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Models, Biological

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  • Faculty Publications
  • Drocco, J A, E F Wieschaus, and D W Tank. (2012) 2012. “The Synthesis-Diffusion-Degradation Model Explains Bicoid Gradient Formation in Unfertilized Eggs.”. Phys Biol 9 (5): 055004.
    Reference Link
  • Tkačik, Gašper, Thomas Gregor, and William Bialek. 2008. “The Role of Input Noise in Transcriptional Regulation.”. PLoS One 3 (7): e2774.
    Reference Link
  • Airoldi, Edoardo M, Curtis Huttenhower, David Gresham, Charles Lu, Amy A Caudy, Maitreya Dunham, James R Broach, David Botstein, and Olga G Troyanskaya. (2009) 2009. “Predicting Cellular Growth from Gene Expression Signatures.”. PLoS Comput Biol 5 (1): e1000257.
    Reference Link
  • Markowetz, Florian, Dennis Kostka, Olga G Troyanskaya, and Rainer Spang. (2007) 2007. “Nested Effects Models for High-Dimensional Phenotyping Screens.”. Bioinformatics 23 (13).
    Reference Link
  • Gordon, Peter, V, Christine Sample, Alexander M Berezhkovskii, Cyrill B Muratov, and Stanislav Y Shvartsman. (2011) 2011. “Local Kinetics of Morphogen Gradients.”. Proc Natl Acad Sci U S A 108 (15): 6157-62.
    Reference Link
  • Park, Christopher Y, Aaron K Wong, Casey S Greene, Jessica Rowland, Yuanfang Guan, Lars A Bongo, Rebecca Burdine, and Olga G Troyanskaya. 2013. “Functional Knowledge Transfer for High-Accuracy Prediction of under-Studied Biological Processes.”. PLoS Comput Biol 9 (3): e1002957.
    Reference Link
  • Shvartsman, Stanislav Y, Mathieu Coppey, and Alexander M Berezhkovskii. (2008) 2008. “Dynamics of Maternal Morphogen Gradients in Drosophila.”. Curr Opin Genet Dev 18 (4): 342-7.
    Reference Link
  • Mukhopadhyay, Ranjan, and Ned S Wingreen. (2009) 2009. “Curvature and Shape Determination of Growing Bacteria.”. Phys Rev E Stat Nonlin Soft Matter Phys 80 (6 Pt 1): 062901.
    Reference Link
  • van Teeffelen, Sven, Siyuan Wang, Leon Furchtgott, Kerwyn Casey Huang, Ned S Wingreen, Joshua W Shaevitz, and Zemer Gitai. (2011) 2011. “The Bacterial Actin MreB Rotates, and Rotation Depends on Cell-Wall Assembly.”. Proc Natl Acad Sci U S A 108 (38): 15822-7.
    Reference Link
  • Kim, Yoosik, Ze’ev Paroush, Knud Nairz, Ernst Hafen, Gerardo Jiménez, and Stanislav Y Shvartsman. (2011) 2011. “Substrate-Dependent Control of MAPK Phosphorylation in Vivo.”. Mol Syst Biol 7: 467.
    Reference Link
  • Nikolić, Djordje L, Alistair N Boettiger, Dafna Bar-Sagi, Jeffrey D Carbeck, and Stanislav Y Shvartsman. (2006) 2006. “Role of Boundary Conditions in an Experimental Model of Epithelial Wound Healing.”. Am J Physiol Cell Physiol 291 (1).
    Reference Link
  • Meir, Yigal, Vladimir Jakovljevic, Olga Oleksiuk, Victor Sourjik, and Ned S Wingreen. (2010) 2010. “Precision and Kinetics of Adaptation in Bacterial Chemotaxis.”. Biophys J 99 (9): 2766-74.
    Reference Link
  • Sample, Christine, and Stanislav Y Shvartsman. (2010) 2010. “Multiscale Modeling of Diffusion in the Early Drosophila Embryo.”. Proc Natl Acad Sci U S A 107 (22): 10092-6.
    Reference Link
  • Gordon, Peter, V, Cyrill B Muratov, and Stanislav Y Shvartsman. (2013) 2013. “Local Accumulation Times for Source, Diffusion, and Degradation Models in Two and Three Dimensions.”. J Chem Phys 138 (10): 104121.
    Reference Link
  • Stephens, Greg J, Bethany Johnson-Kerner, William Bialek, and William S Ryu. 2010. “From Modes to Movement in the Behavior of Caenorhabditis Elegans.”. PLoS One 5 (11): e13914.
    Reference Link
  • Skoge, Monica, Yigal Meir, and Ned S Wingreen. (2011) 2011. “Dynamics of Cooperativity in Chemical Sensing Among Cell-Surface Receptors.”. Phys Rev Lett 107 (17): 178101.
