Mathematics and computation for cryo-electron microscopy
Thursday, November 10, 2016 - 12:30pm
Icahn 101
Quantitative & Computational Biology

Amit SingerMathematics and computation for cryo-electron microscopy

Abstract: Single particle cryo-electron microscopy (EM) recently joined X-ray crystallography and nuclear magnetic resonance (NMR) spectroscopy as a high-resolution structural method for biological macromolecules. Furthermore, cryo-EM has the potential to analyze compositionally and conformationally heterogeneous mixtures and, consequently, can be used to determine the structures of complexes in different functional states.

I will give an overview of the computational challenges in cryo-EM analysis and how we and others are trying to face them, focusing on 3-D ab-initio modelling and the heterogeneity problem of determining structural variability.


For more information about Prof. Singer's work: