List of Faculty Publications

Below is a list of Faculty publications imported from PubMed or manually added. By default, publications are sorted by year with titles displayed in ascending alphabetical order.
Shortcuts: Wühr, Martin | Wingreen, Ned | Wieschaus, Eric | Troyanskaya, Olga | Tilghman, Shirley | Storey, John | Singh, Mona | Shvartsman, Stanislav | Shaevitz, Joshua | Rabinowitz, Joshua | Murphy, Coleen | Levine, Michael {Levine, Michael S.} | Gregor, Thomas | Botstein, David | Bialek, William | Ayroles, Julien | Andolfatto, Peter | Akey, Joshua

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S. D. Kocher, Tsuruda, J. M., Gibson, J. D., Emore, C. M., Arechavaleta-Velasco, M. E., Queller, D. C., Strassmann, J. E., Grozinger, C. M., Gribskov, M. R., San Miguel, P., Westerman, R., and Hunt, G. J., A Search for Parent-of-Origin Effects on Honey Bee Gene Expression., G3 (Bethesda), vol. 5, no. 8, pp. 1657-62, 2015.
B. P. Bratton and Shaevitz, J. W., Simple Experimental Methods for Determining the Apparent Focal Shift in a Microscope System., PLoS One, vol. 10, no. 8, p. e0134616, 2015.
K. M. Kapheim, Pan, H., Li, C., Salzberg, S. L., Puiu, D., Magoc, T., Robertson, H. M., Hudson, M. E., Venkat, A., Fischman, B. J., Hernandez, A., Yandell, M., Ence, D., Holt, C., Yocum, G. D., Kemp, W. P., Bosch, J., Waterhouse, R. M., Zdobnov, E. M., Stolle, E., F Kraus, B., Helbing, S., Moritz, R. F. A., Glastad, K. M., Hunt, B. G., Goodisman, M. A. D., Hauser, F., Grimmelikhuijzen, C. J. P., Pinheiro, D. Guariz, Nunes, F. Morais Fra, Soares, M. Prioli Mir, Tanaka, É. Donato, Simões, Z. Luz Paulin, Hartfelder, K., Evans, J. D., Barribeau, S. M., Johnson, R. M., Massey, J. H., Southey, B. R., Hasselmann, M., Hamacher, D., Biewer, M., Kent, C. F., Zayed, A., Blatti, C., Sinha, S., J Johnston, S., Hanrahan, S. J., Kocher, S. D., Wang, J., Robinson, G. E., and Zhang, G., Social evolution. Genomic signatures of evolutionary transitions from solitary to group living., Science, vol. 348, no. 6239, pp. 1139-43, 2015.
E. K. Farley, Olson, K. M., Zhang, W., Brandt, A. J., Rokhsar, D. S., and Levine, M. S., Suboptimization of developmental enhancers., Science, vol. 350, no. 6258, pp. 325-8, 2015.
A. V. Persikov, Wetzel, J. L., Rowland, E. F., Oakes, B. L., Xu, D. J., Singh, M., and Noyes, M. B., A systematic survey of the Cys2His2 zinc finger DNA-binding landscape., Nucleic Acids Res, vol. 43, no. 3, pp. 1965-84, 2015.
G. Tkačik, Marre, O., Amodei, D., Schneidman, E., Bialek, W., and Berry, M. J., Searching for collective behavior in a large network of sensory neurons., PLoS Comput Biol, vol. 10, no. 1, p. e1003408, 2014.
J. Ye, Fan, J., Venneti, S., Wan, Y. - W., Pawel, B. R., Zhang, J., Finley, L. W. S., Lu, C., Lindsten, T., Cross, J. R., Qing, G., Liu, Z., M Simon, C., Rabinowitz, J. D., and Thompson, C. B., Serine Catabolism Regulates Mitochondrial Redox Control during Hypoxia., Cancer Discov, vol. 4, no. 12, pp. 1406-17, 2014.
S. Di Talia and Wieschaus, E. F., Simple biochemical pathways far from steady state can provide switchlike and integrated responses., Biophys J, vol. 107, no. 3, pp. L1-4, 2014.
W. Bialek, Cavagna, A., Giardina, I., Mora, T., Pohl, O., Silvestri, E., Viale, M., and Walczak, A. M., Social interactions dominate speed control in poising natural flocks near criticality., Proc Natl Acad Sci U S A, vol. 111, no. 20, pp. 7212-7, 2014.
