Regulating shape, size and topology of mitotic chromosomes
Monday, October 14, 2019 - 4:15pm
Icahn 101
Quantitative & Computational Biology

Abstract: During mitosis in eukaryotes, each genomic linear DNA is folded into an individualized chromosome with characteristic shape and size, which differ among cell types and species. While prevailing models suggest that chromosomes are shaped through DNA loop formation, mediated by chromosome-associated ATPases, condensins and DNA topoisomerase II, it remains unclear how these enzymes act on nucleosomes, the fundamental unit of chromatin where DNA wraps around histones. I will present our study on a new role of histones on controlling mitotic chromosome structure and function.

Hironori Funabiki

More information about Dr. Funabiki and his lab may be found here: