List of Faculty Publications

Below is a list of Faculty publications imported from PubMed or manually added. By default, publications are sorted by year with titles displayed in ascending alphabetical order.
Shortcuts: Wühr, Martin | Wingreen, Ned | Wieschaus, Eric | Troyanskaya, Olga | Tilghman, Shirley | Storey, John | Singh, Mona | Shvartsman, Stanislav | Shaevitz, Joshua | Rabinowitz, Joshua | Murphy, Coleen | Levine, Michael {Levine, Michael S.} | Gregor, Thomas | Botstein, David | Bialek, William | Ayroles, Julien | Andolfatto, Peter | Akey, Joshua

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Liver
J. H. Millonig, Emerson, J. A., Levorse, J. M., and Tilghman, S. M., Molecular analysis of the distal enhancer of the mouse alpha-fetoprotein gene., Mol Cell Biol, vol. 15, no. 7, pp. 3848-56, 1995.
K. Pfeifer, Leighton, P. A., and Tilghman, S. M., The structural H19 gene is required for transgene imprinting., Proc Natl Acad Sci U S A, vol. 93, no. 24, pp. 13876-83, 1996.
J. Vacher and Tilghman, S. M., Dominant negative regulation of the mouse alpha-fetoprotein gene in adult liver., Science, vol. 250, no. 4988, pp. 1732-5, 1990.
R. Godbout and Tilghman, S. M., Configuration of the alpha-fetoprotein regulatory domain during development., Genes Dev, vol. 2, no. 8, pp. 949-56, 1988.
M. S. Bartolomei, Zemel, S., and Tilghman, S. M., Parental imprinting of the mouse H19 gene., Nature, vol. 351, no. 6322, pp. 153-5, 1991.
D. L. Metallinos, Oppenheimer, A. J., Rinchik, E. M., Russell, L. B., Dietrich, W., and Tilghman, S. M., Fine structure mapping and deletion analysis of the murine piebald locus., Genetics, vol. 136, no. 1, pp. 217-23, 1994.
A. L. Webber, Ingram, R. S., Levorse, J. M., and Tilghman, S. M., Location of enhancers is essential for the imprinting of H19 and Igf2 genes., Nature, vol. 391, no. 6668, pp. 711-5, 1998.
J. A. Emerson, Vacher, J., Cirillo, L. A., Tilghman, S. M., and Tyner, A. L., The zonal expression of alpha-fetoprotein transgenes in the livers of adult mice., Dev Dyn, vol. 195, no. 1, pp. 55-66, 1992.
Intramolecular Oxidoreductases
W. J. Pavan and Tilghman, S. M., Piebald lethal (sl) acts early to disrupt the development of neural crest-derived melanocytes., Proc Natl Acad Sci U S A, vol. 91, no. 15, pp. 7159-63, 1994.
Insulin-Like Growth Factor II
B. K. Jones, Levorse, J., and Tilghman, S. M., Deletion of a nuclease-sensitive region between the Igf2 and H19 genes leads to Igf2 misregulation and increased adiposity., Hum Mol Genet, vol. 10, no. 8, pp. 807-14, 2001.
J. V. Schmidt, Levorse, J. M., and Tilghman, S. M., Enhancer competition between H19 and Igf2 does not mediate their imprinting., Proc Natl Acad Sci U S A, vol. 96, no. 17, pp. 9733-8, 1999.
S. M. Tilghman, DNA methylation: a phoenix rises., Proc Natl Acad Sci U S A, vol. 90, no. 19, pp. 8761-2, 1993.
M. J. O'Neill, Ingram, R. S., Vrana, P. B., and Tilghman, S. M., Allelic expression of IGF2 in marsupials and birds., Dev Genes Evol, vol. 210, no. 1, pp. 18-20, 2000.
P. A. Leighton, Ingram, R. S., Eggenschwiler, J., Efstratiadis, A., and Tilghman, S. M., Disruption of imprinting caused by deletion of the H19 gene region in mice., Nature, vol. 375, no. 6526, pp. 34-9, 1995.
