. G., Tu, I. - P., Wong, J., So, S., Botstein, D., and Brown, P. O., Phospholipase A2 group IIA expression in gastric adenocarcinoma is associated with prolonged survival and less frequent metastasis., Proc Natl Acad Sci U S A, vol. 99, no. 25, pp. 16203-8, 2002.
J. Lapointe, Li, C., Higgins, J. P., van de Rijn, M., Bair, E., Montgomery, K., Ferrari, M., Egevad, L., Rayford, W., Bergerheim, U., Ekman, P., DeMarzo, A. M., Tibshirani, R., Botstein, D., Brown, P. O., Brooks, J. D., and Pollack, J. R., Gene expression profiling identifies clinically relevant subtypes of prostate cancer., Proc Natl Acad Sci U S A, vol. 101, no. 3, pp. 811-6, 2004.
H. Zhao, Langerød, A., Ji, Y., Nowels, K. W., Nesland, J. M., Tibshirani, R., Bukholm, I. K., Kåresen, R., Botstein, D., Børresen-Dale, A. - L., and Jeffrey, S. S., Different gene expression patterns in invasive lobular and ductal carcinomas of the breast., Mol Biol Cell, vol. 15, no. 6, pp. 2523-36, 2004.
M. E. Schaner, Ross, D. T., Ciaravino, G., Sorlie, T., Troyanskaya, O., Diehn, M., Wang, Y. C., Duran, G. E., Sikic, T. L., Caldeira, S., Skomedal, H., Tu, I. - P., Hernandez-Boussard, T., Johnson, S. W., O'Dwyer, P. J., Fero, M. J., Kristensen, G. B., Borresen-Dale, A. - L., Hastie, T., Tibshirani, R., van de Rijn, M., Teng, N. N., Longacre, T. A., Botstein, D., Brown, P. O., and Sikic, B. I., Gene expression patterns in ovarian carcinomas., Mol Biol Cell, vol. 14, no. 11, pp. 4376-86, 2003.
W. Wang, J Cherry, M., Nochomovitz, Y., Jolly, E., Botstein, D., and Li, H., Inference of combinatorial regulation in yeast transcriptional networks: a case study of sporulation., Proc Natl Acad Sci U S A, vol. 102, no. 6, pp. 1998-2003, 2005.
E. W. Trotter, Kao, C. M. - F., Berenfeld, L., Botstein, D., Petsko, G. A., and Gray, J. V., Misfolded proteins are competent to mediate a subset of the responses to heat shock in Saccharomyces cerevisiae., J Biol Chem, vol. 277, no. 47, pp. 44817-25, 2002.
M. J. Dunham, Badrane, H., Ferea, T., Adams, J., Brown, P. O., Rosenzweig, F., and Botstein, D., Characteristic genome rearrangements in experimental evolution of Saccharomyces cerevisiae., Proc Natl Acad Sci U S A, vol. 99, no. 25, pp. 16144-9, 2002.
S. C. Linn, West, R. B., Pollack, J. R., Zhu, S., Hernandez-Boussard, T., Nielsen, T. O., Rubin, B. P., Patel, iv, R., Goldblum, J. R., Siegmund, D., Botstein, D., Brown, P. O., C Gilks, B., and van de Rijn, M., Gene expression patterns and gene copy number changes in dermatofibrosarcoma protuberans., Am J Pathol, vol. 163, no. 6, pp. 2383-95, 2003.
H. Yoshimoto, Saltsman, K., Gasch, A. P., Li, H. Xia, Ogawa, N., Botstein, D., Brown, P. O., and Cyert, M. S., Genome-wide analysis of gene expression regulated by the calcineurin/Crz1p signaling pathway in Saccharomyces cerevisiae., J Biol Chem, vol. 277, no. 34, pp. 31079-88, 2002.
D. C. Hess, Lu, W., Rabinowitz, J. D., and Botstein, D., Ammonium toxicity and potassium limitation in yeast., PLoS Biol, vol. 4, no. 11, p. e351, 2006.
