for Integrative Genomics Lewis-Sigler Institute

Off screen link: Skip to content Off screen link: Skip to search
Princeton University
Home
for Integrative Genomics
Lewis-Sigler Institute

Main Menu

  • Research
    Research
    • Research Overview
    • Research Areas
      • Biophysics: Theory and Experiment
      • Computational Genomics
      • Evolutionary and Population Genomics
      • Experimental Genomics
      • Statistical Genomics
      • Systems Biology: Development/Aging
      • Systems Biology: Metabolomics/Proteomics
    • Faculty Research Labs
    • Research Facilities & Resources
      • Genomics Computing Resources
      • LSI Media Facility
      • Genomics Core Facility
        • Instructions
        • RNA-Seq
        • Microarray
        • Contacts
    • Research Centers
      • Center for Quantitative Biology
      • Glenn Laboratories For Aging Research
    • Faculty Publications
  • People
    People
    • Faculty
    • Associated Faculty
    • Faculty Emeriti
    • Lewis-Sigler Scholars
    • Graduate Students
    • Staff
  • Education
    Education
    • Education Overview
    • Quantitative & Computational Biology Graduate Program
      • Ph.D. Program Requirements
      • How to Apply
      • Financial Support
      • Faculty & Research
      • Graduate Students
      • Student Committees
      • Peer Mentoring Program
    • Graduate Program in Biophysics
      • Program Requirements
      • Faculty and Research
      • Graduate Students
    • Undergraduate Certificate in Quantitative & Computational Biology
      • Certificate Requirements
      • Application
      • Program Committee
      • Frequently Asked Questions
    • Integrated Science Curriculum
      • Course details
      • Paths from ISC
      • Student perspectives
      • Instructor perspectives
      • ISC Revitalization
    • NIH NHGRI Training Program
    • QCB Scholars Program
  • Seminars & Events
  • News
  • Diversity & Inclusion
  • About
    About
    • Founding Donors
    • History
    • Opportunities
  • Contact Us
  • Visitor Information

