List of Faculty Publications

Below is a list of Faculty publications imported from PubMed or manually added. By default, publications are sorted by year with titles displayed in ascending alphabetical order.
Shortcuts: Wühr, Martin | Wingreen, Ned | Wieschaus, Eric | Troyanskaya, Olga | Tilghman, Shirley | Storey, John | Singh, Mona | Shvartsman, Stanislav | Shaevitz, Joshua | Rabinowitz, Joshua | Murphy, Coleen | Levine, Michael {Levine, Michael S.} | Gregor, Thomas | Botstein, David | Bialek, William | Ayroles, Julien | Andolfatto, Peter | Akey, Joshua

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2018
N. N. Pavlova, Hui, S., Ghergurovich, J. M., Fan, J., Intlekofer, A. M., White, R. M., Rabinowitz, J. D., Thompson, C. B., and Zhang, J., As Extracellular Glutamine Levels Decline, Asparagine Becomes an Essential Amino Acid., Cell Metab, vol. 27, no. 2, pp. 428-438.e5, 2018.
L. Poillet-Perez, Xie, X., Zhan, L., Yang, Y., Sharp, D. W., Hu, Z. Sherrie, Su, X., Maganti, A., Jiang, C., Lu, W., Zheng, H., Bosenberg, M. W., Mehnert, J. M., Guo, J. Yanxiang, Lattime, E., Rabinowitz, J. D., and White, E., Autophagy maintains tumour growth through circulating arginine., Nature, vol. 563, no. 7732, pp. 569-573, 2018.
N. Ron-Harel, Notarangelo, G., Ghergurovich, J. M., Paulo, J. A., Sage, P. T., Santos, D., F Satterstrom, K., Gygi, S. P., Rabinowitz, J. D., Sharpe, A. H., and Haigis, M. C., Defective respiration and one-carbon metabolism contribute to impaired naïve T cell activation in aged mice., Proc Natl Acad Sci U S A, vol. 115, no. 52, pp. 13347-13352, 2018.
D. Guan, Xiong, Y., Borck, P. C., Jang, C., Doulias, P. - T., Papazyan, R., Fang, B., Jiang, C., Zhang, Y., Briggs, E. R., Hu, W., Steger, D., Ischiropoulos, H., Rabinowitz, J. D., and Lazar, M. A., Diet-Induced Circadian Enhancer Remodeling Synchronizes Opposing Hepatic Lipid Metabolic Processes., Cell, vol. 174, no. 4, pp. 831-842.e12, 2018.
M. A. Lanaspa, Andres-Hernando, A., Orlicky, D. J., Cicerchi, C., Jang, C., Li, N., Milagres, T., Kuwabara, M., Wempe, M. F., Rabinowitz, J. D., Johnson, R. J., and Tolan, D. R., Ketohexokinase C blockade ameliorates fructose-induced metabolic dysfunction in fructose-sensitive mice., J Clin Invest, vol. 128, no. 6, pp. 2226-2238, 2018.
A. Davila, Liu, L., Chellappa, K., Redpath, P., Nakamaru-Ogiso, E., Paolella, L. M., Zhang, Z., Migaud, M. E., Rabinowitz, J. D., and Baur, J. A., Nicotinamide adenine dinucleotide is transported into mammalian mitochondria., Elife, vol. 7, 2018.
S. E. McKee, Zhang, S., Chen, L., Rabinowitz, J. D., and Reyes, T. M., Perinatal high fat diet and early life methyl donor supplementation alter one carbon metabolism and DNA methylation in the brain., J Neurochem, vol. 145, no. 5, pp. 362-373, 2018.
R. Menon, Otto, E. A., Kokoruda, A., Zhou, J., Zhang, Z., Yoon, E., Chen, Y. - C., Troyanskaya, O., Spence, J. R., Kretzler, M., and Cebrián, C., Single-cell analysis of progenitor cell dynamics and lineage specification in the human fetal kidney., Development, vol. 145, no. 16, 2018.
C. Jang, Hui, S., Lu, W., Cowan, A. J., Morscher, R. J., Lee, G., Liu, W., Tesz, G. J., Birnbaum, M. J., and Rabinowitz, J. D., The Small Intestine Converts Dietary Fructose into Glucose and Organic Acids., Cell Metab, vol. 27, no. 2, pp. 351-361.e3, 2018.
R. A. Miller, Shi, Y., Lu, W., Pirman, D. A., Jatkar, A., Blatnik, M., Wu, H., Cárdenas, C., Wan, M., J Foskett, K., Park, J. O., Zhang, Y., Holland, W. L., Rabinowitz, J. D., and Birnbaum, M. J., Targeting hepatic glutaminase activity to ameliorate hyperglycemia., Nat Med, vol. 24, no. 4, pp. 518-524, 2018.
2017
J. P. Nguyen, Linder, A. N., Plummer, G. S., Shaevitz, J. W., and Leifer, A. M., Automatically tracking neurons in a moving and deforming brain., PLoS Comput Biol, vol. 13, no. 5, p. e1005517, 2017.
S. M. Davidson, Jonas, O., Keibler, M. A., Hou, H. Wei, Luengo, A., Mayers, J. R., Wyckoff, J., Del Rosario, A. M., Whitman, M., Chin, C. R., Condon, K. J., Lammers, A., Kellersberger, K. A., Stall, B. K., Stephanopoulos, G., Bar-Sagi, D., Han, J., Rabinowitz, J. D., Cima, M. J., Langer, R., and Heiden, M. G. Vander, Direct evidence for cancer-cell-autonomous extracellular protein catabolism in pancreatic tumors., Nat Med, vol. 23, no. 2, pp. 235-241, 2017.
S. Hong, Zhou, W., Fang, B., Lu, W., Loro, E., Damle, M., Ding, G., Jager, J., Zhang, S., Zhang, Y., Feng, D., Chu, Q., Dill, B. D., Molina, H., Khurana, T. S., Rabinowitz, J. D., Lazar, M. A., and Sun, Z., Dissociation of muscle insulin sensitivity from exercise endurance in mice by HDAC3 depletion., Nat Med, vol. 23, no. 2, pp. 223-234, 2017.
Y. Song, Marmion, R. A., Park, J. O., Biswas, D., Rabinowitz, J. D., and Shvartsman, S. Y., Dynamic Control of dNTP Synthesis in Early Embryos., Dev Cell, vol. 42, no. 3, pp. 301-308.e3, 2017.
Y. Zhang, Kurupati, R., Liu, L., Zhou, X. Yang, Zhang, G., Hudaihed, A., Filisio, F., Giles-Davis, W., Xu, X., Karakousis, G. C., Schuchter, L. M., Xu, W., Amaravadi, R., Xiao, M., Sadek, N., Krepler, C., Herlyn, M., Freeman, G. J., Rabinowitz, J. D., and Ertl, H. C. J., Enhancing CD8(+) T Cell Fatty Acid Catabolism within a Metabolically Challenging Tumor Microenvironment Increases the Efficacy of Melanoma Immunotherapy., Cancer Cell, vol. 32, no. 3, pp. 377-391.e9, 2017.
