Rabinowitz, Joshua D, Peter M Lloyd, Patrik Munzar, Daniel J Myers, Steve Cross, Ramesh Damani, Reynaldo Quintana, Daniel A Spyker, Pravin Soni, and James Cassella V. (2006) 2006. “Ultra-Fast Absorption of Amorphous Pure Drug Aerosols via Deep Lung Inhalation.”. J Pharm Sci 95 (11): 2438-51. Reference Link
Waters, Christopher M, Wenyun Lu, Joshua D Rabinowitz, and Bonnie L Bassler. (2008) 2008. “Quorum Sensing Controls Biofilm Formation in Vibrio Cholerae through Modulation of Cyclic Di-GMP Levels and Repression of VpsT.”. J Bacteriol 190 (7): 2527-36. Reference Link
Lu, Wenyun, Yun Kyung Kwon, and Joshua D Rabinowitz. (2007) 2007. “Isotope Ratio-Based Profiling of Microbial Folates.”. J Am Soc Mass Spectrom 18 (5): 898-909. Reference Link
Castellana, Michele, Maxwell Z Wilson, Yifan Xu, Preeti Joshi, Ileana M Cristea, Joshua D Rabinowitz, Zemer Gitai, and Ned S Wingreen. (2014) 2014. “Enzyme Clustering Accelerates Processing of Intermediates through Metabolic Channeling.”. Nat Biotechnol 32 (10): 1011-8. Reference Link
DiMaggio, Peter A, Scott R McAllister, Christodoulos A Floudas, Xiao-Jiang Feng, Joshua D Rabinowitz, and Herschel A Rabitz. 2008. “Biclustering via Optimal Re-Ordering of Data Matrices in Systems Biology: Rigorous Methods and Comparative Studies.”. BMC Bioinformatics 9: 458. Reference Link
Titchenell, Paul M, William J Quinn, Mingjian Lu, Qingwei Chu, Wenyun Lu, Changhong Li, Helen Chen, et al. 2016. “Direct Hepatocyte Insulin Signaling Is Required for Lipogenesis But Is Dispensable for the Suppression of Glucose Production.”. Cell Metab. doi:10.1016/j.cmet.2016.04.022. Reference Link
Papazyan, Romeo, Zheng Sun, Yong Hoon Kim, Paul M Titchenell, David A Hill, Wenyun Lu, Manashree Damle, et al. (2016) 2016. “Physiological Suppression of Lipotoxic Liver Damage by Complementary Actions of HDAC3 and SCAP SREBP.”. Cell Metab 24 (6): 863-74. doi:10.1016/j.cmet.2016.10.012. Reference Link
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Li, Sophia Hsin-Jung, Zhiyuan Li, Junyoung O Park, Christopher G King, Joshua D Rabinowitz, Ned S Wingreen, and Zemer Gitai. (2018) 2018. “Escherichia Coli Translation Strategies Differ across Carbon, Nitrogen and Phosphorus Limitation Conditions.”. Nat Microbiol 3 (8): 939-47. doi:10.1038/s41564-018-0199-2. Reference Link
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Rajeshkumar, N, V, Prasanta Dutta, Shinichi Yabuuchi, Roeland F de Wilde, Gary Martinez V, Anne Le, Jurre J Kamphorst, et al. (2015) 2015. “Therapeutic Targeting of the Warburg Effect in Pancreatic Cancer Relies on an Absence of p53 Function.”. Cancer Res 75 (16): 3355-64. Reference Link
Lemons, Johanna M S, Xiao-Jiang Feng, Bryson D Bennett, Aster Legesse-Miller, Elizabeth L Johnson, Irene Raitman, Elizabeth A Pollina, Herschel A Rabitz, Joshua D Rabinowitz, and Hilary A Coller. 2010. “Quiescent Fibroblasts Exhibit High Metabolic Activity.”. PLoS Biol 8 (10): e1000514. Reference Link
Kimball, Elizabeth, and Joshua D Rabinowitz. (2006) 2006. “Identifying Decomposition Products in Extracts of Cellular Metabolites.”. Anal Biochem 358 (2): 273-80. Reference Link
