TitleFor longevity, perception is everything.
Publication TypeJournal Article
Year of Publication2015
AuthorsLakhina, V, Murphy, CT
JournalCell
Volume160
Issue5
Pagination807-9
Date Published2015 Feb 26
ISSN1097-4172
KeywordsAnimals, Caenorhabditis elegans, Caenorhabditis elegans Proteins, Catecholamines, Mitochondria, Neurons, Signal Transduction, Trans-Activators
Abstract

Aging is a risk factor for chronic diseases, and identifying targets for intervention is a goal of the aging field. Burkewitz et al. now describe a mechanism that mediates the specific role for AMPK in longevity, whereby its activity in neurons modulates metabolism and mitochondrial integrity in peripheral tissues.
DOI10.1016/j.cell.2015.02.027
Alternate JournalCell
PubMed ID25723157