for Integrative Genomics Lewis-Sigler Institute

Off screen link: Skip to content Off screen link: Skip to search
Princeton University
Home
for Integrative Genomics
Lewis-Sigler Institute

Main Menu

  • Research
    Research
    • Research Overview
    • Research Areas
      • Biophysics: Theory and Experiment
      • Computational Genomics
      • Evolutionary and Population Genomics
      • Experimental Genomics
      • Statistical Genomics
      • Systems Biology: Development/Aging
      • Systems Biology: Metabolomics/Proteomics
    • Faculty Research Labs
    • Research Facilities & Resources
      • Genomics Computing Resources
      • LSI Media Facility
      • Genomics Core Facility
        • Instructions
        • RNA-Seq
        • Microarray
        • Contacts
    • Research Centers
      • Center for Quantitative Biology
      • Glenn Laboratories For Aging Research
    • Faculty Publications
  • People
    People
    • Faculty
    • Associated Faculty
    • Faculty Emeriti
    • Lewis-Sigler Scholars
    • Graduate Students
    • Staff
  • Education
    Education
    • Education Overview
    • Quantitative & Computational Biology Graduate Program
      • Ph.D. Program Requirements
      • How to Apply
      • Financial Support
      • Faculty & Research
      • Graduate Students
      • Student Committees
      • Peer Mentoring Program
    • Graduate Program in Biophysics
      • Program Requirements
      • Faculty and Research
      • Graduate Students
    • Undergraduate Minor in Quantitative & Computational Biology
      • Minor Requirements
      • Application
      • Program Committee
      • Frequently Asked Questions
    • Integrated Science Curriculum
      • Course details
      • Paths from ISC
      • Student perspectives
      • Instructor perspectives
      • ISC Revitalization
    • NIH NHGRI Training Program
    • QCB Scholars Program
  • Seminars & Events
  • News
  • Diversity & Inclusion
  • About
    About
    • Founding Donors
    • History
    • Opportunities
  • Contact Us
  • Visitor Information