A. L. Webber, Ingram, R. S., Levorse, J. M., and Tilghman, S. M., Location of enhancers is essential for the imprinting of H19 and Igf2 genes., Nature, vol. 391, no. 6668, pp. 711-5, 1998.
A. L. Webber and Tilghman, S. M., The absence of enhancer competition between Igf2 and H19 following transfer into differentiated cells., Mol Cell Biol, vol. 18, no. 4, pp. 1903-10, 1998.
S. M. Tilghman, Bartolomei, M. S., Webber, A. L., Brunkow, M. E., Saam, J., Leighton, P. A., Pfeifer, K., and Zemel, S., Parental imprinting of the H19 and Igf2 genes in the mouse., Cold Spring Harb Symp Quant Biol, vol. 58, pp. 287-95, 1993.
A. T. Hark, Schoenherr, C. J., Katz, D. J., Ingram, R. S., Levorse, J. M., and Tilghman, S. M., CTCF mediates methylation-sensitive enhancer-blocking activity at the H19/Igf2 locus., Nature, vol. 405, no. 6785, pp. 486-9, 2000.
T. Caspary, Cleary, M. A., Baker, C. C., Guan, X. J., and Tilghman, S. M., Multiple mechanisms regulate imprinting of the mouse distal chromosome 7 gene cluster., Mol Cell Biol, vol. 18, no. 6, pp. 3466-74, 1998.
B. K. Jones, Levorse, J. M., and Tilghman, S. M., Igf2 imprinting does not require its own DNA methylation or H19 RNA., Genes Dev, vol. 12, no. 14, pp. 2200-7, 1998.
S. M. Tilghman, Parental imprinting in the mouse., Harvey Lect, vol. 87, pp. 69-84, 1991.
S. Zemel, Bartolomei, M. S., and Tilghman, S. M., Physical linkage of two mammalian imprinted genes, H19 and insulin-like growth factor 2., Nat Genet, vol. 2, no. 1, pp. 61-5, 1992.
P. A. Leighton, Saam, J. R., Ingram, R. S., Stewart, C. L., and Tilghman, S. M., An enhancer deletion affects both H19 and Igf2 expression., Genes Dev, vol. 9, no. 17, pp. 2079-89, 1995.
T. Caspary, Cleary, M. A., Perlman, E. J., Zhang, P., Elledge, S. J., and Tilghman, S. M., Oppositely imprinted genes p57(Kip2) and igf2 interact in a mouse model for Beckwith-Wiedemann syndrome., Genes Dev, vol. 13, no. 23, pp. 3115-24, 1999.
Immunoglobulin Heavy Chains
S. M. Tilghman, Lessons learned, promises kept: a biologist's eye view of the Genome Project., Genome Res, vol. 6, no. 9, pp. 773-80, 1996.
Humans
S. M. Tilghman, The sins of the fathers and mothers: genomic imprinting in mammalian development., Cell, vol. 96, no. 2, pp. 185-93, 1999.
M. H. Feuerman, Godbout, R., Ingram, R. S., and Tilghman, S. M., Tissue-specific transcription of the mouse alpha-fetoprotein gene promoter is dependent on HNF-1., Mol Cell Biol, vol. 9, no. 10, pp. 4204-12, 1989.
O. G. Vukmirovic and Tilghman, S. M., Exploring genome space., Nature, vol. 405, no. 6788, pp. 820-2, 2000.
A. L. Tyner, Godbout, R., Compton, R. S., and Tilghman, S. M., The ontogeny of alpha-fetoprotein gene expression in the mouse gastrointestinal tract., J Cell Biol, vol. 110, no. 4, pp. 915-27, 1990.
R. Godbout, Ingram, R. S., and Tilghman, S. M., Fine-structure mapping of the three mouse alpha-fetoprotein gene enhancers., Mol Cell Biol, vol. 8, no. 3, pp. 1169-78, 1988.
