List of Faculty Publications

Below is a list of Faculty publications imported from PubMed or manually added. By default, publications are sorted by year with titles displayed in ascending alphabetical order.
Shortcuts: Wühr, Martin | Wingreen, Ned | Wieschaus, Eric | Troyanskaya, Olga | Tilghman, Shirley | Storey, John | Singh, Mona | Shvartsman, Stanislav | Shaevitz, Joshua | Rabinowitz, Joshua | Murphy, Coleen | Levine, Michael {Levine, Michael S.} | Gregor, Thomas | Botstein, David | Bialek, William | Ayroles, Julien | Andolfatto, Peter | Akey, Joshua

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Energy Metabolism
J. D. Rabinowitz and White, E., Autophagy and metabolism., Science, vol. 330, no. 6009, pp. 1344-8, 2010.
D. Amador-Noguez, Brasg, I. A., Feng, X. - J., Roquet, N., and Rabinowitz, J. D., Metabolome remodeling during the acidogenic-solventogenic transition in Clostridium acetobutylicum., Appl Environ Microbiol, vol. 77, no. 22, pp. 7984-97, 2011.
S. Hong, Zhou, W., Fang, B., Lu, W., Loro, E., Damle, M., Ding, G., Jager, J., Zhang, S., Zhang, Y., Feng, D., Chu, Q., Dill, B. D., Molina, H., Khurana, T. S., Rabinowitz, J. D., Lazar, M. A., and Sun, Z., Dissociation of muscle insulin sensitivity from exercise endurance in mice by HDAC3 depletion., Nat Med, vol. 23, no. 2, pp. 223-234, 2017.
M. Nofal, Zhang, K., Han, S., and Rabinowitz, J. D., mTOR Inhibition Restores Amino Acid Balance in Cells Dependent on Catabolism of Extracellular Protein., Mol Cell, vol. 67, no. 6, pp. 936-946.e5, 2017.
L. Vastag, Jorgensen, P., Peshkin, L., Wei, R., Rabinowitz, J. D., and Kirschner, M. W., Remodeling of the metabolome during early frog development., PLoS One, vol. 6, no. 2, p. e16881, 2011.
M. J. Brauer, Yuan, J., Bennett, B. D., Lu, W., Kimball, E., Botstein, D., and Rabinowitz, J. D., Conservation of the metabolomic response to starvation across two divergent microbes., Proc Natl Acad Sci U S A, vol. 103, no. 51, pp. 19302-7, 2006.
S. Hui and Rabinowitz, J. D., An unexpected trigger for calorie burning in brown fat., Nature, vol. 560, no. 7716, pp. 38-39, 2018.
Disease
J. D. Rabinowitz and White, E., Autophagy and metabolism., Science, vol. 330, no. 6009, pp. 1344-8, 2010.
Cytomegalovirus
L. Vastag, Koyuncu, E., Grady, S. L., Shenk, T. E., and Rabinowitz, J. D., Divergent effects of human cytomegalovirus and herpes simplex virus-1 on cellular metabolism., PLoS Pathog, vol. 7, no. 7, p. e1002124, 2011.
J. Munger, Bajad, S. U., Coller, H. A., Shenk, T., and Rabinowitz, J. D., Dynamics of the cellular metabolome during human cytomegalovirus infection., PLoS Pathog, vol. 2, no. 12, p. e132, 2006.
S. T. H. Liu, Sharon-Friling, R., Ivanova, P., Milne, S. B., Myers, D. S., Rabinowitz, J. D., H Brown, A., and Shenk, T., Synaptic vesicle-like lipidome of human cytomegalovirus virions reveals a role for SNARE machinery in virion egress., Proc Natl Acad Sci U S A, vol. 108, no. 31, pp. 12869-74, 2011.
L. J. Terry, Vastag, L., Rabinowitz, J. D., and Shenk, T., Human kinome profiling identifies a requirement for AMP-activated protein kinase during human cytomegalovirus infection., Proc Natl Acad Sci U S A, vol. 109, no. 8, pp. 3071-6, 2012.