Search

  1. Home
  2. Research
  3. Faculty Publications

Caenorhabditis elegans

Section Menu

  • Research Overview
  • Research Areas
  • Faculty Research Labs
  • Research Facilities & Resources
  • Research Centers
  • Faculty Publications
  • Chikina, Maria D, Curtis Huttenhower, Coleen T Murphy, and Olga G Troyanskaya. (2009) 2009. “Global Prediction of Tissue-Specific Gene Expression and Context-Dependent Gene Networks in Caenorhabditis Elegans.”. PLoS Comput Biol 5 (6): e1000417.
    Reference Link
  • Li, Siran, Howard A Stone, and Coleen T Murphy. (2015) 2015. “A Microfluidic Device and Automatic Counting System for the Study of C. Elegans Reproductive Aging.”. Lab Chip 15 (2): 524-31. doi:10.1039/c4lc01028k.
    Reference Link
  • Lakhina, Vanisha, Rachel Arey, Rachel Kaletsky, Amanda Kauffman, Geneva Stein, William Keyes, Daniel Xu, and Coleen T Murphy. (2015) 2015. “Genome-Wide Functional Analysis of CREB Long-Term Memory-Dependent Transcription Reveals Distinct Basal and Memory Gene Expression Programs.”. Neuron 85 (2): 330-45.
    Reference Link
  • Ewald, Collin Y, Jess N Landis, Jess Porter Abate, Coleen T Murphy, and Keith Blackwell. (2015) 2015. “Dauer-Independent Insulin IGF-1-Signalling Implicates Collagen Remodelling in Longevity.”. Nature 519 (7541): 97-101. doi:10.1038/nature14021.
    Reference Link
  • Murphy, Coleen T, Steven A McCarroll, Cornelia I Bargmann, Andrew Fraser, Ravi S Kamath, Julie Ahringer, Hao Li, and Cynthia Kenyon. (2003) 2003. “Genes That Act Downstream of DAF-16 to Influence the Lifespan of Caenorhabditis Elegans.”. Nature 424 (6946): 277-83.
    Reference Link
  • Hahm, Jeong-Hoon, Sunhee Kim, Race DiLoreto, Cheng Shi, Seung-Jae Lee V, Coleen T Murphy, and Hong Gil Nam. (2015) 2015. “C. Elegans Maximum Velocity Correlates With Healthspan and Is Maintained in Worms With an Insulin Receptor Mutation.”. Nat Commun 6: 8919. doi:10.1038/ncomms9919.
    Reference Link
  • Park, Christopher Y, Aaron K Wong, Casey S Greene, Jessica Rowland, Yuanfang Guan, Lars A Bongo, Rebecca Burdine, and Olga G Troyanskaya. 2013. “Functional Knowledge Transfer for High-Accuracy Prediction of under-Studied Biological Processes.”. PLoS Comput Biol 9 (3): e1002957.
    Reference Link
  • Wang, Juan, Rachel Kaletsky, Malan Silva, April Williams, Leonard A Haas, Rebecca J Androwski, Jessica N Landis, et al. (2015) 2015. “Cell-Specific Transcriptional Profiling of Ciliated Sensory Neurons Reveals Regulators of Behavior and Extracellular Vesicle Biogenesis.”. Curr Biol 25 (24): 3232-8. doi:10.1016/j.cub.2015.10.057.
    Reference Link
  • Stephens, Greg J, Bethany Johnson-Kerner, William Bialek, and William S Ryu. 2010. “From Modes to Movement in the Behavior of Caenorhabditis Elegans.”. PLoS One 5 (11): e13914.
    Reference Link
  • Kaletsky, Rachel, Vanisha Lakhina, Rachel Arey, April Williams, Jessica Landis, Jasmine M Ashraf, and Coleen T Murphy. (2016) 2016. “The C. Elegans Adult Neuronal IIS FOXO Transcriptome Reveals Adult Phenotype Regulators.”. Nature 529 (7584): 92-6. doi:10.1038/nature16483.
    Reference Link
  • Murphy, Coleen T, Seung-Jae Lee, and Cynthia Kenyon. (2007) 2007. “Tissue Entrainment by Feedback Regulation of Insulin Gene Expression in the Endoderm of Caenorhabditis Elegans.”. Proc Natl Acad Sci U S A 104 (48): 19046-50.
    Reference Link
  • Rizki, Gizem, Terri Naoko Iwata, Ji Li, Christian G Riedel, Colette Lafontaine Picard, Max Jan, Coleen T Murphy, and Siu Sylvia Lee. (2011) 2011. “The Evolutionarily Conserved Longevity Determinants HCF-1 and SIR-2.1 SIRT1 Collaborate to Regulate DAF-16 FOXO.”. PLoS Genet 7 (9): e1002235.
    Reference Link
  • DiLoreto, Race, and Coleen T Murphy. (2015) 2015. “The Cell Biology of Aging.”. Mol Biol Cell 26 (25): 4524-31. doi:10.1091/mbc.E14-06-1084.
    Reference Link
  • Luo, Shijing, Gunnar A Kleemann, Jasmine M Ashraf, Wendy M Shaw, and Coleen T Murphy. (2010) 2010. “TGF-β and Insulin Signaling Regulate Reproductive Aging via Oocyte and Germline Quality Maintenance.”. Cell 143 (2): 299-312.
    Reference Link
  • Kenyon, Cynthia, and Coleen T Murphy. (2006) 2006. “Enrichment of Regulatory Motifs Upstream of Predicted DAF-16 Targets.”. Nat Genet 38 (4): 397-8; author reply 398.
    Reference Link
  • Li, Ling-Bo, Haoyun Lei, Rachel Arey, Pengpeng Li, Jianfeng Liu, Coleen T Murphy, X Z Shawn Xu, and Kang Shen. (2016) 2016. “The Neuronal Kinesin UNC-104 KIF1A Is a Key Regulator of Synaptic Aging and Insulin Signaling-Regulated Memory.”. Curr Biol 26 (5): 605-15. doi:10.1016/j.cub.2015.12.068.
    Reference Link
  • Luo, Shijing, Wendy M Shaw, Jasmine M Ashraf, and Coleen T Murphy. (2009) 2009. “TGF-Beta Sma Mab Signaling Mutations Uncouple Reproductive Aging from Somatic Aging.”. PLoS Genet 5 (12): e1000789.