K. Drescher, Nadell, C. D., Stone, H. A., Wingreen, N. S., and Bassler, B. L., Solutions to the public goods dilemma in bacterial biofilms., Curr Biol, vol. 24, no. 1, pp. 50-5, 2014.
Y. Deng, Sun, M., Lin, P. - H., Ma, J., and Shaevitz, J. W., Spatial covariance reconstructive (SCORE) super-resolution fluorescence microscopy., PLoS One, vol. 9, no. 4, p. e94807, 2014.
N. Christophe Chung and Storey, J. D., Statistical significance of variables driving systematic variation in high-dimensional data., Bioinformatics, 2014.
D. G. Robinson and Storey, J. D., subSeq: Determining Appropriate Sequencing Depth Through Efficient Read Subsampling., Bioinformatics, vol. 30, no. 23, pp. 3424-6, 2014.
S. R McIsaac, Gibney, P. A., Chandran, S. S., Benjamin, K. R., and Botstein, D., Synthetic biology tools for programming gene expression without nutritional perturbations in Saccharomyces cerevisiae., Nucleic Acids Res, vol. 42, no. 6, p. e48, 2014.
G. J. Stephens, Osborne, L. C., and Bialek, W., Searching for simplicity in the analysis of neurons and behavior., Proc Natl Acad Sci U S A, vol. 108 Suppl 3, pp. 15565-71, 2011.
C. B. Muratov, Gordon, P. V., and Shvartsman, S. Y., Self-similar dynamics of morphogen gradients., Phys Rev E Stat Nonlin Soft Matter Phys, vol. 84, no. 4 Pt 1, p. 041916, 2011.
S. C. Little and Wieschaus, E. F., Shifting patterns: merging molecules, morphogens, motility, and methodology., Dev Cell, vol. 21, no. 1, pp. 2-4, 2011.
J. P. Bothma, Magliocco, J., and Levine, M., The snail repressor inhibits release, not elongation, of paused Pol II in the Drosophila embryo., Curr Biol, vol. 21, no. 18, pp. 1571-7, 2011.
J. P. Huelsenbeck, Andolfatto, P., and Huelsenbeck, E. T., Structurama: bayesian inference of population structure., Evol Bioinform Online, vol. 7, pp. 55-9, 2011.
P. Liu, Kevrekidis, I. G., and Shvartsman, S. Y., Substrate-dependent control of ERK phosphorylation can lead to oscillations., Biophys J, vol. 101, no. 11, pp. 2572-81, 2011.
Y. Kim, Paroush, Z. 'ev, Nairz, K., Hafen, E., Jiménez, G., and Shvartsman, S. Y., Substrate-dependent control of MAPK phosphorylation in vivo., Mol Syst Biol, vol. 7, p. 467, 2011.
A. A. Petti, Crutchfield, C. A., Rabinowitz, J. D., and Botstein, D., Survival of starving yeast is correlated with oxidative stress response and nonrespiratory mitochondrial function., Proc Natl Acad Sci U S A, vol. 108, no. 45, pp. E1089-98, 2011.
S. T. H. Liu, Sharon-Friling, R., Ivanova, P., Milne, S. B., Myers, D. S., Rabinowitz, J. D., H Brown, A., and Shenk, T., Synaptic vesicle-like lipidome of human cytomegalovirus virions reveals a role for SNARE machinery in virion egress., Proc Natl Acad Sci U S A, vol. 108, no. 31, pp. 12869-74, 2011.
E. Schneidman, Puchalla, J. L., Segev, R., Harris, R. A., Bialek, W., and Berry, M. J., Synergy from silence in a combinatorial neural code., J Neurosci, vol. 31, no. 44, pp. 15732-41, 2011.
D. Gresham, Boer, V. M., Caudy, A., Ziv, N., Brandt, N. J., Storey, J. D., and Botstein, D., System-level analysis of genes and functions affecting survival during nutrient starvation in Saccharomyces cerevisiae., Genetics, vol. 187, no. 1, pp. 299-317, 2011.