J. Munger, Bennett, B. D., Parikh, A., Feng, X. - J., McArdle, J., Rabitz, H. A., Shenk, T., and Rabinowitz, J. D., Systems-level metabolic flux profiling identifies fatty acid synthesis as a target for antiviral therapy., Nat Biotechnol, vol. 26, no. 10, pp. 1179-86, 2008.
E. Koyuncu, Purdy, J. G., Rabinowitz, J. D., and Shenk, T., Saturated very long chain fatty acids are required for the production of infectious human cytomegalovirus progeny., PLoS Pathog, vol. 9, no. 5, p. e1003333, 2013.
Computational Biology
W. Lu, Bennett, B. D., and Rabinowitz, J. D., Analytical strategies for LC-MS-based targeted metabolomics., J Chromatogr B Analyt Technol Biomed Life Sci, vol. 871, no. 2, pp. 236-42, 2008.
Chromatography, Liquid
E. Kimball and Rabinowitz, J. D., Identifying decomposition products in extracts of cellular metabolites., Anal Biochem, vol. 358, no. 2, pp. 273-80, 2006.
W. Lu, Su, X., Klein, M. S., Lewis, I. A., Fiehn, O., and Rabinowitz, J. D., Metabolite Measurement: Pitfalls to Avoid and Practices to Follow., Annu Rev Biochem, vol. 86, pp. 277-304, 2017.
W. Lu, Bennett, B. D., and Rabinowitz, J. D., Analytical strategies for LC-MS-based targeted metabolomics., J Chromatogr B Analyt Technol Biomed Life Sci, vol. 871, no. 2, pp. 236-42, 2008.
J. S. Breunig, Hackett, S. R., Rabinowitz, J. D., and Kruglyak, L., Genetic basis of metabolome variation in yeast., PLoS Genet, vol. 10, no. 3, p. e1004142, 2014.
M. F. Clasquin, Melamud, E., and Rabinowitz, J. D., LC-MS data processing with MAVEN: a metabolomic analysis and visualization engine., Curr Protoc Bioinformatics, vol. Chapter 14, p. Unit14.11, 2012.
E. Melamud, Vastag, L., and Rabinowitz, J. D., Metabolomic analysis and visualization engine for LC-MS data., Anal Chem, vol. 82, no. 23, pp. 9818-26, 2010.
P. H. Bradley, Brauer, M. J., Rabinowitz, J. D., and Troyanskaya, O. G., Coordinated concentration changes of transcripts and metabolites in Saccharomyces cerevisiae., PLoS Comput Biol, vol. 5, no. 1, p. e1000270, 2009.
B. D. Bennett, Kimball, E. H., Gao, M., Osterhout, R., Van Dien, S. J., and Rabinowitz, J. D., Absolute metabolite concentrations and implied enzyme active site occupancy in Escherichia coli., Nat Chem Biol, vol. 5, no. 8, pp. 593-9, 2009.
S. U. Bajad, Lu, W., Kimball, E. H., Yuan, J., Peterson, C., and Rabinowitz, J. D., Separation and quantitation of water soluble cellular metabolites by hydrophilic interaction chromatography-tandem mass spectrometry., J Chromatogr A, vol. 1125, no. 1, pp. 76-88, 2006.
C. A. Crutchfield, Lu, W., Melamud, E., and Rabinowitz, J. D., Mass spectrometry-based metabolomics of yeast., Methods Enzymol, vol. 470, pp. 393-426, 2010.
M. Louis Reaves, Sinha, S., Rabinowitz, J. D., Kruglyak, L., and Redfield, R. J., Absence of detectable arsenate in DNA from arsenate-grown GFAJ-1 cells., Science, vol. 337, no. 6093, pp. 470-3, 2012.
J. Munger, Bajad, S. U., Coller, H. A., Shenk, T., and Rabinowitz, J. D., Dynamics of the cellular metabolome during human cytomegalovirus infection., PLoS Pathog, vol. 2, no. 12, p. e132, 2006.
S. T. H. Liu, Sharon-Friling, R., Ivanova, P., Milne, S. B., Myers, D. S., Rabinowitz, J. D., H Brown, A., and Shenk, T., Synaptic vesicle-like lipidome of human cytomegalovirus virions reveals a role for SNARE machinery in virion egress., Proc Natl Acad Sci U S A, vol. 108, no. 31, pp. 12869-74, 2011.
