ICAhN Think & Drink with Lifeng Yang and Yuki Shindo

Lifeng Yang

Title: Effects of Mitochondrial Complex I Activity on Metabolism from in vitro to in vivo

Abstract: NADH provides electrons for aerobic ATP production. In cells with impaired mitochondrial complex I activity, NADH accumulation can be toxic. To minimize such toxicity, elevated NADH inhibits the classical NADH producing pathways: glucose, glutamine, and fatty acid oxidation. Here, through deuterium tracing studies in cultured cells and mice, we show that folate dependent serine catabolism also produces substantial NADH. Strikingly, when

ICAhN Think & Drink featuring Micah Nelp/Groves Lab

The heme enzyme indoleamine 2.3-dioxygenase (IDO1) regulates the immune response through the oxidation and depletion of tryptophan to produce N-formylkynurenine, in the first committed step of the kynurenine pathway. By depleting the local tissue environment of tryptophan, IDO1 activity stalls the proliferation of T-cells and promotes their conversion to T-regulatory cells, an effect further enhanced by downstream kynurenine products.