The virulence of bacterial pathogens, like many other important processes, is multifactorial, genetically robust and under complex regulation. For the water-borne pathogen Vibrio cholerae we are utilizing high throughput genome-wide methods to identify factors that contribute to fitness at each stage of its life cycle. For the respiratory tract pathogen Streptococcus pneumoniae we are comparing in vitro with host environments in order to determine which specific selective forces play a role during infection and how they direct gene utilization and virulence. We are also determining which genes play a role in antibiotic resistance and how evolution has driven highly related strains into utilizing the same genes to different extents under the same circumstances (environments) and how this has resulted in strain-specific genetic networks.
Faculty profile for Andrew Camilli.