H. In Kim, Raffler, J., Lu, W., Lee, J. - J., Abbey, D., Saleheen, D., Rabinowitz, J. D., Bennett, M. J., Hand, N. J., Brown, C., and Rader, D. J., Fine Mapping and Functional Analysis Reveal a Role of SLC22A1 in Acylcarnitine Transport., Am J Hum Genet, vol. 101, no. 4, pp. 489-502, 2017.
C. J. Nirschl, Suárez-Fariñas, M., Izar, B., Prakadan, S., Dannenfelser, R., Tirosh, I., Liu, Y., Zhu, Q., K Devi, S. P., Carroll, S. L., Chau, D., Rezaee, M., Kim, T. - G., Huang, R., Fuentes-Duculan, J., Song-Zhao, G. X., Gulati, N., Lowes, M. A., King, S. L., Quintana, F. J., Lee, Y. -suk, Krueger, J. G., Sarin, K. Y., Yoon, C. H., Garraway, L., Regev, iv, A., Shalek, A. K., Troyanskaya, O. G., and Anandasabapathy, N., IFNγ-Dependent Tissue-Immune Homeostasis Is Co-opted in the Tumor Microenvironment., Cell, vol. 170, no. 1, pp. 127-141.e15, 2017.
Y. Pritykin, Brito, T., Schüpbach, T., Singh, M., and Pane, A., Integrative analysis unveils new functions for the Drosophila Cutoff protein in noncoding RNA biogenesis and gene regulation., RNA, vol. 23, no. 7, pp. 1097-1109, 2017.
W. Lu, Su, X., Klein, M. S., Lewis, I. A., Fiehn, O., and Rabinowitz, J. D., Metabolite Measurement: Pitfalls to Avoid and Practices to Follow., Annu Rev Biochem, vol. 86, pp. 277-304, 2017.
M. Nofal, Zhang, K., Han, S., and Rabinowitz, J. D., mTOR Inhibition Restores Amino Acid Balance in Cells Dependent on Catabolism of Extracellular Protein., Mol Cell, vol. 67, no. 6, pp. 936-946.e5, 2017.
T. M. Bartlett, Bratton, B. P., Duvshani, A., Miguel, A., Sheng, Y., Martin, N. R., Nguyen, J. P., Persat, A., Desmarais, S. M., VanNieuwenhze, M. S., Huang, K. Casey, Zhu, J., Shaevitz, J. W., and Gitai, Z., A Periplasmic Polymer Curves Vibrio cholerae and Promotes Pathogenesis., Cell, vol. 168, no. 1-2, pp. 172-185.e15, 2017.
W. A. Rogers, Goyal, Y., Yamaya, K., Shvartsman, S. Y., and Levine, M. S., Uncoupling neurogenic gene networks in the Drosophila embryo., Genes Dev, vol. 31, no. 7, pp. 634-638, 2017.
U. Klibaite, Berman, G. J., Cande, J., Stern, D. L., and Shaevitz, J. W., An unsupervised method for quantifying the behavior of paired animals., Phys Biol, vol. 14, no. 1, p. 015006, 2017.
2016
P. Engel, Kwong, W. K., McFrederick, Q., Anderson, K. E., Barribeau, S. Michael, Chandler, J. Angus, R Cornman, S., Dainat, J., de Miranda, J. R., Doublet, V., Emery, O., Evans, J. D., Farinelli, L., Flenniken, M. L., Granberg, F., Grasis, J. A., Gauthier, L., Hayer, J., Koch, H., Kocher, S., Martinson, V. G., Moran, N., Munoz-Torres, M., Newton, I., Paxton, R. J., Powell, E., Sadd, B. M., Schmid-Hempel, P., Schmid-Hempel, R., Song, S. Jin, Schwarz, R. S., vanEngelsdorp, D., and Dainat, B., The Bee Microbiome: Impact on Bee Health and Model for Evolution and Ecology of Host-Microbe Interactions., MBio, vol. 7, no. 2, pp. e02164-15, 2016.
R. Kaletsky, Lakhina, V., Arey, R., Williams, A., Landis, J., Ashraf, J., and Murphy, C. T., The C. elegans adult neuronal IIS/FOXO transcriptome reveals adult phenotype regulators., Nature, vol. 529, no. 7584, pp. 92-6, 2016.
X. Nuttle, Giannuzzi, G., Duyzend, M. H., Schraiber, J. G., Narvaiza, I., Sudmant, P. H., Penn, O., Chiatante, G., Malig, M., Huddleston, J., Benner, C., Camponeschi, F., Ciofi-Baffoni, S., Stessman, H. A. F., Marchetto, M. C. N., Denman, L., Harshman, L., Baker, C., Raja, A., Penewit, K., Janke, N., W Tang, J., Ventura, M., Banci, L., Antonacci, F., Akey, J. M., Amemiya, C. T., Gage, F. H., Reymond, A., and Eichler, E. E., Emergence of a Homo sapiens-specific gene family and chromosome 16p11.2 CNV susceptibility., Nature, vol. 536, no. 7615, pp. 205-9, 2016.
C. Shi and Murphy, C. T., Feeding the germline., Genes Dev, vol. 30, no. 3, pp. 249-50, 2016.
L. - B. Li, Lei, H., Arey, R. N., Li, P., Liu, J., Murphy, C. T., Xu, X. Z. Shawn, and Shen, K., The Neuronal Kinesin UNC-104/KIF1A Is a Key Regulator of Synaptic Aging and Insulin Signaling-Regulated Memory., Curr Biol, vol. 26, no. 5, pp. 605-15, 2016.
I. A. Navarrete and Levine, M., Nodal and FGF coordinate ascidian neural tube morphogenesis., Development, vol. 143, no. 24, pp. 4665-4675, 2016.
R. Papazyan, Sun, Z., Kim, Y. Hoon, Titchenell, P. M., Hill, D. A., Lu, W., Damle, M., Wan, M., Zhang, Y., Briggs, E. R., Rabinowitz, J. D., and Lazar, M. A., Physiological Suppression of Lipotoxic Liver Damage by Complementary Actions of HDAC3 and SCAP/SREBP., Cell Metab, vol. 24, no. 6, pp. 863-874, 2016.
Q. Wang, J Taliaferro, M., Klibaite, U., Hilgers, V., Shaevitz, J. W., and Rio, D. C., The PSI-U1 snRNP interaction regulates male mating behavior in Drosophila., Proc Natl Acad Sci U S A, vol. 113, no. 19, pp. 5269-74, 2016.
D. A. Galbraith, Kocher, S. D., Glenn, T., Albert, I., Hunt, G. J., Strassmann, J. E., Queller, D. C., and Grozinger, C. M., Testing the kinship theory of intragenomic conflict in honey bees (Apis mellifera)., Proc Natl Acad Sci U S A, vol. 113, no. 4, pp. 1020-5, 2016.
J. P. Nguyen, Shipley, F. B., Linder, A. N., Plummer, G. S., Liu, M., Setru, S. U., Shaevitz, J. W., and Leifer, A. M., Whole-brain calcium imaging with cellular resolution in freely behaving Caenorhabditis elegans., Proc Natl Acad Sci U S A, vol. 113, no. 8, pp. E1074-81, 2016.
2015
J. - H. Hahm, Kim, S., DiLoreto, R., Shi, C., Lee, S. - J. V., Murphy, C. T., and Nam, H. Gil, C. elegans maximum velocity correlates with healthspan and is maintained in worms with an insulin receptor mutation., Nat Commun, vol. 6, p. 8919, 2015.