Munger, Joshua, Sunil U Bajad, Hilary A Coller, Thomas Shenk, and Joshua D Rabinowitz. (2006) 2006. “Dynamics of the Cellular Metabolome During Human Cytomegalovirus Infection.”. PLoS Pathog 2 (12): e132. Reference Link
Xu, Yi-Fan, Wenyun Lu, and Joshua D Rabinowitz. (2015) 2015. “Avoiding Misannotation of in-Source Fragmentation Products As Cellular Metabolites in Liquid Chromatography-Mass Spectrometry-Based Metabolomics.”. Anal Chem 87 (4): 2273-81. Reference Link
Ducker, Gregory S, Li Chen, Raphael J Morscher, Jonathan M Ghergurovich, Mark Esposito, Xin Teng, Yibin Kang, and Joshua D Rabinowitz. (2016) 2016. “Reversal of Cytosolic One-Carbon Flux Compensates for Loss of the Mitochondrial Folate Pathway.”. Cell Metab. doi:10.1016/j.cmet.2016.04.016. Reference Link
Hong, Sungguan, Wenjun Zhou, Bin Fang, Wenyun Lu, Emanuele Loro, Manashree Damle, Guolian Ding, et al. (2017) 2017. “Dissociation of Muscle Insulin Sensitivity from Exercise Endurance in Mice by HDAC3 Depletion.”. Nat Med 23 (2): 223-34. doi:10.1038/nm.4245. Reference Link
Hui, Sheng, Jonathan M Ghergurovich, Raphael J Morscher, Cholsoon Jang, Xin Teng, Wenyun Lu, Lourdes A Esparza, et al. (2017) 2017. “Glucose Feeds the TCA Cycle via Circulating Lactate.”. Nature 551 (7678): 115-18. doi:10.1038/nature24057. Reference Link
Guan, Dongyin, Ying Xiong, Patricia C Borck, Cholsoon Jang, Paschalis-Thomas Doulias, Romeo Papazyan, Bin Fang, et al. (2018) 2018. “Diet-Induced Circadian Enhancer Remodeling Synchronizes Opposing Hepatic Lipid Metabolic Processes.”. Cell 174 (4): 831-842.e12. doi:10.1016/j.cell.2018.06.031. Reference Link
Dekhne, Aamod S, Khushbu Shah, Gregory S Ducker, Jade M Katinas, Jennifer Wong-Roushar, Md Junayed Nayeen, Arpit Doshi, et al. (2019) 2019. “Novel pyrrolo[3,2-d]pyrimidine Compounds Target Mitochondrial and Cytosolic One-Carbon Metabolism With Broad-Spectrum Antitumor Efficacy.”. Mol Cancer Ther. doi:10.1158/1535-7163.MCT-19-0037. Reference Link
Rabinowitz, Joshua D, and Livia Vastag. (2012) 2012. “Teaching the Design Principles of Metabolism.”. Nat Chem Biol 8 (6): 497-501. Reference Link
Fan, Jing, Jiangbin Ye, Jurre J Kamphorst, Tomer Shlomi, Craig B Thompson, and Joshua D Rabinowitz. (2014) 2014. “Quantitative Flux Analysis Reveals Folate-Dependent NADPH Production.”. Nature 510 (7504): 298-302. Reference Link
Kamphorst, Jurre J, Justin R Cross, Jing Fan, Elisa de Stanchina, Robin Mathew, Eileen P White, Craig B Thompson, and Joshua D Rabinowitz. (2013) 2013. “Hypoxic and Ras-Transformed Cells Support Growth by Scavenging Unsaturated Fatty Acids from Lysophospholipids.”. Proc Natl Acad Sci U S A 110 (22): 8882-7. Reference Link
Kwon, Yun Kyung, Wenyun Lu, Eugene Melamud, Nurussaba Khanam, Andrew Bognar, and Joshua D Rabinowitz. (2008) 2008. “A Domino Effect in Antifolate Drug Action in Escherichia Coli.”. Nat Chem Biol 4 (10): 602-8. Reference Link
Karsli-Uzunbas, Gizem, Jessie Yanxiang Guo, Sandy Price, Xin Teng, Saurabh Laddha V, Sinan Khor, Nada Y Kalaany, et al. (2014) 2014. “Autophagy Is Required for Glucose Homeostasis and Lung Tumor Maintenance.”. Cancer Discov 4 (8): 914-27. Reference Link