Search

  1. Home
  2. Research
  3. Faculty Publications

DNA-Binding Proteins

Section Menu

  • Research Overview
  • Research Areas
  • Faculty Research Labs
  • Research Facilities & Resources
  • Research Centers
  • Faculty Publications
  • Ronen, Michal, and David Botstein. (2006) 2006. “Transcriptional Response of Steady-State Yeast Cultures to Transient Perturbations in Carbon Source.”. Proc Natl Acad Sci U S A 103 (2): 389-94.
    Reference Link
  • Little, Shawn C, Mikhail Tikhonov, and Thomas Gregor. (2013) 2013. “Precise Developmental Gene Expression Arises from Globally Stochastic Transcriptional Activity.”. Cell 154 (4): 789-800.
    Reference Link
  • Morize, P, A E Christiansen, M Costa, S Parks, and E Wieschaus. (1998) 1998. “Hyperactivation of the Folded Gastrulation Pathway Induces Specific Cell Shape Changes.”. Development 125 (4): 589-97.
    Reference Link
  • De Renzis, Stefano, J Yu, R Zinzen, and Eric Wieschaus. (2006) 2006. “Dorsal-Ventral Pattern of Delta Trafficking Is Established by a Snail-Tom-Neuralized Pathway.”. Dev Cell 10 (2): 257-64.
    Reference Link
  • Ewald, Collin Y, Jess N Landis, Jess Porter Abate, Coleen T Murphy, and Keith Blackwell. (2015) 2015. “Dauer-Independent Insulin IGF-1-Signalling Implicates Collagen Remodelling in Longevity.”. Nature 519 (7541): 97-101. doi:10.1038/nature14021.
    Reference Link
  • Endres, Robert G, Thomas C Schulthess, and Ned S Wingreen. (2004) 2004. “Toward an Atomistic Model for Predicting Transcription-Factor Binding Sites.”. Proteins 57 (2): 262-8.
    Reference Link
  • Goodliffe, Julie M, Eric Wieschaus, and Michael D Cole. (2005) 2005. “Polycomb Mediates Myc Autorepression and Its Transcriptional Control of Many Loci in Drosophila.”. Genes Dev 19 (24): 2941-6.
    Reference Link
  • Lee, Seung-Jae, Coleen T Murphy, and Cynthia Kenyon. (2009) 2009. “Glucose Shortens the Life Span of C. Elegans by Downregulating DAF-16 FOXO Activity and Aquaporin Gene Expression.”. Cell Metab 10 (5): 379-91.
    Reference Link
  • Vacher, J, and S M Tilghman. (1990) 1990. “Dominant Negative Regulation of the Mouse Alpha-Fetoprotein Gene in Adult Liver.”. Science 250 (4988): 1732-5.
    Reference Link
  • Kobren, Shilpa Nadimpalli, and Mona Singh. (2019) 2019. “Systematic Domain-Based Aggregation of Protein Structures Highlights DNA-, RNA- and Other Ligand-Binding Positions.”. Nucleic Acids Res 47 (2): 582-93. doi:10.1093/nar/gky1224.
    Reference Link
  • Feuerman, M H, R Godbout, R S Ingram, and S M Tilghman. (1989) 1989. “Tissue-Specific Transcription of the Mouse Alpha-Fetoprotein Gene Promoter Is Dependent on HNF-1.”. Mol Cell Biol 9 (10): 4204-12.
    Reference Link
  • McIsaac, Scott, Allegra A Petti, Harmen J Bussemaker, and David Botstein. (2012) 2012. “Perturbation-Based Analysis and Modeling of Combinatorial Regulation in the Yeast Sulfur Assimilation Pathway.”. Mol Biol Cell 23 (15): 2993-3007.
    Reference Link
  • Diehn, Maximilian, Ash A Alizadeh, Oliver J Rando, Chih Long Liu, Kryn Stankunas, David Botstein, Gerald R Crabtree, and Patrick O Brown. (2002) 2002. “Genomic Expression Programs and the Integration of the CD28 Costimulatory Signal in T Cell Activation.”. Proc Natl Acad Sci U S A 99 (18): 11796-801.
    Reference Link
  • Bothma, Jacques P, and Michael Levine. (2013) 2013. “Development: Lights, Camera, Action--the Drosophila Embryo Goes Live!”. Curr Biol 23 (21).
    Reference Link
  • Munro, Daniel, Dario Ghersi, and Mona Singh. (2018) 2018. “Two Critical Positions in Zinc Finger Domains Are Heavily Mutated in Three Human Cancer Types.”. PLoS Comput Biol 14 (6): e1006290. doi:10.1371/journal.pcbi.1006290.
    Reference Link
  • Roose, Jeroen P, Maximilian Diehn, Michael G Tomlinson, Joseph Lin, Ash A Alizadeh, David Botstein, Patrick O Brown, and Arthur Weiss. (2003) 2003. “T Cell Receptor-Independent Basal Signaling via Erk and Abl Kinases Suppresses RAG Gene Expression.”. PLoS Biol 1 (2): E53.
    Reference Link
  • Zallen, Jennifer A, and Eric Wieschaus. (2004) 2004. “Patterned Gene Expression Directs Bipolar Planar Polarity in Drosophila.”. Dev Cell 6 (3): 343-55.
