How long does it take to establish a morphogen gradient?

Publication Year
2010

Type

Journal Article
Abstract

A morphogen gradient is defined as a concentration field of a molecule that acts as a dose-dependent regulator of cell differentiation. One of the key questions in studies of morphogen gradients is whether they reach steady states on timescales relevant for developmental patterning. We propose a systematic approach for addressing this question and illustrate it by analyzing several models that account for diffusion and degradation of locally produced chemical signals.

Journal
Biophys J
Volume
99
Issue
8
Pages
L59-61
Date Published
10/2010
Alternate Journal
Biophys. J.