Troyanskaya, Olga G, Ora Arbell, Yair Koren, Gad M Landau, and Alexander Bolshoy. (2002) 2002. “Sequence Complexity Profiles of Prokaryotic Genomic Sequences: A Fast Algorithm for Calculating Linguistic Complexity.”. Bioinformatics 18 (5): 679-88. Reference Link
Haarer, Brian, Susan Viggiano, Mathew A Hibbs, Olga G Troyanskaya, and David C Amberg. (2007) 2007. “Modeling Complex Genetic Interactions in a Simple Eukaryotic Genome: Actin Displays a Rich Spectrum of Complex Haploinsufficiencies.”. Genes Dev 21 (2): 148-59. Reference Link
Chikina, Maria D, Curtis Huttenhower, Coleen T Murphy, and Olga G Troyanskaya. (2009) 2009. “Global Prediction of Tissue-Specific Gene Expression and Context-Dependent Gene Networks in Caenorhabditis Elegans.”. PLoS Comput Biol 5 (6): e1000417. Reference Link
Huttenhower, Curtis, Tsheko Mutungu, Natasha Indik, Woongcheol Yang, Mark Schroeder, Joshua J Forman, Olga G Troyanskaya, and Hilary A Coller. (2009) 2009. “Detailing Regulatory Networks through Large Scale Data Integration.”. Bioinformatics 25 (24): 3267-74. Reference Link
Chikina, Maria D, and Olga G Troyanskaya. 2011. “Accurate Quantification of Functional Analogy Among Close Homologs.”. PLoS Comput Biol 7 (2): e1001074. Reference Link
Lee, Young-suk, Aaron K Wong, Alicja Tadych, Boris M Hartmann, Christopher Y Park, Veronica A DeJesus, Irene Ramos, Elena Zaslavsky, Stuart C Sealfon, and Olga G Troyanskaya. (2018) 2018. “Interpretation of an Individual Functional Genomics Experiment Guided by Massive Public Data.”. Nat Methods 15 (12): 1049-52. doi:10.1038/s41592-018-0218-5. Reference Link
Huttenhower, Curtis, Matt Hibbs, Chad Myers, and Olga G Troyanskaya. (2006) 2006. “A Scalable Method for Integration and Functional Analysis of Multiple Microarray Datasets.”. Bioinformatics 22 (23): 2890-7. Reference Link
Markowetz, Florian, Klaas W Mulder, Edoardo M Airoldi, Ihor R Lemischka, and Olga G Troyanskaya. 2010. “Mapping Dynamic Histone Acetylation Patterns to Gene Expression in Nanog-Depleted Murine Embryonic Stem Cells.”. PLoS Comput Biol 6 (12): e1001034. Reference Link
Brown, James A, Gavin Sherlock, Chad L Myers, Nicola M Burrows, Changchun Deng, Irene Wu, Kelly E McCann, Olga G Troyanskaya, and Martin Brown. 2006. “Global Analysis of Gene Function in Yeast by Quantitative Phenotypic Profiling.”. Mol Syst Biol 2: 2006.0001. Reference Link
Ju, Wenjun, Casey S Greene, Felix Eichinger, Viji Nair, Jeffrey B Hodgin, Markus Bitzer, Young-suk Lee, et al. (2013) 2013. “Defining Cell-Type Specificity at the Transcriptional Level in Human Disease.”. Genome Res 23 (11): 1862-73. Reference Link
Greene, Casey S, and Olga G Troyanskaya. (2012) 2012. “Accurate Evaluation and Analysis of Functional Genomics Data and Methods.”. Ann N Y Acad Sci 1260: 95-100. Reference Link
Harder, Jennifer L, Rajasree Menon, Edgar A Otto, Jian Zhou, Sean Eddy, Noel L Wys, Christopher O’Connor, et al. (2019) 2019. “Organoid Single Cell Profiling Identifies a Transcriptional Signature of Glomerular Disease.”. JCI Insight 4 (1). doi:10.1172/jci.insight.122697. Reference Link