Rabinowitz, Joshua D, and Hilary A Coller. 2016. “Partners in the Warburg Effect.”. Elife 5. Reference Link
Davidson, Shawn M, Oliver Jonas, Mark A Keibler, Han Wei Hou, Alba Luengo, Jared R Mayers, Jeffrey Wyckoff, et al. (2017) 2017. “Direct Evidence for Cancer-Cell-Autonomous Extracellular Protein Catabolism in Pancreatic Tumors.”. Nat Med 23 (2): 235-41. doi:10.1038/nm.4256. Reference Link
Ducker, Gregory S, Jonathan M Ghergurovich, Nello Mainolfi, Vipin Suri, Stephanie K Jeong, Sophia Hsin-Jung Li, Adam Friedman, et al. (2017) 2017. “Human SHMT Inhibitors Reveal Defective Glycine Import As a Targetable Metabolic Vulnerability of Diffuse Large B-Cell Lymphoma.”. Proc Natl Acad Sci U S A 114 (43): 11404-9. doi:10.1073/pnas.1706617114. Reference Link
Hui, Sheng, and Joshua D Rabinowitz. (2018) 2018. “An Unexpected Trigger for Calorie Burning in Brown Fat.”. Nature 560 (7716): 38-39. doi:10.1038/d41586-018-05619-7. Reference Link
Ron-Harel, Noga, Jonathan M Ghergurovich, Giulia Notarangelo, Martin W LaFleur, Yoshiki Tsubosaka, Arlene H Sharpe, Joshua D Rabinowitz, and Marcia C Haigis. (2019) 2019. “T Cell Activation Depends on Extracellular Alanine.”. Cell Rep 28 (12): 3011-3021.e4. doi:10.1016/j.celrep.2019.08.034. Reference Link
Munger, Joshua, Bryson D Bennett, Anuraag Parikh, Xiao-Jiang Feng, Jessica McArdle, Herschel A Rabitz, Thomas Shenk, and Joshua D Rabinowitz. (2008) 2008. “Systems-Level Metabolic Flux Profiling Identifies Fatty Acid Synthesis As a Target for Antiviral Therapy.”. Nat Biotechnol 26 (10): 1179-86. Reference Link
Kamphorst, Jurre J, Michelle K Chung, Jing Fan, and Joshua D Rabinowitz. 2014. “Quantitative Analysis of Acetyl-CoA Production in Hypoxic Cancer Cells Reveals Substantial Contribution from Acetate.”. Cancer Metab 2: 23. Reference Link
Fan, Jing, Xin Teng, Ling Liu, Katherine R Mattaini, Ryan E Looper, Matthew G Vander Heiden, and Joshua D Rabinowitz. (2014) 2014. “Human Phosphoglycerate Dehydrogenase Produces the Oncometabolite D-2-Hydroxyglutarate.”. ACS Chem Biol. Reference Link
Piazza, Matthew, Xiao-Jiang Feng, Joshua D Rabinowitz, and Herschel Rabitz. (2008) 2008. “Diverse Metabolic Model Parameters Generate Similar Methionine Cycle Dynamics.”. J Theor Biol 251 (4): 628-39. Reference Link
Rabinowitz, Joshua D, and Eileen White. (2010) 2010. “Autophagy and Metabolism.”. Science 330 (6009): 1344-8. Reference Link
Zong, Wei-Xing, Joshua D Rabinowitz, and Eileen White. (2016) 2016. “Mitochondria and Cancer.”. Mol Cell 61 (5): 667-76. Reference Link
Su, Xiaoyang, Wenyun Lu, and Joshua D Rabinowitz. (2017) 2017. “Metabolite Spectral Accuracy on Orbitraps.”. Anal Chem 89 (11): 5940-48. doi:10.1021/acs.analchem.7b00396. Reference Link
Pavlova, Natalya N, Sheng Hui, Jonathan M Ghergurovich, Jing Fan, Andrew M Intlekofer, Richard M White, Joshua D Rabinowitz, Craig B Thompson, and Ji Zhang. (2018) 2018. “As Extracellular Glutamine Levels Decline, Asparagine Becomes an Essential Amino Acid.”. Cell Metab 27 (2): 428-438.e5. doi:10.1016/j.cmet.2017.12.006. Reference Link
