Lewis Sigler Scholars Program

A Click-chemistry based enrichable cross-linker for structural and protein interaction analysis by mass spectrometry.

M. Stadlmeier, Runtsch, L. Simon, Streshnev, F., Wühr, M., and Carell, T., “A Click-chemistry based enrichable cross-linker for structural and protein interaction analysis by mass spectrometry.”, Chembiochem, 2019.

The long walk to African genomics.

S. Tucci and Akey, J. M., “The long walk to African genomics.”, Genome Biol, vol. 20, no. 1, p. 130, 2019.

Two critical positions in zinc finger domains are heavily mutated in three human cancer types.

D. Munro, Ghersi, D., and Singh, M., “Two critical positions in zinc finger domains are heavily mutated in three human cancer types.”, PLoS Comput Biol, vol. 14, no. 6, p. e1006290, 2018.

Systematic domain-based aggregation of protein structures highlights DNA-, RNA- and other ligand-binding positions.

S. Nadimpalli Kobren and Singh, M., “Systematic domain-based aggregation of protein structures highlights DNA-, RNA- and other ligand-binding positions.”, Nucleic Acids Res, vol. 47, no. 2, pp. 582-593, 2019.

Comprehensive single-cell transcriptome lineages of a proto-vertebrate.

C. Cao, Lemaire, L. A., Wang, W., Yoon, P. H., Choi, Y. A., Parsons, L. R., Matese, J. C., Wang, W., Levine, M., and Chen, K., “Comprehensive single-cell transcriptome lineages of a proto-vertebrate.”, Nature, vol. 571, no. 7765, pp. 349-354, 2019.

Large distances separate coregulated genes in living embryos.

T. Heist, Fukaya, T., and Levine, M., “Large distances separate coregulated genes in living embryos.”, Proc Natl Acad Sci U S A, vol. 116, no. 30, pp. 15062-15067, 2019.

PRDM16 Maintains Homeostasis of the Intestinal Epithelium by Controlling Region-Specific Metabolism.

R. R. Stine, Sakers, A. P., TeSlaa, T., Kissig, M., Stine, Z. E., Kwon, C. Wook, Cheng, L., Lim, H. - W., Kaestner, K. H., Rabinowitz, J. D., and Seale, P., “PRDM16 Maintains Homeostasis of the Intestinal Epithelium by Controlling Region-Specific Metabolism.”, Cell Stem Cell, 2019.

Near-equilibrium glycolysis supports metabolic homeostasis and energy yield.

J. O. Park, Tanner, L. B., Wei, M. H., Khana, D. B., Jacobson, T. B., Zhang, Z., Rubin, S. A., Li, S. Hsin- Jung, Higgins, M. B., Stevenson, D. M., Amador-Noguez, D., and Rabinowitz, J. D., “Near-equilibrium glycolysis supports metabolic homeostasis and energy yield.”, Nat Chem Biol, vol. 15, no. 10, pp. 1001-1008, 2019.

T Cell Activation Depends on Extracellular Alanine.

N. Ron-Harel, Ghergurovich, J. M., Notarangelo, G., LaFleur, M. W., Tsubosaka, Y., Sharpe, A. H., Rabinowitz, J. D., and Haigis, M. C., “T Cell Activation Depends on Extracellular Alanine.”, Cell Rep, vol. 28, no. 12, pp. 3011-3021.e4, 2019.

A Computational Framework for Genome-wide Characterization of the Human Disease Landscape.

Y. -suk Lee, Krishnan, A., Oughtred, R., Rust, J., Chang, C. S., Ryu, J., Kristensen, V. N., Dolinski, K., Theesfeld, C. L., and Troyanskaya, O. G., “A Computational Framework for Genome-wide Characterization of the Human Disease Landscape.”, Cell Syst, vol. 8, no. 2, pp. 152-162.e6, 2019.

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