Abstract: Embryonic development and tissue regeneration both require a high degree of spatiotemporal coordination. I will describe my lab efforts to understand the synchronization of the cell cycle in early Drosophila embryos and the coordination of tissue growth in zebrafish bone regeneration. I will show how synchronization of the cell cycle in Drosophila embryo is linked to precise nuclear positioning, which is in turn driven by cytoplasmic flows generated by actomyosin cortical contractions. Cortical contractions are regulated by oscillations in the activity of mitotic phosphatase PP1, thus forming a self-organized mechanism through which nuclei drive their positioning and synchronization. I will also show that excitable waves of growth factor dynamics drive cell and tissue growth in the osteoblast population controlling zebrafish scale regeneration.
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