List of Faculty Publications

Below is a list of Faculty publications imported from PubMed or manually added. By default, publications are sorted by year with titles displayed in ascending alphabetical order.
Shortcuts: Wühr, Martin | Wingreen, Ned | Wieschaus, Eric | Troyanskaya, Olga | Tilghman, Shirley | Storey, John | Singh, Mona | Shvartsman, Stanislav | Shaevitz, Joshua | Rabinowitz, Joshua | Murphy, Coleen | Levine, Michael {Levine, Michael S.} | Gregor, Thomas | Botstein, David | Bialek, William | Ayroles, Julien | Andolfatto, Peter | Akey, Joshua

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Aging
C. T. Murphy, Aging: miRacles of longevity?, Curr Biol, vol. 20, no. 24, pp. R1076-8, 2010.
A. - L. Hsu, Murphy, C. T., and Kenyon, C., Regulation of aging and age-related disease by DAF-16 and heat-shock factor., Science, vol. 300, no. 5622, pp. 1142-5, 2003.
C. T. Murphy, Lee, S. - J., and Kenyon, C., Tissue entrainment by feedback regulation of insulin gene expression in the endoderm of Caenorhabditis elegans., Proc Natl Acad Sci U S A, vol. 104, no. 48, pp. 19046-50, 2007.
R. DiLoreto and Murphy, C. T., The cell biology of aging., Mol Biol Cell, vol. 26, no. 25, pp. 4524-31, 2015.
C. Y. Ewald, Landis, J. N., Abate, J. Porter, Murphy, C. T., and T Blackwell, K., Dauer-independent insulin/IGF-1-signalling implicates collagen remodelling in longevity., Nature, vol. 519, no. 7541, pp. 97-101, 2015.
S. A. McCarroll, Murphy, C. T., Zou, S., Pletcher, S. D., Chin, C. - S., Jan, Y. Nung, Kenyon, C., Bargmann, C. I., and Li, H., Comparing genomic expression patterns across species identifies shared transcriptional profile in aging., Nat Genet, vol. 36, no. 2, pp. 197-204, 2004.
R. G. Tepper, Murphy, C. T., and Bussemaker, H. J., DAF-16 and PQM-1: partners in longevity., Aging (Albany NY), vol. 6, no. 1, pp. 5-6, 2014.
L. - B. Li, Lei, H., Arey, R. N., Li, P., Liu, J., Murphy, C. T., Xu, X. Z. Shawn, and Shen, K., The Neuronal Kinesin UNC-104/KIF1A Is a Key Regulator of Synaptic Aging and Insulin Signaling-Regulated Memory., Curr Biol, vol. 26, no. 5, pp. 605-15, 2016.
C. T. Murphy, The search for DAF-16/FOXO transcriptional targets: approaches and discoveries., Exp Gerontol, vol. 41, no. 10, pp. 910-21, 2006.
R. Kaletsky, Lakhina, V., Arey, R., Williams, A., Landis, J., Ashraf, J., and Murphy, C. T., The C. elegans adult neuronal IIS/FOXO transcriptome reveals adult phenotype regulators., Nature, vol. 529, no. 7584, pp. 92-6, 2016.
S. Luo, Kleemann, G. A., Ashraf, J. M., Shaw, W. M., and Murphy, C. T., TGF-β and insulin signaling regulate reproductive aging via oocyte and germline quality maintenance., Cell, vol. 143, no. 2, pp. 299-312, 2010.
A. L. Kauffman, Ashraf, J. M., M Corces-Zimmerman, R., Landis, J. N., and Murphy, C. T., Insulin signaling and dietary restriction differentially influence the decline of learning and memory with age., PLoS Biol, vol. 8, no. 5, p. e1000372, 2010.
S. Luo and Murphy, C. T., Caenorhabditis elegans reproductive aging: Regulation and underlying mechanisms., Genesis, vol. 49, no. 2, pp. 53-65, 2011.
C. T. Murphy, McCarroll, S. A., Bargmann, C. I., Fraser, A., Kamath, R. S., Ahringer, J., Li, H., and Kenyon, C., Genes that act downstream of DAF-16 to influence the lifespan of Caenorhabditis elegans., Nature, vol. 424, no. 6946, pp. 277-83, 2003.
G. Liu, Rogers, J., Murphy, C. T., and Rongo, C., EGF signalling activates the ubiquitin proteasome system to modulate C. elegans lifespan., EMBO J, vol. 30, no. 15, pp. 2990-3003, 2011.