S. R. Engel, Balakrishnan, R., Binkley, G., Christie, K. R., Costanzo, M. C., Dwight, S. S., Fisk, D. G., Hirschman, J. E., Hitz, B. C., Hong, E. L., Krieger, C. J., Livstone, M. S., Miyasato, S. R., Nash, R., Oughtred, R., Park, J., Skrzypek, M. S., Weng, S., Wong, E. D., Dolinski, K., Botstein, D., and J Cherry, M., Saccharomyces Genome Database provides mutant phenotype data., Nucleic Acids Res, vol. 38, no. Database issue, pp. D433-6, 2010.
M. W. Perry, Boettiger, A. N., Bothma, J. P., and Levine, M., Shadow enhancers foster robustness of Drosophila gastrulation., Curr Biol, vol. 20, no. 17, pp. 1562-7, 2010.
C. Y. Park, Hess, D. C., Huttenhower, C., and Troyanskaya, O. G., Simultaneous genome-wide inference of physical, genetic, regulatory, and functional pathway components., PLoS Comput Biol, vol. 6, no. 11, p. e1001009, 2010.
P. Jiang and Singh, M., SPICi: a fast clustering algorithm for large biological networks., Bioinformatics, vol. 26, no. 8, pp. 1105-11, 2010.
G. J. Stephens and Bialek, W., Statistical mechanics of letters in words., Phys Rev E Stat Nonlin Soft Matter Phys, vol. 81, no. 6 Pt 2, p. 066119, 2010.
J. W. Shaevitz and Gitai, Z., The structure and function of bacterial actin homologs., Cold Spring Harb Perspect Biol, vol. 2, no. 9, p. a000364, 2010.
Y. Guan, Dunham, M., Caudy, A., and Troyanskaya, O., Systematic planning of genome-scale experiments in poorly studied species., PLoS Comput Biol, vol. 6, no. 3, p. e1000698, 2010.
P. Jumbo-Lucioni, Ayroles, J. F., Chambers, M. Moses, Jordan, K. W., Leips, J., Mackay, T. Fc, and De Luca, M., Systems genetics analysis of body weight and energy metabolism traits in Drosophila melanogaster., BMC Genomics, vol. 11, p. 297, 2010.
D. Amador-Noguez, Feng, X. - J., Fan, J., Roquet, N., Rabitz, H., and Rabinowitz, J. D., Systems-level metabolic flux profiling elucidates a complete, bifurcated tricarboxylic acid cycle in Clostridium acetobutylicum., J Bacteriol, vol. 192, no. 17, pp. 4452-61, 2010.
L. Christiaen, Wagner, E., Shi, W., and Levine, M., The sea squirt Ciona intestinalis., Cold Spring Harb Protoc, vol. 2009, no. 12, p. pdb.emo138, 2009.
A. J. Butte, Sarkar, I. Neil, Ramoni, M., Lussier, Y., and Troyanskaya, O., Selected proceedings of the First Summit on Translational Bioinformatics 2008., BMC Bioinformatics, vol. 10 Suppl 2, p. I1, 2009.
D. Greenfield, McEvoy, A. L., Shroff, H., Crooks, G. E., Wingreen, N. S., Betzig, E., and Liphardt, J., Self-organization of the Escherichia coli chemotaxis network imaged with super-resolution light microscopy., PLoS Biol, vol. 7, no. 6, p. e1000137, 2009.
A. M. Berezhkovskii, Coppey, M., and Shvartsman, S. Y., Signaling gradients in cascades of two-state reaction-diffusion systems., Proc Natl Acad Sci U S A, vol. 106, no. 4, pp. 1087-92, 2009.
C. Lu, Brauer, M. J., and Botstein, D., Slow growth induces heat-shock resistance in normal and respiratory-deficient yeast., Mol Biol Cell, vol. 20, no. 3, pp. 891-903, 2009.
L. Christiaen, Stolfi, A., Davidson, B., and Levine, M., Spatio-temporal intersection of Lhx3 and Tbx6 defines the cardiac field through synergistic activation of Mesp., Dev Biol, vol. 328, no. 2, pp. 552-60, 2009.
V. S. Chopra, Cande, J., Hong, J. - W., and Levine, M., Stalled Hox promoters as chromosomal boundaries., Genes Dev, vol. 23, no. 13, pp. 1505-9, 2009.
T. Mora, Yu, H., Sowa, Y., and Wingreen, N. S., Steps in the bacterial flagellar motor., PLoS Comput Biol, vol. 5, no. 10, p. e1000540, 2009.
