Physical interpretation of mean local accumulation time of morphogen gradient formation.

Publication Year
2011

Type

Journal Article
Abstract

The paper deals with a reaction-diffusion problem that arises in developmental biology when describing the formation of the concentration profiles of signaling molecules, called morphogens, which control gene expression and, hence, cell differentiation. The mean local accumulation time, which is the mean time required to reach the steady state at a fixed point of a patterned tissue, is an important characteristic of the formation process. We show that this time is a sum of two times, the conditional mean first-passage time from the source to the observation point and the mean local accumulation time in the situation when the source is localized at the observation point.

Journal
J Chem Phys
Volume
135
Issue
15
Pages
154115
Date Published
10/2011
Alternate Journal
J Chem Phys