S. Luo, Shaw, W. M., Ashraf, J., and Murphy, C. T., TGF-beta Sma/Mab signaling mutations uncouple reproductive aging from somatic aging., PLoS Genet, vol. 5, no. 12, p. e1000789, 2009.
Animals
S. - J. Lee, Murphy, C. T., and Kenyon, C., Glucose shortens the life span of C. elegans by downregulating DAF-16/FOXO activity and aquaporin gene expression., Cell Metab, vol. 10, no. 5, pp. 379-91, 2009.
V. Lakhina, Arey, R. N., Kaletsky, R., Kauffman, A., Stein, G., Keyes, W., Xu, D., and Murphy, C. T., Genome-wide functional analysis of CREB/long-term memory-dependent transcription reveals distinct basal and memory gene expression programs., Neuron, vol. 85, no. 2, pp. 330-45, 2015.
S. A. McCarroll, Murphy, C. T., Zou, S., Pletcher, S. D., Chin, C. - S., Jan, Y. Nung, Kenyon, C., Bargmann, C. I., and Li, H., Comparing genomic expression patterns across species identifies shared transcriptional profile in aging., Nat Genet, vol. 36, no. 2, pp. 197-204, 2004.
G. Rizki, Iwata, T. Naoko, Li, J., Riedel, C. G., Picard, C. Lafontaine, Jan, M., Murphy, C. T., and Lee, S. Sylvia, The evolutionarily conserved longevity determinants HCF-1 and SIR-2.1/SIRT1 collaborate to regulate DAF-16/FOXO., PLoS Genet, vol. 7, no. 9, p. e1002235, 2011.
J. Wang, Kaletsky, R., Silva, M., Williams, A., Haas, L. A., Androwski, R. J., Landis, J. N., Patrick, C., Rashid, A., Santiago-Martinez, D., Gravato-Nobre, M., Hodgkin, J., Hall, D. H., Murphy, C. T., and Barr, M. M., Cell-Specific Transcriptional Profiling of Ciliated Sensory Neurons Reveals Regulators of Behavior and Extracellular Vesicle Biogenesis., Curr Biol, vol. 25, no. 24, pp. 3232-8, 2015.
C. Y. Ewald, Landis, J. N., Abate, J. Porter, Murphy, C. T., and T Blackwell, K., Dauer-independent insulin/IGF-1-signalling implicates collagen remodelling in longevity., Nature, vol. 519, no. 7541, pp. 97-101, 2015.
R. G. Tepper, Murphy, C. T., and Bussemaker, H. J., DAF-16 and PQM-1: partners in longevity., Aging (Albany NY), vol. 6, no. 1, pp. 5-6, 2014.
S. Li, Stone, H. A., and Murphy, C. T., A microfluidic device and automatic counting system for the study of C. elegans reproductive aging., Lab Chip, vol. 15, no. 2, pp. 524-31, 2015.
J. N. Landis and Murphy, C. T., Integration of diverse inputs in the regulation of Caenorhabditis elegans DAF-16/FOXO., Dev Dyn, vol. 239, no. 5, pp. 1405-12, 2010.
C. T. Murphy, The search for DAF-16/FOXO transcriptional targets: approaches and discoveries., Exp Gerontol, vol. 41, no. 10, pp. 910-21, 2006.
R. G. Tepper, Ashraf, J., Kaletsky, R., Kleemann, G., Murphy, C. T., and Bussemaker, H. J., PQM-1 complements DAF-16 as a key transcriptional regulator of DAF-2-mediated development and longevity., Cell, vol. 154, no. 3, pp. 676-90, 2013.
L. - B. Li, Lei, H., Arey, R. N., Li, P., Liu, J., Murphy, C. T., Xu, X. Z. Shawn, and Shen, K., The Neuronal Kinesin UNC-104/KIF1A Is a Key Regulator of Synaptic Aging and Insulin Signaling-Regulated Memory., Curr Biol, vol. 26, no. 5, pp. 605-15, 2016.
R. Kaletsky, Lakhina, V., Arey, R., Williams, A., Landis, J., Ashraf, J., and Murphy, C. T., The C. elegans adult neuronal IIS/FOXO transcriptome reveals adult phenotype regulators., Nature, vol. 529, no. 7584, pp. 92-6, 2016.
