Integration of diverse inputs in the regulation of Caenorhabditis elegans DAF-16/FOXO.

Publication Year
2010

Type

Journal Article
Abstract

In a remarkably conserved insulin signaling pathway that is well-known for its regulation of longevity in worms, flies, and mammals, the major C. elegans effector of this pathway, DAF-16/FOXO, also modulates many other physiological processes. This raises the question of how DAF-16/FOXO chooses the correct targets to achieve the appropriate response in a particular context. Here, we review current knowledge of tissue-specificity and interacting partners that modulate DAF-16/FOXO functional output.

Journal
Dev Dyn
Volume
239
Issue
5
Pages
1405-12
Date Published
05/2010
Alternate Journal
Dev. Dyn.