R. DiLoreto and Murphy, C. T., The cell biology of aging., Mol Biol Cell, vol. 26, no. 25, pp. 4524-31, 2015.
J. Wang, Kaletsky, R., Silva, M., Williams, A., Haas, L. A., Androwski, R. J., Landis, J. N., Patrick, C., Rashid, A., Santiago-Martinez, D., Gravato-Nobre, M., Hodgkin, J., Hall, D. H., Murphy, C. T., and Barr, M. M., Cell-Specific Transcriptional Profiling of Ciliated Sensory Neurons Reveals Regulators of Behavior and Extracellular Vesicle Biogenesis., Curr Biol, vol. 25, no. 24, pp. 3232-8, 2015.
C. Y. Ewald, Landis, J. N., Abate, J. Porter, Murphy, C. T., and T Blackwell, K., Dauer-independent insulin/IGF-1-signalling implicates collagen remodelling in longevity., Nature, vol. 519, no. 7541, pp. 97-101, 2015.
J. P. Bothma, Garcia, H. G., Ng, S., Perry, M. W., Gregor, T., and Levine, M., Enhancer additivity and non-additivity are determined by enhancer strength in the Drosophila embryo., Elife, vol. 4, 2015.
V. Lakhina and Murphy, C. T., For longevity, perception is everything., Cell, vol. 160, no. 5, pp. 807-9, 2015.
L. Zwarts, Broeck, L. Vanden, Cappuyns, E., Ayroles, J. F., Magwire, M. M., Vulsteke, V., Clements, J., Mackay, T. F. C., and Callaerts, P., The genetic basis of natural variation in mushroom body size in Drosophila melanogaster., Nat Commun, vol. 6, p. 10115, 2015.
V. Lakhina and Murphy, C. T., Genome Sequencing Fishes out Longevity Genes., Cell, vol. 163, no. 6, pp. 1312-3, 2015.
V. Lakhina, Arey, R. N., Kaletsky, R., Kauffman, A., Stein, G., Keyes, W., Xu, D., and Murphy, C. T., Genome-wide functional analysis of CREB/long-term memory-dependent transcription reveals distinct basal and memory gene expression programs., Neuron, vol. 85, no. 2, pp. 330-45, 2015.
V. Lakhina, Arey, R. N., Kaletsky, R., Kauffman, A., Stein, G., Keyes, W., Xu, D., and Murphy, C. T., Genome-wide functional analysis of CREB/long-term memory-dependent transcription reveals distinct basal and memory gene expression programs., Neuron, vol. 85, no. 2, pp. 330-45, 2015.
S. Li, Stone, H. A., and Murphy, C. T., A microfluidic device and automatic counting system for the study of C. elegans reproductive aging., Lab Chip, vol. 15, no. 2, pp. 524-31, 2015.
P. Barron Abitua, T Gainous, B., Kaczmarczyk, A. N., Winchell, C. J., Hudson, C., Kamata, K., Nakagawa, M., Tsuda, M., Kusakabe, T. G., and Levine, M., The pre-vertebrate origins of neurogenic placodes., Nature, vol. 524, no. 7566, pp. 462-5, 2015.
S. D. Kocher, Tsuruda, J. M., Gibson, J. D., Emore, C. M., Arechavaleta-Velasco, M. E., Queller, D. C., Strassmann, J. E., Grozinger, C. M., Gribskov, M. R., San Miguel, P., Westerman, R., and Hunt, G. J., A Search for Parent-of-Origin Effects on Honey Bee Gene Expression., G3 (Bethesda), vol. 5, no. 8, pp. 1657-62, 2015.
K. M. Kapheim, Pan, H., Li, C., Salzberg, S. L., Puiu, D., Magoc, T., Robertson, H. M., Hudson, M. E., Venkat, A., Fischman, B. J., Hernandez, A., Yandell, M., Ence, D., Holt, C., Yocum, G. D., Kemp, W. P., Bosch, J., Waterhouse, R. M., Zdobnov, E. M., Stolle, E., F Kraus, B., Helbing, S., Moritz, R. F. A., Glastad, K. M., Hunt, B. G., Goodisman, M. A. D., Hauser, F., Grimmelikhuijzen, C. J. P., Pinheiro, D. Guariz, Nunes, F. Morais Fra, Soares, M. Prioli Mir, Tanaka, É. Donato, Simões, Z. Luz Paulin, Hartfelder, K., Evans, J. D., Barribeau, S. M., Johnson, R. M., Massey, J. H., Southey, B. R., Hasselmann, M., Hamacher, D., Biewer, M., Kent, C. F., Zayed, A., Blatti, C., Sinha, S., J Johnston, S., Hanrahan, S. J., Kocher, S. D., Wang, J., Robinson, G. E., and Zhang, G., Social evolution. Genomic signatures of evolutionary transitions from solitary to group living., Science, vol. 348, no. 6239, pp. 1139-43, 2015.
E. K. Farley, Olson, K. M., Zhang, W., Brandt, A. J., Rokhsar, D. S., and Levine, M. S., Suboptimization of developmental enhancers., Science, vol. 350, no. 6258, pp. 325-8, 2015.
G. S. Ducker and Rabinowitz, J. D., ZMP: a master regulator of one-carbon metabolism., Mol Cell, vol. 57, no. 2, pp. 203-4, 2015.
2014
B. He, Doubrovinski, K., Polyakov, O., and Wieschaus, E., Apical constriction drives tissue-scale hydrodynamic flow to mediate cell elongation., Nature, vol. 508, no. 7496, pp. 392-6, 2014.
P. Jiang and Singh, M., CCAT: Combinatorial Code Analysis Tool for transcriptional regulation., Nucleic Acids Res, vol. 42, no. 5, pp. 2833-47, 2014.
M. Levine, The contraction of time and space in remote chromosomal interactions., Cell, vol. 158, no. 2, pp. 243-4, 2014.
R. G. Tepper, Murphy, C. T., and Bussemaker, H. J., DAF-16 and PQM-1: partners in longevity., Aging (Albany NY), vol. 6, no. 1, pp. 5-6, 2014.
J. P. Bothma, Garcia, H. G., Esposito, E., Schlissel, G., Gregor, T., and Levine, M., Dynamic regulation of eve stripe 2 expression reveals transcriptional bursts in living Drosophila embryos., Proc Natl Acad Sci U S A, vol. 111, no. 29, pp. 10598-603, 2014.
N. Haupaix, Abitua, P. B., Sirour, C., Yasuo, H., Levine, M., and Hudson, C., Ephrin-mediated restriction of ERK1/2 activity delimits the number of pigment cells in the Ciona CNS., Dev Biol, vol. 394, no. 1, pp. 170-80, 2014.
L. Abouchar, Petkova, M. D., Steinhardt, C. R., and Gregor, T., Fly wing vein patterns have spatial reproducibility of a single cell., J R Soc Interface, vol. 11, no. 97, p. 20140443, 2014.
R. Mathew, Khor, S., Hackett, S. R., Rabinowitz, J. D., Perlman, D. H., and White, E., Functional role of autophagy-mediated proteome remodeling in cell survival signaling and innate immunity., Mol Cell, vol. 55, no. 6, pp. 916-30, 2014.
