TitlePhospholipase A2 group IIA expression in gastric adenocarcinoma is associated with prolonged survival and less frequent metastasis.
Publication TypeJournal Article
Year of Publication2002
AuthorsLeung, SY, Chen, X, Chu, KM, Yuen, ST, Mathy, J, Ji, J, S Y Chan, A, Li, R, Law, S, Troyanskaya, OG, Tu, I-P, Wong, J, So, S, Botstein, D, Brown, PO
JournalProc Natl Acad Sci U S A
Date Published2002 Dec 10
KeywordsAdenocarcinoma, Disease Progression, DNA, Complementary, Enzyme Induction, Gastric Mucosa, Gene Expression Profiling, Gene Expression Regulation, Neoplastic, Group II Phospholipases A2, Humans, In Situ Hybridization, Life Tables, Neoplasm Proteins, Oligonucleotide Array Sequence Analysis, Phospholipases A, Phospholipases A2, Prognosis, Reverse Transcriptase Polymerase Chain Reaction, Stomach Neoplasms, Survival Analysis

We analyzed gene expression patterns in human gastric cancers by using cDNA microarrays representing approximately equal 30,300 genes. Expression of PLA2G2A, a gene previously implicated as a modifier of the Apc(Min/+) (multiple intestinal neoplasia 1) mutant phenotype in the mouse, was significantly correlated with patient survival. We confirmed this observation in an independent set of patient samples by using quantitative RT-PCR. Beyond its potential diagnostic and prognostic significance, this result suggests the intriguing possibility that the activity of PLA2G2A may suppress progression or metastasis of human gastric cancer.

Alternate JournalProc. Natl. Acad. Sci. U.S.A.