The Lewis-Sigler Institute for Integrative Genomics (LSI) at Princeton University was established with a mandate to create innovative research and teaching programs at the interface of modern biology and the more quantitative sciences. One impetus came from the need to deal with the explosion of information based on the genomic sequences of humans and all major experimental organisms. The other major impetus came from the realization that the most interesting and difficult problems in the quantitative disciplines, especially physics, chemistry and computer science, frequently lie in biological phenomena and applications.

Now in its third decade, the LSI is building upon its strong nucleus of a thoroughly modern institute for systems biology, with its combination of high-throughput genome technologies, computational analytics, and quantitative modeling, to expand into areas including mammalian systems biology and the temporal dynamics and quantitative visualization of conserved cellular processes.