J. Gollub, Ball, C. A., Binkley, G., Demeter, J., Finkelstein, D. B., Hebert, J. M., Hernandez-Boussard, T., Jin, H., Kaloper, M., Matese, J. C., Schroeder, M., Brown, P. O., Botstein, D., and Sherlock, G., The Stanford Microarray Database: data access and quality assessment tools., Nucleic Acids Res, vol. 31, no. 1, pp. 94-6, 2003.
I. S. Lossos, Czerwinski, D. K., Alizadeh, A. A., Wechser, M. A., Tibshirani, R., Botstein, D., and Levy, R., Prediction of survival in diffuse large-B-cell lymphoma based on the expression of six genes., N Engl J Med, vol. 350, no. 18, pp. 1828-37, 2004.
M. van de Rijn, Perou, C. M., Tibshirani, R., Haas, P., Kallioniemi, O., Kononen, J., Torhorst, J., Sauter, G., Zuber, M., Köchli, O. R., Mross, F., Dieterich, H., Seitz, R., Ross, D., Botstein, D., and Brown, P., Expression of cytokeratins 17 and 5 identifies a group of breast carcinomas with poor clinical outcome., Am J Pathol, vol. 161, no. 6, pp. 1991-6, 2002.
A. J. Saldanha, Brauer, M. J., and Botstein, D., Nutritional homeostasis in batch and steady-state culture of yeast., Mol Biol Cell, vol. 15, no. 9, pp. 4089-104, 2004.
H. Zhao, Whitfield, M. L., Xu, T., Botstein, D., and Brooks, J. D., Diverse effects of methylseleninic acid on the transcriptional program of human prostate cancer cells., Mol Biol Cell, vol. 15, no. 2, pp. 506-19, 2004.
K. Sayama, Diehn, M., Matsuda, K., Lunderius, C., Tsai, M., Tam, S. - Y., Botstein, D., Brown, P. O., and Galli, S. J., Transcriptional response of human mast cells stimulated via the Fc(epsilon)RI and identification of mast cells as a source of IL-11., BMC Immunol, vol. 3, p. 5, 2002.
T. O. Nielsen, West, R. B., Linn, S. C., Alter, O., Knowling, M. A., O'Connell, J. X., Zhu, S., Fero, M., Sherlock, G., Pollack, J. R., Brown, P. O., Botstein, D., and van de Rijn, M., Molecular characterisation of soft tissue tumours: a gene expression study., Lancet, vol. 359, no. 9314, pp. 1301-7, 2002.
D. Gresham, Ruderfer, D. M., Pratt, S. C., Schacherer, J., Dunham, M. J., Botstein, D., and Kruglyak, L., Genome-wide detection of polymorphisms at nucleotide resolution with a single DNA microarray., Science, vol. 311, no. 5769, pp. 1932-6, 2006.
N. Novoradovskaya, Whitfield, M. L., Basehore, L. S., Novoradovsky, A., Pesich, R., Usary, J., Karaca, M., Wong, W. K., Aprelikova, O., Fero, M., Perou, C. M., Botstein, D., and Braman, J., Universal Reference RNA as a standard for microarray experiments., BMC Genomics, vol. 5, no. 1, p. 20, 2004.
J. P. Roose, Diehn, M., Tomlinson, M. G., Lin, J., Alizadeh, A. A., Botstein, D., Brown, P. O., and Weiss, A., T cell receptor-independent basal signaling via Erk and Abl kinases suppresses RAG gene expression., PLoS Biol, vol. 1, no. 2, p. E53, 2003.
T. Sørlie, Perou, C. M., Fan, C., Geisler, S., Aas, T., Nobel, A., Anker, G., Akslen, L. A., Botstein, D., Børresen-Dale, A. - L., and Lønning, P. Eystein, Gene expression profiles do not consistently predict the clinical treatment response in locally advanced breast cancer., Mol Cancer Ther, vol. 5, no. 11, pp. 2914-8, 2006.