M. J. Brauer, Yuan, J., Bennett, B. D., Lu, W., Kimball, E., Botstein, D., and Rabinowitz, J. D., Conservation of the metabolomic response to starvation across two divergent microbes., Proc Natl Acad Sci U S A, vol. 103, no. 51, pp. 19302-7, 2006.
Chromatography, High Pressure Liquid
J. D. Rabinowitz, Lloyd, P. M., Munzar, P., Myers, D. J., Cross, S., Damani, R., Quintana, R., Spyker, D. A., Soni, P., and Cassella, J. V., Ultra-fast absorption of amorphous pure drug aerosols via deep lung inhalation., J Pharm Sci, vol. 95, no. 11, pp. 2438-51, 2006.
B. D. Bennett, Yuan, J., Kimball, E. H., and Rabinowitz, J. D., Absolute quantitation of intracellular metabolite concentrations by an isotope ratio-based approach., Nat Protoc, vol. 3, no. 8, pp. 1299-311, 2008.
J. Yuan, Doucette, C. D., Fowler, W. U., Feng, X. - J., Piazza, M., Rabitz, H. A., Wingreen, N. S., and Rabinowitz, J. D., Metabolomics-driven quantitative analysis of ammonia assimilation in E. coli., Mol Syst Biol, vol. 5, p. 302, 2009.
J. Yuan, Bennett, B. D., and Rabinowitz, J. D., Kinetic flux profiling for quantitation of cellular metabolic fluxes., Nat Protoc, vol. 3, no. 8, pp. 1328-40, 2008.
W. Lu, Kimball, E., and Rabinowitz, J. D., A high-performance liquid chromatography-tandem mass spectrometry method for quantitation of nitrogen-containing intracellular metabolites., J Am Soc Mass Spectrom, vol. 17, no. 1, pp. 37-50, 2006.
W. Lu, Kwon, Y. Kyung, and Rabinowitz, J. D., Isotope ratio-based profiling of microbial folates., J Am Soc Mass Spectrom, vol. 18, no. 5, pp. 898-909, 2007.
W. Lu, Clasquin, M. F., Melamud, E., Amador-Noguez, D., Caudy, A. A., and Rabinowitz, J. D., Metabolomic analysis via reversed-phase ion-pairing liquid chromatography coupled to a stand alone orbitrap mass spectrometer., Anal Chem, vol. 82, no. 8, pp. 3212-21, 2010.
C. Jang, Chen, L., and Rabinowitz, J. D., Metabolomics and Isotope Tracing., Cell, vol. 173, no. 4, pp. 822-837, 2018.
J. J. Kamphorst, Fan, J., Lu, W., White, E., and Rabinowitz, J. D., Liquid chromatography-high resolution mass spectrometry analysis of fatty acid metabolism., Anal Chem, vol. 83, no. 23, pp. 9114-22, 2011.
Cells, Cultured
E. Melamud, Vastag, L., and Rabinowitz, J. D., Metabolomic analysis and visualization engine for LC-MS data., Anal Chem, vol. 82, no. 23, pp. 9818-26, 2010.
H. In Kim, Raffler, J., Lu, W., Lee, J. - J., Abbey, D., Saleheen, D., Rabinowitz, J. D., Bennett, M. J., Hand, N. J., Brown, C., and Rader, D. J., Fine Mapping and Functional Analysis Reveal a Role of SLC22A1 in Acylcarnitine Transport., Am J Hum Genet, vol. 101, no. 4, pp. 489-502, 2017.
J. M. S. Lemons, Feng, X. - J., Bennett, B. D., Legesse-Miller, A., Johnson, E. L., Raitman, I., Pollina, E. A., Rabitz, H. A., Rabinowitz, J. D., and Coller, H. A., Quiescent fibroblasts exhibit high metabolic activity., PLoS Biol, vol. 8, no. 10, p. e1000514, 2010.
