Signal propagation and failure in discrete autocrine relays. Author Cyrill Muratov, Stanislav Shvartsman Publication Year 2004 Type Journal Article Abstract A mechanistic model of discrete one-dimensional arrays of autocrine cells interacting via diffusible signals is investigated. Under physiologically relevant assumptions, the model is reduced to a system of ordinary differential equations for the intracellular variables, with a particular, biophysically derived type of long-range coupling between cells. Exact discrete traveling wave and static kink solutions are obtained in the model with sharp threshold nonlinearity. It is argued that the considered mechanism may be used extensively for transmission of information in tissues during homeostasis and development. Keywords Signal Transduction, Models, Biological, Receptors, Cell Surface, Protein Binding, Computer Simulation, Autocrine Communication, Diffusion, Biological Transport, Active, Growth Substances, Protein Transport Journal Phys Rev Lett Volume 93 Issue 11 Pages 118101 Date Published 09/2004 Alternate Journal Phys. Rev. Lett. Google ScholarBibTeXEndNote X3 XML