    Reference Link
  • Harbison, Susan T, Mary Anna Carbone, Julien Ayroles, Eric A Stone, Richard F Lyman, and Trudy F C Mackay. (2009) 2009. “Co-Regulated Transcriptional Networks Contribute to Natural Genetic Variation in Drosophila Sleep.”. Nat Genet 41 (3): 371-5.
    Reference Link
  • Wingreen, Ned, and David Botstein. (2006) 2006. “Back to the Future: Education for Systems-Level Biologists.”. Nat Rev Mol Cell Biol 7 (11): 829-32.
    Reference Link
  • Liu, Ping, Ioannis G Kevrekidis, and Stanislav Y Shvartsman. (2011) 2011. “Substrate-Dependent Control of ERK Phosphorylation Can Lead to Oscillations.”. Biophys J 101 (11): 2572-81.
    Reference Link
  • Ursell, Tristan S, Jeffrey Nguyen, Russell D Monds, Alexandre Colavin, Gabriel Billings, Nikolay Ouzounov, Zemer Gitai, Joshua W Shaevitz, and Kerwyn Casey Huang. (2014) 2014. “Rod-Like Bacterial Shape Is Maintained by Feedback Between Cell Curvature and Cytoskeletal Localization.”. Proc Natl Acad Sci U S A 111 (11).
    Reference Link
  • Houchmandzadeh, B, E Wieschaus, and S Leibler. (2005) 2005. “Precise Domain Specification in the Developing Drosophila Embryo.”. Phys Rev E Stat Nonlin Soft Matter Phys 72 (6 Pt 1): 061920.
    Reference Link
  • Sun, Mingzhai, Morgane Wartel, Eric Cascales, Joshua W Shaevitz, and Tâm Mignot. (2011) 2011. “Motor-Driven Intracellular Transport Powers Bacterial Gliding Motility.”. Proc Natl Acad Sci U S A 108 (18): 7559-64.
    Reference Link
  • Shaevitz, Joshua W, and Daniel A Fletcher. (2007) 2007. “Load Fluctuations Drive Actin Network Growth.”. Proc Natl Acad Sci U S A 104 (40): 15688-92.
    Reference Link
  • Little, Shawn C, Gašper Tkačik, Thomas B Kneeland, Eric F Wieschaus, and Thomas Gregor. (2011) 2011. “The Formation of the Bicoid Morphogen Gradient Requires Protein Movement from Anteriorly Localized MRNA.”. PLoS Biol 9 (3): e1000596.
    Reference Link
  • Cheung, Lily S, David S A Simakov, Alisa Fuchs, George Pyrowolakis, and Stanislav Y Shvartsman. (2013) 2013. “Dynamic Model for the Coordination of Two Enhancers of Broad by EGFR Signaling.”. Proc Natl Acad Sci U S A 110 (44): 17939-44.
    Reference Link
  • Brauer, Matthew J, Curtis Huttenhower, Edoardo M Airoldi, Rachel Rosenstein, John C Matese, David Gresham, Viktor M Boer, Olga G Troyanskaya, and David Botstein. (2008) 2008. “Coordination of Growth Rate, Cell Cycle, Stress Response, and Metabolic Activity in Yeast.”. Mol Biol Cell 19 (1): 352-67.
    Reference Link
  • Mehta, Pankaj, and Thomas Gregor. (2010) 2010. “Approaching the Molecular Origins of Collective Dynamics in Oscillating Cell Populations.”. Curr Opin Genet Dev 20 (6): 574-80.
    Reference Link
  • Batsilas, Lazaros, Alexander M Berezhkovskii, and Stanislav Y Shvartsman. (2003) 2003. “Stochastic Model of Autocrine and Paracrine Signals in Cell Culture Assays.”. Biophys J 85 (6): 3659-65.
    Reference Link
  • Leffler, Ellen M, Kevin Bullaughey, Daniel R Matute, Wynn K Meyer, Laure Ségurel, Aarti Venkat, Peter Andolfatto, and Molly Przeworski. 2012. “Revisiting an Old Riddle: What Determines Genetic Diversity Levels Within Species?”. PLoS Biol 10 (9): e1001388.
    Reference Link
  • Endres, Robert G, and Ned S Wingreen. (2006) 2006. “Precise Adaptation in Bacterial Chemotaxis through ‘assistance neighborhoods’.”. Proc Natl Acad Sci U S A 103 (35): 13040-4.
    Reference Link
  • Krotov, Dmitry, Julien Dubuis, Thomas Gregor, and William Bialek. (2014) 2014. “Morphogenesis at Criticality.”. Proc Natl Acad Sci U S A 111 (10): 3683-8.
    Reference Link
  • Mukhopadhyay, Ranjan, Kerwyn Casey Huang, and Ned S Wingreen. (2008) 2008. “Lipid Localization in Bacterial Cells through Curvature-Mediated Microphase Separation.”. Biophys J 95 (3): 1034-49.
