Formation of morphogen gradients: local accumulation time. Author Alexander Berezhkovskii, Christine Sample, Stanislav Shvartsman Publication Year 2011 Type Journal Article Abstract Spatial regulation of cell differentiation in embryos can be provided by morphogen gradients, which are defined as the concentration fields of molecules that control gene expression. For example, a cell can use its surface receptors to measure the local concentration of an extracellular ligand and convert this information into a corresponding change in its transcriptional state. We characterize the time needed to establish a steady-state gradient in problems with diffusion and degradation of locally produced chemical signals. A relaxation function is introduced to describe how the morphogen concentration profile approaches its steady state. This function is used to obtain a local accumulation time that provides a time scale that characterizes relaxation to steady state at an arbitrary position within the patterned field. To illustrate the approach we derive local accumulation times for a number of commonly used models of morphogen gradient formation. Keywords Gene Expression Regulation, Models, Biological, Cell Differentiation, Time Factors, Diffusion Journal Phys Rev E Stat Nonlin Soft Matter Phys Volume 83 Issue 5 Pt 1 Pages 051906 Date Published 05/2011 Alternate Journal Phys Rev E Stat Nonlin Soft Matter Phys Google ScholarBibTeXEndNote X3 XML