A computational statistics approach for estimating the spatial range of morphogen gradients.

Publication Year
2011

Type

Journal Article
Abstract

A crucial issue in studies of morphogen gradients relates to their range: the distance over which they can act as direct regulators of cell signaling, gene expression and cell differentiation. To address this, we present a straightforward statistical framework that can be used in multiple developmental systems. We illustrate the developed approach by providing a point estimate and confidence interval for the spatial range of the graded distribution of nuclear Dorsal, a transcription factor that controls the dorsoventral pattern of the Drosophila embryo.

Journal
Development
Volume
138
Issue
22
Pages
4867-74
Date Published
11/2011
Alternate Journal
Development