LC-MS data processing with MAVEN: a metabolomic analysis and visualization engine. Author Michelle Clasquin, Eugene Melamud, Joshua Rabinowitz Publication Year 2012 Type Journal Article Abstract MAVEN is an open-source software program for interactive processing of LC-MS-based metabolomics data. MAVEN enables rapid and reliable metabolite quantitation from multiple reaction monitoring data or high-resolution full-scan mass spectrometry data. It automatically detects and reports peak intensities for isotope-labeled metabolites. Menu-driven, click-based navigation allows visualization of raw and analyzed data. Here we provide a User Guide for MAVEN. Step-by-step instructions are provided for data import, peak alignment across samples, identification of metabolites that differ strongly between biological conditions, quantitation and visualization of isotope-labeling patterns, and export of tables of metabolite-specific peak intensities. Together, these instructions describe a workflow that allows efficient processing of raw LC-MS data into a form ready for biological analysis. Keywords Algorithms, Software, Mass Spectrometry, Chromatography, Liquid, Metabolomics, Databases, Factual, Isotope Labeling Journal Curr Protoc Bioinformatics Volume Chapter 14 Pages Unit14.11 Date Published 03/2012 Alternate Journal Curr Protoc Bioinformatics Google ScholarBibTeXEndNote X3 XML