A. L. Kauffman, Ashraf, J. M., M Corces-Zimmerman, R., Landis, J. N., and Murphy, C. T., Insulin signaling and dietary restriction differentially influence the decline of learning and memory with age., PLoS Biol, vol. 8, no. 5, p. e1000372, 2010.
S. Luo, Kleemann, G. A., Ashraf, J. M., Shaw, W. M., and Murphy, C. T., TGF-β and insulin signaling regulate reproductive aging via oocyte and germline quality maintenance., Cell, vol. 143, no. 2, pp. 299-312, 2010.
C. T. Murphy, McCarroll, S. A., Bargmann, C. I., Fraser, A., Kamath, R. S., Ahringer, J., Li, H., and Kenyon, C., Genes that act downstream of DAF-16 to influence the lifespan of Caenorhabditis elegans., Nature, vol. 424, no. 6946, pp. 277-83, 2003.
M. D. Chikina, Huttenhower, C., Murphy, C. T., and Troyanskaya, O. G., Global prediction of tissue-specific gene expression and context-dependent gene networks in Caenorhabditis elegans., PLoS Comput Biol, vol. 5, no. 6, p. e1000417, 2009.
V. Lakhina, Arey, R. N., Kaletsky, R., Kauffman, A., Stein, G., Keyes, W., Xu, D., and Murphy, C. T., Genome-wide functional analysis of CREB/long-term memory-dependent transcription reveals distinct basal and memory gene expression programs., Neuron, vol. 85, no. 2, pp. 330-45, 2015.
S. Luo and Murphy, C. T., Caenorhabditis elegans reproductive aging: Regulation and underlying mechanisms., Genesis, vol. 49, no. 2, pp. 53-65, 2011.
R. P. Oliveira, Abate, J. Porter, Dilks, K., Landis, J., Ashraf, J., Murphy, C. T., and T Blackwell, K., Condition-adapted stress and longevity gene regulation by Caenorhabditis elegans SKN-1/Nrf., Aging Cell, vol. 8, no. 5, pp. 524-41, 2009.
J. - H. Hahm, Kim, S., DiLoreto, R., Shi, C., Lee, S. - J. V., Murphy, C. T., and Nam, H. Gil, C. elegans maximum velocity correlates with healthspan and is maintained in worms with an insulin receptor mutation., Nat Commun, vol. 6, p. 8919, 2015.
C. Kenyon and Murphy, C. T., Enrichment of regulatory motifs upstream of predicted DAF-16 targets., Nat Genet, vol. 38, no. 4, pp. 397-8; author reply 398, 2006.
R. Kaletsky and Murphy, C. T., The role of insulin/IGF-like signaling in C. elegans longevity and aging., Dis Model Mech, vol. 3, no. 7-8, pp. 415-9, 2010.
C. Shi and Murphy, C. T., Feeding the germline., Genes Dev, vol. 30, no. 3, pp. 249-50, 2016.
W. M. Shaw, Luo, S., Landis, J., Ashraf, J., and Murphy, C. T., The C. elegans TGF-beta Dauer pathway regulates longevity via insulin signaling., Curr Biol, vol. 17, no. 19, pp. 1635-45, 2007.
S. Luo, Shaw, W. M., Ashraf, J., and Murphy, C. T., TGF-beta Sma/Mab signaling mutations uncouple reproductive aging from somatic aging., PLoS Genet, vol. 5, no. 12, p. e1000789, 2009.
G. Liu, Rogers, J., Murphy, C. T., and Rongo, C., EGF signalling activates the ubiquitin proteasome system to modulate C. elegans lifespan., EMBO J, vol. 30, no. 15, pp. 2990-3003, 2011.
C. Shi and Murphy, C. T., Mating induces shrinking and death in Caenorhabditis mothers., Science, vol. 343, no. 6170, pp. 536-40, 2014.
V. Lakhina and Murphy, C. T., For longevity, perception is everything., Cell, vol. 160, no. 5, pp. 807-9, 2015.
V. Lakhina and Murphy, C. T., Genome Sequencing Fishes out Longevity Genes., Cell, vol. 163, no. 6, pp. 1312-3, 2015.
A. - L. Hsu, Murphy, C. T., and Kenyon, C., Regulation of aging and age-related disease by DAF-16 and heat-shock factor., Science, vol. 300, no. 5622, pp. 1142-5, 2003.