D. Gresham, Desai, M. M., Tucker, C. M., Jenq, H. T., Pai, D. A., Ward, A., DeSevo, C. G., Botstein, D., and Dunham, M. J., The repertoire and dynamics of evolutionary adaptations to controlled nutrient-limited environments in yeast., PLoS Genet, vol. 4, no. 12, p. e1000303, 2008.
D. Gresham, Dunham, M. J., and Botstein, D., Comparing whole genomes using DNA microarrays., Nat Rev Genet, vol. 9, no. 4, pp. 291-302, 2008.
E. I. Boyle, Weng, S., Gollub, J., Jin, H., Botstein, D., J Cherry, M., and Sherlock, G., GO::TermFinder--open source software for accessing Gene Ontology information and finding significantly enriched Gene Ontology terms associated with a list of genes., Bioinformatics, vol. 20, no. 18, pp. 3710-5, 2004.
Osmolar Concentration
J. Mulholland and Botstein, D., Immunoelectron microscopy of aldehyde-fixed yeast cells., Methods Enzymol, vol. 351, pp. 50-81, 2002.
Oxidative Stress
A. A. Petti, Crutchfield, C. A., Rabinowitz, J. D., and Botstein, D., Survival of starving yeast is correlated with oxidative stress response and nonrespiratory mitochondrial function., Proc Natl Acad Sci U S A, vol. 108, no. 45, pp. E1089-98, 2011.
J. Isaac Murray, Whitfield, M. L., Trinklein, N. D., Myers, R. M., Brown, P. O., and Botstein, D., Diverse and specific gene expression responses to stresses in cultured human cells., Mol Biol Cell, vol. 15, no. 5, pp. 2361-74, 2004.
A. A. Caudy, Guan, Y., Jia, Y., Hansen, C., DeSevo, C., Hayes, A. P., Agee, J., Alvarez-Dominguez, J. R., Arellano, H., Barrett, D., Bauerle, C., Bisaria, N., Bradley, P. H., J Breunig, S., Bush, E., Cappel, D., Capra, E., Chen, W., Clore, J., Combs, P. A., Doucette, C., Demuren, O., Fellowes, P., Freeman, S., Frenkel, E., Gadala-Maria, D., Gawande, R., Glass, D., Grossberg, S., Gupta, A., Hammonds-Odie, L., Hoisos, A., Hsi, J., Hsu, Y. - H. Huang, Inukai, S., Karczewski, K. J., Ke, X., Kojima, M., Leachman, S., Lieber, D., Liebowitz, A., Liu, J., Liu, Y., Martin, T., Mena, J., Mendoza, R., Myhrvold, C., Millian, C., Pfau, S., Raj, S., Rich, M., Rokicki, J., Rounds, W., Salazar, M., Salesi, M., Sharma, R., Silverman, S., Singer, C., Sinha, S., Staller, M., Stern, P., Tang, H., Weeks, S., Weidmann, M., Wolf, A., Young, C., Yuan, J., Crutchfield, C., McClean, M., Murphy, C. T., Llinás, M., Botstein, D., Troyanskaya, O. G., and Dunham, M. J., A new system for comparative functional genomics of Saccharomyces yeasts., Genetics, vol. 195, no. 1, pp. 275-87, 2013.
M. Shapira, Segal, E., and Botstein, D., Disruption of yeast forkhead-associated cell cycle transcription by oxidative stress., Mol Biol Cell, vol. 15, no. 12, pp. 5659-69, 2004.
Phenotype
D. Botstein and Risch, N., Discovering genotypes underlying human phenotypes: past successes for mendelian disease, future approaches for complex disease., Nat Genet, vol. 33 Suppl, pp. 228-37, 2003.
