A genome scan for hypertension susceptibility loci in populations of Chinese and Japanese origins. Author Koustubh Ranade, David Hinds, Chao Hsiung, Lee-Ming Chuang, Mau-Song Chang, Ying-Tsung Chen, Robert Pesich, Joan Hebert, Yii-Der Chen, Victor Dzau, Richard Olshen, David Curb, David Botstein, David Cox, Neil Risch Publication Year 2003 Type Journal Article Abstract BACKGROUND: Our understanding of genes that predispose to essential hypertension is poor.METHODS: A genome-wide scan for linkage at approximately 10 cM resolution was done on 1425 sibpairs of Chinese and Japanese origins that were concordant for hypertension (N = 661), low-normal blood pressure (BP) (N = 184), or discordant for BP (N = 580).RESULTS: There was no significant evidence of linkage to a single locus in the genome. There was suggestive evidence of linkage to chromosome 10p, with a LOD score of 2.5.CONCLUSIONS: We can exclude the possibility that a single gene accounts for at least 15% of the variance in hypertension in this population. Keywords Humans, Chromosome Mapping, Genome, Human, Adult, Middle Aged, Genetic Predisposition to Disease, Asian Continental Ancestry Group, China, Hypertension, Japan, Chromosomes, Human, Pair 10, Lod Score Journal Am J Hypertens Volume 16 Issue 2 Pages 158-62 Date Published 02/2003 Alternate Journal Am. J. Hypertens. Google ScholarBibTeXEndNote X3 XML