A. M. Berezhkovskii and Shvartsman, S. Y., On the GFP-based analysis of dynamic concentration profiles., Biophys J, vol. 106, no. 3, pp. L13-5, 2014.
J. Zhou and Troyanskaya, O. G., Global quantitative modeling of chromatin factor interactions., PLoS Comput Biol, vol. 10, no. 3, p. e1003525, 2014.
D. Botstein, Lasker∼Koshland to genetics pioneer., Cell, vol. 158, no. 6, pp. 1230-2, 2014.
M. Levine, Cattoglio, C., and Tjian, R., Looping back to leap forward: transcription enters a new era., Cell, vol. 157, no. 1, pp. 13-25, 2014.
C. Shi and Murphy, C. T., Mating induces shrinking and death in Caenorhabditis mothers., Science, vol. 343, no. 6170, pp. 536-40, 2014.
D. Krotov, Dubuis, J. O., Gregor, T., and Bialek, W., Morphogenesis at criticality., Proc Natl Acad Sci U S A, vol. 111, no. 10, pp. 3683-8, 2014.
Z. Khan, Wang, Y. - C., Wieschaus, E. F., and Kaschube, M., Quantitative 4D analyses of epithelial folding during Drosophila gastrulation., Development, vol. 141, no. 14, pp. 2895-900, 2014.
J. Fan, Ye, J., Kamphorst, J. J., Shlomi, T., Thompson, C. B., and Rabinowitz, J. D., Quantitative flux analysis reveals folate-dependent NADPH production., Nature, vol. 510, no. 7504, pp. 298-302, 2014.
M. Levine, Retrospective. Walter Gehring (1939-2014)., Science, vol. 345, no. 6194, p. 277, 2014.
G. Tkačik, Marre, O., Amodei, D., Schneidman, E., Bialek, W., and Berry, M. J., Searching for collective behavior in a large network of sensory neurons., PLoS Comput Biol, vol. 10, no. 1, p. e1003408, 2014.
W. Bialek, Cavagna, A., Giardina, I., Mora, T., Pohl, O., Silvestri, E., Viale, M., and Walczak, A. M., Social interactions dominate speed control in poising natural flocks near criticality., Proc Natl Acad Sci U S A, vol. 111, no. 20, pp. 7212-7, 2014.
2013
J. O. Dubuis, Samanta, R., and Gregor, T., Accurate measurements of dynamics and reproducibility in small genetic networks., Mol Syst Biol, vol. 9, p. 639, 2013.
S. L. Grady, Purdy, J. G., Rabinowitz, J. D., and Shenk, T., Argininosuccinate synthetase 1 depletion produces a metabolic state conducive to herpes simplex virus 1 infection., Proc Natl Acad Sci U S A, vol. 110, no. 51, pp. E5006-15, 2013.
P. Jiang, Singh, M., and Coller, H. A., Computational assessment of the cooperativity between RNA binding proteins and MicroRNAs in Transcript Decay., PLoS Comput Biol, vol. 9, no. 5, p. e1003075, 2013.
Y. Kim, Iagovitina, A., Ishihara, K., Fitzgerald, K. M., Deplancke, B., Papatsenko, D., and Shvartsman, S. Y., Context-dependent transcriptional interpretation of mitogen activated protein kinase signaling in the Drosophila embryo., Chaos, vol. 23, no. 2, p. 025105, 2013.
W. Ju, Greene, C. S., Eichinger, F., Nair, V., Hodgin, J. B., Bitzer, M., Lee, Y. -suk, Zhu, Q., Kehata, M., Li, M., Jiang, S., Rastaldi, M. Pia, Cohen, C. D., Troyanskaya, O. G., and Kretzler, M., Defining cell-type specificity at the transcriptional level in human disease., Genome Res, vol. 23, no. 11, pp. 1862-73, 2013.
J. Bothma and Levine, M., Development: lights, camera, action--the Drosophila embryo goes live!, Curr Biol, vol. 23, no. 21, pp. R965-7, 2013.
Y. - C. Wang, Khan, Z., and Wieschaus, E. F., Distinct Rap1 activity states control the extent of epithelial invagination via α-catenin., Dev Cell, vol. 25, no. 3, pp. 299-309, 2013.
F. Liu, Morrison, A. H., and Gregor, T., Dynamic interpretation of maternal inputs by the Drosophila segmentation gene network., Proc Natl Acad Sci U S A, vol. 110, no. 17, pp. 6724-9, 2013.
L. S. Cheung, Simakov, D. S. A., Fuchs, A., Pyrowolakis, G., and Shvartsman, S. Y., Dynamic model for the coordination of two enhancers of broad by EGFR signaling., Proc Natl Acad Sci U S A, vol. 110, no. 44, pp. 17939-44, 2013.
Y. Deng, Coen, P., Sun, M., and Shaevitz, J. W., Efficient multiple object tracking using mutually repulsive active membranes., PLoS One, vol. 8, no. 6, p. e65769, 2013.
A. S. Futran, A Link, J., Seger, R., and Shvartsman, S. Y., ERK as a model for systems biology of enzyme kinetics in cells., Curr Biol, vol. 23, no. 21, pp. R972-9, 2013.
M. Schumer, Cui, R., Boussau, B., Walter, R., Rosenthal, G., and Andolfatto, P., An evaluation of the hybrid speciation hypothesis for Xiphophorus clemenciae based on whole genome sequences., Evolution, vol. 67, no. 4, pp. 1155-68, 2013.
C. Y. Park, Wong, A. K., Greene, C. S., Rowland, J., Guan, Y., Bongo, L. A., Burdine, R. D., and Troyanskaya, O. G., Functional knowledge transfer for high-accuracy prediction of under-studied biological processes., PLoS Comput Biol, vol. 9, no. 3, p. e1002957, 2013.
R. B. Corbett-Detig, Zhou, J., Clark, A. G., Hartl, D. L., and Ayroles, J. F., Genetic incompatibilities are widespread within species., Nature, vol. 504, no. 7478, pp. 135-7, 2013.
J. Fan, Kamphorst, J. J., Mathew, R., Chung, M. K., White, E., Shlomi, T., and Rabinowitz, J. D., Glutamine-driven oxidative phosphorylation is a major ATP source in transformed mammalian cells in both normoxia and hypoxia., Mol Syst Biol, vol. 9, p. 712, 2013.
J. J. Kamphorst, Cross, J. R., Fan, J., de Stanchina, E., Mathew, R., White, E. P., Thompson, C. B., and Rabinowitz, J. D., Hypoxic and Ras-transformed cells support growth by scavenging unsaturated fatty acids from lysophospholipids., Proc Natl Acad Sci U S A, vol. 110, no. 22, pp. 8882-7, 2013.
B. Lim, Samper, N., Lu, H., Rushlow, C., Jiménez, G., and Shvartsman, S. Y., Kinetics of gene derepression by ERK signaling., Proc Natl Acad Sci U S A, vol. 110, no. 25, pp. 10330-5, 2013.
A. M. Berezhkovskii and Shvartsman, S. Y., Kinetics of receptor occupancy during morphogen gradient formation., J Chem Phys, vol. 138, no. 24, p. 244105, 2013.
T. J. Levario, Zhan, M., Lim, B., Shvartsman, S. Y., and Lu, H., Microfluidic trap array for massively parallel imaging of Drosophila embryos., Nat Protoc, vol. 8, no. 4, pp. 721-36, 2013.