C. T. Murphy, Lee, S. - J., and Kenyon, C., Tissue entrainment by feedback regulation of insulin gene expression in the endoderm of Caenorhabditis elegans., Proc Natl Acad Sci U S A, vol. 104, no. 48, pp. 19046-50, 2007.
C. T. Murphy, Aging: miRacles of longevity?, Curr Biol, vol. 20, no. 24, pp. R1076-8, 2010.
R. DiLoreto and Murphy, C. T., The cell biology of aging., Mol Biol Cell, vol. 26, no. 25, pp. 4524-31, 2015.
Caenorhabditis elegans
V. Lakhina and Murphy, C. T., For longevity, perception is everything., Cell, vol. 160, no. 5, pp. 807-9, 2015.
A. - L. Hsu, Murphy, C. T., and Kenyon, C., Regulation of aging and age-related disease by DAF-16 and heat-shock factor., Science, vol. 300, no. 5622, pp. 1142-5, 2003.
C. T. Murphy, Lee, S. - J., and Kenyon, C., Tissue entrainment by feedback regulation of insulin gene expression in the endoderm of Caenorhabditis elegans., Proc Natl Acad Sci U S A, vol. 104, no. 48, pp. 19046-50, 2007.
R. DiLoreto and Murphy, C. T., The cell biology of aging., Mol Biol Cell, vol. 26, no. 25, pp. 4524-31, 2015.
V. Lakhina, Arey, R. N., Kaletsky, R., Kauffman, A., Stein, G., Keyes, W., Xu, D., and Murphy, C. T., Genome-wide functional analysis of CREB/long-term memory-dependent transcription reveals distinct basal and memory gene expression programs., Neuron, vol. 85, no. 2, pp. 330-45, 2015.
S. - J. Lee, Murphy, C. T., and Kenyon, C., Glucose shortens the life span of C. elegans by downregulating DAF-16/FOXO activity and aquaporin gene expression., Cell Metab, vol. 10, no. 5, pp. 379-91, 2009.
S. Li, Stone, H. A., and Murphy, C. T., A microfluidic device and automatic counting system for the study of C. elegans reproductive aging., Lab Chip, vol. 15, no. 2, pp. 524-31, 2015.
J. Wang, Kaletsky, R., Silva, M., Williams, A., Haas, L. A., Androwski, R. J., Landis, J. N., Patrick, C., Rashid, A., Santiago-Martinez, D., Gravato-Nobre, M., Hodgkin, J., Hall, D. H., Murphy, C. T., and Barr, M. M., Cell-Specific Transcriptional Profiling of Ciliated Sensory Neurons Reveals Regulators of Behavior and Extracellular Vesicle Biogenesis., Curr Biol, vol. 25, no. 24, pp. 3232-8, 2015.
C. Y. Ewald, Landis, J. N., Abate, J. Porter, Murphy, C. T., and T Blackwell, K., Dauer-independent insulin/IGF-1-signalling implicates collagen remodelling in longevity., Nature, vol. 519, no. 7541, pp. 97-101, 2015.
G. Rizki, Iwata, T. Naoko, Li, J., Riedel, C. G., Picard, C. Lafontaine, Jan, M., Murphy, C. T., and Lee, S. Sylvia, The evolutionarily conserved longevity determinants HCF-1 and SIR-2.1/SIRT1 collaborate to regulate DAF-16/FOXO., PLoS Genet, vol. 7, no. 9, p. e1002235, 2011.
J. N. Landis and Murphy, C. T., Integration of diverse inputs in the regulation of Caenorhabditis elegans DAF-16/FOXO., Dev Dyn, vol. 239, no. 5, pp. 1405-12, 2010.
L. - B. Li, Lei, H., Arey, R. N., Li, P., Liu, J., Murphy, C. T., Xu, X. Z. Shawn, and Shen, K., The Neuronal Kinesin UNC-104/KIF1A Is a Key Regulator of Synaptic Aging and Insulin Signaling-Regulated Memory., Curr Biol, vol. 26, no. 5, pp. 605-15, 2016.
S. A. McCarroll, Murphy, C. T., Zou, S., Pletcher, S. D., Chin, C. - S., Jan, Y. Nung, Kenyon, C., Bargmann, C. I., and Li, H., Comparing genomic expression patterns across species identifies shared transcriptional profile in aging., Nat Genet, vol. 36, no. 2, pp. 197-204, 2004.
