Chemical Sensing by Nonequilibrium Cooperative Receptors. Author Monica Skoge, Sahin Naqvi, Yigal Meir, Ned Wingreen Publication Year 2013 Type Journal Article Abstract Cooperativity arising from local interactions in equilibrium receptor systems provides gain, but does not increase sensory performance, as measured by the signal-to-noise ratio (SNR) due to a fundamental tradeoff between gain and intrinsic noise. Here we allow sensing to be a nonequilibrium process and show that energy dissipation cannot circumvent the fundamental tradeoff, so that the SNR is still optimal for independent receptors. For systems requiring high gain, nonequilibrium 2D-coupled receptors maximize the SNR, revealing a new design principle for biological sensors. Journal Phys Rev Lett Volume 110 Issue 24 Date Published 06/2013 Alternate Journal Phys. Rev. Lett. Google ScholarBibTeXEndNote X3 XML