    Reference Link
  • Yoshimoto, Hiroyuki, Kirstie Saltsman, Audrey P Gasch, Hong Xia Li, Nobuo Ogawa, David Botstein, Patrick O Brown, and Martha S Cyert. (2002) 2002. “Genome-Wide Analysis of Gene Expression Regulated by the Calcineurin Crz1p Signaling Pathway in Saccharomyces Cerevisiae.”. J Biol Chem 277 (34): 31079-88.
    Reference Link
  • Persikov, Anton, V, Elizabeth F Rowland, Benjamin L Oakes, Mona Singh, and Marcus B Noyes. (2014) 2014. “Deep Sequencing of Large Library Selections Allows Computational Discovery of Diverse Sets of Zinc Fingers That Bind Common Targets.”. Nucleic Acids Res 42 (3): 1497-508.
    Reference Link
  • Wetzel, Joshua L, and Mona Singh. (2020) 2020. “Sharing DNA-Binding Information across Structurally Similar Proteins Enables Accurate Specificity Determination.”. Nucleic Acids Res 48 (2): e9. doi:10.1093/nar/gkz1087.
    Reference Link
  • Biemar, Frédéric, Robert Zinzen, Matthew Ronshaugen, Victor Sementchenko, Robert Manak, and Michael S Levine. (2005) 2005. “Spatial Regulation of MicroRNA Gene Expression in the Drosophila Embryo.”. Proc Natl Acad Sci U S A 102 (44): 15907-11.
    Reference Link
  • Armand, P, A C Knapp, A J Hirsch, E F Wieschaus, and M D Cole. (1994) 1994. “A Novel Basic Helix-Loop-Helix Protein Is Expressed in Muscle Attachment Sites of the Drosophila Epidermis.”. Mol Cell Biol 14 (6): 4145-54.
    Reference Link
  • Schaner, Marci E, Douglas T Ross, Giuseppe Ciaravino, Therese Sorlie, Olga Troyanskaya, Maximilian Diehn, Yan C Wang, et al. (2003) 2003. “Gene Expression Patterns in Ovarian Carcinomas.”. Mol Biol Cell 14 (11): 4376-86.
    Reference Link
  • Persikov, Anton, V, and Mona Singh. (2014) 2014. “De Novo Prediction of DNA-Binding Specificities for Cys2His2 Zinc Finger Proteins.”. Nucleic Acids Res 42 (1): 97-108.
    Reference Link
  • Diehn, Maximilian, Gavin Sherlock, Gail Binkley, Heng Jin, John C Matese, Tina Hernandez-Boussard, Christian A Rees, et al. (2003) 2003. “SOURCE: A Unified Genomic Resource of Functional Annotations, Ontologies, and Gene Expression Data.”. Nucleic Acids Res 31 (1): 219-23.
    Reference Link
  • Hilgers, Valérie, Michael W Perry, David Hendrix, Alexander Stark, Michael Levine, and Benjamin Haley. (2011) 2011. “Neural-Specific Elongation of 3’ UTRs During Drosophila Development.”. Proc Natl Acad Sci U S A 108 (38): 15864-9.
    Reference Link
  • Katz, David J, Michael A Beer, John M Levorse, and Shirley M Tilghman. (2005) 2005. “Functional Characterization of a Novel Ku70 80 Pause Site at the H19 Igf2 Imprinting Control Region.”. Mol Cell Biol 25 (10): 3855-63.
    Reference Link
  • Hark, A T, C J Schoenherr, D J Katz, R S Ingram, J M Levorse, and S M Tilghman. (2000) 2000. “CTCF Mediates Methylation-Sensitive Enhancer-Blocking Activity at the H19 Igf2 Locus.”. Nature 405 (6785): 486-9.
    Reference Link
  • Cowden, John, and Michael Levine. (2002) 2002. “The Snail Repressor Positions Notch Signaling in the Drosophila Embryo.”. Development 129 (7): 1785-93.
    Reference Link
  • Peifer, M, and E Wieschaus. (1990) 1990. “Mutations in the Drosophila Gene Extradenticle Affect the Way Specific Homeo Domain Proteins Regulate Segmental Identity.”. Genes Dev 4 (7): 1209-23.
    Reference Link
  • Zartman, Jeremiah J, Jitendra S Kanodia, Lily S Cheung, and Stanislav Y Shvartsman. (2009) 2009. “Feedback Control of the EGFR Signaling Gradient: Superposition of Domain-Splitting Events in Drosophila Oogenesis.”. Development 136 (17): 2903-11.
    Reference Link
  • Nibu, Yutaka, Kate Senger, and Michael Levine. (2003) 2003. “CtBP-Independent Repression in the Drosophila Embryo.”. Mol Cell Biol 23 (11): 3990-9.
    Reference Link
  • Trinklein, Nathan D, John I Murray, Sara J Hartman, David Botstein, and Richard M Myers. (2004) 2004. “The Role of Heat Shock Transcription Factor 1 in the Genome-Wide Regulation of the Mammalian Heat Shock Response.”. Mol Biol Cell 15 (3): 1254-61.
    Reference Link
  • Caspary, T, M A Cleary, C C Baker, X J Guan, and S M Tilghman. (1998) 1998. “Multiple Mechanisms Regulate Imprinting of the Mouse Distal Chromosome 7 Gene Cluster.”. Mol Cell Biol 18 (6): 3466-74.
