Dynamics of maternal morphogen gradients in Drosophila. Author Stanislav Shvartsman, Mathieu Coppey, Alexander Berezhkovskii Publication Year 2008 Type Journal Article Abstract The first direct studies of morphogen gradients were done in the end of 1980s, in the early Drosophila embryo, which is patterned under the action of four maternally determined morphogens. Since the early studies of maternal morphogens were done with fixed embryos, they were viewed as relatively static signals. Several recent studies analyze dynamics of the anterior, dorsoventral, and terminal patterning signals. The results of these quantitative studies provide critical tests of classical models and reveal new modes of morphogen regulation and readout in one of the most extensively studied patterning systems. Keywords Animals, Drosophila, Extracellular Signal-Regulated MAP Kinases, Gene Expression Regulation, Developmental, Signal Transduction, Embryo, Nonmammalian, Models, Biological, Morphogenesis, Body Patterning, Protein Transport, Insect Proteins Journal Curr Opin Genet Dev Volume 18 Issue 4 Pages 342-7 Date Published 08/2008 Alternate Journal Curr. Opin. Genet. Dev. Google ScholarBibTeXEndNote X3 XML