M. Lagha, Bothma, J. P., Esposito, E., Ng, S., Stefanik, L., Tsui, C., Johnston, J., Chen, K., Gilmour, D. S., Zeitlinger, J., and Levine, M. S., Paused Pol II coordinates tissue morphogenesis in the Drosophila embryo., Cell, vol. 153, no. 5, pp. 976-87, 2013.
P. A. Gibney, Hickman, M. J., Bradley, P. H., Matese, J. C., and Botstein, D., Phylogenetic portrait of the Saccharomyces cerevisiae functional genome., G3 (Bethesda), vol. 3, no. 8, pp. 1335-40, 2013.
R. Cui, Schumer, M., Kruesi, K., Walter, R., Andolfatto, P., and Rosenthal, G. G., Phylogenomics reveals extensive reticulate evolution in Xiphophorus fishes., Evolution, vol. 67, no. 8, pp. 2166-79, 2013.
J. O. Dubuis, Tkačik, G., Wieschaus, E. F., Gregor, T., and Bialek, W., Positional information, in bits., Proc Natl Acad Sci U S A, vol. 110, no. 41, pp. 16301-8, 2013.
S. Di Talia, She, R., Blythe, S. A., Lu, X., Zhang, Q. Fan, and Wieschaus, E. F., Posttranslational control of Cdc25 degradation terminates Drosophila's early cell-cycle program., Curr Biol, vol. 23, no. 2, pp. 127-32, 2013.
R. G. Tepper, Ashraf, J., Kaletsky, R., Kleemann, G., Murphy, C. T., and Bussemaker, H. J., PQM-1 complements DAF-16 as a key transcriptional regulator of DAF-2-mediated development and longevity., Cell, vol. 154, no. 3, pp. 676-90, 2013.
S. C. Little, Tikhonov, M., and Gregor, T., Precise developmental gene expression arises from globally stochastic transcriptional activity., Cell, vol. 154, no. 4, pp. 789-800, 2013.
H. G. Garcia, Tikhonov, M., Lin, A., and Gregor, T., Quantitative imaging of transcription in living Drosophila embryos links polymerase activity to patterning., Curr Biol, vol. 23, no. 21, pp. 2140-5, 2013.
T. T. Hu, Eisen, M. B., Thornton, K. R., and Andolfatto, P., A second-generation assembly of the Drosophila simulans genome provides new insights into patterns of lineage-specific divergence., Genome Res, vol. 23, no. 1, pp. 89-98, 2013.
Y. Pritykin and Singh, M., Simple topological features reflect dynamics and modularity in protein interaction networks., PLoS Comput Biol, vol. 9, no. 10, p. e1003243, 2013.
S. R McIsaac, Oakes, B. L., Wang, X., Dummit, K. A., Botstein, D., and Noyes, M. B., Synthetic gene expression perturbation systems with rapid, tunable, single-gene specificity in yeast., Nucleic Acids Res, vol. 41, no. 4, p. e57, 2013.
M. Osterfield, Du, X. X., Schüpbach, T., Wieschaus, E., and Shvartsman, S. Y., Three-dimensional epithelial morphogenesis in the developing Drosophila egg., Dev Cell, vol. 24, no. 4, pp. 400-10, 2013.
2012
G. Jiménez, Shvartsman, S. Y., and Paroush, Z. 'ev, The Capicua repressor--a general sensor of RTK signaling in development and disease., J Cell Sci, vol. 125, no. Pt 6, pp. 1383-91, 2012.
Y. - C. Wang, Khan, Z., Kaschube, M., and Wieschaus, E. F., Differential positioning of adherens junctions is associated with initiation of epithelial folding., Nature, vol. 484, no. 7394, pp. 390-3, 2012.
T. F. C. Mackay, Richards, S., Stone, E. A., Barbadilla, A., Ayroles, J. F., Zhu, D., Casillas, S., Han, Y., Magwire, M. M., Cridland, J. M., Richardson, M. F., Anholt, R. R. H., Barrón, M., Bess, C., Blankenburg, K. Petra, Carbone, M. Anna, Castellano, D., Chaboub, L., Duncan, L., Harris, Z., Javaid, M., Jayaseelan, J. Christina, Jhangiani, S. N., Jordan, K. W., Lara, F., Lawrence, F., Lee, S. L., Librado, P., Linheiro, R. S., Lyman, R. F., Mackey, A. J., Munidasa, M., Muzny, D. Marie, Nazareth, L., Newsham, I., Perales, L., Pu, L. - L., Qu, C., Ràmia, M., Reid, J. G., Rollmann, S. M., Rozas, J., Saada, N., Turlapati, L., Worley, K. C., Wu, Y. - Q., Yamamoto, A., Zhu, Y., Bergman, C. M., Thornton, K. R., Mittelman, D., and Gibbs, R. A., The Drosophila melanogaster Genetic Reference Panel., Nature, vol. 482, no. 7384, pp. 173-8, 2012.
D. S. A. Simakov, Cheung, L. S., Pismen, L. M., and Shvartsman, S. Y., EGFR-dependent network interactions that pattern Drosophila eggshell appendages., Development, vol. 139, no. 15, pp. 2814-20, 2012.
V. Hilgers, Lemke, S. B., and Levine, M., ELAV mediates 3' UTR extension in the Drosophila nervous system., Genes Dev, vol. 26, no. 20, pp. 2259-64, 2012.
W. Huang, Richards, S., Carbone, M. Anna, Zhu, D., Anholt, R. R. H., Ayroles, J. F., Duncan, L., Jordan, K. W., Lawrence, F., Magwire, M. M., Warner, C. B., Blankenburg, K., Han, Y., Javaid, M., Jayaseelan, J., Jhangiani, S. N., Muzny, D., Ongeri, F., Perales, L., Wu, Y. - Q., Zhang, Y., Zou, X., Stone, E. A., Gibbs, R. A., and Mackay, T. F. C., Epistasis dominates the genetic architecture of Drosophila quantitative traits., Proc Natl Acad Sci U S A, vol. 109, no. 39, pp. 15553-9, 2012.
M. L. Aardema, Zhen, Y., and Andolfatto, P., The evolution of cardenolide-resistant forms of Na⁺,K⁺ -ATPase in Danainae butterflies., Mol Ecol, vol. 21, no. 2, pp. 340-9, 2012.
J. Cande, Andolfatto, P., Prud'homme, B., Stern, D. L., and Gompel, N., Evolution of multiple additive loci caused divergence between Drosophila yakuba and D. santomea in wing rowing during male courtship., PLoS One, vol. 7, no. 8, p. e43888, 2012.
R. M. Cooper, Wingreen, N. S., and Cox, E. C., An excitable cortex and memory model successfully predicts new pseudopod dynamics., PLoS One, vol. 7, no. 3, p. e33528, 2012.
E. Wagner and Levine, M., FGF signaling establishes the anterior border of the Ciona neural tube., Development, vol. 139, no. 13, pp. 2351-9, 2012.
D. Garrigan, Kingan, S. B., Geneva, A. J., Andolfatto, P., Clark, A. G., Thornton, K. R., and Presgraves, D. C., Genome sequencing reveals complex speciation in the Drosophila simulans clade., Genome Res, vol. 22, no. 8, pp. 1499-511, 2012.