R. A. Miller, Shi, Y., Lu, W., Pirman, D. A., Jatkar, A., Blatnik, M., Wu, H., Cárdenas, C., Wan, M., J Foskett, K., Park, J. O., Zhang, Y., Holland, W. L., Rabinowitz, J. D., and Birnbaum, M. J., Targeting hepatic glutaminase activity to ameliorate hyperglycemia., Nat Med, vol. 24, no. 4, pp. 518-524, 2018.
S. T. H. Liu, Sharon-Friling, R., Ivanova, P., Milne, S. B., Myers, D. S., Rabinowitz, J. D., H Brown, A., and Shenk, T., Synaptic vesicle-like lipidome of human cytomegalovirus virions reveals a role for SNARE machinery in virion egress., Proc Natl Acad Sci U S A, vol. 108, no. 31, pp. 12869-74, 2011.
J. Munger, Bajad, S. U., Coller, H. A., Shenk, T., and Rabinowitz, J. D., Dynamics of the cellular metabolome during human cytomegalovirus infection., PLoS Pathog, vol. 2, no. 12, p. e132, 2006.
S. L. Grady, Hwang, J., Vastag, L., Rabinowitz, J. D., and Shenk, T., Herpes simplex virus 1 infection activates poly(ADP-ribose) polymerase and triggers the degradation of poly(ADP-ribose) glycohydrolase., J Virol, vol. 86, no. 15, pp. 8259-68, 2012.
P. S. Minhas, Liu, L., Moon, P. K., Joshi, A. U., Dove, C., Mhatre, S., Contrepois, K., Wang, Q., Lee, B. A., Coronado, M., Bernstein, D., Snyder, M. P., Migaud, M., Majeti, R., Mochly-Rosen, D., Rabinowitz, J. D., and Andreasson, K. I., Macrophage de novo NAD synthesis specifies immune function in aging and inflammation., Nat Immunol, vol. 20, no. 1, pp. 50-63, 2019.
Cells
J. D. Rabinowitz, Cellular metabolomics of Escherchia coli., Expert Rev Proteomics, vol. 4, no. 2, pp. 187-98, 2007.
Cell Proliferation
J. J. Kamphorst, Cross, J. R., Fan, J., de Stanchina, E., Mathew, R., White, E. P., Thompson, C. B., and Rabinowitz, J. D., Hypoxic and Ras-transformed cells support growth by scavenging unsaturated fatty acids from lysophospholipids., Proc Natl Acad Sci U S A, vol. 110, no. 22, pp. 8882-7, 2013.
J. M. S. Lemons, Feng, X. - J., Bennett, B. D., Legesse-Miller, A., Johnson, E. L., Raitman, I., Pollina, E. A., Rabitz, H. A., Rabinowitz, J. D., and Coller, H. A., Quiescent fibroblasts exhibit high metabolic activity., PLoS Biol, vol. 8, no. 10, p. e1000514, 2010.
L. Poillet-Perez, Xie, X., Zhan, L., Yang, Y., Sharp, D. W., Hu, Z. Sherrie, Su, X., Maganti, A., Jiang, C., Lu, W., Zheng, H., Bosenberg, M. W., Mehnert, J. M., Guo, J. Yanxiang, Lattime, E., Rabinowitz, J. D., and White, E., Autophagy maintains tumour growth through circulating arginine., Nature, vol. 563, no. 7732, pp. 569-573, 2018.
M. Nofal, Zhang, K., Han, S., and Rabinowitz, J. D., mTOR Inhibition Restores Amino Acid Balance in Cells Dependent on Catabolism of Extracellular Protein., Mol Cell, vol. 67, no. 6, pp. 936-946.e5, 2017.
M. M. Klosinska, Crutchfield, C. A., Bradley, P. H., Rabinowitz, J. D., and Broach, J. R., Yeast cells can access distinct quiescent states., Genes Dev, vol. 25, no. 4, pp. 336-49, 2011.
N. N. Pavlova, Hui, S., Ghergurovich, J. M., Fan, J., Intlekofer, A. M., White, R. M., Rabinowitz, J. D., Thompson, C. B., and Zhang, J., As Extracellular Glutamine Levels Decline, Asparagine Becomes an Essential Amino Acid., Cell Metab, vol. 27, no. 2, pp. 428-438.e5, 2018.