E. S. Click, Stearns, T., and Botstein, D., Systematic structure-function analysis of the small GTPase Arf1 in yeast., Mol Biol Cell, vol. 13, no. 5, pp. 1652-64, 2002.
H. Y. Chang, Chi, J. - T., Dudoit, S., Bondre, C., van de Rijn, M., Botstein, D., and Brown, P. O., Diversity, topographic differentiation, and positional memory in human fibroblasts., Proc Natl Acad Sci U S A, vol. 99, no. 20, pp. 12877-82, 2002.
M. J. Dunham, Badrane, H., Ferea, T., Adams, J., Brown, P. O., Rosenzweig, F., and Botstein, D., Characteristic genome rearrangements in experimental evolution of Saccharomyces cerevisiae., Proc Natl Acad Sci U S A, vol. 99, no. 25, pp. 16144-9, 2002.
D. Gresham, Ruderfer, D. M., Pratt, S. C., Schacherer, J., Dunham, M. J., Botstein, D., and Kruglyak, L., Genome-wide detection of polymorphisms at nucleotide resolution with a single DNA microarray., Science, vol. 311, no. 5769, pp. 1932-6, 2006.
D. Gresham, Desai, M. M., Tucker, C. M., Jenq, H. T., Pai, D. A., Ward, A., DeSevo, C. G., Botstein, D., and Dunham, M. J., The repertoire and dynamics of evolutionary adaptations to controlled nutrient-limited environments in yeast., PLoS Genet, vol. 4, no. 12, p. e1000303, 2008.
S. R. Engel, Balakrishnan, R., Binkley, G., Christie, K. R., Costanzo, M. C., Dwight, S. S., Fisk, D. G., Hirschman, J. E., Hitz, B. C., Hong, E. L., Krieger, C. J., Livstone, M. S., Miyasato, S. R., Nash, R., Oughtred, R., Park, J., Skrzypek, M. S., Weng, S., Wong, E. D., Dolinski, K., Botstein, D., and J Cherry, M., Saccharomyces Genome Database provides mutant phenotype data., Nucleic Acids Res, vol. 38, no. Database issue, pp. D433-6, 2010.
Phosphates
D. Gresham, Desai, M. M., Tucker, C. M., Jenq, H. T., Pai, D. A., Ward, A., DeSevo, C. G., Botstein, D., and Dunham, M. J., The repertoire and dynamics of evolutionary adaptations to controlled nutrient-limited environments in yeast., PLoS Genet, vol. 4, no. 12, p. e1000303, 2008.
A. J. Saldanha, Brauer, M. J., and Botstein, D., Nutritional homeostasis in batch and steady-state culture of yeast., Mol Biol Cell, vol. 15, no. 9, pp. 4089-104, 2004.
V. M. Boer, Crutchfield, C. A., Bradley, P. H., Botstein, D., and Rabinowitz, J. D., Growth-limiting intracellular metabolites in yeast growing under diverse nutrient limitations., Mol Biol Cell, vol. 21, no. 1, pp. 198-211, 2010.
D. Gresham, Boer, V. M., Caudy, A., Ziv, N., Brandt, N. J., Storey, J. D., and Botstein, D., System-level analysis of genes and functions affecting survival during nutrient starvation in Saccharomyces cerevisiae., Genetics, vol. 187, no. 1, pp. 299-317, 2011.
V. M. Boer, Amini, S., and Botstein, D., Influence of genotype and nutrition on survival and metabolism of starving yeast., Proc Natl Acad Sci U S A, vol. 105, no. 19, pp. 6930-5, 2008.
S. J. Silverman, Petti, A. A., Slavov, N., Parsons, L., Briehof, R., Thiberge, S. Y., Zenklusen, D., Gandhi, S. J., Larson, D. R., Singer, R. H., and Botstein, D., Metabolic cycling in single yeast cells from unsynchronized steady-state populations limited on glucose or phosphate., Proc Natl Acad Sci U S A, vol. 107, no. 15, pp. 6946-51, 2010.