Xu, Yi-Fan, Wenyun Lu, Jonathan C Chen, Sarah A Johnson, Patrick A Gibney, David G Thomas, Greg Brown, et al. (2018) 2018. “Discovery and Functional Characterization of a Yeast Sugar Alcohol Phosphatase.”. ACS Chem Biol 13 (10): 3011-20. doi:10.1021/acschembio.8b00804. Reference Link
Park, Junyoung O, Lukas B Tanner, Monica H Wei, Daven B Khana, Tyler B Jacobson, Zheyun Zhang, Sara A Rubin, et al. (2019) 2019. “Near-Equilibrium Glycolysis Supports Metabolic Homeostasis and Energy Yield.”. Nat Chem Biol 15 (10): 1001-8. doi:10.1038/s41589-019-0364-9. Reference Link
Amador-Noguez, Daniel, Xiao-Jiang Feng, Jing Fan, Nathaniel Roquet, Herschel Rabitz, and Joshua D Rabinowitz. (2010) 2010. “Systems-Level Metabolic Flux Profiling Elucidates a Complete, Bifurcated Tricarboxylic Acid Cycle in Clostridium Acetobutylicum.”. J Bacteriol 192 (17): 4452-61. Reference Link
Reaves, Marshall Louis, Brian D Young, Aaron M Hosios, Yi-Fan Xu, and Joshua D Rabinowitz. (2013) 2013. “Pyrimidine Homeostasis Is Accomplished by Directed Overflow Metabolism.”. Nature 500 (7461): 237-41. Reference Link
Kamphorst, Jurre J, Michel Nofal, Cosimo Commisso, Sean R Hackett, Wenyun Lu, Elda Grabocka, Matthew G Vander Heiden, et al. (2015) 2015. “Human Pancreatic Cancer Tumors Are Nutrient Poor and Tumor Cells Actively Scavenge Extracellular Protein.”. Cancer Res 75 (3): 544-53. Reference Link
Vastag, Livia, Emre Koyuncu, Sarah L Grady, Thomas E Shenk, and Joshua D Rabinowitz. (2011) 2011. “Divergent Effects of Human Cytomegalovirus and Herpes Simplex Virus-1 on Cellular Metabolism.”. PLoS Pathog 7 (7): e1002124. Reference Link
Zhang, Ji, Jing Fan, Sriram Venneti, Justin R Cross, Toshimitsu Takagi, Bhavneet Bhinder, Hakim Djaballah, et al. (2014) 2014. “Asparagine Plays a Critical Role in Regulating Cellular Adaptation to Glutamine Depletion.”. Mol Cell 56 (2): 205-18. Reference Link
Park, Junyoung O, Sara A Rubin, Yi-Fan Xu, Daniel Amador-Noguez, Jing Fan, Tomer Shlomi, and Joshua D Rabinowitz. (2016) 2016. “Metabolite Concentrations, Fluxes and Free Energies Imply Efficient Enzyme Usage.”. Nat Chem Biol. Reference Link
Lu, Wenyun, Lin Wang, Li Chen, Sheng Hui, and Joshua D Rabinowitz. (2017) 2017. “Extraction and Quantitation of Nicotinamide Adenine Dinucleotide Redox Cofactors.”. Antioxid Redox Signal. doi:10.1089/ars.2017.7014. Reference Link
Morscher, Raphael J, Gregory S Ducker, Sophia Hsin-Jung Li, Johannes A Mayer, Zemer Gitai, Wolfgang Sperl, and Joshua D Rabinowitz. (2018) 2018. “Mitochondrial Translation Requires Folate-Dependent TRNA Methylation.”. Nature 554 (7690): 128-32. doi:10.1038/nature25460. Reference Link
Poillet-Perez, Laura, Xiaoqi Xie, Le Zhan, Yang Yang, Daniel W Sharp, Zhixian Sherrie Hu, Xiaoyang Su, et al. (2018) 2018. “Autophagy Maintains Tumour Growth through Circulating Arginine.”. Nature 563 (7732): 569-73. doi:10.1038/s41586-018-0697-7. Reference Link
Stine, Rachel R, Alexander P Sakers, Tara TeSlaa, Megan Kissig, Zachary E Stine, Chan Wook Kwon, Lan Cheng, et al. (2019) 2019. “PRDM16 Maintains Homeostasis of the Intestinal Epithelium by Controlling Region-Specific Metabolism.”. Cell Stem Cell. doi:10.1016/j.stem.2019.08.017. Reference Link