R. G. Tepper, Murphy, C. T., and Bussemaker, H. J., DAF-16 and PQM-1: partners in longevity., Aging (Albany NY), vol. 6, no. 1, pp. 5-6, 2014.
C. T. Murphy, The search for DAF-16/FOXO transcriptional targets: approaches and discoveries., Exp Gerontol, vol. 41, no. 10, pp. 910-21, 2006.
R. G. Tepper, Ashraf, J., Kaletsky, R., Kleemann, G., Murphy, C. T., and Bussemaker, H. J., PQM-1 complements DAF-16 as a key transcriptional regulator of DAF-2-mediated development and longevity., Cell, vol. 154, no. 3, pp. 676-90, 2013.
R. Kaletsky, Lakhina, V., Arey, R., Williams, A., Landis, J., Ashraf, J., and Murphy, C. T., The C. elegans adult neuronal IIS/FOXO transcriptome reveals adult phenotype regulators., Nature, vol. 529, no. 7584, pp. 92-6, 2016.
S. Luo, Kleemann, G. A., Ashraf, J. M., Shaw, W. M., and Murphy, C. T., TGF-β and insulin signaling regulate reproductive aging via oocyte and germline quality maintenance., Cell, vol. 143, no. 2, pp. 299-312, 2010.
V. Lakhina, Arey, R. N., Kaletsky, R., Kauffman, A., Stein, G., Keyes, W., Xu, D., and Murphy, C. T., Genome-wide functional analysis of CREB/long-term memory-dependent transcription reveals distinct basal and memory gene expression programs., Neuron, vol. 85, no. 2, pp. 330-45, 2015.
A. L. Kauffman, Ashraf, J. M., M Corces-Zimmerman, R., Landis, J. N., and Murphy, C. T., Insulin signaling and dietary restriction differentially influence the decline of learning and memory with age., PLoS Biol, vol. 8, no. 5, p. e1000372, 2010.
S. Luo and Murphy, C. T., Caenorhabditis elegans reproductive aging: Regulation and underlying mechanisms., Genesis, vol. 49, no. 2, pp. 53-65, 2011.
C. Kenyon and Murphy, C. T., Enrichment of regulatory motifs upstream of predicted DAF-16 targets., Nat Genet, vol. 38, no. 4, pp. 397-8; author reply 398, 2006.
J. - H. Hahm, Kim, S., DiLoreto, R., Shi, C., Lee, S. - J. V., Murphy, C. T., and Nam, H. Gil, C. elegans maximum velocity correlates with healthspan and is maintained in worms with an insulin receptor mutation., Nat Commun, vol. 6, p. 8919, 2015.
C. Shi and Murphy, C. T., Feeding the germline., Genes Dev, vol. 30, no. 3, pp. 249-50, 2016.
R. Kaletsky and Murphy, C. T., The role of insulin/IGF-like signaling in C. elegans longevity and aging., Dis Model Mech, vol. 3, no. 7-8, pp. 415-9, 2010.
W. M. Shaw, Luo, S., Landis, J., Ashraf, J., and Murphy, C. T., The C. elegans TGF-beta Dauer pathway regulates longevity via insulin signaling., Curr Biol, vol. 17, no. 19, pp. 1635-45, 2007.
C. T. Murphy, McCarroll, S. A., Bargmann, C. I., Fraser, A., Kamath, R. S., Ahringer, J., Li, H., and Kenyon, C., Genes that act downstream of DAF-16 to influence the lifespan of Caenorhabditis elegans., Nature, vol. 424, no. 6946, pp. 277-83, 2003.
R. P. Oliveira, Abate, J. Porter, Dilks, K., Landis, J., Ashraf, J., Murphy, C. T., and T Blackwell, K., Condition-adapted stress and longevity gene regulation by Caenorhabditis elegans SKN-1/Nrf., Aging Cell, vol. 8, no. 5, pp. 524-41, 2009.
C. Shi and Murphy, C. T., Mating induces shrinking and death in Caenorhabditis mothers., Science, vol. 343, no. 6170, pp. 536-40, 2014.
G. Liu, Rogers, J., Murphy, C. T., and Rongo, C., EGF signalling activates the ubiquitin proteasome system to modulate C. elegans lifespan., EMBO J, vol. 30, no. 15, pp. 2990-3003, 2011.
M. D. Chikina, Huttenhower, C., Murphy, C. T., and Troyanskaya, O. G., Global prediction of tissue-specific gene expression and context-dependent gene networks in Caenorhabditis elegans., PLoS Comput Biol, vol. 5, no. 6, p. e1000417, 2009.