A. N. Boettiger and Levine, M., Synchronous and stochastic patterns of gene activation in the Drosophila embryo., Science, vol. 325, no. 5939, pp. 471-3, 2009.
J. F. Ayroles, Carbone, M. Anna, Stone, E. A., Jordan, K. W., Lyman, R. F., Magwire, M. M., Rollmann, S. M., Duncan, L. H., Lawrence, F., Anholt, R. R. H., and Mackay, T. F. C., Systems genetics of complex traits in Drosophila melanogaster., Nat Genet, vol. 41, no. 3, pp. 299-307, 2009.
R. Lu, Markowetz, F., Unwin, R. D., Leek, J. T., Airoldi, E. M., MacArthur, B. D., Lachmann, A., Rozov, R., Ma'ayan, A., Boyer, L. A., Troyanskaya, O. G., Whetton, A. D., and Lemischka, I. R., Systems-level dynamic analyses of fate change in murine embryonic stem cells., Nature, vol. 462, no. 7271, pp. 358-62, 2009.
H. Wang, Wingreen, N. S., and Mukhopadhyay, R., Self-organized periodicity of protein clusters in growing bacteria., Phys Rev Lett, vol. 101, no. 21, p. 218101, 2008.
J. - W. Hong, Hendrix, D. A., and Levine, M. S., Shadow enhancers as a source of evolutionary novelty., Science, vol. 321, no. 5894, p. 1314, 2008.
T. Gregor, McGregor, A. P., and Wieschaus, E. F., Shape and function of the Bicoid morphogen gradient in dipteran species with different sized embryos., Dev Biol, vol. 316, no. 2, pp. 350-8, 2008.
B. Haley, Hendrix, D., Trang, V., and Levine, M., A simplified miRNA-based gene silencing method for Drosophila melanogaster., Dev Biol, vol. 321, no. 2, pp. 482-90, 2008.
C. Huttenhower, Schroeder, M., Chikina, M. D., and Troyanskaya, O. G., The Sleipnir library for computational functional genomics., Bioinformatics, vol. 24, no. 13, pp. 1559-61, 2008.
M. J. Rosenbluth, Crow, A., Shaevitz, J. W., and Fletcher, D. A., Slow stress propagation in adherent cells., Biophys J, vol. 95, no. 12, pp. 6052-9, 2008.
J. Lembong, Yakoby, N., and Shvartsman, S. Y., Spatial regulation of BMP signaling by patterned receptor expression., Tissue Eng Part A, vol. 14, no. 9, pp. 1469-77, 2008.
J. W. Shaevitz, Super-resolution for a 3D world., Nat Methods, vol. 5, no. 6, pp. 471-2, 2008.
J. Munger, Bennett, B. D., Parikh, A., Feng, X. - J., McArdle, J., Rabitz, H. A., Shenk, T., and Rabinowitz, J. D., Systems-level metabolic flux profiling identifies fatty acid synthesis as a target for antiviral therapy., Nat Biotechnol, vol. 26, no. 10, pp. 1179-86, 2008.
D. G. Fisk, Ball, C. A., Dolinski, K., Engel, S. R., Hong, E. L., Issel-Tarver, L., Schwartz, K., Sethuraman, A., Botstein, D., and J Cherry, M., Saccharomyces cerevisiae S288C genome annotation: a working hypothesis., Yeast, vol. 23, no. 12, pp. 857-65, 2006.
C. Huttenhower, Hibbs, M., Myers, C., and Troyanskaya, O. G., A scalable method for integration and functional analysis of multiple microarray datasets., Bioinformatics, vol. 22, no. 23, pp. 2890-7, 2006.
C. T. Murphy, The search for DAF-16/FOXO transcriptional targets: approaches and discoveries., Exp Gerontol, vol. 41, no. 10, pp. 910-21, 2006.
K. A. Hughes, Ayroles, J. F., Reedy, M. M., Drnevich, J. M., Rowe, K. C., Ruedi, E. A., Cáceres, C. E., and Paige, K. N., Segregating variation in the transcriptome: cis regulation and additivity of effects., Genetics, vol. 173, no. 3, pp. 1347-55, 2006.
D. Bachtrog and Andolfatto, P., Selection, recombination and demographic history in Drosophila miranda., Genetics, vol. 174, no. 4, pp. 2045-59, 2006.
