LC-MS data processing with MAVEN: a metabolomic analysis and visualization engine.

Publication Year
2012

Type

Journal Article
Abstract

MAVEN is an open-source software program for interactive processing of LC-MS-based metabolomics data. MAVEN enables rapid and reliable metabolite quantitation from multiple reaction monitoring data or high-resolution full-scan mass spectrometry data. It automatically detects and reports peak intensities for isotope-labeled metabolites. Menu-driven, click-based navigation allows visualization of raw and analyzed data. Here we provide a User Guide for MAVEN. Step-by-step instructions are provided for data import, peak alignment across samples, identification of metabolites that differ strongly between biological conditions, quantitation and visualization of isotope-labeling patterns, and export of tables of metabolite-specific peak intensities. Together, these instructions describe a workflow that allows efficient processing of raw LC-MS data into a form ready for biological analysis.

Journal
Curr Protoc Bioinformatics
Volume
Chapter 14
Pages
Unit14.11
Date Published
03/2012
Alternate Journal
Curr Protoc Bioinformatics