Local kinetics of morphogen gradients. Author Peter Gordon V, Christine Sample, Alexander Berezhkovskii, Cyrill Muratov, Stanislav Shvartsman Publication Year 2011 Type Journal Article Abstract Some aspects of pattern formation in developing embryos can be described by nonlinear reaction-diffusion equations. An important class of these models accounts for diffusion and degradation of a locally produced single chemical species. At long times, solutions of such models approach a steady state in which the concentration decays with distance from the source of production. We present analytical results that characterize the dynamics of this process and are in quantitative agreement with numerical solutions of the underlying nonlinear equations. The derived results provide an explicit connection between the parameters of the problem and the time needed to reach a steady state value at a given position. Our approach can be used for the quantitative analysis of tissue patterning by morphogen gradients, a subject of active research in biophysics and developmental biology. Keywords Models, Biological, Body Patterning Journal Proc Natl Acad Sci U S A Volume 108 Issue 15 Pages 6157-62 Date Published 04/2011 Alternate Journal Proc. Natl. Acad. Sci. U.S.A. Google ScholarBibTeXEndNote X3 XML