Stanislav Y. Shvartsman

Professor, Molecular Biology and the Lewis-Sigler Institute for Integrative Genomics
NIGMS Postdoctoral Fellow, Massachusetts Institute of Technology, 1999-2001
Molecular Biology and the Lewis-Sigler Institute for Integrative Genomics
Office Phone
248 Carl Icahn Laboratory

The 3 main research areas that I am involved in are:

  1. Quantitative cell signaling and metabolism.
  2. Pattern formation and gene expression
  3. Mechanisms of developmental abnormalities.

Research Focus

Dynamics of living tissues

Our lab uses experiments, theory, and computation to develop predictive models of dynamical processes in cells and tissues. We are interested in the extent to which simple physicochemical principles can be discerned in complex biological systems, such as developing embryos. Current projects in the group fall into three broad categories. First, we are developing quantitative descriptions of enzymatic networks. The experimental systems here are Drosophila embryos and theory is based on more or less conventional chemical kinetics models. Second, we are studying the processes by which two-dimensional sheets of cells give rise to three-dimensional structures of tissues and organs. Here, experiments are done in developing Drosophila eggs and zebrafish embryos and theory relies on either continuum or discrete mechanical models of epithelial tissues. Third, we are studying how developing tissues manage their constant need for energy. This project is still very young; we are exploring multiple avenues for quantitative experiments, from single embryo calorimetry to in vivo imaging of mitochondrial networks and cell metabolism.

Complete list of Publications

Selected Publications

NIH NHGRI Training Program
Biophysics Graduate Program
QCB Graduate Program
LSI Research Lab