Mathematics and computation for cryo-electron microscopy
Abstract: Single particle cryo-electron microscopy (EM) recently joined X-ray crystallography and nuclear magnetic resonance (NMR) spectroscopy as a high-resolution structural method for biological macromolecules. Furthermore, cryo-EM has the potential to analyze compositionally and conformationally heterogeneous mixtures and, consequently, can be used to determine the structures of complexes in different functional states.
I will give an overview of the computational challenges in cryo-EM analysis and how we and others are trying to face them, focusing on 3-D ab-initio modelling and the heterogeneity problem of determining structural variability.
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