Multiple Inputs / Multiple Outputs information processing
Monday, November 6, 2017 - 12:00pm
Joseph Henry Room, Jadwin Hall
CUNY-Princeton Biophysics Seminar
Physics and Lewis-Sigler Institute

Cells perform signal/information processing functions typically in more complicated scenarios than one transmitter/one receiver, envisioned by Shannon. In this talk, I will show our recent results on advantages and limitations of various multiple inputs-multiple outputs information channels in cellular systems. I will talk about multiple receptors measuring the same signal, or multiple signals measured by one receptor, and eventually move to information processing properties of large random networks and of information relays. For the latter, in joint work with Andre Levchenko at Yale, we showed experimentally that cells in developing mammary ducts in mice exchange information through gap junctions in order to estimate collectively the incredibly small gradients of EGF that guide directed motility during development. We build a full theory of the information relay channel involved in this communication.