J. M. Rossi, Chen, H., and Tilghman, S. M., Genetic map of the fused locus on mouse chromosome 17., Genomics, vol. 23, no. 1, pp. 178-84, 1994.
H. Yoo-Warren, Pachnis, V., Ingram, R. S., and Tilghman, S. M., Two regulatory domains flank the mouse H19 gene., Mol Cell Biol, vol. 8, no. 11, pp. 4707-15, 1988.
T. Caspary, Cleary, M. A., Perlman, E. J., Zhang, P., Elledge, S. J., and Tilghman, S. M., Oppositely imprinted genes p57(Kip2) and igf2 interact in a mouse model for Beckwith-Wiedemann syndrome., Genes Dev, vol. 13, no. 23, pp. 3115-24, 1999.
S. Zemel, Bartolomei, M. S., and Tilghman, S. M., Physical linkage of two mammalian imprinted genes, H19 and insulin-like growth factor 2., Nat Genet, vol. 2, no. 1, pp. 61-5, 1992.
B. T. Spear and Tilghman, S. M., Role of alpha-fetoprotein regulatory elements in transcriptional activation in transient heterokaryons., Mol Cell Biol, vol. 10, no. 10, pp. 5047-54, 1990.
J. H. Millonig, Emerson, J. A., Levorse, J. M., and Tilghman, S. M., Molecular analysis of the distal enhancer of the mouse alpha-fetoprotein gene., Mol Cell Biol, vol. 15, no. 7, pp. 3848-56, 1995.
K. Pfeifer and Tilghman, S. M., Allele-specific gene expression in mammals: the curious case of the imprinted RNAs., Genes Dev, vol. 8, no. 16, pp. 1867-74, 1994.
S. M. Tilghman, Lessons learned, promises kept: a biologist's eye view of the Genome Project., Genome Res, vol. 6, no. 9, pp. 773-80, 1996.
T. Caspary, Cleary, M. A., Baker, C. C., Guan, X. J., and Tilghman, S. M., Multiple mechanisms regulate imprinting of the mouse distal chromosome 7 gene cluster., Mol Cell Biol, vol. 18, no. 6, pp. 3466-74, 1998.
C. I. Brannan, Dees, E. C., Ingram, R. S., and Tilghman, S. M., The product of the H19 gene may function as an RNA., Mol Cell Biol, vol. 10, no. 1, pp. 28-36, 1990.
A. T. Hark, Schoenherr, C. J., Katz, D. J., Ingram, R. S., Levorse, J. M., and Tilghman, S. M., CTCF mediates methylation-sensitive enhancer-blocking activity at the H19/Igf2 locus., Nature, vol. 405, no. 6785, pp. 486-9, 2000.
Hepatocyte Nuclear Factor 1-beta
J. Vacher and Tilghman, S. M., Dominant negative regulation of the mouse alpha-fetoprotein gene in adult liver., Science, vol. 250, no. 4988, pp. 1732-5, 1990.
Hepatocyte Nuclear Factor 1-alpha
J. Vacher and Tilghman, S. M., Dominant negative regulation of the mouse alpha-fetoprotein gene in adult liver., Science, vol. 250, no. 4988, pp. 1732-5, 1990.
Hepatocyte Nuclear Factor 1
J. Vacher and Tilghman, S. M., Dominant negative regulation of the mouse alpha-fetoprotein gene in adult liver., Science, vol. 250, no. 4988, pp. 1732-5, 1990.
Germ-Line Mutation
M. K. Shin, Russell, L. B., and Tilghman, S. M., Molecular characterization of four induced alleles at the Ednrb locus., Proc Natl Acad Sci U S A, vol. 94, no. 24, pp. 13105-10, 1997.
Genomic Imprinting
A. L. Webber, Ingram, R. S., Levorse, J. M., and Tilghman, S. M., Location of enhancers is essential for the imprinting of H19 and Igf2 genes., Nature, vol. 391, no. 6668, pp. 711-5, 1998.