A. Massouras, Waszak, S. M., Albarca-Aguilera, M., Hens, K., Holcombe, W., Ayroles, J. F., Dermitzakis, E. T., Stone, E. A., Jensen, J. D., Mackay, T. F. C., and Deplancke, B., Genomic variation and its impact on gene expression in Drosophila melanogaster., PLoS Genet, vol. 8, no. 11, p. e1003055, 2012.
E. Farley and Levine, M., HOT DNAs: a novel class of developmental enhancers., Genes Dev, vol. 26, no. 9, pp. 873-6, 2012.
P. Barron Abitua, Wagner, E., Navarrete, I. A., and Levine, M., Identification of a rudimentary neural crest in a non-vertebrate chordate., Nature, vol. 492, no. 7427, pp. 104-7, 2012.
A. K. Wong, Park, C. Y., Greene, C. S., Bongo, L. A., Guan, Y., and Troyanskaya, O. G., IMP: a multi-species functional genomics portal for integration, visualization and prediction of protein functions and networks., Nucleic Acids Res, vol. 40, no. Web Server issue, pp. W484-90, 2012.
V. D. Nair, Ge, Y., Balasubramaniyan, N., Kim, J., Okawa, Y., Chikina, M., Troyanskaya, O., and Sealfon, S. C., Involvement of histone demethylase LSD1 in short-time-scale gene expression changes during cell cycle progression in embryonic stem cells., Mol Cell Biol, vol. 32, no. 23, pp. 4861-76, 2012.
B. He, Caudy, A., Parsons, L., Rosebrock, A., Pane, A., Raj, S., and Wieschaus, E., Mapping the pericentric heterochromatin by comparative genomic hybridization analysis and chromosome deletions in Drosophila melanogaster., Genome Res, vol. 22, no. 12, pp. 2507-19, 2012.
S. Y. Shvartsman and Baker, R. E., Mathematical models of morphogen gradients and their effects on gene expression., Wiley Interdiscip Rev Dev Biol, vol. 1, no. 5, pp. 715-30, 2012.
M. Lagha, Bothma, J. P., and Levine, M., Mechanisms of transcriptional precision in animal development., Trends Genet, vol. 28, no. 8, pp. 409-16, 2012.
Y. Zhen and Andolfatto, P., Methods to detect selection on noncoding DNA., Methods Mol Biol, vol. 856, pp. 141-59, 2012.
G. Tkačik, Walczak, A. M., and Bialek, W., Optimizing information flow in small genetic networks. III. A self-interacting gene., Phys Rev E Stat Nonlin Soft Matter Phys, vol. 85, no. 4 Pt 1, p. 041903, 2012.
Y. Zhen, Aardema, M. L., Medina, E. M., Schumer, M., and Andolfatto, P., Parallel molecular evolution in an herbivore community., Science, vol. 337, no. 6102, pp. 1634-7, 2012.
J. S. Kanodia, Liang, H. - L., Kim, Y., Lim, B., Zhan, M., Lu, H., Rushlow, C. A., and Shvartsman, S. Y., Pattern formation by graded and uniform signals in the early Drosophila embryo., Biophys J, vol. 102, no. 3, pp. 427-33, 2012.
M. W. Perry, Bothma, J. P., Luu, R. D., and Levine, M., Precision of hunchback expression in the Drosophila embryo., Curr Biol, vol. 22, no. 23, pp. 2247-52, 2012.
A. H. Morrison, Scheeler, M., Dubuis, J., and Gregor, T., Quantifying the Bicoid morphogen gradient in living fly embryos., Cold Spring Harb Protoc, vol. 2012, no. 4, pp. 398-406, 2012.
E. M. Leffler, Bullaughey, K., Matute, D. R., Meyer, W. K., Ségurel, L., Venkat, A., Andolfatto, P., and Przeworski, M., Revisiting an old riddle: what determines genetic diversity levels within species?, PLoS Biol, vol. 10, no. 9, p. e1001388, 2012.
A. Helman, Lim, B., Andreu, M. José, Kim, Y., Shestkin, T., Lu, H., Jiménez, G., Shvartsman, S. Y., and Paroush, Z. 'ev, RTK signaling modulates the Dorsal gradient., Development, vol. 139, no. 16, pp. 3032-9, 2012.
S. Di Talia and Wieschaus, E. F., Short-term integration of Cdc25 dynamics controls mitotic entry during Drosophila gastrulation., Dev Cell, vol. 22, no. 4, pp. 763-74, 2012.
W. Bialek, Cavagna, A., Giardina, I., Mora, T., Silvestri, E., Viale, M., and Walczak, A. M., Statistical mechanics for natural flocks of birds., Proc Natl Acad Sci U S A, vol. 109, no. 13, pp. 4786-91, 2012.
J. A. Drocco, Wieschaus, E. F., and Tank, D. W., The synthesis-diffusion-degradation model explains Bicoid gradient formation in unfertilized eggs., Phys Biol, vol. 9, no. 5, p. 055004, 2012.
C. A. Rushlow and Shvartsman, S. Y., Temporal dynamics, spatial range, and transcriptional interpretation of the Dorsal morphogen gradient., Curr Opin Genet Dev, vol. 22, no. 6, pp. 542-6, 2012.
Y. Guan, Gorenshteyn, D., Burmeister, M., Wong, A. K., Schimenti, J. C., Handel, M. Ann, Bult, C. J., Hibbs, M. A., and Troyanskaya, O. G., Tissue-specific functional networks for prioritizing phenotype and disease genes., PLoS Comput Biol, vol. 8, no. 9, p. e1002694, 2012.
O. Grimm, Zini, V. Sanchez, Kim, Y., Casanova, J., Shvartsman, S. Y., and Wieschaus, E., Torso RTK controls Capicua degradation by changing its subcellular localization., Development, vol. 139, no. 21, pp. 3962-8, 2012.
A. Fuchs, Cheung, L. S., Charbonnier, E., Shvartsman, S. Y., and Pyrowolakis, G., Transcriptional interpretation of the EGF receptor signaling gradient., Proc Natl Acad Sci U S A, vol. 109, no. 5, pp. 1572-7, 2012.
V. S. Chopra, Kong, N., and Levine, M., Transcriptional repression via antilooping in the Drosophila embryo., Proc Natl Acad Sci U S A, vol. 109, no. 24, pp. 9460-4, 2012.
U. Ober, Ayroles, J. F., Stone, E. A., Richards, S., Zhu, D., Gibbs, R. A., Stricker, C., Gianola, D., Schlather, M., Mackay, T. F. C., and Simianer, H., Using whole-genome sequence data to predict quantitative trait phenotypes in Drosophila melanogaster., PLoS Genet, vol. 8, no. 5, p. e1002685, 2012.
M. A. Gelbart, He, B., Martin, A. C., Thiberge, S. Y., Wieschaus, E. F., and Kaschube, M., Volume conservation principle involved in cell lengthening and nucleus movement during tissue morphogenesis., Proc Natl Acad Sci U S A, vol. 109, no. 47, pp. 19298-303, 2012.
2011
M. D. Chikina and Troyanskaya, O. G., Accurate quantification of functional analogy among close homologs., PLoS Comput Biol, vol. 7, no. 2, p. e1001074, 2011.