S. Luo, Shaw, W. M., Ashraf, J., and Murphy, C. T., TGF-beta Sma/Mab signaling mutations uncouple reproductive aging from somatic aging., PLoS Genet, vol. 5, no. 12, p. e1000789, 2009.
Caenorhabditis elegans Proteins
V. Lakhina and Murphy, C. T., For longevity, perception is everything., Cell, vol. 160, no. 5, pp. 807-9, 2015.
A. - L. Hsu, Murphy, C. T., and Kenyon, C., Regulation of aging and age-related disease by DAF-16 and heat-shock factor., Science, vol. 300, no. 5622, pp. 1142-5, 2003.
C. T. Murphy, Lee, S. - J., and Kenyon, C., Tissue entrainment by feedback regulation of insulin gene expression in the endoderm of Caenorhabditis elegans., Proc Natl Acad Sci U S A, vol. 104, no. 48, pp. 19046-50, 2007.
V. Lakhina, Arey, R. N., Kaletsky, R., Kauffman, A., Stein, G., Keyes, W., Xu, D., and Murphy, C. T., Genome-wide functional analysis of CREB/long-term memory-dependent transcription reveals distinct basal and memory gene expression programs., Neuron, vol. 85, no. 2, pp. 330-45, 2015.
S. - J. Lee, Murphy, C. T., and Kenyon, C., Glucose shortens the life span of C. elegans by downregulating DAF-16/FOXO activity and aquaporin gene expression., Cell Metab, vol. 10, no. 5, pp. 379-91, 2009.
S. Li, Stone, H. A., and Murphy, C. T., A microfluidic device and automatic counting system for the study of C. elegans reproductive aging., Lab Chip, vol. 15, no. 2, pp. 524-31, 2015.
C. Y. Ewald, Landis, J. N., Abate, J. Porter, Murphy, C. T., and T Blackwell, K., Dauer-independent insulin/IGF-1-signalling implicates collagen remodelling in longevity., Nature, vol. 519, no. 7541, pp. 97-101, 2015.
G. Rizki, Iwata, T. Naoko, Li, J., Riedel, C. G., Picard, C. Lafontaine, Jan, M., Murphy, C. T., and Lee, S. Sylvia, The evolutionarily conserved longevity determinants HCF-1 and SIR-2.1/SIRT1 collaborate to regulate DAF-16/FOXO., PLoS Genet, vol. 7, no. 9, p. e1002235, 2011.
J. N. Landis and Murphy, C. T., Integration of diverse inputs in the regulation of Caenorhabditis elegans DAF-16/FOXO., Dev Dyn, vol. 239, no. 5, pp. 1405-12, 2010.
L. - B. Li, Lei, H., Arey, R. N., Li, P., Liu, J., Murphy, C. T., Xu, X. Z. Shawn, and Shen, K., The Neuronal Kinesin UNC-104/KIF1A Is a Key Regulator of Synaptic Aging and Insulin Signaling-Regulated Memory., Curr Biol, vol. 26, no. 5, pp. 605-15, 2016.
R. G. Tepper, Murphy, C. T., and Bussemaker, H. J., DAF-16 and PQM-1: partners in longevity., Aging (Albany NY), vol. 6, no. 1, pp. 5-6, 2014.
C. T. Murphy, The search for DAF-16/FOXO transcriptional targets: approaches and discoveries., Exp Gerontol, vol. 41, no. 10, pp. 910-21, 2006.
R. G. Tepper, Ashraf, J., Kaletsky, R., Kleemann, G., Murphy, C. T., and Bussemaker, H. J., PQM-1 complements DAF-16 as a key transcriptional regulator of DAF-2-mediated development and longevity., Cell, vol. 154, no. 3, pp. 676-90, 2013.
R. Kaletsky, Lakhina, V., Arey, R., Williams, A., Landis, J., Ashraf, J., and Murphy, C. T., The C. elegans adult neuronal IIS/FOXO transcriptome reveals adult phenotype regulators., Nature, vol. 529, no. 7584, pp. 92-6, 2016.
V. Lakhina, Arey, R. N., Kaletsky, R., Kauffman, A., Stein, G., Keyes, W., Xu, D., and Murphy, C. T., Genome-wide functional analysis of CREB/long-term memory-dependent transcription reveals distinct basal and memory gene expression programs., Neuron, vol. 85, no. 2, pp. 330-45, 2015.
