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Computational Biology

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  • Faculty Publications
  • Hibbs, Matthew A, Nathaniel C Dirksen, Kai Li, and Olga G Troyanskaya. 2005. “Visualization Methods for Statistical Analysis of Microarray Clusters.”. BMC Bioinformatics 6: 115.
    Reference Link
  • Fong, Jessica H, Amy E Keating, and Mona Singh. 2004. “Predicting Specificity in BZIP Coiled-Coil Protein Interactions.”. Genome Biol 5 (2): R11.
    Reference Link
  • Song, Jimin, and Mona Singh. (2009) 2009. “How and When Should Interactome-Derived Clusters Be Used to Predict Functional Modules and Protein Function?”. Bioinformatics 25 (23): 3143-50.
    Reference Link
  • Huttenhower, Curtis, Erin M Haley, Matthew A Hibbs, Vanessa Dumeaux, Daniel R Barrett, Hilary A Coller, and Olga G Troyanskaya. (2009) 2009. “Exploring the Human Genome With Functional Maps.”. Genome Res 19 (6): 1093-106.
    Reference Link
  • Jiang, Peng, Mona Singh, and Hilary A Coller. 2013. “Computational Assessment of the Cooperativity Between RNA Binding Proteins and MicroRNAs in Transcript Decay.”. PLoS Comput Biol 9 (5): e1003075.
    Reference Link
  • Edwards, Alexis C, Julien Ayroles, Eric A Stone, Mary Anna Carbone, Richard F Lyman, and Trudy F C Mackay. 2009. “A Transcriptional Network Associated With Natural Variation in Drosophila Aggressive Behavior.”. Genome Biol 10 (7): R76.
    Reference Link
  • Capra, John A, Roman A Laskowski, Janet M Thornton, Mona Singh, and Thomas A Funkhouser. (2009) 2009. “Predicting Protein Ligand Binding Sites by Combining Evolutionary Sequence Conservation and 3D Structure.”. PLoS Comput Biol 5 (12): e1000585.
    Reference Link
  • Barutcuoglu, Zafer, Robert E Schapire, and Olga G Troyanskaya. (2006) 2006. “Hierarchical Multi-Label Prediction of Gene Function.”. Bioinformatics 22 (7): 830-6.
    Reference Link
  • Wyart, Matthieu, David Botstein, and Ned S Wingreen. 2010. “Evaluating Gene Expression Dynamics Using Pairwise RNA FISH Data.”. PLoS Comput Biol 6 (11): e1000979.
    Reference Link
  • Huttenhower, Curtis, Chad L Myers, Matthew A Hibbs, and Olga G Troyanskaya. 2009. “Computational Analysis of the Yeast Proteome: Understanding and Exploiting Functional Specificity in Genomic Data.”. Methods Mol Biol 548: 273-93.
    Reference Link
  • Endres, Robert G, Thomas C Schulthess, and Ned S Wingreen. (2004) 2004. “Toward an Atomistic Model for Predicting Transcription-Factor Binding Sites.”. Proteins 57 (2): 262-8.
    Reference Link
  • Dwyer, Robert S, Dante P Ricci, Lucy J Colwell, Thomas J Silhavy, and Ned S Wingreen. (2013) 2013. “Predicting Functionally Informative Mutations in Escherichia Coli BamA Using Evolutionary Covariance Analysis.”. Genetics 195 (2): 443-55.
    Reference Link
  • Wang, Siyuan, Leon Furchtgott, Kerwyn Casey Huang, and Joshua W Shaevitz. (2012) 2012. “Helical Insertion of Peptidoglycan Produces Chiral Ordering of the Bacterial Cell Wall.”. Proc Natl Acad Sci U S A 109 (10).
    Reference Link
  • Cheung, Lily S, David S A Simakov, Alisa Fuchs, George Pyrowolakis, and Stanislav Y Shvartsman. (2013) 2013. “Dynamic Model for the Coordination of Two Enhancers of Broad by EGFR Signaling.”. Proc Natl Acad Sci U S A 110 (44): 17939-44.
    Reference Link
  • Reeves, Gregory T, Rachel Kalifa, Daryl E Klein, Mark A Lemmon, and Stanislav Y Shvartsman. (2005) 2005. “Computational Analysis of EGFR Inhibition by Argos.”. Dev Biol 284 (2): 523-35.
    Reference Link
  • Lembong, Jessica, Nir Yakoby, and Stanislav Y Shvartsman. (2008) 2008. “Spatial Regulation of BMP Signaling by Patterned Receptor Expression.”. Tissue Eng Part A 14 (9): 1469-77.
    Reference Link
  • Persikov, Anton, V, Robert Osada, and Mona Singh. (2009) 2009. “Predicting DNA Recognition by Cys2His2 Zinc Finger Proteins.”. Bioinformatics 25 (1): 22-9.
    Reference Link
  • Huttenhower, Curtis, Sajid O Mehmood, and Olga G Troyanskaya. 2009. “Graphle: Interactive Exploration of Large, Dense Graphs.”. BMC Bioinformatics 10: 417.
    Reference Link
  • Ghersi, Dario, and Mona Singh. 2013. “Disentangling Function from Topology to Infer the Network Properties of Disease Genes.”. BMC Syst Biol 7: 5.
    Reference Link
  • Reguly, Teresa, Ashton Breitkreutz, Lorrie Boucher, Bobby-Joe Breitkreutz, Gary C Hon, Chad L Myers, Ainslie Parsons, et al. 2006. “Comprehensive Curation and Analysis of Global Interaction Networks in Saccharomyces Cerevisiae.”. J Biol 5 (4): 11.
    Reference Link
  • Lenz, Derrick H, Kenny C Mok, Brendan N Lilley, Rahul Kulkarni V, Ned S Wingreen, and Bonnie L Bassler. (2004) 2004. “The Small RNA Chaperone Hfq and Multiple Small RNAs Control Quorum Sensing in Vibrio Harveyi and Vibrio Cholerae.”. Cell 118 (1): 69-82.
    Reference Link
  • Banks, Eric, Elena Nabieva, Bernard Chazelle, and Mona Singh. (2008) 2008. “Organization of Physical Interactomes As Uncovered by Network Schemas.”. PLoS Comput Biol 4 (10): e1000203.
    Reference Link
  • Zhou, Jian, and Olga G Troyanskaya. (2014) 2014. “Global Quantitative Modeling of Chromatin Factor Interactions.”. PLoS Comput Biol 10 (3): e1003525.
    Reference Link
  • Myers, Chad L, Drew Robson, Adam Wible, Matthew A Hibbs, Camelia Chiriac, Chandra L Theesfeld, Kara Dolinski, and Olga G Troyanskaya. 2005. “Discovery of Biological Networks from Diverse Functional Genomic Data.”. Genome Biol 6 (13): R114.
    Reference Link
  • Huttenhower, Curtis, and Olga G Troyanskaya. 2006. “Bayesian Data Integration: A Functional Perspective.”. Comput Syst Bioinformatics Conf, 341-51.
    Reference Link
  • Huttenhower, Curtis, Mark Schroeder, Maria D Chikina, and Olga G Troyanskaya. (2008) 2008. “The Sleipnir Library for Computational Functional Genomics.”. Bioinformatics 24 (13): 1559-61.
    Reference Link
  • Lee, Young-suk, Arjun Krishnan, Qian Zhu, and Olga G Troyanskaya. (2013) 2013. “Ontology-Aware Classification of Tissue and Cell-Type Signals in Gene Expression Profiles across Platforms and Technologies.”. Bioinformatics 29 (23): 3036-44.
    Reference Link
  • Troyanskaya, Olga. (2007) 2007. “‘Getting Started in. ’: A Series Not to Miss.”. PLoS Comput Biol 3 (10): 1841.
    Reference Link
  • Huttenhower, Curtis, Tsheko Mutungu, Natasha Indik, Woongcheol Yang, Mark Schroeder, Joshua J Forman, Olga G Troyanskaya, and Hilary A Coller. (2009) 2009. “Detailing Regulatory Networks through Large Scale Data Integration.”. Bioinformatics 25 (24): 3267-74.
    Reference Link
  • Barutcuoglu, Zafer, Edoardo M Airoldi, Vanessa Dumeaux, Robert E Schapire, and Olga G Troyanskaya. (2009) 2009. “Aneuploidy Prediction and Tumor Classification With Heterogeneous Hidden Conditional Random Fields.”. Bioinformatics 25 (10): 1307-13.
    Reference Link
  • Pritykin, Yuri, and Mona Singh. 2013. “Simple Topological Features Reflect Dynamics and Modularity in Protein Interaction Networks.”. PLoS Comput Biol 9 (10): e1003243.
    Reference Link
  • Andolfatto, Peter, Dan Davison, Deniz Erezyilmaz, Tina T Hu, Joshua Mast, Tomoko Sunayama-Morita, and David L Stern. (2011) 2011. “Multiplexed Shotgun Genotyping for Rapid and Efficient Genetic Mapping.”. Genome Res 21 (4): 610-7.
    Reference Link
  • Guan, Yuanfang, Chad L Myers, Rong Lu, Ihor R Lemischka, Carol J Bult, and Olga G Troyanskaya. 2008. “A Genomewide Functional Network for the Laboratory Mouse.”. PLoS Comput Biol 4 (9): e1000165.
