Time and length scales of autocrine signals in three dimensions. Author Mathieu Coppey, Alexander Berezhkovskii, Stuart Sealfon, Stanislav Shvartsman Publication Year 2007 Type Journal Article Abstract A model of autocrine signaling in cultures of suspended cells is developed on the basis of the effective medium approximation. The fraction of autocrine ligands, the mean and distribution of distances traveled by paracrine ligands before binding, as well as the mean and distribution of the ligand lifetime are derived. Interferon signaling by dendritic immune cells is considered as an illustration. Keywords Cells, Cultured, Models, Biological, Ligands, Autocrine Communication, Biophysical Phenomena, Biophysics, Dendritic Cells, Interferons, Paracrine Communication Journal Biophys J Volume 93 Issue 6 Pages 1917-22 Date Published 09/2007 Alternate Journal Biophys. J. Google ScholarBibTeXEndNote X3 XML