A. L. Kauffman, Ashraf, J. M., M Corces-Zimmerman, R., Landis, J. N., and Murphy, C. T., Insulin signaling and dietary restriction differentially influence the decline of learning and memory with age., PLoS Biol, vol. 8, no. 5, p. e1000372, 2010.
C. Kenyon and Murphy, C. T., Enrichment of regulatory motifs upstream of predicted DAF-16 targets., Nat Genet, vol. 38, no. 4, pp. 397-8; author reply 398, 2006.
J. - H. Hahm, Kim, S., DiLoreto, R., Shi, C., Lee, S. - J. V., Murphy, C. T., and Nam, H. Gil, C. elegans maximum velocity correlates with healthspan and is maintained in worms with an insulin receptor mutation., Nat Commun, vol. 6, p. 8919, 2015.
C. T. Murphy, McCarroll, S. A., Bargmann, C. I., Fraser, A., Kamath, R. S., Ahringer, J., Li, H., and Kenyon, C., Genes that act downstream of DAF-16 to influence the lifespan of Caenorhabditis elegans., Nature, vol. 424, no. 6946, pp. 277-83, 2003.
R. P. Oliveira, Abate, J. Porter, Dilks, K., Landis, J., Ashraf, J., Murphy, C. T., and T Blackwell, K., Condition-adapted stress and longevity gene regulation by Caenorhabditis elegans SKN-1/Nrf., Aging Cell, vol. 8, no. 5, pp. 524-41, 2009.
C. Shi and Murphy, C. T., Mating induces shrinking and death in Caenorhabditis mothers., Science, vol. 343, no. 6170, pp. 536-40, 2014.
G. Liu, Rogers, J., Murphy, C. T., and Rongo, C., EGF signalling activates the ubiquitin proteasome system to modulate C. elegans lifespan., EMBO J, vol. 30, no. 15, pp. 2990-3003, 2011.
S. Luo, Shaw, W. M., Ashraf, J., and Murphy, C. T., TGF-beta Sma/Mab signaling mutations uncouple reproductive aging from somatic aging., PLoS Genet, vol. 5, no. 12, p. e1000789, 2009.
Catecholamines
V. Lakhina and Murphy, C. T., For longevity, perception is everything., Cell, vol. 160, no. 5, pp. 807-9, 2015.
Cytochrome P-450 Enzyme System
C. Shi and Murphy, C. T., Mating induces shrinking and death in Caenorhabditis mothers., Science, vol. 343, no. 6170, pp. 536-40, 2014.
Floxuridine
C. Shi and Murphy, C. T., Mating induces shrinking and death in Caenorhabditis mothers., Science, vol. 343, no. 6170, pp. 536-40, 2014.
Gene Expression Profiling
V. Lakhina, Arey, R. N., Kaletsky, R., Kauffman, A., Stein, G., Keyes, W., Xu, D., and Murphy, C. T., Genome-wide functional analysis of CREB/long-term memory-dependent transcription reveals distinct basal and memory gene expression programs., Neuron, vol. 85, no. 2, pp. 330-45, 2015.
S. A. McCarroll, Murphy, C. T., Zou, S., Pletcher, S. D., Chin, C. - S., Jan, Y. Nung, Kenyon, C., Bargmann, C. I., and Li, H., Comparing genomic expression patterns across species identifies shared transcriptional profile in aging., Nat Genet, vol. 36, no. 2, pp. 197-204, 2004.
J. Wang, Kaletsky, R., Silva, M., Williams, A., Haas, L. A., Androwski, R. J., Landis, J. N., Patrick, C., Rashid, A., Santiago-Martinez, D., Gravato-Nobre, M., Hodgkin, J., Hall, D. H., Murphy, C. T., and Barr, M. M., Cell-Specific Transcriptional Profiling of Ciliated Sensory Neurons Reveals Regulators of Behavior and Extracellular Vesicle Biogenesis., Curr Biol, vol. 25, no. 24, pp. 3232-8, 2015.
V. Lakhina, Arey, R. N., Kaletsky, R., Kauffman, A., Stein, G., Keyes, W., Xu, D., and Murphy, C. T., Genome-wide functional analysis of CREB/long-term memory-dependent transcription reveals distinct basal and memory gene expression programs., Neuron, vol. 85, no. 2, pp. 330-45, 2015.