Polymorphism, Single Nucleotide
D. Gresham, Dunham, M. J., and Botstein, D., Comparing whole genomes using DNA microarrays., Nat Rev Genet, vol. 9, no. 4, pp. 291-302, 2008.
D. Botstein and Risch, N., Discovering genotypes underlying human phenotypes: past successes for mendelian disease, future approaches for complex disease., Nat Genet, vol. 33 Suppl, pp. 228-37, 2003.
J. Schacherer, Ruderfer, D. M., Gresham, D., Dolinski, K., Botstein, D., and Kruglyak, L., Genome-wide analysis of nucleotide-level variation in commonly used Saccharomyces cerevisiae strains., PLoS One, vol. 2, no. 3, p. e322, 2007.
K. Ranade, Jorgenson, E., Sheu, W. H. - H., Pei, D., Hsiung, C. Agnes, Chiang, F. -tien, Chen, Y. - D. I., Pratt, R., Olshen, R. A., Curb, D., Cox, D. R., Botstein, D., and Risch, N., A polymorphism in the beta1 adrenergic receptor is associated with resting heart rate., Am J Hum Genet, vol. 70, no. 4, pp. 935-42, 2002.
M. J. Hickman, Petti, A. A., Ho-Shing, O., Silverman, S. J., R McIsaac, S., Lee, T. A., and Botstein, D., Coordinated regulation of sulfur and phospholipid metabolism reflects the importance of methylation in the growth of yeast., Mol Biol Cell, vol. 22, no. 21, pp. 4192-204, 2011.
D. Gresham, Curry, B., Ward, A., D Gordon, B., Brizuela, L., Kruglyak, L., and Botstein, D., Optimized detection of sequence variation in heterozygous genomes using DNA microarrays with isothermal-melting probes., Proc Natl Acad Sci U S A, vol. 107, no. 4, pp. 1482-7, 2010.
D. Gresham, Ruderfer, D. M., Pratt, S. C., Schacherer, J., Dunham, M. J., Botstein, D., and Kruglyak, L., Genome-wide detection of polymorphisms at nucleotide resolution with a single DNA microarray., Science, vol. 311, no. 5769, pp. 1932-6, 2006.
Principal Component Analysis
M. Wyart, Botstein, D., and Wingreen, N. S., Evaluating gene expression dynamics using pairwise RNA FISH data., PLoS Comput Biol, vol. 6, no. 11, p. e1000979, 2010.
Prognosis
I. S. Lossos, Czerwinski, D. K., Alizadeh, A. A., Wechser, M. A., Tibshirani, R., Botstein, D., and Levy, R., Prediction of survival in diffuse large-B-cell lymphoma based on the expression of six genes., N Engl J Med, vol. 350, no. 18, pp. 1828-37, 2004.
J. Lapointe, Li, C., Higgins, J. P., van de Rijn, M., Bair, E., Montgomery, K., Ferrari, M., Egevad, L., Rayford, W., Bergerheim, U., Ekman, P., DeMarzo, A. M., Tibshirani, R., Botstein, D., Brown, P. O., Brooks, J. D., and Pollack, J. R., Gene expression profiling identifies clinically relevant subtypes of prostate cancer., Proc Natl Acad Sci U S A, vol. 101, no. 3, pp. 811-6, 2004.
M. van de Rijn, Perou, C. M., Tibshirani, R., Haas, P., Kallioniemi, O., Kononen, J., Torhorst, J., Sauter, G., Zuber, M., Köchli, O. R., Mross, F., Dieterich, H., Seitz, R., Ross, D., Botstein, D., and Brown, P., Expression of cytokeratins 17 and 5 identifies a group of breast carcinomas with poor clinical outcome., Am J Pathol, vol. 161, no. 6, pp. 1991-6, 2002.