S. U. Bajad, Lu, W., Kimball, E. H., Yuan, J., Peterson, C., and Rabinowitz, J. D., Separation and quantitation of water soluble cellular metabolites by hydrophilic interaction chromatography-tandem mass spectrometry., J Chromatogr A, vol. 1125, no. 1, pp. 76-88, 2006.
H. M. Frydman, Li, J. M., Robson, D. N., and Wieschaus, E., Somatic stem cell niche tropism in Wolbachia., Nature, vol. 441, no. 7092, pp. 509-12, 2006.
K. R. Christie, Weng, S., Balakrishnan, R., Costanzo, M. C., Dolinski, K., Dwight, S. S., Engel, S. R., Feierbach, B., Fisk, D. G., Hirschman, J. E., Hong, E. L., Issel-Tarver, L., Nash, R., Sethuraman, A., Starr, B., Theesfeld, C. L., Andrada, R., Binkley, G., Dong, Q., Lane, C., Schroeder, M., Botstein, D., and J Cherry, M., Saccharomyces Genome Database (SGD) provides tools to identify and analyze sequences from Saccharomyces cerevisiae and related sequences from other organisms., Nucleic Acids Res, vol. 32, no. Database issue, pp. D311-4, 2004.
S. S. Dwight, Balakrishnan, R., Christie, K. R., Costanzo, M. C., Dolinski, K., Engel, S. R., Feierbach, B., Fisk, D. G., Hirschman, J., Hong, E. L., Issel-Tarver, L., Nash, R. S., Sethuraman, A., Starr, B., Theesfeld, C. L., Andrada, R., Binkley, G., Dong, Q., Lane, C., Schroeder, M., Weng, S., Botstein, D., and J Cherry, M., Saccharomyces genome database: underlying principles and organisation., Brief Bioinform, vol. 5, no. 1, pp. 9-22, 2004.
C. B. Muratov and Shvartsman, S. Y., Signal propagation and failure in discrete autocrine relays., Phys Rev Lett, vol. 93, no. 11, p. 118101, 2004.
D. H. Lenz, Mok, K. C., Lilley, B. N., Kulkarni, R. V., Wingreen, N. S., and Bassler, B. L., The small RNA chaperone Hfq and multiple small RNAs control quorum sensing in Vibrio harveyi and Vibrio cholerae., Cell, vol. 118, no. 1, pp. 69-82, 2004.
J. H. Thomas and Wieschaus, E., src64 and tec29 are required for microfilament contraction during Drosophila cellularization., Development, vol. 131, no. 4, pp. 863-71, 2004.
S. Weng, Dong, Q., Balakrishnan, R., Christie, K., Costanzo, M., Dolinski, K., Dwight, S. S., Engel, S., Fisk, D. G., Hong, E., Issel-Tarver, L., Sethuraman, A., Theesfeld, C., Andrada, R., Binkley, G., Lane, C., Schroeder, M., Botstein, D., and J Cherry, M., Saccharomyces Genome Database (SGD) provides biochemical and structural information for budding yeast proteins., Nucleic Acids Res, vol. 31, no. 1, pp. 216-8, 2003.
N. S. Wingreen, Miller, J., and Cox, E. C., Scaling of mutational effects in models for pleiotropy., Genetics, vol. 164, no. 3, pp. 1221-8, 2003.
M. Diehn, Sherlock, G., Binkley, G., Jin, H., Matese, J. C., Hernandez-Boussard, T., Rees, C. A., J Cherry, M., Botstein, D., Brown, P. O., and Alizadeh, A. A., SOURCE: a unified genomic resource of functional annotations, ontologies, and gene expression data., Nucleic Acids Res, vol. 31, no. 1, pp. 219-23, 2003.
J. Gollub, Ball, C. A., Binkley, G., Demeter, J., Finkelstein, D. B., Hebert, J. M., Hernandez-Boussard, T., Jin, H., Kaloper, M., Matese, J. C., Schroeder, M., Brown, P. O., Botstein, D., and Sherlock, G., The Stanford Microarray Database: data access and quality assessment tools., Nucleic Acids Res, vol. 31, no. 1, pp. 94-6, 2003.
