Mona Singh Position Wang Family Professor in Computer Science and the Lewis Sigler Institute for Integrative Genomics Title Computer Science and the Lewis-Sigler Institute for Integrative Genomics Office Phone 609-258-2087 Email [email protected] Assistant Kevin Bernal Office 250 Carl Icahn Laboratory Bio/Description Research FocusComputational molecular biologyMy group develops algorithms for a diverse set of problems in computational molecular biology. We are particularly interested in predicting specificity in protein interactions and uncovering how molecular interactions and functions vary across context, organisms and individuals. We leverage high-throughput biological datasets in order to develop data-driven algorithms for predicting protein interactions and specificity; for analyzing biological networks in order to uncover cellular organization, functioning, and pathways; for uncovering protein functions via sequences and structures; and for analyzing proteomics and sequencing data. An appreciation of protein structure guides much of our research.Complete list of Publications Selected Publications Chacha, Prakriti, Ryoko Horie, Takehiro Kusakabe, Yasunori Sasakura, Mona Singh, Takeo Horie, and Michael Levine. (2022) 2022. “Neuronal Identities Derived by Misexpression of the POU IV Sensory Determinant in a Protovertebrate.”. Proceedings of the National Academy of Sciences of the United States of America 119 (4). doi:10.1073/pnas.2118817119. King, Sean, and Mona Singh. (2021) 2021. “Comparative Genomic Analysis Reveals Varying Levels of Mammalian Adaptation to Coronavirus Infections.”. PLoS Computational Biology 17 (11): e1009560. doi:10.1371/journal.pcbi.1009560. Chen, Li, Wenyun Lu, Lin Wang, Xi Xing, Ziyang Chen, Xin Teng, Xianfeng Zeng, et al. (2021) 2021. “Metabolite Discovery through Global Annotation of Untargeted Metabolomics Data.”. Nature Methods 18 (11): 1377-85. doi:10.1038/s41592-021-01303-3. Aluru, Chaitanya, and Mona Singh. (2021) 2021. “Improved Inference of Tandem Domain Duplications.”. Bioinformatics (Oxford, England) 37 (Suppl_1): i133-i141. doi:10.1093/bioinformatics/btab329. Etzion-Fuchs, Anat, David Todd, and Mona Singh. (2021) 2021. “DSPRINT: Predicting DNA, RNA, Ion, Peptide and Small Molecule Interaction Sites Within Protein Domains.”. Nucleic Acids Research 49 (13): e78. doi:10.1093/nar/gkab356. Marmion, Robert, Liu Yang, Yogesh Goyal, Granton Jindal, Joshua Wetzel, Mona Singh, Trudi Schüpbach, and Stanislav Shvartsman. (2021) 2021. “Molecular Mechanisms Underlying Cellular Effects of Human MEK1 Mutations.”. Molecular Biology of the Cell 32 (9): 974-83. doi:10.1091/mbc.E20-10-0625. Munro, Daniel, and Mona Singh. (2021) 2021. “DeMaSk: A Deep Mutational Scanning Substitution Matrix and Its Use for Variant Impact Prediction.”. Bioinformatics (Oxford, England) 36 (22-23): 5322-29. doi:10.1093/bioinformatics/btaa1030. Related News Mona Singh tailors tools to crack the cancer code Program(s) NIH NHGRI Training Program QCB Graduate Program Research Area Computational Genomics LSI Research Lab Singh Research Lab