Baryshnikova, Anastasia, Michael Costanzo, Yungil Kim, Huiming Ding, Judice Koh, Kiana Toufighi, Ji-Young Youn, et al. (2010) 2010. “Quantitative Analysis of Fitness and Genetic Interactions in Yeast on a Genome Scale.”. Nat Methods 7 (12): 1017-24. Reference Link
Chikina, Maria D, Christophe P Gerald, Xianting Li, Yongchao Ge, Hanna Pincas, Venugopalan D Nair, Aaron K Wong, et al. (2015) 2015. “Low-Variance RNAs Identify Parkinson’s Disease Molecular Signature in Blood.”. Mov Disord 30 (6): 813-21. Reference Link
Guan, Yuanfang, Chad L Myers, Rong Lu, Ihor R Lemischka, Carol J Bult, and Olga G Troyanskaya. 2008. “A Genomewide Functional Network for the Laboratory Mouse.”. PLoS Comput Biol 4 (9): e1000165. Reference Link
Peña-Castillo, Lourdes, Murat Tasan, Chad L Myers, Hyunju Lee, Trupti Joshi, Chao Zhang, Yuanfang Guan, et al. 2008. “A Critical Assessment of Mus Musculus Gene Function Prediction Using Integrated Genomic Evidence.”. Genome Biol 9 Suppl 1: S2. Reference Link
Myers, Chad L, Maitreya Dunham, S Y Kung, and Olga G Troyanskaya. (2004) 2004. “Accurate Detection of Aneuploidies in Array CGH and Gene Expression Microarray Data.”. Bioinformatics 20 (18): 3533-43. Reference Link
Zhou, Jian, Christopher Y Park, Chandra L Theesfeld, Aaron K Wong, Yuan Yuan, Claudia Scheckel, John J Fak, et al. (2019) 2019. “Whole-Genome Deep-Learning Analysis Identifies Contribution of Noncoding Mutations to Autism Risk.”. Nat Genet 51 (6): 973-80. doi:10.1038/s41588-019-0420-0. Reference Link
Troyanskaya, Olga G. 2005. “Putting the ’bio’ into Bioinformatics.”. Genome Biol 6 (10): 351. Reference Link
Greene, Casey S, and Olga G Troyanskaya. (2010) 2010. “Integrative Systems Biology for Data-Driven Knowledge Discovery.”. Semin Nephrol 30 (5): 443-54. Reference Link
Costanzo, Michael, Anastasia Baryshnikova, Jeremy Bellay, Yungil Kim, Eric D Spear, Carolyn S Sevier, Huiming Ding, et al. (2010) 2010. “The Genetic Landscape of a Cell.”. Science 327 (5964): 425-31. Reference Link
Brauer, Matthew J, Curtis Huttenhower, Edoardo M Airoldi, Rachel Rosenstein, John C Matese, David Gresham, Viktor M Boer, Olga G Troyanskaya, and David Botstein. (2008) 2008. “Coordination of Growth Rate, Cell Cycle, Stress Response, and Metabolic Activity in Yeast.”. Mol Biol Cell 19 (1): 352-67. Reference Link
Zhou, Jian, and Olga G Troyanskaya. 2016. “Probabilistic Modelling of Chromatin Code Landscape Reveals Functional Diversity of Enhancer-Like Chromatin States.”. Nat Commun 7: 10528. Reference Link
Chen, Kathleen M, Evan M Cofer, Jian Zhou, and Olga G Troyanskaya. (2019) 2019. “Selene: A PyTorch-Based Deep Learning Library for Sequence Data.”. Nat Methods 16 (4): 315-18. doi:10.1038/s41592-019-0360-8. Reference Link
Myers, Chad L, Xing Chen, and Olga G Troyanskaya. 2005. “Visualization-Based Discovery and Analysis of Genomic Aberrations in Microarray Data.”. BMC Bioinformatics 6: 146. Reference Link
