Optimizing information flow in small genetic networks. Author Gašper Tkačik, Aleksandra Walczak, William Bialek Publication Year 2009 Type Journal Article Abstract In order to survive, reproduce, and (in multicellular organisms) differentiate, cells must control the concentrations of the myriad different proteins that are encoded in the genome. The precision of this control is limited by the inevitable randomness of individual molecular events. Here we explore how cells can maximize their control power in the presence of these physical limits; formally, we solve the theoretical problem of maximizing the information transferred from inputs to outputs when the number of available molecules is held fixed. We start with the simplest version of the problem, in which a single transcription factor protein controls the readout of one or more genes by binding to DNA. We further simplify by assuming that this regulatory network operates in steady state, that the noise is small relative to the available dynamic range, and that the target genes do not interact. Even in this simple limit, we find a surprisingly rich set of optimal solutions. Importantly, for each locally optimal regulatory network, all parameters are determined once the physical constraints on the number of available molecules are specified. Although we are solving an oversimplified version of the problem facing real cells, we see parallels between the structure of these optimal solutions and the behavior of actual genetic regulatory networks. Subsequent papers will discuss more complete versions of the problem. Keywords Animals, Models, Genetic, Gene Expression Regulation, Gene Regulatory Networks, Transcription Factors, Cells Journal Phys Rev E Stat Nonlin Soft Matter Phys Volume 80 Issue 3 Pt 1 Pages 031920 Date Published 09/2009 Alternate Journal Phys Rev E Stat Nonlin Soft Matter Phys Google ScholarBibTeXEndNote X3 XML