Large populations may contain numerous simultaneously segregating polymorphisms subject to natural selection. In order to understand population genetics in this case, theoretical models must account for interactions between polymorphisms at different genetic loci and in different individuals. The effect of these interactions depends on the effective rate of recombination. The talk will use simple models of facultatively sexual populations (motivated by HIV intra-patient evolution) to provide quantitative insight into the effect of interaction and recombination on the dynamics of alleles.
Interaction and recombination in genetically diverse populations
Monday, November 21, 2011 - 12:00pm to 1:00pm
Joseph Henry Room, Jadwin Hall