R. Mukhopadhyay, Emberly, E., Tang, C., and Wingreen, N. S., Statistical mechanics of RNA folding: importance of alphabet size., Phys Rev E Stat Nonlin Soft Matter Phys, vol. 68, no. 4 Pt 1, p. 041904, 2003.
L. Batsilas, Berezhkovskii, A. M., and Shvartsman, S. Y., Stochastic model of autocrine and paracrine signals in cell culture assays., Biophys J, vol. 85, no. 6, pp. 3659-65, 2003.
E. Schneidman, Bialek, W., and Berry, M. J., Synergy, redundancy, and independence in population codes., J Neurosci, vol. 23, no. 37, pp. 11539-53, 2003.
M. L. Whitfield, Finlay, D. R., Murray, J. Isaac, Troyanskaya, O. G., Chi, J. - T., Pergamenschikov, A., McCalmont, T. H., Brown, P. O., Botstein, D., and M Connolly, K., Systemic and cell type-specific gene expression patterns in scleroderma skin., Proc Natl Acad Sci U S A, vol. 100, no. 21, pp. 12319-24, 2003.
L. Issel-Tarver, Christie, K. R., Dolinski, K., Andrada, R., Balakrishnan, R., Ball, C. A., Binkley, G., Dong, S., Dwight, S. S., Fisk, D. G., Harris, M., Schroeder, M., Sethuraman, A., Tse, K., Weng, S., Botstein, D., and J Cherry, M., Saccharomyces Genome Database., Methods Enzymol, vol. 350, pp. 329-46, 2002.
S. S. Dwight, Harris, M. A., Dolinski, K., Ball, C. A., Binkley, G., Christie, K. R., Fisk, D. G., Issel-Tarver, L., Schroeder, M., Sherlock, G., Sethuraman, A., Weng, S., Botstein, D., and J Cherry, M., Saccharomyces Genome Database (SGD) provides secondary gene annotation using the Gene Ontology (GO)., Nucleic Acids Res, vol. 30, no. 1, pp. 69-72, 2002.
J. A. Zallen, Cohen, Y., Hudson, A. M., Cooley, L., Wieschaus, E., and Schejter, E. D., SCAR is a primary regulator of Arp2/3-dependent morphological events in Drosophila., J Cell Biol, vol. 156, no. 4, pp. 689-701, 2002.
O. G. Troyanskaya, Arbell, O., Koren, Y., Landau, G. M., and Bolshoy, A., Sequence complexity profiles of prokaryotic genomic sequences: a fast algorithm for calculating linguistic complexity., Bioinformatics, vol. 18, no. 5, pp. 679-88, 2002.
S. Y. Shvartsman, Shooting from the hip: spatial control of signal release by intracellular waves., Proc Natl Acad Sci U S A, vol. 99, no. 14, pp. 9087-9, 2002.
T. Lecuit, Samanta, R., and Wieschaus, E., slam encodes a developmental regulator of polarized membrane growth during cleavage of the Drosophila embryo., Dev Cell, vol. 2, no. 4, pp. 425-36, 2002.
J. Cowden and Levine, M., The Snail repressor positions Notch signaling in the Drosophila embryo., Development, vol. 129, no. 7, pp. 1785-93, 2002.
N. Brenner, Agam, O., Bialek, W., and van Steveninck, Rde Ruyter, Statistical properties of spike trains: universal and stimulus-dependent aspects., Phys Rev E Stat Nonlin Soft Matter Phys, vol. 66, no. 3 Pt 1, p. 031907, 2002.
J. C. Boldrick, Alizadeh, A. A., Diehn, M., Dudoit, S., Liu, C. Long, Belcher, C. E., Botstein, D., Staudt, L. M., Brown, P. O., and Relman, D. A., Stereotyped and specific gene expression programs in human innate immune responses to bacteria., Proc Natl Acad Sci U S A, vol. 99, no. 2, pp. 972-7, 2002.
W. Wang, J Cherry, M., Botstein, D., and Li, H., A systematic approach to reconstructing transcription networks in Saccharomycescerevisiae., Proc Natl Acad Sci U S A, vol. 99, no. 26, pp. 16893-8, 2002.
E. S. Click, Stearns, T., and Botstein, D., Systematic structure-function analysis of the small GTPase Arf1 in yeast., Mol Biol Cell, vol. 13, no. 5, pp. 1652-64, 2002.