Troyanskaya, Olga G. (2005) 2005. “Putting Microarrays in a Context: Integrated Analysis of Diverse Biological Data.”. Brief Bioinform 6 (1): 34-43. Reference Link
Kristensen, Vessela N, Charles J Vaske, Josie Ursini-Siegel, Peter Van Loo, Silje H Nordgard, Ravi Sachidanandam, Therese Sørlie, et al. (2012) 2012. “Integrated Molecular Profiles of Invasive Breast Tumors and Ductal Carcinoma in Situ (DCIS) Reveal Differential Vascular and Interleukin Signaling.”. Proc Natl Acad Sci U S A 109 (8): 2802-7. Reference Link
Park, Christopher Y, Aaron K Wong, Casey S Greene, Jessica Rowland, Yuanfang Guan, Lars A Bongo, Rebecca Burdine, and Olga G Troyanskaya. 2013. “Functional Knowledge Transfer for High-Accuracy Prediction of under-Studied Biological Processes.”. PLoS Comput Biol 9 (3): e1002957. Reference Link
Bradley, Patrick H, Matthew J Brauer, Joshua D Rabinowitz, and Olga G Troyanskaya. (2009) 2009. “Coordinated Concentration Changes of Transcripts and Metabolites in Saccharomyces Cerevisiae.”. PLoS Comput Biol 5 (1): e1000270. Reference Link
Gorenshteyn, Dmitriy, Elena Zaslavsky, Miguel Fribourg, Christopher Y Park, Aaron K Wong, Alicja Tadych, Boris M Hartmann, et al. (2015) 2015. “Interactive Big Data Resource to Elucidate Human Immune Pathways and Diseases.”. Immunity 43 (3): 605-14. Reference Link
Lee, Young-suk, Arjun Krishnan, Rose Oughtred, Jennifer Rust, Christie S Chang, Joseph Ryu, Vessela N Kristensen, Kara Dolinski, Chandra L Theesfeld, and Olga G Troyanskaya. (2019) 2019. “A Computational Framework for Genome-Wide Characterization of the Human Disease Landscape.”. Cell Syst 8 (2): 152-162.e6. doi:10.1016/j.cels.2018.12.010. Reference Link
Hibbs, Matthew A, Nathaniel C Dirksen, Kai Li, and Olga G Troyanskaya. 2005. “Visualization Methods for Statistical Analysis of Microarray Clusters.”. BMC Bioinformatics 6: 115. Reference Link
Guan, Yuanfang, Chad L Myers, David C Hess, Zafer Barutcuoglu, Amy A Caudy, and Olga G Troyanskaya. 2008. “Predicting Gene Function in a Hierarchical Context With an Ensemble of Classifiers.”. Genome Biol 9 Suppl 1: S3. Reference Link
Pop, Ana, Curtis Huttenhower, Anjali Iyer-Pascuzzi, Philip N Benfey, and Olga G Troyanskaya. 2010. “Integrated Functional Networks of Process, Tissue, and Developmental Stage Specific Interactions in Arabidopsis Thaliana.”. BMC Syst Biol 4: 180. Reference Link
Guan, Yuanfang, Cheryl L Ackert-Bicknell, Braden Kell, Olga G Troyanskaya, and Matthew A Hibbs. 2010. “Functional Genomics Complements Quantitative Genetics in Identifying Disease-Gene Associations.”. PLoS Comput Biol 6 (11): e1000991. Reference Link
Myers, Chad L, and Olga G Troyanskaya. (2007) 2007. “Context-Sensitive Data Integration and Prediction of Biological Networks.”. Bioinformatics 23 (17): 2322-30. Reference Link
Roberts, Andrew M, Aaron K Wong, Ian Fisk, and Olga G Troyanskaya. (2016) 2016. “GIANT API: An Application Programming Interface for Functional Genomics.”. Nucleic Acids Res. Reference Link