    Reference Link
  • Stephens, Greg J, Matthew Bueno de Mesquita, William S Ryu, and William Bialek. (2011) 2011. “Emergence of Long Timescales and Stereotyped Behaviors in Caenorhabditis Elegans.”. Proc Natl Acad Sci U S A 108 (18): 7286-9.
    Reference Link
  • Shi, Cheng, and Coleen T Murphy. (2016) 2016. “Feeding the Germline.”. Genes Dev 30 (3): 249-50. doi:10.1101/gad.276980.115.
    Reference Link
  • Murphy, Coleen T. (2006) 2006. “The Search for DAF-16 FOXO Transcriptional Targets: Approaches and Discoveries.”. Exp Gerontol 41 (10): 910-21.
    Reference Link
  • Liu, Gang, Jason Rogers, Coleen T Murphy, and Christopher Rongo. (2011) 2011. “EGF Signalling Activates the Ubiquitin Proteasome System to Modulate C. Elegans Lifespan.”. EMBO J 30 (15): 2990-3003.
    Reference Link
  • Nguyen, Jeffrey P, Frederick B Shipley, Ashley N Linder, George S Plummer, Mochi Liu, Sagar U Setru, Joshua W Shaevitz, and Andrew M Leifer. (2016) 2016. “Whole-Brain Calcium Imaging With Cellular Resolution in Freely Behaving Caenorhabditis Elegans.”. Proc Natl Acad Sci U S A 113 (8). doi:10.1073/pnas.1507110112.
    Reference Link
  • Kaletsky, Rachel, and Coleen T Murphy. (2010) 2010. “The Role of Insulin IGF-Like Signaling in C. Elegans Longevity and Aging.”. Dis Model Mech 3 (7-8): 415-9.
    Reference Link
  • Stephens, Greg J, Bethany Johnson-Kerner, William Bialek, and William S Ryu. (2008) 2008. “Dimensionality and Dynamics in the Behavior of C. Elegans.”. PLoS Comput Biol 4 (4): e1000028.
    Reference Link
  • Nguyen, Jeffrey P, Ashley N Linder, George S Plummer, Joshua W Shaevitz, and Andrew M Leifer. (2017) 2017. “Automatically Tracking Neurons in a Moving and Deforming Brain.”. PLoS Comput Biol 13 (5): e1005517. doi:10.1371/journal.pcbi.1005517.
    Reference Link
  • Hsu, Ao-Lin, Coleen T Murphy, and Cynthia Kenyon. (2003) 2003. “Regulation of Aging and Age-Related Disease by DAF-16 and Heat-Shock Factor.”. Science 300 (5622): 1142-5.
    Reference Link
  • Tepper, Ronald G, Coleen T Murphy, and Harmen J Bussemaker. (2014) 2014. “DAF-16 and PQM-1: Partners in Longevity.”. Aging (Albany NY) 6 (1): 5-6.
    Reference Link
  • Tepper, Ronald G, Jasmine M Ashraf, Rachel Kaletsky, Gunnar Kleemann, Coleen T Murphy, and Harmen J Bussemaker. (2013) 2013. “PQM-1 Complements DAF-16 As a Key Transcriptional Regulator of DAF-2-Mediated Development and Longevity.”. Cell 154 (3): 676-90.
    Reference Link
  • Oliveira, Riva P, Jess Porter Abate, Kieran Dilks, Jessica Landis, Jasmine M Ashraf, Coleen T Murphy, and Keith Blackwell. (2009) 2009. “Condition-Adapted Stress and Longevity Gene Regulation by Caenorhabditis Elegans SKN-1 Nrf.”. Aging Cell 8 (5): 524-41.
    Reference Link
  • Shi, Cheng, and Coleen T Murphy. (2014) 2014. “Mating Induces Shrinking and Death in Caenorhabditis Mothers.”. Science 343 (6170): 536-40.
    Reference Link
  • McCarroll, Steven A, Coleen T Murphy, Sige Zou, Scott D Pletcher, Chen-Shan Chin, Yuh Nung Jan, Cynthia Kenyon, Cornelia I Bargmann, and Hao Li. (2004) 2004. “Comparing Genomic Expression Patterns across Species Identifies Shared Transcriptional Profile in Aging.”. Nat Genet 36 (2): 197-204.
    Reference Link
  • Landis, Jessica N, and Coleen T Murphy. (2010) 2010. “Integration of Diverse Inputs in the Regulation of Caenorhabditis Elegans DAF-16 FOXO.”. Dev Dyn 239 (5): 1405-12.
    Reference Link
  • Luo, Shijing, and Coleen T Murphy. (2011) 2011. “Caenorhabditis Elegans Reproductive Aging: Regulation and Underlying Mechanisms.”. Genesis 49 (2): 53-65.
    Reference Link
  • Kauffman, Amanda L, Jasmine M Ashraf, Ryan Corces-Zimmerman, Jessica N Landis, and Coleen T Murphy. (2010) 2010. “Insulin Signaling and Dietary Restriction Differentially Influence the Decline of Learning and Memory With Age.”. PLoS Biol 8 (5): e1000372.
    Reference Link
  • Shaw, Wendy M, Shijing Luo, Jessica Landis, Jasmine M Ashraf, and Coleen T Murphy. (2007) 2007. “The C. Elegans TGF-Beta Dauer Pathway Regulates Longevity via Insulin Signaling.”. Curr Biol 17 (19): 1635-45.
    Reference Link
  • Lee, Seung-Jae, Coleen T Murphy, and Cynthia Kenyon. (2009) 2009. “Glucose Shortens the Life Span of C. Elegans by Downregulating DAF-16 FOXO Activity and Aquaporin Gene Expression.”. Cell Metab 10 (5): 379-91.
    Reference Link
  • Dawes-Hoang, Rachel E, Jennifer A Zallen, and Eric F Wieschaus. (2003) 2003. “Bringing Classical Embryology to C Elegans Gastrulation.”. Dev Cell 4 (1): 6-8.
    Reference Link

Footer

Lewis-Sigler Institute for Integrative Genomics
South Drive, Carl Icahn Laboratory
Princeton University
Princeton, NJ 08544 USA

General Information:  [email protected]

  • Diversity & Non-Discrimination
  • Accessibility Help

© 2025 The Trustees of Princeton University

Princeton University