Lewis Sigler Scholars Program

ICAhN Think & Drink with Lifeng Yang and Yuki Shindo

Lifeng Yang

Title: Effects of Mitochondrial Complex I Activity on Metabolism from in vitro to in vivo

Abstract: NADH provides electrons for aerobic ATP production. In cells with impaired mitochondrial complex I activity, NADH accumulation can be toxic. To minimize such toxicity, elevated NADH inhibits the classical NADH producing pathways: glucose, glutamine, and fatty acid oxidation. Here, through deuterium tracing studies in cultured cells and mice, we show that folate dependent serine catabolism also produces substantial NADH. Strikingly, when

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ICAhN Think & Drink featuring Xi Chen and Pierre Ronceray

Xi Chen (Troyanskaya Lab)

"Tissue-specific enhancer functional networks for associating distal regulatory regions to disease"

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ICAhN Think & Drink featuring Micah Nelp/Groves Lab

The heme enzyme indoleamine 2.3-dioxygenase (IDO1) regulates the immune response through the oxidation and depletion of tryptophan to produce N-formylkynurenine, in the first committed step of the kynurenine pathway. By depleting the local tissue environment of tryptophan, IDO1 activity stalls the proliferation of T-cells and promotes their conversion to T-regulatory cells, an effect further enhanced by downstream kynurenine products.

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Energy budget of Drosophila embryogenesis.

Y. Song, Park, J. O., Tanner, L., Nagano, Y., Rabinowitz, J. D., and Shvartsman, S. Y., “Energy budget of Drosophila embryogenesis.”, Curr Biol, vol. 29, no. 12, pp. R566-R567, 2019.

A Two-Enzyme Adaptive Unit within Bacterial Folate Metabolism.

A. F. Schober, Mathis, A. D., Ingle, C., Park, J. O., Chen, L., Rabinowitz, J. D., Junier, I., Rivoire, O., and Reynolds, K. A., “A Two-Enzyme Adaptive Unit within Bacterial Folate Metabolism.”, Cell Rep, vol. 27, no. 11, pp. 3359-3370.e7, 2019.

The Tumor Metabolic Microenvironment: Lessons from Lactate.

J. C. García-Cañaveras, Chen, L., and Rabinowitz, J. D., “The Tumor Metabolic Microenvironment: Lessons from Lactate.”, Cancer Res, vol. 79, no. 13, pp. 3155-3162, 2019.

NADPH production by the oxidative pentose-phosphate pathway supports folate metabolism.

L. Chen, Zhang, Z., Hoshino, A., Zheng, H. D., Morley, M., Arany, Z., and Rabinowitz, J. D., “NADPH production by the oxidative pentose-phosphate pathway supports folate metabolism.”, Nat Metab, vol. 1, pp. 404-415, 2019.

Minor Isozymes Tailor Yeast Metabolism to Carbon Availability.

P. H. Bradley, Gibney, P. A., Botstein, D., Troyanskaya, O. G., and Rabinowitz, J. D., “Minor Isozymes Tailor Yeast Metabolism to Carbon Availability.”, mSystems, vol. 4, no. 1, 2019.

Serine Metabolism Supports Macrophage IL-1β Production.

A. E. Rodriguez, Ducker, G. S., Billingham, L. K., Martinez, C. A., Mainolfi, N., Suri, V., Friedman, A., Manfredi, M. G., Weinberg, S. E., Rabinowitz, J. D., and Chandel, N. S., “Serine Metabolism Supports Macrophage IL-1β Production.”, Cell Metab, vol. 29, no. 4, pp. 1003-1011.e4, 2019.

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