S. Luo and Murphy, C. T., Caenorhabditis elegans reproductive aging: Regulation and underlying mechanisms., Genesis, vol. 49, no. 2, pp. 53-65, 2011.
D. Papatsenko, Levine, M., and Goltsev, Y., Clusters of temporal discordances reveal distinct embryonic patterning mechanisms in Drosophila and anopheles., PLoS Biol, vol. 9, no. 1, p. e1000584, 2011.
J. S. Kanodia, Kim, Y., Tomer, R., Khan, Z., Chung, K., Storey, J. D., Lu, H., Keller, P. J., and Shvartsman, S. Y., A computational statistics approach for estimating the spatial range of morphogen gradients., Development, vol. 138, no. 22, pp. 4867-74, 2011.
B. Callahan, Neher, R. A., Bachtrog, D., Andolfatto, P., and Shraiman, B. I., Correlated evolution of nearby residues in Drosophilid proteins., PLoS Genet, vol. 7, no. 2, p. e1001315, 2011.
A. Pane, Jiang, P., Zhao, D. Yanling, Singh, M., and Schüpbach, T., The Cutoff protein regulates piRNA cluster expression and piRNA production in the Drosophila germline., EMBO J, vol. 30, no. 22, pp. 4601-15, 2011.
L. Vastag, Koyuncu, E., Grady, S. L., Shenk, T. E., and Rabinowitz, J. D., Divergent effects of human cytomegalovirus and herpes simplex virus-1 on cellular metabolism., PLoS Pathog, vol. 7, no. 7, p. e1002124, 2011.
S. R McIsaac, Huang, K. Casey, Sengupta, A., and Wingreen, N. S., Does the potential for chaos constrain the embryonic cell-cycle oscillator?, PLoS Comput Biol, vol. 7, no. 7, p. e1002109, 2011.
P. Andolfatto, Wong, K. M., and Bachtrog, D., Effective population size and the efficacy of selection on the X chromosomes of two closely related Drosophila species., Genome Biol Evol, vol. 3, pp. 114-28, 2011.
G. Liu, Rogers, J., Murphy, C. T., and Rongo, C., EGF signalling activates the ubiquitin proteasome system to modulate C. elegans lifespan., EMBO J, vol. 30, no. 15, pp. 2990-3003, 2011.
G. J. Stephens, de Mesquita, M. Bueno, Ryu, W. S., and Bialek, W., Emergence of long timescales and stereotyped behaviors in Caenorhabditis elegans., Proc Natl Acad Sci U S A, vol. 108, no. 18, pp. 7286-9, 2011.
G. Rizki, Iwata, T. Naoko, Li, J., Riedel, C. G., Picard, C. Lafontaine, Jan, M., Murphy, C. T., and Lee, S. Sylvia, The evolutionarily conserved longevity determinants HCF-1 and SIR-2.1/SIRT1 collaborate to regulate DAF-16/FOXO., PLoS Genet, vol. 7, no. 9, p. e1002235, 2011.
S. C. Little, Tkačik, G., Kneeland, T. B., Wieschaus, E. F., and Gregor, T., The formation of the Bicoid morphogen gradient requires protein movement from anteriorly localized mRNA., PLoS Biol, vol. 9, no. 3, p. e1000596, 2011.
J. F. Ayroles, Laflamme, B. A., Stone, E. A., Wolfner, M. F., and Mackay, T. F. C., Functional genome annotation of Drosophila seminal fluid proteins using transcriptional genetic networks., Genet Res (Camb), vol. 93, no. 6, pp. 387-95, 2011.
Y. Kim, Andreu, M. José, Lim, B., Chung, K., Terayama, M., Jiménez, G., Berg, C. A., Lu, H., and Shvartsman, S. Y., Gene regulation by MAPK substrate competition., Dev Cell, vol. 20, no. 6, pp. 880-7, 2011.
D. Botstein, Genome-sequencing anniversary. Fruits of genome sequences for biology., Science, vol. 331, no. 6020, p. 1025, 2011.
J. J. Kamphorst, Fan, J., Lu, W., White, E., and Rabinowitz, J. D., Liquid chromatography-high resolution mass spectrometry analysis of fatty acid metabolism., Anal Chem, vol. 83, no. 23, pp. 9114-22, 2011.
J. A. Drocco, Grimm, O., Tank, D. W., and Wieschaus, E., Measurement and perturbation of morphogen lifetime: effects on gradient shape., Biophys J, vol. 101, no. 8, pp. 1807-15, 2011.
K. Chung, Kim, Y., Kanodia, J. S., Gong, E., Shvartsman, S. Y., and Lu, H., A microfluidic array for large-scale ordering and orientation of embryos., Nat Methods, vol. 8, no. 2, pp. 171-6, 2011.
M. W. Perry, Boettiger, A. N., and Levine, M., Multiple enhancers ensure precision of gap gene-expression patterns in the Drosophila embryo., Proc Natl Acad Sci U S A, vol. 108, no. 33, pp. 13570-5, 2011.
P. Andolfatto, Davison, D., Erezyilmaz, D., Hu, T. T., Mast, J., Sunayama-Morita, T., and Stern, D. L., Multiplexed shotgun genotyping for rapid and efficient genetic mapping., Genome Res, vol. 21, no. 4, pp. 610-7, 2011.
K. C. Rowe, Singhal, S., Macmanes, M. D., Ayroles, J. F., Morelli, T. Lyn, Rubidge, E. M., Bi, K., and Moritz, C. C., Museum genomics: low-cost and high-accuracy genetic data from historical specimens., Mol Ecol Resour, vol. 11, no. 6, pp. 1082-92, 2011.
A. Stolfi, Wagner, E., J Taliaferro, M., Chou, S., and Levine, M., Neural tube patterning by Ephrin, FGF and Notch signaling relays., Development, vol. 138, no. 24, pp. 5429-39, 2011.
V. Hilgers, Perry, M. W., Hendrix, D., Stark, A., Levine, M., and Haley, B., Neural-specific elongation of 3' UTRs during Drosophila development., Proc Natl Acad Sci U S A, vol. 108, no. 38, pp. 15864-9, 2011.
A. Stolfi and Levine, M., Neuronal subtype specification in the spinal cord of a protovertebrate., Development, vol. 138, no. 5, pp. 995-1004, 2011.
J. J. Zartman, Cheung, L. S., Niepielko, M. G., Bonini, C., Haley, B., Yakoby, N., and Shvartsman, S. Y., Pattern formation by a moving morphogen source., Phys Biol, vol. 8, no. 4, p. 045003, 2011.
L. S. Cheung, Schüpbach, T., and Shvartsman, S. Y., Pattern formation by receptor tyrosine kinases: analysis of the Gurken gradient in Drosophila oogenesis., Curr Opin Genet Dev, vol. 21, no. 6, pp. 719-25, 2011.
M. Levine, Paused RNA polymerase II as a developmental checkpoint., Cell, vol. 145, no. 4, pp. 502-11, 2011.
C. S. Greene and Troyanskaya, O. G., PILGRM: an interactive data-driven discovery platform for expert biologists., Nucleic Acids Res, vol. 39, no. Web Server issue, pp. W368-74, 2011.