Cell Line, Tumor
N. N. Pavlova, Hui, S., Ghergurovich, J. M., Fan, J., Intlekofer, A. M., White, R. M., Rabinowitz, J. D., Thompson, C. B., and Zhang, J., As Extracellular Glutamine Levels Decline, Asparagine Becomes an Essential Amino Acid., Cell Metab, vol. 27, no. 2, pp. 428-438.e5, 2018.
J. J. Kamphorst, Cross, J. R., Fan, J., de Stanchina, E., Mathew, R., White, E. P., Thompson, C. B., and Rabinowitz, J. D., Hypoxic and Ras-transformed cells support growth by scavenging unsaturated fatty acids from lysophospholipids., Proc Natl Acad Sci U S A, vol. 110, no. 22, pp. 8882-7, 2013.
S. M. Davidson, Jonas, O., Keibler, M. A., Hou, H. Wei, Luengo, A., Mayers, J. R., Wyckoff, J., Del Rosario, A. M., Whitman, M., Chin, C. R., Condon, K. J., Lammers, A., Kellersberger, K. A., Stall, B. K., Stephanopoulos, G., Bar-Sagi, D., Han, J., Rabinowitz, J. D., Cima, M. J., Langer, R., and Heiden, M. G. Vander, Direct evidence for cancer-cell-autonomous extracellular protein catabolism in pancreatic tumors., Nat Med, vol. 23, no. 2, pp. 235-241, 2017.
R. Mathew, Khor, S., Hackett, S. R., Rabinowitz, J. D., Perlman, D. H., and White, E., Functional role of autophagy-mediated proteome remodeling in cell survival signaling and innate immunity., Mol Cell, vol. 55, no. 6, pp. 916-30, 2014.
J. Fan, Ye, J., Kamphorst, J. J., Shlomi, T., Thompson, C. B., and Rabinowitz, J. D., Quantitative flux analysis reveals folate-dependent NADPH production., Nature, vol. 510, no. 7504, pp. 298-302, 2014.
J. Fan, Kamphorst, J. J., Mathew, R., Chung, M. K., White, E., Shlomi, T., and Rabinowitz, J. D., Glutamine-driven oxidative phosphorylation is a major ATP source in transformed mammalian cells in both normoxia and hypoxia., Mol Syst Biol, vol. 9, p. 712, 2013.
L. Vastag, Koyuncu, E., Grady, S. L., Shenk, T. E., and Rabinowitz, J. D., Divergent effects of human cytomegalovirus and herpes simplex virus-1 on cellular metabolism., PLoS Pathog, vol. 7, no. 7, p. e1002124, 2011.
Cell Line
A. Davila, Liu, L., Chellappa, K., Redpath, P., Nakamaru-Ogiso, E., Paolella, L. M., Zhang, Z., Migaud, M. E., Rabinowitz, J. D., and Baur, J. A., Nicotinamide adenine dinucleotide is transported into mammalian mitochondria., Elife, vol. 7, 2018.
J. Fan, Ye, J., Kamphorst, J. J., Shlomi, T., Thompson, C. B., and Rabinowitz, J. D., Quantitative flux analysis reveals folate-dependent NADPH production., Nature, vol. 510, no. 7504, pp. 298-302, 2014.
M. Nofal, Zhang, K., Han, S., and Rabinowitz, J. D., mTOR Inhibition Restores Amino Acid Balance in Cells Dependent on Catabolism of Extracellular Protein., Mol Cell, vol. 67, no. 6, pp. 936-946.e5, 2017.
S. T. H. Liu, Sharon-Friling, R., Ivanova, P., Milne, S. B., Myers, D. S., Rabinowitz, J. D., H Brown, A., and Shenk, T., Synaptic vesicle-like lipidome of human cytomegalovirus virions reveals a role for SNARE machinery in virion egress., Proc Natl Acad Sci U S A, vol. 108, no. 31, pp. 12869-74, 2011.
L. J. Terry, Vastag, L., Rabinowitz, J. D., and Shenk, T., Human kinome profiling identifies a requirement for AMP-activated protein kinase during human cytomegalovirus infection., Proc Natl Acad Sci U S A, vol. 109, no. 8, pp. 3071-6, 2012.