S. M. Tilghman, The sins of the fathers and mothers: genomic imprinting in mammalian development., Cell, vol. 96, no. 2, pp. 185-93, 1999.
P. B. Vrana, Guan, X. J., Ingram, R. S., and Tilghman, S. M., Genomic imprinting is disrupted in interspecific Peromyscus hybrids., Nat Genet, vol. 20, no. 4, pp. 362-5, 1998.
A. L. Webber and Tilghman, S. M., The absence of enhancer competition between Igf2 and H19 following transfer into differentiated cells., Mol Cell Biol, vol. 18, no. 4, pp. 1903-10, 1998.
M. J. O'Neill, Ingram, R. S., Vrana, P. B., and Tilghman, S. M., Allelic expression of IGF2 in marsupials and birds., Dev Genes Evol, vol. 210, no. 1, pp. 18-20, 2000.
P. A. Leighton, Ingram, R. S., Eggenschwiler, J., Efstratiadis, A., and Tilghman, S. M., Disruption of imprinting caused by deletion of the H19 gene region in mice., Nature, vol. 375, no. 6526, pp. 34-9, 1995.
T. Caspary, Cleary, M. A., Baker, C. C., Guan, X. J., and Tilghman, S. M., Multiple mechanisms regulate imprinting of the mouse distal chromosome 7 gene cluster., Mol Cell Biol, vol. 18, no. 6, pp. 3466-74, 1998.
A. T. Hark, Schoenherr, C. J., Katz, D. J., Ingram, R. S., Levorse, J. M., and Tilghman, S. M., CTCF mediates methylation-sensitive enhancer-blocking activity at the H19/Igf2 locus., Nature, vol. 405, no. 6785, pp. 486-9, 2000.
B. K. Jones, Levorse, J. M., and Tilghman, S. M., Igf2 imprinting does not require its own DNA methylation or H19 RNA., Genes Dev, vol. 12, no. 14, pp. 2200-7, 1998.
P. A. Leighton, Saam, J. R., Ingram, R. S., Stewart, C. L., and Tilghman, S. M., An enhancer deletion affects both H19 and Igf2 expression., Genes Dev, vol. 9, no. 17, pp. 2079-89, 1995.
T. Caspary, Cleary, M. A., Perlman, E. J., Zhang, P., Elledge, S. J., and Tilghman, S. M., Oppositely imprinted genes p57(Kip2) and igf2 interact in a mouse model for Beckwith-Wiedemann syndrome., Genes Dev, vol. 13, no. 23, pp. 3115-24, 1999.
P. A. Leighton, Saam, J. R., Ingram, R. S., and Tilghman, S. M., Genomic imprinting in mice: its function and mechanism., Biol Reprod, vol. 54, no. 2, pp. 273-8, 1996.
M. A. Cleary, van Raamsdonk, C. D., Levorse, J., Zheng, B., Bradley, A., and Tilghman, S. M., Disruption of an imprinted gene cluster by a targeted chromosomal translocation in mice., Nat Genet, vol. 29, no. 1, pp. 78-82, 2001.
J. V. Schmidt, Matteson, P. G., Jones, B. K., Guan, X. J., and Tilghman, S. M., The Dlk1 and Gtl2 genes are linked and reciprocally imprinted., Genes Dev, vol. 14, no. 16, pp. 1997-2002, 2000.
K. Pfeifer, Leighton, P. A., and Tilghman, S. M., The structural H19 gene is required for transgene imprinting., Proc Natl Acad Sci U S A, vol. 93, no. 24, pp. 13876-83, 1996.
P. B. Vrana, Matteson, P. G., Schmidt, J. V., Ingram, R. S., Joyce, A., Prince, K. L., Dewey, M. J., and Tilghman, S. M., Genomic imprinting of a placental lactogen gene in Peromyscus., Dev Genes Evol, vol. 211, no. 11, pp. 523-32, 2001.
B. K. Jones, Levorse, J., and Tilghman, S. M., Deletion of a nuclease-sensitive region between the Igf2 and H19 genes leads to Igf2 misregulation and increased adiposity., Hum Mol Genet, vol. 10, no. 8, pp. 807-14, 2001.
