Splicing Regulatory Networks in Nervous System Development
Monday, November 28, 2011 - 4:15pm to 5:15pm
Carl Icahn Lab 101
Home & Away Harvard-Princeton Series
Lewis-Sigler Institute

FAS Center for Systems Biology
Bauer Fellow

Reception follows seminar

Recent genome-wide analyses of transcriptomes from several metazoans have identified networks of spatio-temporally regulated alternative splicing events. The existence of these highly regulated splice variants, and their elevated levels of conservation relative to other classes of splicing events, suggests that they play critical roles in development and in the generation of tissue diversity. A major challenge that lies ahead is to determine the functional role of these isoforms in the cell and the mechanisms that govern their regulation. In this talk, I will discuss our work focusing on splicing regulation in the nervous system. First, I will present our discovery of a novel neural-specific splicing regulator and its role in vertebrate nervous system development. Additionally, I will present recent and ongoing research investigating developmental stage- and neuron-specific alternative splicing regulation in Caenorhabditis elegans.