Sargin, Derya, Revathy U Chottekalapanda, Kristina E Perit, Victoria Yao, Duong Chu, Daniel W Sparks, Salina Kalik, et al. (2019) 2019. “Mapping the Physiological and Molecular Markers of Stress and SSRI Antidepressant Treatment in S100a10 Corticostriatal Neurons.”. Mol Psychiatry. doi:10.1038/s41380-019-0473-6. Reference Link
Chen, Xin, Suet Y Leung, Siu T Yuen, Kent-Man Chu, Jiafu Ji, Rui Li, Annie S Y Chan, et al. (2003) 2003. “Variation in Gene Expression Patterns in Human Gastric Cancers.”. Mol Biol Cell 14 (8): 3208-15. Reference Link
Zhou, Jian, and Olga G Troyanskaya. (2015) 2015. “Predicting Effects of Noncoding Variants With Deep Learning-Based Sequence Model.”. Nat Methods. Reference Link
Troyanskaya, Olga G. 2007. “Integrated Analysis of Microarray Results.”. Methods Mol Biol 382: 429-37. Reference Link
Guan, Yuanfang, Maitreya Dunham, and Olga G Troyanskaya. (2007) 2007. “Functional Analysis of Gene Duplications in Saccharomyces Cerevisiae.”. Genetics 175 (2): 933-43. Reference Link
Hess, David C, Chad L Myers, Curtis Huttenhower, Matthew A Hibbs, Alicia P Hayes, Jadine Paw, John J Clore, et al. (2009) 2009. “Computationally Driven, Quantitative Experiments Discover Genes Required for Mitochondrial Biogenesis.”. PLoS Genet 5 (3): e1000407. Reference Link
Watson, Emma, Viridiana Olin-Sandoval, Michael J Hoy, Chi-Hua Li, Timo Louisse, Victoria Yao, Akihiro Mori, et al. (2016) 2016. “Metabolic Network Rewiring of Propionate Flux Compensates Vitamin B12 Deficiency in C. Elegans.”. Elife 5. doi:10.7554/eLife.17670. Reference Link
Zhou, Jian, Ignacio E Schor, Victoria Yao, Chandra L Theesfeld, Raquel Marco-Ferreres, Alicja Tadych, Eileen E M Furlong, and Olga G Troyanskaya. (2019) 2019. “Accurate Genome-Wide Predictions of Spatio-Temporal Gene Expression During Embryonic Development.”. PLoS Genet 15 (9): e1008382. doi:10.1371/journal.pgen.1008382. Reference Link
Bohen, Sean P, Olga G Troyanskaya, Orly Alter, Roger Warnke, David Botstein, Patrick O Brown, and Ronald Levy. (2003) 2003. “Variation in Gene Expression Patterns in Follicular Lymphoma and the Response to Rituximab.”. Proc Natl Acad Sci U S A 100 (4): 1926-30. Reference Link
Airoldi, Edoardo M, Curtis Huttenhower, David Gresham, Charles Lu, Amy A Caudy, Maitreya Dunham, James R Broach, David Botstein, and Olga G Troyanskaya. (2009) 2009. “Predicting Cellular Growth from Gene Expression Signatures.”. PLoS Comput Biol 5 (1): e1000257. Reference Link
Aure, Miriam R, Suvi-Katri Leivonen, Thomas Fleischer, Qian Zhu, Jens Overgaard, Jan Alsner, Trine Tramm, et al. 2013. “Individual and Combined Effects of DNA Methylation and Copy Number Alterations on MiRNA Expression in Breast Tumors.”. Genome Biol 14 (11): R126. Reference Link
Goya, Jonathan, Aaron K Wong, Victoria Yao, Arjun Krishnan, Max Homilius, and Olga G Troyanskaya. (2015) 2015. “FNTM: A Server for Predicting Functional Networks of Tissues in Mouse.”. Nucleic Acids Res. Reference Link
Markowetz, Florian, and Olga G Troyanskaya. (2007) 2007. “Computational Identification of Cellular Networks and Pathways.”. Mol Biosyst 3 (7): 478-82. Reference Link