TitleOrthology and functional conservation in eukaryotes.
Publication TypeJournal Article
Year of Publication2007
AuthorsDolinski, K, Botstein, D
JournalAnnu Rev Genet
Date Published2007
KeywordsAnimals, Biological Evolution, Eukaryotic Cells, Humans, Saccharomyces cerevisiae, Species Specificity

In recent years, it has become clear that all of the organisms on the Earth are related to each other in ways that can be documented by molecular sequence comparison. In this review, we focus on the evolutionary relationships among the proteins of the eukaryotes, especially those that allow inference of function from one species to another. Data and illustrations are derived from specific comparison of eight species: Homo sapiens, Mus musculus, Arabidopsis thaliana, Caenorhabditis elegans, Danio rerio, Saccharomyces cerevisiae, and Plasmodium falciparum.

Alternate JournalAnnu. Rev. Genet.