S. Y. Leung, Chen, X., Chu, K. M., Yuen, S. T., Mathy, J., Ji, J., S Y Chan, A., Li, R., Law, S., Troyanskaya, O. G., Tu, I. - P., Wong, J., So, S., Botstein, D., and Brown, P. O., Phospholipase A2 group IIA expression in gastric adenocarcinoma is associated with prolonged survival and less frequent metastasis., Proc Natl Acad Sci U S A, vol. 99, no. 25, pp. 16203-8, 2002.
H. Y. Chang, Sneddon, J. B., Alizadeh, A. A., Sood, R., West, R. B., Montgomery, K., Chi, J. - T., van de Rijn, M., Botstein, D., and Brown, P. O., Gene expression signature of fibroblast serum response predicts human cancer progression: similarities between tumors and wounds., PLoS Biol, vol. 2, no. 2, p. E7, 2004.
Protein Interaction Maps
D. Botstein and Fink, G. R., Yeast: an experimental organism for 21st Century biology., Genetics, vol. 189, no. 3, pp. 695-704, 2011.
Protein-Serine-Threonine Kinases
M. Ronen and Botstein, D., Transcriptional response of steady-state yeast cultures to transient perturbations in carbon source., Proc Natl Acad Sci U S A, vol. 103, no. 2, pp. 389-94, 2006.
Regulatory Sequences, Nucleic Acid
W. Wang, J Cherry, M., Botstein, D., and Li, H., A systematic approach to reconstructing transcription networks in Saccharomycescerevisiae., Proc Natl Acad Sci U S A, vol. 99, no. 26, pp. 16893-8, 2002.
Reproduction
G. I. Lang, Murray, A. W., and Botstein, D., The cost of gene expression underlies a fitness trade-off in yeast., Proc Natl Acad Sci U S A, vol. 106, no. 14, pp. 5755-60, 2009.
Research
D. Botstein, Why we need more basic biology research, not less., Mol Biol Cell, vol. 23, no. 21, pp. 4160-1, 2012.
A. G. Gilman, Simon, M. I., Bourne, H. R., Harris, B. A., Long, R., Ross, E. M., Stull, J. T., Taussig, R., Bourne, H. R., Arkin, A. P., Cobb, M. H., Cyster, J. G., Devreotes, P. N., Ferrell, J. E., Fruman, D., Gold, M., Weiss, A., Stull, J. T., Berridge, M. J., Cantley, L. C., Catterall, W. A., Coughlin, S. R., Olson, E. N., Smith, T. F., Brugge, J. S., Botstein, D., Dixon, J. E., Hunter, T., Lefkowitz, R. J., Pawson, A. J., Sternberg, P. W., Varmus, H., Subramaniam, S., Sinkovits, R. S., Li, J., Mock, D., Ning, Y., Saunders, B., Sternweis, P. C., Hilgemann, D., Scheuermann, R. H., DeCamp, D., Hsueh, R., Lin, K. - M., Ni, Y., Seaman, W. E., Simpson, P. C., O'Connell, T. D., Roach, T., Simon, M. I., Choi, S., Eversole-Cire, P., Fraser, I., Mumby, M. C., Zhao, Y., Brekken, D., Shu, H., Meyer, T., Chandy, G., Heo, W. Do, Liou, J., O'Rourke, N., Verghese, M., Mumby, S. M., Han, H., H Brown, A., Forrester, J. S., Ivanova, P., Milne, S. B., Casey, P. J., T Harden, K., Arkin, A. P., Doyle, J., Gray, M. L., Meyer, T., Michnick, S., Schmidt, M. A., Toner, M., Tsien, R. Y., Natarajan, M., Ranganathan, R., and Sambrano, G. R., Overview of the Alliance for Cellular Signaling., Nature, vol. 420, no. 6916, pp. 703-6, 2002.
K. Dolinski and Botstein, D., Changing perspectives in yeast research nearly a decade after the genome sequence., Genome Res, vol. 15, no. 12, pp. 1611-9, 2005.

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