Profile

Dr. McClean studies the design principles underlying the signal processing capabilities of biological networks. Cellular signaling networks transmit information about environmental stimuli to the interior of the cell where appropriate cellular responses take place. How these networks process their input dictates cellular behavior and fitness. She is interested in how signaling pathways and transcriptional networks are designed to appropriately filter input and set thresholds so that cells respond optimally to changes in their environment. She is also interested in understanding how these networks are adapted and fine-tuned throughout development (short timescale) or evolution (long timescale). Her lab takes an experimental approach combining microfluidics with microscopy to monitor the responses of signaling pathways to complex stimuli.

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