    Reference Link
  • Ju, Wenjun, Casey S Greene, Felix Eichinger, Viji Nair, Jeffrey B Hodgin, Markus Bitzer, Young-suk Lee, et al. (2013) 2013. “Defining Cell-Type Specificity at the Transcriptional Level in Human Disease.”. Genome Res 23 (11): 1862-73.
    Reference Link
  • Lu, Wenyun, Bryson D Bennett, and Joshua D Rabinowitz. (2008) 2008. “Analytical Strategies for LC-MS-Based Targeted Metabolomics.”. J Chromatogr B Analyt Technol Biomed Life Sci 871 (2): 236-42.
    Reference Link
  • Hong, Joung-Woo, David A Hendrix, and Michael S Levine. (2008) 2008. “Shadow Enhancers As a Source of Evolutionary Novelty.”. Science 321 (5894): 1314.
    Reference Link
  • Hendrix, David, Michael Levine, and Weiyang Shi. 2010. “MiRTRAP, a Computational Method for the Systematic Identification of MiRNAs from High Throughput Sequencing Data.”. Genome Biol 11 (4): R39.
    Reference Link
  • Diehn, Maximilian, Ramona Bhattacharya, David Botstein, and Patrick O Brown. (2006) 2006. “Genome-Scale Identification of Membrane-Associated Human MRNAs.”. PLoS Genet 2 (1): e11.
    Reference Link
  • Persikov, Anton, V, Elizabeth F Rowland, Benjamin L Oakes, Mona Singh, and Marcus B Noyes. (2014) 2014. “Deep Sequencing of Large Library Selections Allows Computational Discovery of Diverse Sets of Zinc Fingers That Bind Common Targets.”. Nucleic Acids Res 42 (3): 1497-508.
    Reference Link
  • Chikina, Maria D, and Olga G Troyanskaya. 2011. “Accurate Quantification of Functional Analogy Among Close Homologs.”. PLoS Comput Biol 7 (2): e1001074.
    Reference Link
  • Butte, Atul J, Indra Neil Sarkar, Marco Ramoni, Yves Lussier, and Olga Troyanskaya. 2009. “Selected Proceedings of the First Summit on Translational Bioinformatics 2008.”. BMC Bioinformatics 10 Suppl 2: I1.
    Reference Link
  • Zhen, Ying, and Peter Andolfatto. 2012. “Methods to Detect Selection on Noncoding DNA.”. Methods Mol Biol 856: 141-59.
    Reference Link
  • Costanzo, Michael, Anastasia Baryshnikova, Jeremy Bellay, Yungil Kim, Eric D Spear, Carolyn S Sevier, Huiming Ding, et al. (2010) 2010. “The Genetic Landscape of a Cell.”. Science 327 (5964): 425-31.
    Reference Link
  • Markstein, Michele, and Michael Levine. (2002) 2002. “Decoding Cis-Regulatory DNAs in the Drosophila Genome.”. Curr Opin Genet Dev 12 (5): 601-6.
    Reference Link
  • Gorenshteyn, Dmitriy, Elena Zaslavsky, Miguel Fribourg, Christopher Y Park, Aaron K Wong, Alicja Tadych, Boris M Hartmann, et al. (2015) 2015. “Interactive Big Data Resource to Elucidate Human Immune Pathways and Diseases.”. Immunity 43 (3): 605-14.
    Reference Link
  • Tkačik, Gašper, Olivier Marre, Dario Amodei, Elad Schneidman, William Bialek, and Michael J Berry. (2014) 2014. “Searching for Collective Behavior in a Large Network of Sensory Neurons.”. PLoS Comput Biol 10 (1): e1003408.
    Reference Link
  • Markowetz, Florian, Klaas W Mulder, Edoardo M Airoldi, Ihor R Lemischka, and Olga G Troyanskaya. 2010. “Mapping Dynamic Histone Acetylation Patterns to Gene Expression in Nanog-Depleted Murine Embryonic Stem Cells.”. PLoS Comput Biol 6 (12): e1001034.
    Reference Link
  • Consortium, Gene Ontology. (2010) 2010. “The Gene Ontology in 2010: Extensions and Refinements.”. Nucleic Acids Res 38 (Database issue).
    Reference Link
  • Erives, Albert, and Michael Levine. (2004) 2004. “Coordinate Enhancers Share Common Organizational Features in the Drosophila Genome.”. Proc Natl Acad Sci U S A 101 (11): 3851-6.
    Reference Link
  • Zhou, Jian, Christopher Y Park, Chandra L Theesfeld, Aaron K Wong, Yuan Yuan, Claudia Scheckel, John J Fak, et al. (2019) 2019. “Whole-Genome Deep-Learning Analysis Identifies Contribution of Noncoding Mutations to Autism Risk.”. Nat Genet 51 (6): 973-80. doi:10.1038/s41588-019-0420-0.
    Reference Link

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