    Reference Link
  • Berezhkovskii, Alexander M, Christine Sample, and Stanislav Y Shvartsman. (2011) 2011. “Formation of Morphogen Gradients: Local Accumulation Time.”. Phys Rev E Stat Nonlin Soft Matter Phys 83 (5 Pt 1): 051906.
    Reference Link
  • Papatsenko, Dmitri, and Michael S Levine. (2008) 2008. “Dual Regulation by the Hunchback Gradient in the Drosophila Embryo.”. Proc Natl Acad Sci U S A 105 (8): 2901-6.
    Reference Link
  • Bialek, William, and Sima Setayeshgar. (2008) 2008. “Cooperativity, Sensitivity, and Noise in Biochemical Signaling.”. Phys Rev Lett 100 (25): 258101.
    Reference Link
  • Teng, Shu-Wen, Jessica N Schaffer, Kimberly C Tu, Pankaj Mehta, Wenyun Lu, N P Ong, Bonnie L Bassler, and Ned S Wingreen. (2011) 2011. “Active Regulation of Receptor Ratios Controls Integration of Quorum-Sensing Signals in Vibrio Harveyi.”. Mol Syst Biol 7: 491.
    Reference Link
  • Mora, Thierry, Howard Yu, Yoshiyuki Sowa, and Ned S Wingreen. (2009) 2009. “Steps in the Bacterial Flagellar Motor.”. PLoS Comput Biol 5 (10): e1000540.
    Reference Link
  • Tolwinski, Nicholas S, and Eric Wieschaus. (2004) 2004. “Rethinking WNT Signaling.”. Trends Genet 20 (4): 177-81.
    Reference Link
  • Dubuis, Julien, Gašper Tkačik, Eric F Wieschaus, Thomas Gregor, and William Bialek. (2013) 2013. “Positional Information, in Bits.”. Proc Natl Acad Sci U S A 110 (41): 16301-8.
    Reference Link
  • Huang, Kerwyn Casey, David W Ehrhardt, and Joshua W Shaevitz. (2012) 2012. “The Molecular Origins of Chiral Growth in Walled Cells.”. Curr Opin Microbiol 15 (6): 707-14.
    Reference Link
  • Mora, Thierry, and Ned S Wingreen. (2010) 2010. “Limits of Sensing Temporal Concentration Changes by Single Cells.”. Phys Rev Lett 104 (24): 248101.
    Reference Link
  • Dawes-Hoang, Rachel E, Kush M Parmar, Audrey E Christiansen, Chris B Phelps, Andrea H Brand, and Eric F Wieschaus. (2005) 2005. “Folded Gastrulation, Cell Shape Change and the Control of Myosin Localization.”. Development 132 (18): 4165-78.
    Reference Link
  • Yakoby, Nir, Jessica Lembong, Trudi Schüpbach, and Stanislav Y Shvartsman. (2008) 2008. “Drosophila Eggshell Is Patterned by Sequential Action of Feedforward and Feedback Loops.”. Development 135 (2): 343-51.
    Reference Link
  • Wingreen, Ned S, and Simon A Levin. (2006) 2006. “Cooperation Among Microorganisms.”. PLoS Biol 4 (9): e299.
    Reference Link
  • Swanson, Douglas, and Ned S Wingreen. (2011) 2011. “Active Biopolymers Confer Fast Reorganization Kinetics.”. Phys Rev Lett 107 (21): 218103.
    Reference Link
  • Bialek, William, Andrea Cavagna, Irene Giardina, Thierry Mora, Edmondo Silvestri, Massimiliano Viale, and Aleksandra M Walczak. (2012) 2012. “Statistical Mechanics for Natural Flocks of Birds.”. Proc Natl Acad Sci U S A 109 (13): 4786-91.
    Reference Link
  • Sourjik, Victor, and Ned S Wingreen. (2012) 2012. “Responding to Chemical Gradients: Bacterial Chemotaxis.”. Curr Opin Cell Biol 24 (2): 262-8.
    Reference Link
  • Bialek, William, and Sima Setayeshgar. (2005) 2005. “Physical Limits to Biochemical Signaling.”. Proc Natl Acad Sci U S A 102 (29): 10040-5.
    Reference Link
  • Grimm, Oliver, Mathieu Coppey, and Eric Wieschaus. (2010) 2010. “Modelling the Bicoid Gradient.”. Development 137 (14): 2253-64.
    Reference Link
  • Monine, Michael I, Alexander M Berezhkovskii, Elizabeth J Joslin, Steven Wiley, Douglas A Lauffenburger, and Stanislav Y Shvartsman. (2005) 2005. “Ligand Accumulation in Autocrine Cell Cultures.”. Biophys J 88 (4): 2384-90.
    Reference Link

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