Integration of diverse inputs in the regulation of Caenorhabditis elegans DAF-16/FOXO. Author Jessica Landis, Coleen Murphy Publication Year 2010 Type Journal Article Abstract In a remarkably conserved insulin signaling pathway that is well-known for its regulation of longevity in worms, flies, and mammals, the major C. elegans effector of this pathway, DAF-16/FOXO, also modulates many other physiological processes. This raises the question of how DAF-16/FOXO chooses the correct targets to achieve the appropriate response in a particular context. Here, we review current knowledge of tissue-specificity and interacting partners that modulate DAF-16/FOXO functional output. Keywords Animals, Signal Transduction, Transcription Factors, Organ Specificity, Caenorhabditis elegans, Caenorhabditis elegans Proteins, Forkhead Transcription Factors Journal Dev Dyn Volume 239 Issue 5 Pages 1405-12 Date Published 05/2010 Alternate Journal Dev. Dyn. Google ScholarBibTeXEndNote X3 XML