V. S. Chopra, Hendrix, D. A., Core, L. J., Tsui, C., Lis, J. T., and Levine, M., The polycomb group mutant esc leads to augmented levels of paused Pol II in the Drosophila embryo., Mol Cell, vol. 42, no. 6, pp. 837-44, 2011.
D. J. Wilson, Hernandez, R. D., Andolfatto, P., and Przeworski, M., A population genetics-phylogenetics approach to inferring natural selection in coding sequences., PLoS Genet, vol. 7, no. 12, p. e1002395, 2011.
L. Vastag, Jorgensen, P., Peshkin, L., Wei, R., Rabinowitz, J. D., and Kirschner, M. W., Remodeling of the metabolome during early frog development., PLoS One, vol. 6, no. 2, p. e16881, 2011.
G. J. Stephens, Osborne, L. C., and Bialek, W., Searching for simplicity in the analysis of neurons and behavior., Proc Natl Acad Sci U S A, vol. 108 Suppl 3, pp. 15565-71, 2011.
J. P. Bothma, Magliocco, J., and Levine, M., The snail repressor inhibits release, not elongation, of paused Pol II in the Drosophila embryo., Curr Biol, vol. 21, no. 18, pp. 1571-7, 2011.
Y. Kim, Paroush, Z. 'ev, Nairz, K., Hafen, E., Jiménez, G., and Shvartsman, S. Y., Substrate-dependent control of MAPK phosphorylation in vivo., Mol Syst Biol, vol. 7, p. 467, 2011.
E. Schneidman, Puchalla, J. L., Segev, R., Harris, R. A., Bialek, W., and Berry, M. J., Synergy from silence in a combinatorial neural code., J Neurosci, vol. 31, no. 44, pp. 15732-41, 2011.
A. Ochoa, Llinás, M., and Singh, M., Using context to improve protein domain identification., BMC Bioinformatics, vol. 12, p. 90, 2011.
D. Botstein and Fink, G. R., Yeast: an experimental organism for 21st Century biology., Genetics, vol. 189, no. 3, pp. 695-704, 2011.
2010
C. T. Murphy, Aging: miRacles of longevity?, Curr Biol, vol. 20, no. 24, pp. R1076-8, 2010.
P. Mehta and Gregor, T., Approaching the molecular origins of collective dynamics in oscillating cell populations., Curr Opin Genet Dev, vol. 20, no. 6, pp. 574-80, 2010.
J. D. Rabinowitz and White, E., Autophagy and metabolism., Science, vol. 330, no. 6009, pp. 1344-8, 2010.
O. Grimm and Wieschaus, E., The Bicoid gradient is shaped independently of nuclei., Development, vol. 137, no. 17, pp. 2857-62, 2010.
L. Christiaen, Stolfi, A., and Levine, M., BMP signaling coordinates gene expression and cell migration during precardiac mesoderm development., Dev Biol, vol. 340, no. 2, pp. 179-87, 2010.
K. L. Olszewski, Mather, M. W., Morrisey, J. M., Garcia, B. A., Vaidya, A. B., Rabinowitz, J. D., and Llinás, M., Branched tricarboxylic acid metabolism in Plasmodium falciparum., Nature, vol. 466, no. 7307, pp. 774-8, 2010.
X. Lu, Drocco, J., and Wieschaus, E. F., Cell cycle regulation via inter-nuclear communication during the early embryonic development of Drosophila melanogaster., Cell Cycle, vol. 9, no. 14, pp. 2908-10, 2010.
M. E. Kavousanakis, Kanodia, J. S., Kim, Y., Kevrekidis, I. G., and Shvartsman, S. Y., A compartmental model for the bicoid gradient., Dev Biol, vol. 345, no. 1, pp. 12-7, 2010.
A. Stolfi, T Gainous, B., Young, J. J., Mori, A., Levine, M., and Christiaen, L., Early chordate origins of the vertebrate second heart field., Science, vol. 329, no. 5991, pp. 565-8, 2010.
G. J. Stephens, Johnson-Kerner, B., Bialek, W., and Ryu, W. S., From modes to movement in the behavior of Caenorhabditis elegans., PLoS One, vol. 5, no. 11, p. e13914, 2010.
Y. Guan, Ackert-Bicknell, C. L., Kell, B., Troyanskaya, O. G., and Hibbs, M. A., Functional genomics complements quantitative genetics in identifying disease-gene associations., PLoS Comput Biol, vol. 6, no. 11, p. e1000991, 2010.
The Gene Ontology in 2010: extensions and refinements., Nucleic Acids Res, vol. 38, no. Database issue, pp. D331-5, 2010.
S. D. Kocher, Ayroles, J. F., Stone, E. A., and Grozinger, C. M., Individual variation in pheromone response correlates with reproductive traits and brain gene expression in worker honey bees., PLoS One, vol. 5, no. 2, p. e9116, 2010.
A. L. Kauffman, Ashraf, J. M., M Corces-Zimmerman, R., Landis, J. N., and Murphy, C. T., Insulin signaling and dietary restriction differentially influence the decline of learning and memory with age., PLoS Biol, vol. 8, no. 5, p. e1000372, 2010.
A. C. Martin, Gelbart, M., Fernandez-Gonzalez, R., Kaschube, M., and Wieschaus, E. F., Integration of contractile forces during tissue invagination., J Cell Biol, vol. 188, no. 5, pp. 735-49, 2010.
J. N. Landis and Murphy, C. T., Integration of diverse inputs in the regulation of Caenorhabditis elegans DAF-16/FOXO., Dev Dyn, vol. 239, no. 5, pp. 1405-12, 2010.
C. S. Greene and Troyanskaya, O. G., Integrative systems biology for data-driven knowledge discovery., Semin Nephrol, vol. 30, no. 5, pp. 443-54, 2010.
Y. Kim, Coppey, M., Grossman, R., Ajuria, L., Jiménez, G., Paroush, Z. 'ev, and Shvartsman, S. Y., MAPK substrate competition integrates patterning signals in the Drosophila embryo., Curr Biol, vol. 20, no. 5, pp. 446-51, 2010.
F. Markowetz, Mulder, K. W., Airoldi, E. M., Lemischka, I. R., and Troyanskaya, O. G., Mapping dynamic histone acetylation patterns to gene expression in nanog-depleted murine embryonic stem cells., PLoS Comput Biol, vol. 6, no. 12, p. e1001034, 2010.
T. Mora, Walczak, A. M., Bialek, W., and Callan, C. G., Maximum entropy models for antibody diversity., Proc Natl Acad Sci U S A, vol. 107, no. 12, pp. 5405-10, 2010.
D. Hendrix, Levine, M., and Shi, W., miRTRAP, a computational method for the systematic identification of miRNAs from high throughput sequencing data., Genome Biol, vol. 11, no. 4, p. R39, 2010.
O. Grimm, Coppey, M., and Wieschaus, E., Modelling the Bicoid gradient., Development, vol. 137, no. 14, pp. 2253-64, 2010.
J. P. Bothma, Levine, M., and Boettiger, A., Morphogen gradients: limits to signaling or limits to measurement?, Curr Biol, vol. 20, no. 5, pp. R232-4, 2010.
C. Sample and Shvartsman, S. Y., Multiscale modeling of diffusion in the early Drosophila embryo., Proc Natl Acad Sci U S A, vol. 107, no. 22, pp. 10092-6, 2010.

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