    Reference Link
  • Rauskolb, C, K M Smith, M Peifer, and E Wieschaus. (1995) 1995. “Extradenticle Determines Segmental Identities Throughout Drosophila Development.”. Development 121 (11): 3663-73.
    Reference Link
  • Goodliffe, Julie M, Michael D Cole, and Eric Wieschaus. 2007. “Coordinated Regulation of Myc Trans-Activation Targets by Polycomb and the Trithorax Group Protein Ash1.”. BMC Mol Biol 8: 40.
    Reference Link
  • Ahmed, Yashi, S Hayashi, A Levine, and E Wieschaus. (1998) 1998. “Regulation of Armadillo by a Drosophila APC Inhibits Neuronal Apoptosis During Retinal Development.”. Cell 93 (7): 1171-82.
    Reference Link
  • Krotov, Dmitry, Julien Dubuis, Thomas Gregor, and William Bialek. (2014) 2014. “Morphogenesis at Criticality.”. Proc Natl Acad Sci U S A 111 (10): 3683-8.
    Reference Link
  • Rauskolb, C, M Peifer, and E Wieschaus. (1993) 1993. “Extradenticle, a Regulator of Homeotic Gene Activity, Is a Homolog of the Homeobox-Containing Human Proto-Oncogene pbx1.”. Cell 74 (6): 1101-12.
    Reference Link
  • Rauskolb, C, and E Wieschaus. (1994) 1994. “Coordinate Regulation of Downstream Genes by Extradenticle and the Homeotic Selector Proteins.”. EMBO J 13 (15): 3561-9.
    Reference Link
  • Goentoro, Lea A, Nir Yakoby, Joseph Goodhouse, Trudi Schüpbach, and Stanislav Y Shvartsman. (2006) 2006. “Quantitative Analysis of the GAL4 UAS System in Drosophila Oogenesis.”. Genesis 44 (2): 66-74.
    Reference Link
  • Millonig, J H, J A Emerson, J M Levorse, and S M Tilghman. (1995) 1995. “Molecular Analysis of the Distal Enhancer of the Mouse Alpha-Fetoprotein Gene.”. Mol Cell Biol 15 (7): 3848-56.
    Reference Link
  • Persikov, Anton, V, and Mona Singh. (2011) 2011. “An Expanded Binding Model for Cys2His2 Zinc Finger Protein-DNA Interfaces.”. Phys Biol 8 (3): 035010.
    Reference Link
  • Oliveira, Riva P, Jess Porter Abate, Kieran Dilks, Jessica Landis, Jasmine M Ashraf, Coleen T Murphy, and Keith Blackwell. (2009) 2009. “Condition-Adapted Stress and Longevity Gene Regulation by Caenorhabditis Elegans SKN-1 Nrf.”. Aging Cell 8 (5): 524-41.
    Reference Link
  • Hendrix, David A, Joung-Woo Hong, Julia Zeitlinger, Daniel S Rokhsar, and Michael S Levine. (2008) 2008. “Promoter Elements Associated With RNA Pol II Stalling in the Drosophila Embryo.”. Proc Natl Acad Sci U S A 105 (22): 7762-7.
    Reference Link
  • Coulter, D E, E A Swaykus, M A Beran-Koehn, D Goldberg, E Wieschaus, and P Schedl. (1990) 1990. “Molecular Analysis of Odd-Skipped, a Zinc Finger Encoding Segmentation Gene With a Novel Pair-Rule Expression Pattern.”. EMBO J 9 (11): 3795-804.
    Reference Link
  • Rebeiz, Mark, Margarita Ramos-Womack, Sangyun Jeong, Peter Andolfatto, Thomas Werner, John True, David L Stern, and Sean B Carroll. (2009) 2009. “Evolution of the Tan Locus Contributed to Pigment Loss in Drosophila Santomea: A Response to Matute Et Al.”. Cell 139 (6): 1189-96.
    Reference Link
  • Broedersz, Chase P, Xindan Wang, Yigal Meir, Joseph J Loparo, David Z Rudner, and Ned S Wingreen. (2014) 2014. “Condensation and Localization of the Partitioning Protein ParB on the Bacterial Chromosome.”. Proc Natl Acad Sci U S A 111 (24): 8809-14.
    Reference Link
  • Gregor, Thomas, David W Tank, Eric F Wieschaus, and William Bialek. (2007) 2007. “Probing the Limits to Positional Information.”. Cell 130 (1): 153-64.
    Reference Link
  • Trotter, Eleanor W, Camilla M-F Kao, Ludmilla Berenfeld, David Botstein, Gregory A Petsko, and Joseph Gray V. (2002) 2002. “Misfolded Proteins Are Competent to Mediate a Subset of the Responses to Heat Shock in Saccharomyces Cerevisiae.”. J Biol Chem 277 (47): 44817-25.
    Reference Link

Pagination

  • Page 1
  • Next page ››

Footer

Lewis-Sigler Institute for Integrative Genomics
South Drive, Carl Icahn Laboratory
Princeton University
Princeton, NJ 08544 USA

General Information:  [email protected]

  • Diversity & Non-Discrimination
  • Accessibility Help

© 2025 The Trustees of Princeton University

Princeton University