J. J. Kamphorst, Fan, J., Lu, W., White, E., and Rabinowitz, J. D., Liquid chromatography-high resolution mass spectrometry analysis of fatty acid metabolism., Anal Chem, vol. 83, no. 23, pp. 9114-22, 2011.
E. Koyuncu, Purdy, J. G., Rabinowitz, J. D., and Shenk, T., Saturated very long chain fatty acids are required for the production of infectious human cytomegalovirus progeny., PLoS Pathog, vol. 9, no. 5, p. e1003333, 2013.
N. N. Pavlova, Hui, S., Ghergurovich, J. M., Fan, J., Intlekofer, A. M., White, R. M., Rabinowitz, J. D., Thompson, C. B., and Zhang, J., As Extracellular Glutamine Levels Decline, Asparagine Becomes an Essential Amino Acid., Cell Metab, vol. 27, no. 2, pp. 428-438.e5, 2018.
Cell Compartmentation
M. Louis Reaves and Rabinowitz, J. D., Metabolomics in systems microbiology., Curr Opin Biotechnol, vol. 22, no. 1, pp. 17-25, 2011.
Cation Transport Proteins
D. C. Hess, Lu, W., Rabinowitz, J. D., and Botstein, D., Ammonium toxicity and potassium limitation in yeast., PLoS Biol, vol. 4, no. 11, p. e351, 2006.
Carbon Radioisotopes
E. Melamud, Vastag, L., and Rabinowitz, J. D., Metabolomic analysis and visualization engine for LC-MS data., Anal Chem, vol. 82, no. 23, pp. 9818-26, 2010.
Carbon Cycle
M. Louis Reaves and Rabinowitz, J. D., Metabolomics in systems microbiology., Curr Opin Biotechnol, vol. 22, no. 1, pp. 17-25, 2011.
Carbon
C. D. Doucette, Schwab, D. J., Wingreen, N. S., and Rabinowitz, J. D., α-Ketoglutarate coordinates carbon and nitrogen utilization via enzyme I inhibition., Nat Chem Biol, vol. 7, no. 12, pp. 894-901, 2011.
P. H. Bradley, Brauer, M. J., Rabinowitz, J. D., and Troyanskaya, O. G., Coordinated concentration changes of transcripts and metabolites in Saccharomyces cerevisiae., PLoS Comput Biol, vol. 5, no. 1, p. e1000270, 2009.
B. D. Bennett, Yuan, J., Kimball, E. H., and Rabinowitz, J. D., Absolute quantitation of intracellular metabolite concentrations by an isotope ratio-based approach., Nat Protoc, vol. 3, no. 8, pp. 1299-311, 2008.
K. L. Olszewski, Mather, M. W., Morrisey, J. M., Garcia, B. A., Vaidya, A. B., Rabinowitz, J. D., and Llinás, M., Branched tricarboxylic acid metabolism in Plasmodium falciparum., Nature, vol. 466, no. 7307, pp. 774-8, 2010.
J. M. S. Lemons, Feng, X. - J., Bennett, B. D., Legesse-Miller, A., Johnson, E. L., Raitman, I., Pollina, E. A., Rabitz, H. A., Rabinowitz, J. D., and Coller, H. A., Quiescent fibroblasts exhibit high metabolic activity., PLoS Biol, vol. 8, no. 10, p. e1000514, 2010.
M. Louis Reaves, Young, B. D., Hosios, A. M., Xu, Y. - F., and Rabinowitz, J. D., Pyrimidine homeostasis is accomplished by directed overflow metabolism., Nature, vol. 500, no. 7461, pp. 237-41, 2013.
V. M. Boer, Crutchfield, C. A., Bradley, P. H., Botstein, D., and Rabinowitz, J. D., Growth-limiting intracellular metabolites in yeast growing under diverse nutrient limitations., Mol Biol Cell, vol. 21, no. 1, pp. 198-211, 2010.
S. Hsin- Jung Li, Li, Z., Park, J. O., King, C. G., Rabinowitz, J. D., Wingreen, N. S., and Gitai, Z., Escherichia coli translation strategies differ across carbon, nitrogen and phosphorus limitation conditions., Nat Microbiol, vol. 3, no. 8, pp. 939-947, 2018.

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