J. V. Schmidt, Levorse, J. M., and Tilghman, S. M., Enhancer competition between H19 and Igf2 does not mediate their imprinting., Proc Natl Acad Sci U S A, vol. 96, no. 17, pp. 9733-8, 1999.
A. T. Hark and Tilghman, S. M., Chromatin conformation of the H19 epigenetic mark., Hum Mol Genet, vol. 7, no. 12, pp. 1979-85, 1998.
Genome, Human
O. G. Vukmirovic and Tilghman, S. M., Exploring genome space., Nature, vol. 405, no. 6788, pp. 820-2, 2000.
Genetic Linkage
D. L. Metallinos, Oppenheimer, A. J., Rinchik, E. M., Russell, L. B., Dietrich, W., and Tilghman, S. M., Fine structure mapping and deletion analysis of the murine piebald locus., Genetics, vol. 136, no. 1, pp. 217-23, 1994.
T. Caspary, Cleary, M. A., Baker, C. C., Guan, X. J., and Tilghman, S. M., Multiple mechanisms regulate imprinting of the mouse distal chromosome 7 gene cluster., Mol Cell Biol, vol. 18, no. 6, pp. 3466-74, 1998.
S. Zemel, Bartolomei, M. S., and Tilghman, S. M., Physical linkage of two mammalian imprinted genes, H19 and insulin-like growth factor 2., Nat Genet, vol. 2, no. 1, pp. 61-5, 1992.
J. V. Schmidt, Matteson, P. G., Jones, B. K., Guan, X. J., and Tilghman, S. M., The Dlk1 and Gtl2 genes are linked and reciprocally imprinted., Genes Dev, vol. 14, no. 16, pp. 1997-2002, 2000.
M. A. Cleary, van Raamsdonk, C. D., Levorse, J., Zheng, B., Bradley, A., and Tilghman, S. M., Disruption of an imprinted gene cluster by a targeted chromosomal translocation in mice., Nat Genet, vol. 29, no. 1, pp. 78-82, 2001.
X. J. Guan, Arhin, G., Leung, J., and Tilghman, S. M., Linkage between vitamin D-binding protein and alpha-fetoprotein in the mouse., Mamm Genome, vol. 7, no. 2, pp. 103-6, 1996.
J. V. Schmidt, Levorse, J. M., and Tilghman, S. M., Enhancer competition between H19 and Igf2 does not mediate their imprinting., Proc Natl Acad Sci U S A, vol. 96, no. 17, pp. 9733-8, 1999.
Genes, Reporter
K. Pfeifer, Leighton, P. A., and Tilghman, S. M., The structural H19 gene is required for transgene imprinting., Proc Natl Acad Sci U S A, vol. 93, no. 24, pp. 13876-83, 1996.
Gene Transfer Techniques
S. M. Tilghman, DNA methylation: a phoenix rises., Proc Natl Acad Sci U S A, vol. 90, no. 19, pp. 8761-2, 1993.
Gene Expression Regulation, Developmental
W. J. Pavan, Mac, S., Cheng, M., and Tilghman, S. M., Quantitative trait loci that modify the severity of spotting in piebald mice., Genome Res, vol. 5, no. 1, pp. 29-41, 1995.
J. V. Schmidt, Matteson, P. G., Jones, B. K., Guan, X. J., and Tilghman, S. M., The Dlk1 and Gtl2 genes are linked and reciprocally imprinted., Genes Dev, vol. 14, no. 16, pp. 1997-2002, 2000.
L. J. Kurihara, Semenova, E., Levorse, J. M., and Tilghman, S. M., Expression and functional analysis of Uch-L3 during mouse development., Mol Cell Biol, vol. 20, no. 7, pp. 2498-504, 2000.
M. K. Shin, Levorse, J. M., Ingram, R. S., and Tilghman, S. M., The temporal requirement for endothelin receptor-B signalling during neural crest development., Nature, vol. 402, no. 6761, pp. 496-501, 1999.
