Thomas Gregor Position Professor of Physics and the Lewis-Sigler Institute for Integrative Genomics Title Physics and the Lewis-Sigler Institute for Integrative Genomics CV Thomas Gregor CV Office Phone 609-258-4335 Email [email protected] Office 122 Jadwin Hall Bio/Description Research FocusBiophysical Approaches to Systems and Developmental Biology My group studies the basic physical principles that govern the existence of multicellular life. A core focus of the lab is to understand biological development–the complex process through which an organism grows from a single cell into a differentiated, multicellular organism–from a physics perspective. As such, we formulate and experimentally validate quantitative models that describe how individual cells interact and organize in order to generate complex life forms.Our main interests lie in:multicellular pattern formationtranscriptional regulation in the context of developmentmolecular limits to biochemical sensingemergence of collective behaviors in multicellular systems.Our main tools consist in:live and super-resolution microscopygenome editing and geneticsimage analysis and quantitative modelinginstrument design and development.We are looking for Ph.D. and postdoc candidates with interests in the broader fields of biophysics and/or cell and developmental biology. In particular, physicists or engineers with expertise in a subset of nonlinear and ultrafast optics, super-resolution imaging, instrumentation (design and implementation), photomanipulation, optogenetics, advanced image analysis, statistics, live imaging of stem cells, tissues, or embryos; biologists or computer scientists with expertise in a subset of insect or mammalian development, gene regulation and epigenetics, cloning and transfection, genetics, live imaging.Specific topics (in progress…):precision and reproducibility in early mammalian developmentsize control in insect developmentsuper-resolution imaging of subnuclear structuresoptogenetic pathway activationinformation transmission in developmental pathwaysPlease do not hesitate to contact me if you are a potentially interested undergraduate student, graduate student, postdoc, or collaborator. For more information please visit my laboratory's homepage.Complete list of PublicationsGoogle Scholar Selected Publications Petkova, Mariela, Gašper Tkačik, William Bialek, Eric Wieschaus, and Thomas Gregor. (2019) 2019. “Optimal Decoding of Cellular Identities in a Genetic Network.”. Cell 176 (4): 844-855.e15. doi:10.1016/j.cell.2019.01.007. Zoller, Benjamin, Shawn Little, and Thomas Gregor. (2018) 2018. “Diverse Spatial Expression Patterns Emerge from Unified Kinetics of Transcriptional Bursting.”. Cell 175 (3): 835-847.e25. doi:10.1016/j.cell.2018.09.056. Chen, Hongtao, Michal Levo, Lev Barinov, Miki Fujioka, James Jaynes, and Thomas Gregor. (2018) 2018. “Dynamic Interplay Between Enhancer-Promoter Topology and Gene Activity.”. Nature Genetics 50 (9): 1296-1303. doi:10.1038/s41588-018-0175-z. Gregor, Thomas, Hernan G Garcia, and Shawn C Little. (2014) 2014. “The Embryo As a Laboratory: Quantifying Transcription in Drosophila.”. Trends Genet 30 (8): 364-75. Related News Transcriptional coupling of distant regulatory genes in living embryosHow the fruit fly got its stripes: Researchers explore the precision of embryonic development Program(s) Biophysics Graduate Program NIH NHGRI Training Program QCB Graduate Program Research Area Biophysics: Theory and Experiment Systems Biology: Development/Aging LSI Research Lab Gregor Research Lab