Female sterile mutations on the second chromosome of Drosophila melanogaster. I. Maternal effect mutations. Author T Schupbach, E Wieschaus Publication Year 1989 Type Journal Article Abstract In mutagenesis screens for recessive female sterile mutations on the second chromosome of Drosophila melanogaster 529 chromosomes were isolated which allow the homozygous females to survive, but cause them to be sterile. In 136 of these lines, mutant females produce morphologically normal eggs which cannot support normal embryonic development. These "maternal-effect" mutations fall into 67 complementation groups which define 23 multiply hit and 44 singly hit loci. In eggs from 14 complementation groups development is blocked before the formation of a syncytial blastoderm. In eggs from 12 complementation groups development is abnormal before cellularization, 17 complementation groups cause abnormal cellularization, 12 complementation groups cause changes in cellular morphology in early gastrulation stages, and 12 complementation groups seem to affect later embryonic development. Keywords Animals, Mutation, Female, Zygote, Drosophila melanogaster, Oogenesis, Phenotype, Gastrula, Chromosome Mapping, Blastoderm, Ovum, Homozygote, Chromosomes, Crosses, Genetic, Genetic Complementation Test, Ethyl Methanesulfonate, Fertility Journal Genetics Volume 121 Issue 1 Pages 101-17 Date Published 01/1989 Alternate Journal Genetics Google ScholarBibTeXEndNote X3 XML