C. D. van Raamsdonk and Tilghman, S. M., Dosage requirement and allelic expression of PAX6 during lens placode formation., Development, vol. 127, no. 24, pp. 5439-48, 2000.
A. T. Hark and Tilghman, S. M., Chromatin conformation of the H19 epigenetic mark., Hum Mol Genet, vol. 7, no. 12, pp. 1979-85, 1998.
C. D. van Raamsdonk and Tilghman, S. M., Optimizing the detection of nascent transcripts by RNA fluorescence in situ hybridization., Nucleic Acids Res, vol. 29, no. 8, pp. E42-2, 2001.
P. A. Leighton, Saam, J. R., Ingram, R. S., Stewart, C. L., and Tilghman, S. M., An enhancer deletion affects both H19 and Igf2 expression., Genes Dev, vol. 9, no. 17, pp. 2079-89, 1995.
S. M. Tilghman, The sins of the fathers and mothers: genomic imprinting in mammalian development., Cell, vol. 96, no. 2, pp. 185-93, 1999.
Gene Expression Regulation
V. Pachnis, Brannan, C. I., and Tilghman, S. M., The structure and expression of a novel gene activated in early mouse embryogenesis., EMBO J, vol. 7, no. 3, pp. 673-81, 1988.
R. Godbout, Ingram, R. S., and Tilghman, S. M., Fine-structure mapping of the three mouse alpha-fetoprotein gene enhancers., Mol Cell Biol, vol. 8, no. 3, pp. 1169-78, 1988.
B. K. Jones, Levorse, J. M., and Tilghman, S. M., Igf2 imprinting does not require its own DNA methylation or H19 RNA., Genes Dev, vol. 12, no. 14, pp. 2200-7, 1998.
B. T. Spear and Tilghman, S. M., Role of alpha-fetoprotein regulatory elements in transcriptional activation in transient heterokaryons., Mol Cell Biol, vol. 10, no. 10, pp. 5047-54, 1990.
S. A. Camper and Tilghman, S. M., Postnatal repression of the alpha-fetoprotein gene is enhancer independent., Genes Dev, vol. 3, no. 4, pp. 537-46, 1989.
J. Vacher and Tilghman, S. M., Dominant negative regulation of the mouse alpha-fetoprotein gene in adult liver., Science, vol. 250, no. 4988, pp. 1732-5, 1990.
R. Godbout and Tilghman, S. M., Configuration of the alpha-fetoprotein regulatory domain during development., Genes Dev, vol. 2, no. 8, pp. 949-56, 1988.
M. S. Bartolomei, Zemel, S., and Tilghman, S. M., Parental imprinting of the mouse H19 gene., Nature, vol. 351, no. 6322, pp. 153-5, 1991.
J. A. Emerson, Vacher, J., Cirillo, L. A., Tilghman, S. M., and Tyner, A. L., The zonal expression of alpha-fetoprotein transgenes in the livers of adult mice., Dev Dyn, vol. 195, no. 1, pp. 55-66, 1992.
B. K. Jones, Levorse, J., and Tilghman, S. M., Deletion of a nuclease-sensitive region between the Igf2 and H19 genes leads to Igf2 misregulation and increased adiposity., Hum Mol Genet, vol. 10, no. 8, pp. 807-14, 2001.
J. Vacher, Camper, S. A., Krumlauf, R., Compton, R. S., and Tilghman, S. M., raf regulates the postnatal repression of the mouse alpha-fetoprotein gene at the posttranscriptional level., Mol Cell Biol, vol. 12, no. 2, pp. 856-64, 1992.
A. T. Hark, Schoenherr, C. J., Katz, D. J., Ingram, R. S., Levorse, J. M., and Tilghman, S. M., CTCF mediates methylation-sensitive enhancer-blocking activity at the H19/Igf2 locus., Nature, vol. 405, no. 6785, pp. 486-9, 2000.

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