M. D. Chikina, Huttenhower, C., Murphy, C. T., and Troyanskaya, O. G., Global prediction of tissue-specific gene expression and context-dependent gene networks in Caenorhabditis elegans., PLoS Comput Biol, vol. 5, no. 6, p. e1000417, 2009.
A. A. Caudy, Guan, Y., Jia, Y., Hansen, C., DeSevo, C., Hayes, A. P., Agee, J., Alvarez-Dominguez, J. R., Arellano, H., Barrett, D., Bauerle, C., Bisaria, N., Bradley, P. H., J Breunig, S., Bush, E., Cappel, D., Capra, E., Chen, W., Clore, J., Combs, P. A., Doucette, C., Demuren, O., Fellowes, P., Freeman, S., Frenkel, E., Gadala-Maria, D., Gawande, R., Glass, D., Grossberg, S., Gupta, A., Hammonds-Odie, L., Hoisos, A., Hsi, J., Hsu, Y. - H. Huang, Inukai, S., Karczewski, K. J., Ke, X., Kojima, M., Leachman, S., Lieber, D., Liebowitz, A., Liu, J., Liu, Y., Martin, T., Mena, J., Mendoza, R., Myhrvold, C., Millian, C., Pfau, S., Raj, S., Rich, M., Rokicki, J., Rounds, W., Salazar, M., Salesi, M., Sharma, R., Silverman, S., Singer, C., Sinha, S., Staller, M., Stern, P., Tang, H., Weeks, S., Weidmann, M., Wolf, A., Young, C., Yuan, J., Crutchfield, C., McClean, M., Murphy, C. T., Llinás, M., Botstein, D., Troyanskaya, O. G., and Dunham, M. J., A new system for comparative functional genomics of Saccharomyces yeasts., Genetics, vol. 195, no. 1, pp. 275-87, 2013.
Gene Expression Regulation
R. DiLoreto and Murphy, C. T., The cell biology of aging., Mol Biol Cell, vol. 26, no. 25, pp. 4524-31, 2015.
S. A. McCarroll, Murphy, C. T., Zou, S., Pletcher, S. D., Chin, C. - S., Jan, Y. Nung, Kenyon, C., Bargmann, C. I., and Li, H., Comparing genomic expression patterns across species identifies shared transcriptional profile in aging., Nat Genet, vol. 36, no. 2, pp. 197-204, 2004.
V. Lakhina, Arey, R. N., Kaletsky, R., Kauffman, A., Stein, G., Keyes, W., Xu, D., and Murphy, C. T., Genome-wide functional analysis of CREB/long-term memory-dependent transcription reveals distinct basal and memory gene expression programs., Neuron, vol. 85, no. 2, pp. 330-45, 2015.
V. Lakhina, Arey, R. N., Kaletsky, R., Kauffman, A., Stein, G., Keyes, W., Xu, D., and Murphy, C. T., Genome-wide functional analysis of CREB/long-term memory-dependent transcription reveals distinct basal and memory gene expression programs., Neuron, vol. 85, no. 2, pp. 330-45, 2015.
M. D. Chikina, Huttenhower, C., Murphy, C. T., and Troyanskaya, O. G., Global prediction of tissue-specific gene expression and context-dependent gene networks in Caenorhabditis elegans., PLoS Comput Biol, vol. 5, no. 6, p. e1000417, 2009.
R. P. Oliveira, Abate, J. Porter, Dilks, K., Landis, J., Ashraf, J., Murphy, C. T., and T Blackwell, K., Condition-adapted stress and longevity gene regulation by Caenorhabditis elegans SKN-1/Nrf., Aging Cell, vol. 8, no. 5, pp. 524-41, 2009.
A. - L. Hsu, Murphy, C. T., and Kenyon, C., Regulation of aging and age-related disease by DAF-16 and heat-shock factor., Science, vol. 300, no. 5622, pp. 1142-5, 2003.
C. T. Murphy, Aging: miRacles of longevity?, Curr Biol, vol. 20, no. 24, pp. R1076-8, 2010.
Genotype
R. G. Tepper, Murphy, C. T., and Bussemaker, H. J., DAF-16 and PQM-1: partners in longevity., Aging (Albany NY), vol. 6, no. 1, pp. 5-6, 2014.
Glucagon-Like Peptide 1
C. Shi and Murphy, C. T., Feeding the germline., Genes Dev, vol. 30, no. 3, pp. 249-50, 2016.

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